hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01784
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKAP9 | A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) | UniProt NCBI |
| AKAP1 | A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) | UniProt NCBI |
| PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | UniProt NCBI |
| AKAP11 | A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11) | UniProt NCBI |
| CDK5RAP2 | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) | UniProt NCBI |
| PRKACA | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11) | UniProt NCBI |
| AKAP14 | A-kinase anchor protein 14 (AKAP-14) (A-kinase anchor protein 28 kDa) (AKAP 28) (Protein kinase A-anchoring protein 14) (PRKA14) | UniProt NCBI |
| AKAP5 | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 79 kDa) (AKAP 79) (H21) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | UniProt NCBI |
| PRKACG | cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11) | UniProt NCBI |
| PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | UniProt NCBI |
| PRKACB | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP35 | 1.90695248789e-17 | 0.818181818182 | PRKACA PRKACB PRKAR2A AKAP1 AKAP9 PRKACG AKAP5 AKAP11 PRKAR2B | G Protein Signaling Pathways |
| GO:0051018 | 1.61452732522e-14 | 0.727272727273 | PRKACA PRKAR2A AKAP5 AKAP1 AKAP9 AKAP14 AKAP11 PRKAR2B | protein kinase A binding |
| REAC:R-HSA-9010642 | 9.2863201334e-13 | 0.454545454545 | AKAP5 PRKACG PRKACB PRKACA PRKAR2A | ROBO receptors bind AKAP5 |
| REAC:R-HSA-442720 | 7.65349689179e-12 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | CREB1 phosphorylation through the activation of Adenylate Cyclase |
| REAC:R-HSA-381676 | 1.07674183987e-11 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKACG AKAP5 PRKAR2B | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-163615 | 7.22388695951e-11 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | PKA activation |
| REAC:R-HSA-164378 | 1.02304013336e-10 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | PKA activation in glucagon signalling |
| REAC:R-HSA-111931 | 1.4160411413e-10 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | PKA-mediated phosphorylation of CREB |
| WP:WP2012 | 3.34512860058e-10 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | miRs in Muscle Cell Differentiation |
| WP:WP3965 | 4.99450047628e-10 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Lipid Metabolism Pathway |
| REAC:R-HSA-180024 | 5.55186257817e-10 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | DARPP-32 events |
| REAC:R-HSA-422356 | 7.8745617238e-10 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKACG AKAP5 PRKAR2B | Regulation of insulin secretion |
| REAC:R-HSA-163359 | 2.7958887615e-09 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-111997 | 3.90274254397e-09 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | CaM pathway |
| REAC:R-HSA-111933 | 3.90274254397e-09 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Calmodulin induced events |
| REAC:R-HSA-111996 | 5.33464439743e-09 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Ca-dependent events |
| REAC:R-HSA-163685 | 6.43882080532e-09 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKACG AKAP5 PRKAR2B | Integration of energy metabolism |
| REAC:R-HSA-432040 | 7.15823353922e-09 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-1489509 | 9.44863380121e-09 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | DAG and IP3 signaling |
