hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01787

Confidence: Medium High

Genename	Protein Name	Links
MT-ATP8	ATP synthase protein 8 (A6L) (F-ATPase subunit 8)	UniProt NCBI
DNAJC28	DnaJ homolog subfamily C member 28	UniProt NCBI
CERS2	Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Tumor metastasis-suppressor gene 1 protein)	UniProt NCBI
STOML2	Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)	UniProt NCBI
NDUFA9	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit)	UniProt NCBI
ATP5PB	ATP synthase F(0) complex subunit B1, mitochondrial (ATP synthase peripheral stalk-membrane subunit b) (ATP synthase proton-transporting mitochondrial F(0) complex subunit B1) (ATP synthase subunit b) (ATPase subunit b)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP111	0.000192159737634	0.5	ATP5PB NDUFA9 MT-ATP8	Electron Transport Chain (OXPHOS system in mitochondria)
KEGG:00190	0.000441153492847	0.5	ATP5PB NDUFA9 MT-ATP8	Oxidative phosphorylation
KEGG:05012	0.000537326639668	0.5	ATP5PB NDUFA9 MT-ATP8	Parkinson disease
KEGG:05010	0.000981167923329	0.5	ATP5PB NDUFA9 MT-ATP8	Alzheimer disease
CORUM:563	0.00100428015077	0.333333333333	ATP5PB MT-ATP8	F1F0-ATP synthase, mitochondrial
KEGG:05016	0.00146330063488	0.5	ATP5PB NDUFA9 MT-ATP8	Huntington disease
REAC:R-HSA-163200	0.00148381707922	0.5	ATP5PB NDUFA9 MT-ATP8	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
KEGG:04714	0.00244472448991	0.5	ATP5PB NDUFA9 MT-ATP8	Thermogenesis
GO:0006119	0.0028699930952	0.666666666667	MT-ATP8 ATP5PB NDUFA9 STOML2	oxidative phosphorylation
GO:0042776	0.0032070828615	0.5	ATP5PB STOML2 MT-ATP8	mitochondrial ATP synthesis coupled proton transport
REAC:R-HSA-163210	0.00338255333894	0.333333333333	ATP5PB MT-ATP8	Formation of ATP by chemiosmotic coupling
GO:0015985	0.00366468326223	0.5	ATP5PB STOML2 MT-ATP8	energy coupled proton transport, down electrochemical gradient
GO:0015986	0.00366468326223	0.5	ATP5PB STOML2 MT-ATP8	ATP synthesis coupled proton transport
REAC:R-HSA-1428517	0.00427169353229	0.5	ATP5PB NDUFA9 MT-ATP8	The citric acid (TCA) cycle and respiratory electron transport
WP:WP623	0.00822079355503	0.333333333333	ATP5PB NDUFA9	Oxidative phosphorylation
REAC:R-HSA-8949613	0.00959640616298	0.333333333333	ATP5PB MT-ATP8	Cristae formation
GO:0006754	0.0129043378459	0.5	ATP5PB STOML2 MT-ATP8	ATP biosynthetic process
GO:0009206	0.0152420239566	0.5	ATP5PB STOML2 MT-ATP8	purine ribonucleoside triphosphate biosynthetic process
GO:0009145	0.0152420239566	0.5	ATP5PB STOML2 MT-ATP8	purine nucleoside triphosphate biosynthetic process
GO:0009201	0.0192515670318	0.5	ATP5PB STOML2 MT-ATP8	ribonucleoside triphosphate biosynthetic process
GO:0009205	0.0312028564126	0.5	ATP5PB STOML2 MT-ATP8	purine ribonucleoside triphosphate metabolic process
KEGG:01100	0.0331288091988	0.666666666667	MT-ATP8 CERS2 NDUFA9 ATP5PB	Metabolic pathways
GO:0009142	0.0332327932613	0.5	ATP5PB STOML2 MT-ATP8	nucleoside triphosphate biosynthetic process
GO:0009199	0.0375522887938	0.5	ATP5PB STOML2 MT-ATP8	ribonucleoside triphosphate metabolic process
GO:0009144	0.0398453744123	0.5	ATP5PB STOML2 MT-ATP8	purine nucleoside triphosphate metabolic process
GO:0046034	0.0457293961323	0.666666666667	MT-ATP8 ATP5PB NDUFA9 STOML2	ATP metabolic process

Edges

Protein 1	Protein 2	Score	Precision	Evidence
ATP5PB	DNAJC28	0.429	0.577	bioplex (ATP5PB) bioplex_WMM
ATP5PB	CERS2	0.151	0.411	hein_WMM bioplex (ATP5PB) bioplex_WMM boldt gupta_WMM boldt_WMM
ATP5PB	MT-ATP8	0.095	0.357	bioplex (ATP5PB) bioplex_WMM youn_WMM gupta_WMM
ATP5PB	STOML2	0.087	0.353	bioplex (ATP5PB) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
NDUFA9	STOML2	0.07	0.349	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
ATP5PB	NDUFA9	0.049	0.296	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
CERS2	MT-ATP8	0.009	0.107	bioplex_WMM WMM_only
DNAJC28	MT-ATP8	0.009	0.108	bioplex_WMM WMM_only
CERS2	DNAJC28	0.007	0.008	bioplex_WMM WMM_only
STOML2	MT-ATP8	0.007	0.007	bioplex_WMM youn_WMM gupta_WMM WMM_only
NDUFA9	MT-ATP8	0.006	0.002	bioplex_WMM youn_WMM gupta_WMM WMM_only
CERS2	STOML2	0.006	0.007	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
CERS2	NDUFA9	0.005	0.008	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM

Images

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Complex HuMAP2_01787 has an average edge precision of 0.199 which is ranked 6188 out of all 6965 complexes.

Related Complexes

Genename	Complexes
MT-ATP8	HuMAP2_01787 HuMAP2_03970 HuMAP2_05503 HuMAP2_05883 HuMAP2_06081
DNAJC28	HuMAP2_01787 HuMAP2_03970 HuMAP2_05503 HuMAP2_05883 HuMAP2_06081 HuMAP2_06253
CERS2	HuMAP2_01266 HuMAP2_01787 HuMAP2_03970 HuMAP2_06380
STOML2	HuMAP2_01373 HuMAP2_01573 HuMAP2_01787 HuMAP2_02483 HuMAP2_05031
NDUFA9	HuMAP2_01373 HuMAP2_01573 HuMAP2_01787 HuMAP2_05031
ATP5PB	HuMAP2_00218 HuMAP2_01266 HuMAP2_01787 HuMAP2_02410 HuMAP2_02521 HuMAP2_03970 HuMAP2_04624 HuMAP2_05503 HuMAP2_05883 HuMAP2_06081 HuMAP2_06253

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01787