hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01804
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNG4 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | UniProt NCBI |
| GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | UniProt NCBI |
| GNA11 | Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha) | UniProt NCBI |
| GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | UniProt NCBI |
| GNB3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (Transducin beta chain 3) | UniProt NCBI |
| RGS12 | Regulator of G-protein signaling 12 (RGS12) | UniProt NCBI |
| RIC8A | Synembryn-A (Protein Ric-8A) | UniProt NCBI |
| GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | UniProt NCBI |
| GNAI1 | Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein) | UniProt NCBI |
| GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha (G(i) alpha-3) | UniProt NCBI |
| GNAO1 | Guanine nucleotide-binding protein G(o) subunit alpha | UniProt NCBI |
| GNB4 | Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202040 | 1.66947786502e-21 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | G-protein activation |
| REAC:R-HSA-392518 | 5.34820138725e-21 | 0.75 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNA11 GNB4 GNG4 GNAI2 | Signal amplification |
| REAC:R-HSA-6814122 | 1.12961269519e-19 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| KEGG:04725 | 2.2688979175e-19 | 0.833333333333 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNA11 GNB4 GNG4 GNAI2 | Cholinergic synapse |
| REAC:R-HSA-392170 | 2.5053763583e-19 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | ADP signalling through P2Y purinoceptor 12 |
| WP:WP536 | 3.44623459919e-18 | 0.833333333333 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNA11 GNB4 GNG4 GNAI2 | Calcium Regulation in the Cardiac Cell |
| KEGG:04727 | 2.04953004116e-17 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | GABAergic synapse |
| KEGG:05032 | 2.59704945616e-17 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Morphine addiction |
| KEGG:04713 | 5.68034806372e-17 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Circadian entrainment |
| WP:WP35 | 7.55096380177e-17 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | G Protein Signaling Pathways |
| KEGG:04726 | 1.16668414705e-16 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Serotonergic synapse |
| KEGG:04724 | 1.88706003164e-16 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Glutamatergic synapse |
| REAC:R-HSA-111885 | 2.43038654293e-16 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Opioid Signalling |
| REAC:R-HSA-418597 | 3.50474384135e-16 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | G alpha (z) signalling events |
| REAC:R-HSA-390466 | 3.72989395106e-16 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Chaperonin-mediated protein folding |
| KEGG:05170 | 4.23601639049e-16 | 0.833333333333 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNA11 GNB4 GNG4 GNAI2 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 4.93498502025e-16 | 0.833333333333 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNA11 GNB4 GNG4 GNAI2 | Human cytomegalovirus infection |
| GO:1905360 | 6.42259722228e-16 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | GTPase complex |
| GO:0005834 | 6.42259722228e-16 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | heterotrimeric G-protein complex |