| REAC:R-HSA-445717 | 9.44863380121e-09 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Aquaporin-mediated transport |
| CORUM:878 | 2.02774899104e-08 | 0.272727272727 | PRKAR2A PRKAR2B AKAP5 | PKA (RII-alpha and RII-beta)-AKAP5-ADRB1 complex |
| GO:0034199 | 2.33253150406e-08 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | activation of protein kinase A activity |
| GO:0034237 | 2.33253150406e-08 | 0.454545454545 | AKAP14 PRKACA AKAP5 AKAP9 AKAP1 | protein kinase A regulatory subunit binding |
| GO:0071377 | 2.33253150406e-08 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | cellular response to glucagon stimulus |
| REAC:R-HSA-112043 | 3.83946007528e-08 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | PLC beta mediated events |
| REAC:R-HSA-112040 | 4.24648359477e-08 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | G-protein mediated events |
| GO:0033762 | 4.38016352248e-08 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | response to glucagon |
| CORUM:520 | 8.10772781726e-08 | 0.272727272727 | PRKAR2A AKAP9 PRKACA | KCNQ1 macromolecular complex |
| WP:WP3869 | 9.57775712527e-08 | 0.363636363636 | PRKACG PRKACB PRKAR2B PRKACA | Cannabinoid receptor signaling |
| REAC:R-HSA-983231 | 1.30547877361e-07 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | Factors involved in megakaryocyte development and platelet production |
| WP:WP4540 | 1.84082250451e-07 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Pathways Regulating Hippo Signaling |
| REAC:R-HSA-112314 | 2.33038765476e-07 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKACG AKAP5 PRKAR2B | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-438064 | 2.43690058385e-07 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Post NMDA receptor activation events |
| GO:0097546 | 2.47205003583e-07 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | ciliary base |
| GO:0005952 | 2.81450928027e-07 | 0.363636363636 | AKAP14 PRKAR2A PRKACA PRKACB | cAMP-dependent protein kinase complex |
| WP:WP4541 | 4.12860489899e-07 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Hippo-Merlin Signaling Dysregulation |
| GO:0003091 | 4.45838145745e-07 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | renal water homeostasis |
| REAC:R-HSA-442755 | 4.99014338822e-07 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-111885 | 5.62551831799e-07 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Opioid Signalling |
| REAC:R-HSA-163358 | 6.56710154024e-07 | 0.272727272727 | PRKACG PRKACA PRKACB | PKA-mediated phosphorylation of key metabolic factors |
| KEGG:04910 | 7.67982906387e-07 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Insulin signaling pathway |
| REAC:R-HSA-112315 | 1.11551333338e-06 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKACG AKAP5 PRKAR2B | Transmission across Chemical Synapses |
| REAC:R-HSA-5610787 | 2.05286596256e-06 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Hedgehog 'off' state |
| REAC:R-HSA-8963896 | 2.29663353989e-06 | 0.272727272727 | PRKACG PRKACA PRKACB | HDL assembly |
| WP:WP2436 | 5.7760343755e-06 | 0.272727272727 | PRKACG PRKACA PRKACB | Dopamine metabolism |
| REAC:R-HSA-5358351 | 7.10218522746e-06 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Signaling by Hedgehog |
| GO:0050891 | 7.89839487997e-06 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | multicellular organismal water homeostasis |
