hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01793
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MOB1A | MOB kinase activator 1A (Mob1 alpha) (Mob1A) (Mob1 homolog 1B) (Mps one binder kinase activator-like 1B) | UniProt NCBI |
| STK38L | Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2) | UniProt NCBI |
| MOB1B | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | UniProt NCBI |
| LATS1 | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | UniProt NCBI |
| MOB2 | MOB kinase activator 2 (HCCA2) (Mob2 homolog) (Mps one binder kinase activator-like 2) | UniProt NCBI |
| LATS2 | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2028269 | 4.64286129501e-09 | 0.666666666667 | LATS2 MOB1B LATS1 MOB1A | Signaling by Hippo |
| KEGG:04392 | 5.05349951212e-09 | 0.666666666667 | LATS2 MOB1B LATS1 MOB1A | Hippo signaling pathway - multiple species |
| WP:WP4542 | 8.2647995135e-09 | 0.666666666667 | STK38L LATS1 LATS2 MOB1A | Overview of leukocyte-intrinsic Hippo pathway functions |
| WP:WP4537 | 1.70690021658e-06 | 0.5 | STK38L LATS1 LATS2 | Hippo-Yap signaling pathway |
| KEGG:04390 | 5.41943690311e-06 | 0.666666666667 | LATS2 MOB1B LATS1 MOB1A | Hippo signaling pathway |
| GO:0035329 | 2.40824494048e-05 | 0.666666666667 | LATS2 MOB1B LATS1 MOB1A | hippo signaling |
| WP:WP4533 | 0.000852627081304 | 0.333333333333 | LATS2 LATS1 | Transcription co-factors SKI and SKIL protein partners |
| WP:WP4540 | 0.0205911896387 | 0.333333333333 | LATS2 LATS1 | Pathways Regulating Hippo Signaling |
| WP:WP4541 | 0.0282758493646 | 0.333333333333 | LATS2 LATS1 | Hippo-Merlin Signaling Dysregulation |
| CORUM:6660 | 0.0499726005494 | 0.166666666667 | LATS1 | LATS1-NPHP4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MOB1B | MOB1A | 1.0 | 0.949 | bioplex (MOB1B) bioplex_WMM |
| MOB1B | LATS2 | 1.0 | 0.949 | bioplex (MOB1B) bioplex_WMM |
| MOB1A | STK38L | 0.961 | 0.869 | bioplex (STK38L) bioplex_WMM |
| MOB1B | LATS1 | 0.927 | 0.844 | bioplex (MOB1B) bioplex_WMM |
| MOB2 | STK38L | 0.585 | 0.663 | bioplex (STK38L) bioplex_WMM boldt_WMM |
| MOB1B | STK38L | 0.425 | 0.575 | bioplex (MOB1B,STK38L) bioplex_WMM |
| LATS1 | LATS2 | 0.009 | 0.108 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| STK38L | LATS2 | 0.008 | 0.093 | bioplex_WMM WMM_only |
| LATS1 | STK38L | 0.008 | 0.093 | bioplex_WMM WMM_only |
| MOB1A | LATS1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MOB1A | LATS2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MOB1A | MOB2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MOB1B | MOB2 | 0.008 | 0.081 | bioplex_WMM WMM_only |
| MOB2 | LATS1 | 0.007 | 0.002 | youn_WMM WMM_only |
| MOB2 | LATS2 | 0.007 | 0.0 | youn_WMM WMM_only |
Images
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Complex HuMAP2_01793 has an average edge precision of 0.367 which is ranked 3679 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MOB1A | HuMAP2_01510 HuMAP2_01598 HuMAP2_01793 HuMAP2_03103 HuMAP2_06016 |
| STK38L | HuMAP2_01598 HuMAP2_01793 HuMAP2_06016 |
| MOB1B | HuMAP2_01510 HuMAP2_01598 HuMAP2_01793 HuMAP2_01881 |
| LATS1 | HuMAP2_01598 HuMAP2_01793 HuMAP2_01881 |
| MOB2 | HuMAP2_01598 HuMAP2_01793 |
| LATS2 | HuMAP2_01598 HuMAP2_01793 HuMAP2_01881 |