| REAC:R-HSA-391251 | 6.83987916257e-16 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Protein folding |
| KEGG:04926 | 1.03354014e-15 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Relaxin signaling pathway |
| KEGG:04728 | 1.11638859276e-15 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Dopaminergic synapse |
| KEGG:04723 | 2.50216744254e-15 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-400042 | 3.88468390166e-15 | 0.583333333333 | GNB3 GNAI2 GNAI1 GNB1 GNG11 GNG4 GNB4 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-9009391 | 1.12981201032e-14 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-422356 | 1.64359042844e-14 | 0.666666666667 | GNB3 GNAI2 GNAI1 GNB1 GNG11 GNA11 GNG4 GNB4 | Regulation of insulin secretion |
| KEGG:05034 | 2.0732884825e-14 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Alcoholism |
| REAC:R-HSA-418594 | 3.55570058619e-14 | 0.833333333333 | GNB3 GNAI2 GNAI1 RGS12 GNB1 GNG11 GNAO1 GNB4 GNG4 GNAI3 | G alpha (i) signalling events |
| REAC:R-HSA-163685 | 2.82177938107e-13 | 0.666666666667 | GNB3 GNAI2 GNAI1 GNB1 GNG11 GNA11 GNG4 GNB4 | Integration of energy metabolism |
| REAC:R-HSA-388396 | 3.46932429436e-13 | 0.916666666667 | GNB3 GNAI2 GNAI1 RGS12 GNB1 GNG11 GNA11 GNAO1 GNB4 GNG4 GNAI3 | GPCR downstream signalling |
| KEGG:04371 | 4.01885249098e-13 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Apelin signaling pathway |
| KEGG:04062 | 5.9205406137e-13 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Chemokine signaling pathway |
| WP:WP3929 | 5.94984890993e-13 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Chemokine signaling pathway |
| REAC:R-HSA-428930 | 7.95488222525e-13 | 0.5 | GNB3 GNB4 GNB1 GNG11 GNA11 GNG4 | Thromboxane signalling through TP receptor |
| REAC:R-HSA-372790 | 8.5990215466e-13 | 0.916666666667 | GNB3 GNAI2 GNAI1 RGS12 GNB1 GNG11 GNA11 GNAO1 GNB4 GNG4 GNAI3 | Signaling by GPCR |
| REAC:R-HSA-418592 | 1.09341817644e-12 | 0.5 | GNB3 GNB4 GNB1 GNG11 GNA11 GNG4 | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-76002 | 1.64485795331e-12 | 0.75 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNA11 GNB4 GNG4 GNAI2 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-456926 | 5.50950242225e-12 | 0.5 | GNB3 GNB4 GNB1 GNG11 GNA11 GNG4 | Thrombin signalling through proteinase activated receptors (PARs) |
| GO:0031234 | 8.54550314915e-12 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | extrinsic component of cytoplasmic side of plasma membrane |
| REAC:R-HSA-991365 | 1.32339641049e-11 | 0.5 | GNB3 GNAI3 GNAI1 GNB1 GNG4 GNAI2 | Activation of GABAB receptors |
| REAC:R-HSA-977444 | 1.32339641049e-11 | 0.5 | GNB3 GNAI3 GNAI1 GNB1 GNG4 GNAI2 | GABA B receptor activation |
| REAC:R-HSA-112314 | 3.55406202462e-11 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-418555 | 3.72240513966e-11 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | G alpha (s) signalling events |
| GO:0007186 | 6.61207285611e-11 | 0.916666666667 | GNB3 RIC8A GNAI1 RGS12 GNB1 GNG11 GNA11 GNAI3 GNAO1 GNG4 GNAI2 | G protein-coupled receptor signaling pathway |
| REAC:R-HSA-8939211 | 1.23188466786e-10 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | ESR-mediated signaling |
| REAC:R-HSA-977443 | 1.36131199682e-10 | 0.5 | GNB3 GNAI3 GNAI1 GNB1 GNG4 GNAI2 | GABA receptor activation |
| REAC:R-HSA-8964315 | 1.36317345883e-10 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | G beta:gamma signalling through BTK |