| GO:0030104 | 9.68198259607e-06 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | water homeostasis |
| REAC:R-HSA-112316 | 1.26795964894e-05 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKACG AKAP5 PRKAR2B | Neuronal System |
| REAC:R-HSA-9634600 | 1.44069176994e-05 | 0.272727272727 | PRKACG PRKACA PRKACB | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism |
| REAC:R-HSA-392517 | 1.44069176994e-05 | 0.272727272727 | PRKACG PRKACA PRKACB | Rap1 signalling |
| REAC:R-HSA-380259 | 2.64293129245e-05 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 2.64293129245e-05 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8963898 | 2.9760113022e-05 | 0.272727272727 | PRKACG PRKACA PRKACB | Plasma lipoprotein assembly |
| GO:0003014 | 3.06364005417e-05 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | renal system process |
| REAC:R-HSA-8854518 | 3.15800846965e-05 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | AURKA Activation by TPX2 |
| KEGG:05020 | 4.88148579647e-05 | 0.272727272727 | PRKACG PRKACA PRKACB | Prion diseases |
| REAC:R-HSA-380287 | 5.15743805147e-05 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Centrosome maturation |
| REAC:R-HSA-380270 | 5.15743805147e-05 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-376176 | 5.3924171777e-05 | 0.454545454545 | AKAP5 PRKACG PRKACB PRKACA PRKAR2A | Signaling by ROBO receptors |
| REAC:R-HSA-2565942 | 6.61066115411e-05 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Regulation of PLK1 Activity at G2/M Transition |
| GO:0010737 | 7.07796251557e-05 | 0.363636363636 | PRKACG AKAP5 PRKACA PRKACB | protein kinase A signaling |
| WP:WP536 | 8.56585787571e-05 | 0.363636363636 | PRKAR2A PRKACB PRKAR2B PRKACA | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-5621575 | 8.67809228368e-05 | 0.272727272727 | PRKACG PRKACA PRKACB | CD209 (DC-SIGN) signaling |
| REAC:R-HSA-380320 | 8.73453192841e-05 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-163560 | 0.000100442666789 | 0.272727272727 | PRKACG PRKACA PRKACB | Triglyceride catabolism |
| CORUM:517 | 0.000100616904936 | 0.181818181818 | PRKAR2A AKAP5 | AKAP5-PRKAR2A-PPP3CA complex |
| CORUM:519 | 0.000100616904936 | 0.181818181818 | AKAP1 PRKAR2B | AMY-1-S-AKAP84-RII-beta complex |
| CORUM:4869 | 0.000100616904936 | 0.181818181818 | PRKAR2A AKAP5 | beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A) |
| REAC:R-HSA-5620912 | 0.000108619476808 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Anchoring of the basal body to the plasma membrane |
| WP:WP706 | 0.000110906197781 | 0.363636363636 | PRKAR2A PRKACB PRKAR2B PRKACA | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| KEGG:04913 | 0.000112290643275 | 0.272727272727 | PRKACG PRKACA PRKACB | Ovarian steroidogenesis |
| WP:WP289 | 0.00012166994995 | 0.363636363636 | PRKAR2A PRKACB PRKAR2B PRKACA | Myometrial Relaxation and Contraction Pathways |
| KEGG:04962 | 0.000131405505449 | 0.272727272727 | PRKACG PRKACA PRKACB | Vasopressin-regulated water reabsorption |
| REAC:R-HSA-418594 | 0.000147844907192 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | G alpha (i) signalling events |
| REAC:R-HSA-9006925 | 0.000153537767447 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Intracellular signaling by second messengers |
| WP:WP2636 | 0.000168663889087 | 0.272727272727 | PRKACG PRKACA PRKACB | Common Pathways Underlying Drug Addiction |
| WP:WP4249 | 0.000168663889087 | 0.272727272727 | PRKACG PRKACA PRKACB | Hedgehog Signaling Pathway |
