hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01803
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GINS2 | DNA replication complex GINS protein PSF2 (GINS complex subunit 2) | UniProt NCBI |
| GINS1 | DNA replication complex GINS protein PSF1 (GINS complex subunit 1) | UniProt NCBI |
| GINS3 | DNA replication complex GINS protein PSF3 (GINS complex subunit 3) | UniProt NCBI |
| NEU4 | Sialidase-4 (EC 3.2.1.18) (N-acetyl-alpha-neuraminidase 4) | UniProt NCBI |
| ZPR1 | Zinc finger protein ZPR1 (Zinc finger protein 259) | UniProt NCBI |
| GINS4 | DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] | UniProt NCBI |
| TIPIN | TIMELESS-interacting protein | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:678 | 9.08345369489e-13 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | GINS complex |
| REAC:R-HSA-176974 | 1.41173351619e-09 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | Unwinding of DNA |
| REAC:R-HSA-69190 | 1.02227062123e-07 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | DNA strand elongation |
| GO:0006261 | 1.18623922239e-07 | 0.857142857143 | TIPIN GINS3 GINS4 GINS2 ZPR1 GINS1 | DNA-dependent DNA replication |
| GO:0006271 | 2.02789502131e-06 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | DNA strand elongation involved in DNA replication |
| GO:0006260 | 2.38857038708e-06 | 0.857142857143 | TIPIN GINS3 GINS4 GINS2 ZPR1 GINS1 | DNA replication |
| GO:0000811 | 3.17865016081e-06 | 0.428571428571 | GINS2 GINS1 GINS4 | GINS complex |
| GO:0022616 | 9.04373637949e-06 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | DNA strand elongation |
| REAC:R-HSA-69239 | 2.15138012589e-05 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | Synthesis of DNA |
| REAC:R-HSA-69306 | 2.80244760686e-05 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | DNA Replication |
| GO:0031261 | 3.17736949706e-05 | 0.428571428571 | GINS2 GINS1 GINS4 | DNA replication preinitiation complex |
| REAC:R-HSA-69242 | 7.13974352246e-05 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | S Phase |
| GO:0031298 | 0.000177825159425 | 0.428571428571 | TIPIN GINS4 GINS2 | replication fork protection complex |
| GO:0043138 | 0.00115446662879 | 0.428571428571 | GINS2 GINS1 GINS4 | 3'-5' DNA helicase activity |
| REAC:R-HSA-69278 | 0.0076688970217 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 0.0155446721983 | 0.571428571429 | GINS2 GINS3 GINS1 GINS4 | Cell Cycle |
| GO:0043596 | 0.0336257766492 | 0.428571428571 | TIPIN GINS4 GINS2 | nuclear replication fork |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GINS1 | GINS4 | 1.0 | 0.949 | bioplex_WMM Malo fraction |
| GINS1 | GINS2 | 1.0 | 0.949 | bioplex_WMM youn_WMM Malo fraction |
| GINS3 | GINS1 | 0.997 | 0.931 | bioplex (GINS3) bioplex_WMM youn_WMM Malo fraction |
| GINS3 | TIPIN | 0.929 | 0.845 | hein_WMM bioplex (GINS3,TIPIN) bioplex_WMM youn_WMM hein (TIPIN) |
| GINS3 | GINS2 | 0.929 | 0.845 | bioplex (GINS3) bioplex_WMM youn_WMM Malo fraction |
| GINS4 | GINS2 | 0.66 | 0.697 | bioplex_WMM Malo fraction |
| GINS3 | GINS4 | 0.434 | 0.578 | hein_WMM bioplex (GINS3) bioplex_WMM Guru Malo fraction |
| TIPIN | GINS4 | 0.285 | 0.489 | hein_WMM bioplex (TIPIN) bioplex_WMM hein (TIPIN) |
| ZPR1 | GINS3 | 0.064 | 0.348 | bioplex_WMM fraction |
| ZPR1 | NEU4 | 0.045 | 0.279 | bioplex (NEU4) bioplex_WMM |
| TIPIN | GINS2 | 0.012 | 0.149 | bioplex_WMM youn_WMM WMM_only |
| ZPR1 | GINS1 | 0.0 | 0.009 | bioplex_WMM fraction |
| ZPR1 | GINS4 | 0.0 | 0.007 | bioplex_WMM fraction |
| GINS1 | TIPIN | 0.0 | 0.009 | bioplex (TIPIN) bioplex_WMM |
Images
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Complex HuMAP2_01803 has an average edge precision of 0.506 which is ranked 2464 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GINS2 | HuMAP2_01803 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| GINS1 | HuMAP2_01803 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| GINS3 | HuMAP2_01803 HuMAP2_02711 HuMAP2_03617 HuMAP2_03710 |
| NEU4 | HuMAP2_01615 HuMAP2_01803 |
| ZPR1 | HuMAP2_01615 HuMAP2_01803 |
| GINS4 | HuMAP2_01803 HuMAP2_02711 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| TIPIN | HuMAP2_01803 HuMAP2_02711 HuMAP2_06094 |