| REAC:R-HSA-392851 | 1.9304054075e-10 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Prostacyclin signalling through prostacyclin receptor |
| KEGG:05200 | 2.40312489261e-10 | 0.75 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNA11 GNB4 GNG4 GNAI2 | Pathways in cancer |
| REAC:R-HSA-8964616 | 2.67182124456e-10 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | G beta:gamma signalling through CDC42 |
| REAC:R-HSA-418217 | 2.67182124456e-10 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-112315 | 2.92081944891e-10 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Transmission across Chemical Synapses |
| REAC:R-HSA-4086398 | 3.32841212339e-10 | 0.5 | GNB3 GNB4 GNAO1 GNB1 GNG11 GNG4 | Ca2+ pathway |
| REAC:R-HSA-500657 | 3.62462162035e-10 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Presynaptic function of Kainate receptors |
| GO:0019897 | 4.42073774008e-10 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | extrinsic component of plasma membrane |
| REAC:R-HSA-9006931 | 5.22929426723e-10 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Signaling by Nuclear Receptors |
| GO:0009898 | 5.73555071298e-10 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | cytoplasmic side of plasma membrane |
| REAC:R-HSA-392451 | 6.33811517458e-10 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-420092 | 6.33811517458e-10 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Glucagon-type ligand receptors |
| GO:0003924 | 8.33014747589e-10 | 0.75 | GNB3 GNAI3 GNAI1 RGS12 GNB1 GNA11 GNAO1 GNG11 GNAI2 | GTPase activity |
| WP:WP2355 | 1.62430982395e-09 | 0.5 | GNB3 GNAI2 GNAI1 GNAO1 GNB1 GNA11 | Corticotropin-releasing hormone signaling pathway |
| GO:0098562 | 1.88028778612e-09 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | cytoplasmic side of membrane |
| REAC:R-HSA-451326 | 2.50859193913e-09 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-397795 | 3.05274029493e-09 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | G-protein beta:gamma signalling |
| REAC:R-HSA-109582 | 4.57455822683e-09 | 0.75 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNA11 GNB4 GNG4 GNAI2 | Hemostasis |
| REAC:R-HSA-163359 | 5.27151060328e-09 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-112316 | 7.68351877398e-09 | 0.666666666667 | GNB3 GNAI3 GNAI1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Neuronal System |
| REAC:R-HSA-381676 | 1.00559546934e-08 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-432040 | 1.34919588922e-08 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Vasopressin regulates renal water homeostasis via Aquaporins |
| KEGG:04730 | 1.66102078667e-08 | 0.416666666667 | GNA11 GNAI1 GNAO1 GNAI2 GNAI3 | Long-term depression |
| REAC:R-HSA-445717 | 1.78069472844e-08 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Aquaporin-mediated transport |
| CORUM:7034 | 2.47891894852e-08 | 0.25 | GNAI1 GNG4 GNB4 | GNAI1-GNB4-GNG4 complex |
| CORUM:7033 | 2.47891894852e-08 | 0.25 | GNB3 GNG4 GNAI1 | GNAI1-GNB3-GNG4 complex |
| CORUM:7081 | 2.47891894852e-08 | 0.25 | GNAI1 GNB1 GNG11 | GNAI1-GNB1-GNG11 complex |
| CORUM:7031 | 2.47891894852e-08 | 0.25 | GNAI1 GNG4 GNB1 | GNAI1-GNB1-GNG4 complex |
| CORUM:7084 | 2.47891894852e-08 | 0.25 | GNAI1 GNB4 GNG11 | GNAI1-GNB4-GNG11 complex |
| CORUM:7083 | 2.47891894852e-08 | 0.25 | GNB3 GNG11 GNAI1 | GNAI1-GNB3-GNG11 complex |