| KEGG:04923 | 0.000175863198683 | 0.272727272727 | PRKACG PRKACA PRKACB | Regulation of lipolysis in adipocytes |
| KEGG:04340 | 0.000175863198683 | 0.272727272727 | PRKACG PRKACA PRKACB | Hedgehog signaling pathway |
| REAC:R-HSA-109582 | 0.000183497676145 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | Hemostasis |
| KEGG:05030 | 0.000201408191216 | 0.272727272727 | PRKACG PRKACA PRKACB | Cocaine addiction |
| KEGG:05110 | 0.000229298163963 | 0.272727272727 | PRKACG PRKACA PRKACB | Vibrio cholerae infection |
| KEGG:04961 | 0.000259633361548 | 0.272727272727 | PRKACG PRKACA PRKACB | Endocrine and other factor-regulated calcium reabsorption |
| REAC:R-HSA-8853659 | 0.000292113088734 | 0.272727272727 | PRKACG PRKACA PRKACB | RET signaling |
| GO:0004691 | 0.000299339163023 | 0.272727272727 | PRKACG PRKACA PRKACB | cAMP-dependent protein kinase activity |
| KEGG:04924 | 0.000309939419538 | 0.272727272727 | PRKACG PRKACA PRKACB | Renin secretion |
| REAC:R-HSA-382551 | 0.000362291515824 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | Transport of small molecules |
| KEGG:04976 | 0.000366307753875 | 0.272727272727 | PRKACG PRKACA PRKACB | Bile secretion |
| KEGG:04213 | 0.000366307753875 | 0.272727272727 | PRKACG PRKACA PRKACB | Longevity regulating pathway - multiple species |
| KEGG:04927 | 0.000386502168359 | 0.272727272727 | PRKACG PRKACA PRKACB | Cortisol synthesis and secretion |
| REAC:R-HSA-8979227 | 0.000388407335649 | 0.272727272727 | PRKACG PRKACA PRKACB | Triglyceride metabolism |
| KEGG:04742 | 0.000407419640558 | 0.272727272727 | PRKACG PRKACA PRKACB | Taste transduction |
| KEGG:04971 | 0.000474633427553 | 0.272727272727 | PRKACG PRKACA PRKACB | Gastric acid secretion |
| KEGG:05031 | 0.000498566051632 | 0.272727272727 | PRKACG PRKACA PRKACB | Amphetamine addiction |
| KEGG:04720 | 0.000498566051632 | 0.272727272727 | PRKACG PRKACA PRKACB | Long-term potentiation |
| GO:0007596 | 0.000600513618634 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | blood coagulation |
| GO:0007599 | 0.000628457929619 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | hemostasis |
| GO:0050817 | 0.000642829149286 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | coagulation |
| KEGG:04918 | 0.000659061138506 | 0.272727272727 | PRKACG PRKACA PRKACB | Thyroid hormone synthesis |
| KEGG:04911 | 0.000783042970688 | 0.272727272727 | PRKACG PRKACA PRKACB | Insulin secretion |
| GO:0004690 | 0.000837474301274 | 0.272727272727 | PRKACG PRKACA PRKACB | cyclic nucleotide-dependent protein kinase activity |
| KEGG:04970 | 0.000850419259028 | 0.272727272727 | PRKACG PRKACA PRKACB | Salivary secretion |
| KEGG:04727 | 0.00103533667757 | 0.272727272727 | PRKACG PRKACA PRKACB | GABAergic synapse |
| KEGG:04750 | 0.00111614472947 | 0.272727272727 | PRKACG PRKACA PRKACB | Inflammatory mediator regulation of TRP channels |
| KEGG:04912 | 0.00111614472947 | 0.272727272727 | PRKACG PRKACA PRKACB | GnRH signaling pathway |
| KEGG:04914 | 0.00111614472947 | 0.272727272727 | PRKACG PRKACA PRKACB | Progesterone-mediated oocyte maturation |
| KEGG:05032 | 0.00111614472947 | 0.272727272727 | PRKACG PRKACA PRKACB | Morphine addiction |
| KEGG:04211 | 0.00115806219587 | 0.272727272727 | PRKACG PRKACA PRKACB | Longevity regulating pathway |
| KEGG:04540 | 0.00124498312423 | 0.272727272727 | PRKACG PRKACA PRKACB | Gap junction |
| KEGG:05414 | 0.00129001017159 | 0.272727272727 | PRKACG PRKACA PRKACB | Dilated cardiomyopathy (DCM) |
