hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01811
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKR1C3 | Aldo-keto reductase family 1 member C3 (EC 1.-.-.-) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Indanol dehydrogenase) (EC 1.1.1.112) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239) (EC 1.1.1.64) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20) | UniProt NCBI |
| AKR1C4 | Aldo-keto reductase family 1 member C4 (EC 1.1.1.-) (3-alpha-HSD1) (3-alpha-hydroxysteroid dehydrogenase type I) (EC 1.1.1.357) (Chlordecone reductase) (CDR) (EC 1.1.1.225) (Dihydrodiol dehydrogenase 4) (DD-4) (DD4) (HAKRA) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP696 | 1.04322772881e-05 | 1.0 | AKR1C4 AKR1C3 | Benzo(a)pyrene metabolism |
| REAC:R-HSA-193807 | 0.000130722030065 | 1.0 | AKR1C4 AKR1C3 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| REAC:R-HSA-193775 | 0.000130722030065 | 1.0 | AKR1C4 AKR1C3 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| KEGG:00140 | 0.000138019076752 | 1.0 | AKR1C4 AKR1C3 | Steroid hormone biosynthesis |
| REAC:R-HSA-193368 | 0.000351943927099 | 1.0 | AKR1C4 AKR1C3 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| REAC:R-HSA-192105 | 0.000729026706133 | 1.0 | AKR1C4 AKR1C3 | Synthesis of bile acids and bile salts |
| REAC:R-HSA-194068 | 0.0010558317813 | 1.0 | AKR1C4 AKR1C3 | Bile acid and bile salt metabolism |
| REAC:R-HSA-975634 | 0.00137425723915 | 1.0 | AKR1C4 AKR1C3 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.00158542359541 | 1.0 | AKR1C4 AKR1C3 | Metabolism of fat-soluble vitamins |
| GO:0071395 | 0.00270494046827 | 1.0 | AKR1C4 AKR1C3 | cellular response to jasmonic acid stimulus |
| GO:0009753 | 0.00270494046827 | 1.0 | AKR1C4 AKR1C3 | response to jasmonic acid |
| GO:0047086 | 0.00450823411379 | 1.0 | AKR1C4 AKR1C3 | ketosteroid monooxygenase activity |
| REAC:R-HSA-2187338 | 0.00465068760809 | 1.0 | AKR1C4 AKR1C3 | Visual phototransduction |
| WP:WP702 | 0.00467999410771 | 1.0 | AKR1C4 AKR1C3 | Metapathway biotransformation Phase I and II |
| GO:0047023 | 0.00946729163895 | 1.0 | AKR1C4 AKR1C3 | androsterone dehydrogenase activity |
| GO:0032052 | 0.00946729163895 | 1.0 | AKR1C4 AKR1C3 | bile acid binding |
| GO:0001758 | 0.0126230555186 | 1.0 | AKR1C4 AKR1C3 | retinal dehydrogenase activity |
| REAC:R-HSA-8957322 | 0.0131978972662 | 1.0 | AKR1C4 AKR1C3 | Metabolism of steroids |
| GO:0044597 | 0.0162296428096 | 1.0 | AKR1C4 AKR1C3 | daunorubicin metabolic process |
| GO:0042448 | 0.0162296428096 | 1.0 | AKR1C4 AKR1C3 | progesterone metabolic process |
| GO:0030647 | 0.0162296428096 | 1.0 | AKR1C4 AKR1C3 | aminoglycoside antibiotic metabolic process |
| GO:0030638 | 0.0162296428096 | 1.0 | AKR1C4 AKR1C3 | polyketide metabolic process |
| GO:0044598 | 0.0162296428096 | 1.0 | AKR1C4 AKR1C3 | doxorubicin metabolic process |
| REAC:R-HSA-196854 | 0.024074640537 | 1.0 | AKR1C4 AKR1C3 | Metabolism of vitamins and cofactors |
| GO:0004032 | 0.0247952876258 | 1.0 | AKR1C4 AKR1C3 | alditol:NADP+ 1-oxidoreductase activity |
| KEGG:00120 | 0.03257746263 | 0.5 | AKR1C4 | Primary bile acid biosynthesis |
| GO:0016137 | 0.0473364581948 | 1.0 | AKR1C4 AKR1C3 | glycoside metabolic process |
| WP:WP4524 | 0.0499262710315 | 0.5 | AKR1C4 | The alternative pathway of fetal androgen synthesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1C3 | AKR1C4 | 0.95 | 0.858 | bioplex (AKR1C3,AKR1C4) bioplex_WMM |
Images
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Complex HuMAP2_01811 has an average edge precision of 0.858 which is ranked 720 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AKR1C3 | HuMAP2_00882 HuMAP2_01811 HuMAP2_03661 |
| AKR1C4 | HuMAP2_00882 HuMAP2_01811 HuMAP2_03661 HuMAP2_05598 |