| GO:0031683 | 2.82176905979e-08 | 0.416666666667 | GNA11 GNAI1 GNAO1 GNAI2 GNAI3 | G-protein beta/gamma-subunit complex binding |
| GO:0019898 | 4.87022452925e-08 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | extrinsic component of membrane |
| WP:WP2032 | 7.0448472037e-08 | 0.416666666667 | GNAI3 GNAI1 GNAO1 GNB1 GNAI2 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| REAC:R-HSA-416476 | 9.66858136583e-08 | 0.5 | GNB3 GNB4 GNB1 GNG11 GNA11 GNG4 | G alpha (q) signalling events |
| REAC:R-HSA-3858494 | 1.15729022056e-07 | 0.5 | GNB3 GNB4 GNAO1 GNB1 GNG11 GNG4 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-373080 | 1.98334995958e-07 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Class B/2 (Secretin family receptors) |
| KEGG:05142 | 2.23657634181e-07 | 0.416666666667 | GNA11 GNAI1 GNAO1 GNAI2 GNAI3 | Chagas disease (American trypanosomiasis) |
| REAC:R-HSA-416482 | 4.58384562869e-07 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | G alpha (12/13) signalling events |
| REAC:R-HSA-162582 | 5.2454256646e-07 | 0.916666666667 | GNB3 GNAI2 GNAI1 RGS12 GNB1 GNG11 GNA11 GNAO1 GNB4 GNG4 GNAI3 | Signal Transduction |
| REAC:R-HSA-418346 | 6.02013694607e-07 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Platelet homeostasis |
| GO:0098552 | 7.80603382968e-07 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | side of membrane |
| GO:0006457 | 1.11961867931e-06 | 0.583333333333 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNB4 GNAI2 | protein folding |
| GO:0017111 | 1.80479781177e-06 | 0.75 | GNB3 GNAI3 GNAI1 RGS12 GNB1 GNA11 GNAO1 GNG11 GNAI2 | nucleoside-triphosphatase activity |
| WP:WP289 | 2.473168566e-06 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Myometrial Relaxation and Contraction Pathways |
| GO:0016462 | 3.29129960224e-06 | 0.75 | GNB3 GNAI3 GNAI1 RGS12 GNB1 GNA11 GNAO1 GNG11 GNAI2 | pyrophosphatase activity |
| GO:0016818 | 3.38810404503e-06 | 0.75 | GNB3 GNAI3 GNAI1 RGS12 GNB1 GNA11 GNAO1 GNG11 GNAI2 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016817 | 3.38810404503e-06 | 0.75 | GNB3 GNAI3 GNAI1 RGS12 GNB1 GNA11 GNAO1 GNG11 GNAI2 | hydrolase activity, acting on acid anhydrides |
| KEGG:05167 | 5.3096196979e-06 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Kaposi sarcoma-associated herpesvirus infection |
| GO:0098797 | 5.46637210484e-06 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | plasma membrane protein complex |
| WP:WP4223 | 5.75028642222e-06 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Ras Signaling |
| GO:0007188 | 7.03446142422e-06 | 0.5 | GNAI1 GNAI3 GNAO1 GNB1 GNA11 GNAI2 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| KEGG:04014 | 9.14617570605e-06 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Ras signaling pathway |
| REAC:R-HSA-112043 | 1.42866027721e-05 | 0.333333333333 | GNAO1 GNAI1 GNAI2 GNAI3 | PLC beta mediated events |
| GO:0007187 | 1.51206393495e-05 | 0.5 | GNAI1 GNAI3 GNAO1 GNB1 GNA11 GNAI2 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| REAC:R-HSA-112040 | 1.54704887407e-05 | 0.333333333333 | GNAO1 GNAI1 GNAI2 GNAI3 | G-protein mediated events |
| REAC:R-HSA-195721 | 1.55631581952e-05 | 0.5 | GNB3 GNB4 GNAO1 GNB1 GNG11 GNG4 | Signaling by WNT |
| KEGG:04540 | 2.04648822817e-05 | 0.333333333333 | GNA11 GNAI1 GNAI2 GNAI3 | Gap junction |
| KEGG:04916 | 2.58408581393e-05 | 0.333333333333 | GNAO1 GNAI1 GNAI2 GNAI3 | Melanogenesis |
| KEGG:05145 | 3.22047507062e-05 | 0.333333333333 | GNAO1 GNAI1 GNAI2 GNAI3 | Toxoplasmosis |