| KEGG:05146 | 0.00129001017159 | 0.272727272727 | PRKACG PRKACA PRKACB | Amoebiasis |
| KEGG:04713 | 0.00143149873601 | 0.272727272727 | PRKACG PRKACA PRKACB | Circadian entrainment |
| KEGG:04925 | 0.00143149873601 | 0.272727272727 | PRKACG PRKACA PRKACB | Aldosterone synthesis and secretion |
| KEGG:04916 | 0.00148083647263 | 0.272727272727 | PRKACG PRKACA PRKACB | Melanogenesis |
| KEGG:01522 | 0.00153128113718 | 0.272727272727 | PRKACG PRKACA PRKACB | Endocrine resistance |
| REAC:R-HSA-69275 | 0.00173138738924 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | G2/M Transition |
| REAC:R-HSA-68877 | 0.00176775233438 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Mitotic Prometaphase |
| REAC:R-HSA-5617833 | 0.00176775233438 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Cilium Assembly |
| REAC:R-HSA-174824 | 0.00178334038071 | 0.272727272727 | PRKACG PRKACA PRKACB | Plasma lipoprotein assembly, remodeling, and clearance |
| KEGG:04726 | 0.00180051585439 | 0.272727272727 | PRKACG PRKACA PRKACB | Serotonergic synapse |
| REAC:R-HSA-453274 | 0.00180467998181 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Mitotic G2-G2/M phases |
| KEGG:04725 | 0.00185784629213 | 0.272727272727 | PRKACG PRKACA PRKACB | Cholinergic synapse |
| KEGG:04922 | 0.00185784629213 | 0.272727272727 | PRKACG PRKACA PRKACB | Glucagon signaling pathway |
| KEGG:04928 | 0.00191636487336 | 0.272727272727 | PRKACG PRKACA PRKACB | Parathyroid hormone synthesis, secretion and action |
| KEGG:04270 | 0.00203701253642 | 0.272727272727 | PRKACG PRKACA PRKACB | Vascular smooth muscle contraction |
| REAC:R-HSA-5610780 | 0.0020889055103 | 0.272727272727 | PRKACG PRKACA PRKACB | Degradation of GLI1 by the proteasome |
| KEGG:04724 | 0.00209916460361 | 0.272727272727 | PRKACG PRKACA PRKACB | Glutamatergic synapse |
| REAC:R-HSA-5610783 | 0.00219796060127 | 0.272727272727 | PRKACG PRKACA PRKACB | Degradation of GLI2 by the proteasome |
| REAC:R-HSA-5610785 | 0.00219796060127 | 0.272727272727 | PRKACG PRKACA PRKACB | GLI3 is processed to GLI3R by the proteasome |
| GO:0050878 | 0.00233620908715 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | regulation of body fluid levels |
| GO:0044441 | 0.00233620908715 | 0.545454545455 | PRKACA PRKACB AKAP14 PRKACG PRKAR2A PRKAR2B | ciliary part |
| GO:0034380 | 0.0024645761864 | 0.272727272727 | PRKACG PRKACA PRKACB | high-density lipoprotein particle assembly |
| KEGG:04114 | 0.00256942370337 | 0.272727272727 | PRKACG PRKACA PRKACB | Oocyte meiosis |
| KEGG:04611 | 0.0028667965846 | 0.272727272727 | PRKACG PRKACA PRKACB | Platelet activation |
| REAC:R-HSA-70171 | 0.002932068383 | 0.272727272727 | PRKACG PRKACA PRKACB | Glycolysis |
| KEGG:04919 | 0.00302359138887 | 0.272727272727 | PRKACG PRKACA PRKACB | Thyroid hormone signaling pathway |
| WP:WP4321 | 0.00315300772667 | 0.272727272727 | PRKACG PRKACA PRKACB | Thermogenesis |
| KEGG:04926 | 0.00361647117654 | 0.272727272727 | PRKACG PRKACA PRKACB | Relaxin signaling pathway |
| KEGG:04728 | 0.0037069164787 | 0.272727272727 | PRKACG PRKACA PRKACB | Dopaminergic synapse |
| KEGG:04915 | 0.00379883206809 | 0.272727272727 | PRKACG PRKACA PRKACB | Estrogen signaling pathway |
| KEGG:04740 | 0.00398711821454 | 0.272727272727 | PRKACG PRKACA PRKACB | Olfactory transduction |
| KEGG:04371 | 0.00398711821454 | 0.272727272727 | PRKACG PRKACA PRKACB | Apelin signaling pathway |