| REAC:R-HSA-170670 | 3.49592549484e-05 | 0.25 | GNAI1 GNAI2 GNAI3 | Adenylate cyclase inhibitory pathway |
| KEGG:04928 | 3.65436803333e-05 | 0.333333333333 | GNA11 GNAI1 GNAI2 GNAI3 | Parathyroid hormone synthesis, secretion and action |
| CORUM:7086 | 3.69160609814e-05 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNB1-GNG12 complex |
| CORUM:7017 | 3.69160609814e-05 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNGT1 complex |
| CORUM:7014 | 3.69160609814e-05 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNGT1-GNB1 complex |
| CORUM:7016 | 3.69160609814e-05 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNGT1 complex |
| WP:WP26 | 6.12355122509e-05 | 0.25 | GNAI1 GNAI2 GNAI3 | Signal Transduction of S1P Receptor |
| WP:WP3932 | 6.96804668341e-05 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-997272 | 7.82281539474e-05 | 0.25 | GNB3 GNG4 GNB1 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REAC:R-HSA-1296041 | 7.82281539474e-05 | 0.25 | GNB3 GNG4 GNB1 | Activation of G protein gated Potassium channels |
| REAC:R-HSA-1296059 | 7.82281539474e-05 | 0.25 | GNB3 GNG4 GNB1 | G protein gated Potassium channels |
| GO:0031821 | 7.98841194917e-05 | 0.25 | GNAO1 GNAI1 GNA11 | G protein-coupled serotonin receptor binding |
| REAC:R-HSA-500792 | 9.15965354976e-05 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | GPCR ligand binding |
| KEGG:04915 | 9.16441874102e-05 | 0.333333333333 | GNAO1 GNAI1 GNAI2 GNAI3 | Estrogen signaling pathway |
| KEGG:04151 | 0.000102812441213 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | PI3K-Akt signaling pathway |
| CORUM:7024 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNB1-GNG3 complex |
| CORUM:7036 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNB1-GNG5 complex |
| CORUM:7073 | 0.000110698604565 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNG8 complex |
| CORUM:7088 | 0.000110698604565 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNG12 complex |
| CORUM:7074 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNG8 complex |
| CORUM:7019 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNB1-GNG2 complex |
| CORUM:7032 | 0.000110698604565 | 0.166666666667 | GNAI1 GNG4 | GNAI1-GNB2-GNG4 complex |
| CORUM:7059 | 0.000110698604565 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNG5 complex |
| CORUM:7060 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNG5 complex |
| CORUM:7076 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNB1-GNG10 complex |
| CORUM:7066 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNB1-GNG7 complex |
| CORUM:7085 | 0.000110698604565 | 0.166666666667 | GNAI1 GNG11 | GNAI1-GNB5-GNG11 complex |
| CORUM:7027 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNG3 complex |
| CORUM:7071 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNB1-GNG8 complex |
| CORUM:7068 | 0.000110698604565 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNG7 complex |
| CORUM:7035 | 0.000110698604565 | 0.166666666667 | GNAI1 GNG4 | GNAI1- GNB5-GNG4 complex |
| CORUM:7078 | 0.000110698604565 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNG10 complex |
| CORUM:7082 | 0.000110698604565 | 0.166666666667 | GNAI1 GNG11 | GNAI1-GNB2-GNG11 complex |
| CORUM:7069 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNG7 complex |
| CORUM:7079 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNG10 complex |
| CORUM:7022 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNG2 complex |
| CORUM:7026 | 0.000110698604565 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNG3 complex |
| CORUM:7021 | 0.000110698604565 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNG2 complex |
| CORUM:7163 | 0.000110698604565 | 0.166666666667 | GNG4 GNB4 | GNAS-L-GNB4-GNG4 complex |
| CORUM:7092 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB1 | GNAI1-GNB1-GNG13 complex |
| CORUM:7094 | 0.000110698604565 | 0.166666666667 | GNB3 GNAI1 | GNAI1-GNB3-GNG13 complex |
| CORUM:7095 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNG13 complex |
| CORUM:7160 | 0.000110698604565 | 0.166666666667 | GNG4 GNB1 | GNAS-L-GNB1-GNG4 complex |
| CORUM:7195 | 0.000110698604565 | 0.166666666667 | GNB1 GNG11 | GNAS-L-GNB1-GNG11 complex |
| CORUM:7201 | 0.000110698604565 | 0.166666666667 | GNB3 GNG11 | GNAS-L-GNB3-GNG11 complex |
| CORUM:7202 | 0.000110698604565 | 0.166666666667 | GNB4 GNG11 | GNAS-L-GNB4-GNG11 complex |
| CORUM:7089 | 0.000110698604565 | 0.166666666667 | GNAI1 GNB4 | GNAI1-GNB4-GNG12 complex |
| CORUM:7162 | 0.000110698604565 | 0.166666666667 | GNB3 GNG4 | GNAS-L-GNB3-GNG4 complex |
| WP:WP4172 | 0.000122414375005 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | PI3K-Akt Signaling Pathway |
| KEGG:04921 | 0.000137295722082 | 0.333333333333 | GNAO1 GNAI1 GNAI2 GNAI3 | Oxytocin signaling pathway |
| KEGG:04934 | 0.000163270591598 | 0.333333333333 | GNA11 GNAI1 GNAI2 GNAI3 | Cushing syndrome |
| KEGG:04022 | 0.000163270591598 | 0.333333333333 | GNA11 GNAI1 GNAI2 GNAI3 | cGMP-PKG signaling pathway |
| REAC:R-HSA-1296065 | 0.000169397327062 | 0.25 | GNB3 GNG4 GNB1 | Inwardly rectifying K+ channels |
| REAC:R-HSA-392499 | 0.000212678742663 | 0.75 | GNB3 GNAI3 GNAI1 GNAO1 GNB1 GNG11 GNB4 GNG4 GNAI2 | Metabolism of proteins |
| CORUM:6806 | 0.00022129809732 | 0.166666666667 | GNB1 GNAI2 | IGF1R-CXCR4-GNAI2-GNB1 complex |
| CORUM:117 | 0.00022129809732 | 0.166666666667 | GNA11 GNB1 | GPR56-CD81-Galpha(q/11)-Gbeta complex |
| KEGG:04923 | 0.000236127657443 | 0.25 | GNAI1 GNAI2 GNAI3 | Regulation of lipolysis in adipocytes |
| GO:0007212 | 0.000244712961137 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | dopamine receptor signaling pathway |
| KEGG:05030 | 0.000270399111681 | 0.25 | GNAI1 GNAI2 GNAI3 | Cocaine addiction |
| KEGG:04015 | 0.000367855466025 | 0.333333333333 | GNAO1 GNAI1 GNAI2 GNAI3 | Rap1 signaling pathway |
| KEGG:04924 | 0.000415960213158 | 0.25 | GNAI1 GNAI2 GNAI3 | Renin secretion |
| KEGG:05133 | 0.000605694455726 | 0.25 | GNAI1 GNAI2 GNAI3 | Pertussis |
| KEGG:04971 | 0.000636734336256 | 0.25 | GNAI1 GNAI2 GNAI3 | Gastric acid secretion |
| GO:1903351 | 0.0012036047613 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | cellular response to dopamine |
| GO:1903350 | 0.0012036047613 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | response to dopamine |
| KEGG:04914 | 0.00149583233955 | 0.25 | GNAI1 GNAI2 GNAI3 | Progesterone-mediated oocyte maturation |
| GO:1903831 | 0.00176777446203 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | signal transduction involved in cellular response to ammonium ion |
| KEGG:04670 | 0.00191778644203 | 0.25 | GNAI1 GNAI2 GNAI3 | Leukocyte transendothelial migration |
| GO:0071869 | 0.00250950974654 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | response to catecholamine |