| REAC:R-HSA-422475 | 0.00405504349953 | 0.454545454545 | AKAP5 PRKACG PRKACB PRKACA PRKAR2A | Axon guidance |
| KEGG:05012 | 0.00418141763392 | 0.272727272727 | PRKACG PRKACA PRKACB | Parkinson disease |
| KEGG:04261 | 0.00448433342699 | 0.272727272727 | PRKACG PRKACA PRKACB | Adrenergic signaling in cardiomyocytes |
| KEGG:04062 | 0.0045884068153 | 0.272727272727 | PRKACG PRKACA PRKACB | Chemokine signaling pathway |
| KEGG:04723 | 0.00480127106684 | 0.272727272727 | PRKACG PRKACA PRKACB | Retrograde endocannabinoid signaling |
| GO:0071417 | 0.00484653513515 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKAR2B PRKACG AKAP9 | cellular response to organonitrogen compound |
| KEGG:04140 | 0.00491008362567 | 0.272727272727 | PRKACG PRKACA PRKACB | Autophagy - animal |
| GO:0042060 | 0.00508300248839 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | wound healing |
| REAC:R-HSA-388396 | 0.00510477316786 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | GPCR downstream signalling |
| KEGG:04921 | 0.00513252370439 | 0.272727272727 | PRKACG PRKACA PRKACB | Oxytocin signaling pathway |
| REAC:R-HSA-70326 | 0.00563793437463 | 0.272727272727 | PRKACG PRKACA PRKACB | Glucose metabolism |
| KEGG:04934 | 0.0058391388001 | 0.272727272727 | PRKACG PRKACA PRKACB | Cushing syndrome |
| KEGG:04530 | 0.00634381757845 | 0.272727272727 | PRKACG PRKACA PRKACB | Tight junction |
| KEGG:04310 | 0.00660649288056 | 0.272727272727 | PRKACG PRKACA PRKACB | Wnt signaling pathway |
| REAC:R-HSA-5687128 | 0.00673427382496 | 0.272727272727 | PRKACG PRKACA PRKACB | MAPK6/MAPK4 signaling |
| REAC:R-HSA-372790 | 0.00758361834146 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | Signaling by GPCR |
| REAC:R-HSA-4420097 | 0.00770595296013 | 0.272727272727 | PRKACG PRKACA PRKACB | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-1852241 | 0.00786217599111 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | Organelle biogenesis and maintenance |
| GO:0071375 | 0.00792015866896 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | cellular response to peptide hormone stimulus |
| GO:0005929 | 0.00813714178658 | 0.545454545455 | PRKACA PRKACB AKAP14 PRKACG PRKAR2A PRKAR2B | cilium |
| KEGG:04020 | 0.00833255140444 | 0.272727272727 | PRKACG PRKACA PRKACB | Calcium signaling pathway |
| GO:1901699 | 0.00926415067314 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKAR2B PRKACG AKAP9 | cellular response to nitrogen compound |
| KEGG:05034 | 0.00946301812603 | 0.272727272727 | PRKACG PRKACA PRKACB | Alcoholism |
| GO:0009611 | 0.00980485486812 | 0.545454545455 | PRKACA PRKACB PRKAR2A AKAP1 PRKACG PRKAR2B | response to wounding |
| REAC:R-HSA-194138 | 0.00991703471677 | 0.272727272727 | PRKACG PRKACA PRKACB | Signaling by VEGF |
| KEGG:04024 | 0.0101516244569 | 0.272727272727 | PRKACG PRKACA PRKACB | cAMP signaling pathway |
| WP:WP4223 | 0.0116077883797 | 0.272727272727 | PRKACG PRKACA PRKACB | Ras Signaling |
| KEGG:04014 | 0.0128164961746 | 0.272727272727 | PRKACG PRKACA PRKACB | Ras signaling pathway |
| KEGG:05203 | 0.013653309193 | 0.272727272727 | PRKACG PRKACA PRKACB | Viral carcinogenesis |
| KEGG:05205 | 0.013653309193 | 0.272727272727 | PRKACG PRKACA PRKACB | Proteoglycans in cancer |
| GO:0044463 | 0.0141789142551 | 0.636363636364 | PRKACA PRKACB AKAP14 PRKACG PRKAR2A AKAP5 PRKAR2B | cell projection part |
| GO:0120038 | 0.0141789142551 | 0.636363636364 | PRKACA PRKACB AKAP14 PRKACG PRKAR2A AKAP5 PRKAR2B | plasma membrane bounded cell projection part |