| GO:0071870 | 0.00250950974654 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | cellular response to catecholamine stimulus |
| GO:0071868 | 0.00250950974654 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | cellular response to monoamine stimulus |
| GO:0071867 | 0.00250950974654 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | response to monoamine |
| GO:0098796 | 0.00254147261806 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | membrane protein complex |
| WP:WP4540 | 0.00274370655997 | 0.25 | GNA11 GNAI2 GNAI3 | Pathways Regulating Hippo Signaling |
| GO:0001664 | 0.00350613114248 | 0.416666666667 | GNA11 GNAI1 GNAO1 GNAI2 GNAI3 | G protein-coupled receptor binding |
| KEGG:04071 | 0.00363404002896 | 0.25 | GNAI1 GNAI2 GNAI3 | Sphingolipid signaling pathway |
| KEGG:04611 | 0.00383621596611 | 0.25 | GNAI1 GNAI2 GNAI3 | Platelet activation |
| REAC:R-HSA-1430728 | 0.00468258658432 | 0.666666666667 | GNB3 GNAI2 GNAI1 GNB1 GNG11 GNA11 GNG4 GNB4 | Metabolism |
| WP:WP1602 | 0.0054098305295 | 0.166666666667 | GNAI1 GNB1 | Nicotine Activity on Dopaminergic Neurons |
| KEGG:05012 | 0.0055911563553 | 0.25 | GNAI1 GNAI2 GNAI3 | Parkinson disease |
| REAC:R-HSA-1296071 | 0.00581560398629 | 0.25 | GNB3 GNG4 GNB1 | Potassium Channels |
| KEGG:04261 | 0.00599529247902 | 0.25 | GNAI1 GNAI2 GNAI3 | Adrenergic signaling in cardiomyocytes |
| GO:0071242 | 0.00796394320987 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | cellular response to ammonium ion |
| GO:0060359 | 0.00956714039826 | 0.333333333333 | GNAO1 GNA11 GNB1 GNAI3 | response to ammonium ion |
| KEGG:04360 | 0.0124053831682 | 0.25 | GNAI1 GNAI2 GNAI3 | Axon guidance |
| KEGG:04024 | 0.0135441399408 | 0.25 | GNAI1 GNAI2 GNAI3 | cAMP signaling pathway |
| REAC:R-HSA-382551 | 0.0160210411191 | 0.416666666667 | GNB3 GNB4 GNG4 GNG11 GNB1 | Transport of small molecules |
| GO:0035690 | 0.0203507370121 | 0.416666666667 | GNA11 GNAI1 GNAO1 GNB1 GNAI3 | cellular response to drug |
| GO:1902494 | 0.0310109063256 | 0.666666666667 | GNAI1 GNAI3 GNAO1 GNB1 GNG11 GNA11 GNG4 GNAI2 | catalytic complex |
| GO:0005886 | 0.0320464593779 | 0.916666666667 | GNB3 RIC8A GNAI1 RGS12 GNB1 GNG11 GNA11 GNAI3 GNAO1 GNG4 GNAI2 | plasma membrane |
| GO:0044877 | 0.0322091870895 | 0.583333333333 | GNAI1 GNAI3 GNAO1 GNB1 GNA11 GNB4 GNAI2 | protein-containing complex binding |
| GO:0016787 | 0.0379063564144 | 0.75 | GNB3 GNAI3 GNAI1 RGS12 GNB1 GNA11 GNAO1 GNG11 GNAI2 | hydrolase activity |
| GO:0071944 | 0.0416561100359 | 0.916666666667 | GNB3 RIC8A GNAI1 RGS12 GNB1 GNG11 GNA11 GNAI3 GNAO1 GNG4 GNAI2 | cell periphery |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAI1 | GNAI3 | 1.0 | 0.949 | hein_WMM bioplex (GNAI1,GNAI3) bioplex_WMM |
| GNAI2 | GNAI3 | 1.0 | 0.949 | hein_WMM bioplex (GNAI3) bioplex_WMM youn_WMM |
| GNAI1 | GNAO1 | 0.995 | 0.924 | bioplex (GNAI1) bioplex_WMM |
| GNAI1 | RGS12 | 0.994 | 0.919 | bioplex (GNAI1) bioplex_WMM |
| RGS12 | GNAI3 | 0.989 | 0.904 | bioplex (GNAI3) bioplex_WMM |
| GNAI3 | GNAO1 | 0.978 | 0.894 | bioplex (GNAI3) bioplex_WMM |
| GNG11 | GNAI3 | 0.83 | 0.778 | bioplex (GNAI3) bioplex_WMM |
| RIC8A | GNAI3 | 0.745 | 0.74 | bioplex (GNAI3,RIC8A) bioplex_WMM youn_WMM |
| GNAI2 | GNAO1 | 0.602 | 0.671 | bioplex (GNAI2) bioplex_WMM |
| GNB1 | GNAI3 | 0.515 | 0.632 | hein_WMM bioplex (GNAI3) bioplex_WMM youn_WMM gupta_WMM |
| RIC8A | GNAI2 | 0.5 | 0.621 | bioplex (GNAI2,RIC8A) bioplex_WMM treiber_WMM |