| GO:0043434 | 0.0144397646406 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | response to peptide hormone |
| KEGG:05166 | 0.0156638791101 | 0.272727272727 | PRKACG PRKACA PRKACB | Human T-cell leukemia virus 1 infection |
| GO:0005813 | 0.0157479266602 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKAR2B CDK5RAP2 AKAP9 | centrosome |
| GO:0032147 | 0.0161460761571 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | activation of protein kinase activity |
| KEGG:05163 | 0.0168593245035 | 0.272727272727 | PRKACG PRKACA PRKACB | Human cytomegalovirus infection |
| GO:0034377 | 0.0169663110948 | 0.272727272727 | PRKACG PRKACA PRKACB | plasma lipoprotein particle assembly |
| KEGG:04714 | 0.0186299199627 | 0.272727272727 | PRKACG PRKACA PRKACB | Thermogenesis |
| GO:1901653 | 0.0192055167874 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | cellular response to peptide |
| REAC:R-HSA-5621481 | 0.0203569016388 | 0.272727272727 | PRKACG PRKACA PRKACB | C-type lectin receptors (CLRs) |
| GO:0065005 | 0.022900928028 | 0.272727272727 | PRKACG PRKACA PRKACB | protein-lipid complex assembly |
| GO:0097711 | 0.0237314513131 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | ciliary basal body-plasma membrane docking |
| REAC:R-HSA-68886 | 0.0253932343026 | 0.363636363636 | CDK5RAP2 PRKACA AKAP9 PRKAR2B | M Phase |
| WP:WP382 | 0.0320855812058 | 0.272727272727 | PRKACG PRKACA PRKACB | MAPK Signaling Pathway |
| KEGG:04010 | 0.0336797574151 | 0.272727272727 | PRKACG PRKACA PRKACB | MAPK signaling pathway |
| GO:1901652 | 0.0384253986639 | 0.454545454545 | PRKACG PRKACA PRKACB PRKAR2B PRKAR2A | response to peptide |
| GO:0010243 | 0.0413813931853 | 0.545454545455 | PRKACA PRKACB PRKAR2A PRKAR2B PRKACG AKAP9 | response to organonitrogen compound |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKAR2A | PRKACA | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (PRKAR2A) Malo gupta_WMM fraction |
| AKAP9 | PRKAR2B | 1.0 | 0.949 | hein_WMM bioplex (PRKAR2B) bioplex_WMM hein (PRKAR2B) |
| PRKACB | PRKAR2B | 1.0 | 0.949 | hein_WMM bioplex (PRKACB,PRKAR2B) bioplex_WMM youn_WMM hein (PRKAR2B) gupta_WMM |
| PRKAR2A | PRKAR2B | 1.0 | 0.949 | hein_WMM bioplex (PRKAR2B) bioplex_WMM youn_WMM hein (PRKAR2B) gupta_WMM |
| PRKACA | PRKAR2B | 0.999 | 0.949 | hein_WMM bioplex (PRKAR2B) bioplex_WMM youn_WMM hein (PRKAR2B) gupta_WMM |
| PRKACB | AKAP11 | 0.997 | 0.929 | hein_WMM bioplex (PRKACB) bioplex_WMM youn_WMM hein (PRKACB) |
| PRKACB | PRKACA | 0.993 | 0.918 | hein_WMM bioplex (PRKACB) bioplex_WMM youn_WMM hein (PRKACB) gupta_WMM |
| PRKACB | AKAP9 | 0.993 | 0.917 | hein_WMM bioplex (PRKACB) bioplex_WMM hein (PRKACB) |
| AKAP1 | PRKAR2B | 0.988 | 0.902 | bioplex (PRKAR2B) bioplex_WMM youn_WMM gupta_WMM |
| PRKACB | AKAP5 | 0.982 | 0.898 | hein_WMM bioplex (PRKACB) bioplex_WMM hein (AKAP5) gupta_WMM |
| PRKAR2B | AKAP14 | 0.965 | 0.874 | bioplex (AKAP14) bioplex_WMM |
| PRKAR2B | AKAP5 | 0.929 | 0.846 | bioplex (PRKAR2B) bioplex_WMM gupta_WMM |
| PRKACG | PRKAR2B | 0.907 | 0.83 | bioplex (PRKACG,PRKAR2B) bioplex_WMM |
| PRKACB | PRKAR2A | 0.737 | 0.738 | hein_WMM bioplex (PRKACB) bioplex_WMM youn_WMM hein (PRKACB,PRKAR2A) gupta_WMM |
| PRKAR2A | AKAP5 | 0.523 | 0.633 | hein_WMM bioplex_WMM hein (AKAP5) gupta_WMM |
| AKAP11 | PRKAR2B | 0.5 | 0.621 | bioplex (PRKAR2B) bioplex_WMM youn_WMM gupta_WMM |
| PRKACB | AKAP14 | 0.488 | 0.616 | bioplex (AKAP14) bioplex_WMM |
| PRKACG | AKAP14 | 0.443 | 0.586 | bioplex (AKAP14) bioplex_WMM |
| PRKAR2A | AKAP14 | 0.426 | 0.575 | bioplex (AKAP14) bioplex_WMM |
| PRKACB | CDK5RAP2 | 0.231 | 0.469 | hein_WMM bioplex (PRKACB) bioplex_WMM youn_WMM hein (CDK5RAP2,PRKACB) |
| PRKACB | AKAP1 | 0.201 | 0.451 | hein_WMM bioplex (PRKACB) bioplex_WMM youn_WMM hein (PRKACB) |
| PRKACA | AKAP14 | 0.187 | 0.44 | bioplex (AKAP14) bioplex_WMM |
| PRKACA | AKAP5 | 0.185 | 0.439 | hein_WMM bioplex_WMM hein (AKAP5) gupta_WMM |
| PRKACG | AKAP5 | 0.09 | 0.356 | bioplex (PRKACG) bioplex_WMM |
| PRKAR2A | AKAP9 | 0.078 | 0.352 | hein_WMM bioplex (AKAP9) bioplex_WMM hein (PRKAR2A) |
| PRKAR2B | CDK5RAP2 | 0.066 | 0.349 | hein_WMM bioplex (PRKAR2B) bioplex_WMM youn_WMM hein (PRKAR2B) |
| PRKACB | PRKACG | 0.047 | 0.29 | bioplex (PRKACB,PRKACG) bioplex_WMM |
| PRKAR2A | CDK5RAP2 | 0.035 | 0.265 | hein_WMM bioplex_WMM hein (CDK5RAP2,PRKAR2A) |
| AKAP9 | CDK5RAP2 | 0.031 | 0.24 | hein_WMM bioplex_WMM youn_WMM hein (CDK5RAP2) boldt_WMM |
| AKAP9 | PRKACG | 0.026 | 0.224 | bioplex (PRKACG) bioplex_WMM |
| PRKACA | PRKACG | 0.026 | 0.218 | bioplex (PRKACG) bioplex_WMM |
| PRKAR2A | AKAP1 | 0.023 | 0.21 | hein_WMM bioplex_WMM youn_WMM hein (AKAP1,PRKAR2A) gupta_WMM |
| PRKAR2A | PRKACG | 0.018 | 0.181 | bioplex (PRKACG) bioplex_WMM |
| PRKACA | AKAP9 | 0.015 | 0.142 | hein_WMM bioplex (AKAP9) bioplex_WMM boldt_WMM |
| PRKACA | AKAP11 | 0.011 | 0.148 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AKAP1 | AKAP5 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| AKAP9 | AKAP5 | 0.011 | 0.139 | bioplex_WMM WMM_only |
| PRKACG | AKAP1 | 0.01 | 0.126 | bioplex (PRKACG) bioplex_WMM |
| AKAP11 | PRKACG | 0.01 | 0.118 | bioplex (PRKACG) bioplex_WMM |
| AKAP9 | AKAP1 | 0.009 | 0.116 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CDK5RAP2 | AKAP5 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| AKAP11 | AKAP1 | 0.009 | 0.095 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AKAP11 | AKAP5 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| AKAP11 | CDK5RAP2 | 0.008 | 0.058 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AKAP1 | CDK5RAP2 | 0.008 | 0.043 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PRKAR2A | AKAP11 | 0.008 | 0.035 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AKAP11 | AKAP9 | 0.008 | 0.034 | hein_WMM bioplex_WMM WMM_only |
| PRKACG | CDK5RAP2 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PRKACA | CDK5RAP2 | 0.007 | 0.003 | hein_WMM bioplex_WMM youn_WMM hein (CDK5RAP2) |
| PRKACA | AKAP1 | 0.003 | 0.012 | hein_WMM bioplex_WMM youn_WMM hein (AKAP1) gupta_WMM |
Images
Click to enlarge
Complex HuMAP2_01784 has an average edge precision of 0.43 which is ranked 3021 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AKAP9 | HuMAP2_01784 HuMAP2_01832 HuMAP2_03596 HuMAP2_04684 HuMAP2_05056 |
| AKAP1 | HuMAP2_01784 HuMAP2_01832 |
| PRKAR2A | HuMAP2_00084 HuMAP2_01784 HuMAP2_01832 HuMAP2_04684 |
| AKAP11 | HuMAP2_00871 HuMAP2_01784 HuMAP2_01832 HuMAP2_03596 HuMAP2_04684 |
| CDK5RAP2 | HuMAP2_01784 HuMAP2_01832 HuMAP2_06309 |
| PRKACA | HuMAP2_00084 HuMAP2_01784 HuMAP2_01832 HuMAP2_04684 |
| AKAP14 | HuMAP2_01784 HuMAP2_01832 HuMAP2_02902 HuMAP2_06401 |
| AKAP5 | HuMAP2_01784 HuMAP2_01832 HuMAP2_03596 HuMAP2_04684 |
| PRKACG | HuMAP2_01784 HuMAP2_01832 HuMAP2_02640 HuMAP2_04684 HuMAP2_05056 |
| PRKAR2B | HuMAP2_01784 HuMAP2_01832 HuMAP2_04684 HuMAP2_06335 |
| PRKACB | HuMAP2_00037 HuMAP2_01784 HuMAP2_01832 HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 |