| GNAI1 | GNB4 | 0.378 | 0.547 | hein_WMM bioplex (GNAI1) bioplex_WMM gupta_WMM |
| GNAI3 | GNB4 | 0.335 | 0.527 | hein_WMM bioplex (GNAI3) bioplex_WMM gupta_WMM |
| GNB3 | GNAI2 | 0.299 | 0.496 | bioplex (GNAI2) bioplex_WMM |
| GNG4 | GNAI3 | 0.273 | 0.486 | bioplex (GNAI3,GNG4) bioplex_WMM |
| GNAI1 | GNG11 | 0.215 | 0.464 | bioplex (GNAI1) bioplex_WMM |
| GNA11 | GNB4 | 0.1 | 0.361 | bioplex_WMM Guru gupta_WMM fraction |
| GNG4 | GNB4 | 0.086 | 0.351 | bioplex (GNG4) bioplex_WMM |
| GNB1 | GNA11 | 0.079 | 0.351 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| GNAI2 | GNB4 | 0.055 | 0.311 | hein_WMM bioplex (GNAI2) bioplex_WMM |
| GNAI1 | GNB1 | 0.051 | 0.294 | hein_WMM bioplex (GNAI1) bioplex_WMM |
| GNG4 | GNAI2 | 0.049 | 0.296 | bioplex (GNAI2,GNG4) bioplex_WMM |
| GNG4 | GNB1 | 0.047 | 0.291 | bioplex (GNG4) bioplex_WMM |
| GNG11 | GNB1 | 0.013 | 0.141 | bioplex (GNG11) bioplex_WMM |
| GNG4 | RIC8A | 0.013 | 0.154 | bioplex_WMM WMM_only |
| GNB1 | GNAI2 | 0.013 | 0.155 | hein_WMM bioplex (GNAI2) bioplex_WMM |
| RIC8A | GNB1 | 0.013 | 0.15 | hein_WMM bioplex (RIC8A) bioplex_WMM youn_WMM |
| GNB1 | GNB4 | 0.013 | 0.148 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| GNAI1 | GNG4 | 0.012 | 0.148 | bioplex (GNAI1,GNG4) bioplex_WMM |
| GNG4 | GNA11 | 0.012 | 0.149 | bioplex (GNG4) bioplex_WMM |
| GNG11 | RGS12 | 0.011 | 0.148 | bioplex_WMM WMM_only |
| RIC8A | GNAO1 | 0.011 | 0.144 | bioplex_WMM WMM_only |
| GNG4 | GNAO1 | 0.011 | 0.14 | bioplex_WMM WMM_only |
| GNB1 | GNAO1 | 0.011 | 0.142 | bioplex_WMM gupta_WMM WMM_only |
| GNG11 | RIC8A | 0.011 | 0.141 | bioplex_WMM WMM_only |
| RGS12 | RIC8A | 0.011 | 0.141 | bioplex_WMM WMM_only |
| GNG11 | GNG4 | 0.01 | 0.14 | bioplex_WMM WMM_only |
| RGS12 | GNG4 | 0.01 | 0.14 | bioplex_WMM WMM_only |
| GNG11 | GNAO1 | 0.01 | 0.1 | bioplex_WMM WMM_only |
| RGS12 | GNAO1 | 0.01 | 0.1 | bioplex_WMM WMM_only |
| RGS12 | GNB1 | 0.01 | 0.102 | bioplex_WMM WMM_only |
| GNAI1 | GNAI2 | 0.009 | 0.088 | hein_WMM bioplex_WMM WMM_only |
| RIC8A | GNB4 | 0.008 | 0.034 | bioplex_WMM WMM_only |
| GNG11 | GNB4 | 0.008 | 0.022 | bioplex (GNG11) bioplex_WMM |
| GNAI2 | GNA11 | 0.008 | 0.024 | hein_WMM bioplex_WMM WMM_only |
| RGS12 | GNB4 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| GNAO1 | GNB4 | 0.008 | 0.01 | bioplex_WMM gupta_WMM WMM_only |
| GNG11 | GNAI2 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RGS12 | GNAI2 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| GNB3 | RIC8A | 0.007 | 0.007 | bioplex_WMM WMM_only |
| GNAI1 | GNA11 | 0.007 | 0.002 | hein_WMM bioplex_WMM WMM_only |
| GNB3 | GNG4 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| GNB3 | GNAI3 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| GNAI1 | GNB3 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| RIC8A | GNA11 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| GNB3 | GNAO1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| GNB3 | GNB1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| GNAI3 | GNA11 | 0.006 | 0.006 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| GNA11 | GNAO1 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| GNB3 | GNB4 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| GNAI1 | RIC8A | 0.0 | 0.0 | bioplex (GNAI1) bioplex_WMM |
Images
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Complex HuMAP2_01804 has an average edge precision of 0.27 which is ranked 5017 out of all 6965 complexes.
Related Complexes