hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01819

Confidence: Medium

Genename	Protein Name	Links
NEFM	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	UniProt NCBI
NEFL	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	UniProt NCBI
NEFH	Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)	UniProt NCBI
INA	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)	UniProt NCBI
NES	Nestin	UniProt NCBI
SPATA22	Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)	UniProt NCBI
DES	Desmin	UniProt NCBI
VIM	Vimentin	UniProt NCBI
XPNPEP3	Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005882	2.1445988403e-11	0.777777777778	NEFL NEFH INA VIM NES DES NEFM	intermediate filament
GO:0045111	6.11079088616e-10	0.777777777778	NEFL NEFH INA VIM NES DES NEFM	intermediate filament cytoskeleton
GO:0005883	4.60828413382e-08	0.444444444444	NEFH NEFL INA NEFM	neurofilament
GO:0005200	1.70158852211e-07	0.666666666667	NEFL NEFH INA NEFM DES VIM	structural constituent of cytoskeleton
GO:0045103	3.32834717277e-07	0.555555555556	NEFL NES DES NEFM NEFH	intermediate filament-based process
GO:0045104	3.32834717277e-07	0.555555555556	NEFL NES DES NEFM NEFH	intermediate filament cytoskeleton organization
GO:0045109	7.29022664366e-06	0.444444444444	NEFL DES NEFM NEFH	intermediate filament organization
GO:0033693	7.62876038594e-06	0.333333333333	NEFL NEFM NEFH	neurofilament bundle assembly
GO:0099513	1.23531646606e-05	0.777777777778	NEFL NEFH INA VIM NES DES NEFM	polymeric cytoskeletal fiber
WP:WP2447	7.62618405823e-05	0.333333333333	NEFL NEFM NEFH	Amyotrophic lateral sclerosis (ALS)
GO:0099512	0.000104340186358	0.777777777778	NEFL NEFH INA VIM NES DES NEFM	supramolecular fiber
GO:0099081	0.000113017853245	0.777777777778	NEFL NEFH INA VIM NES DES NEFM	supramolecular polymer
GO:0099080	0.000114522445972	0.777777777778	NEFL NEFH INA VIM NES DES NEFM	supramolecular complex
KEGG:05014	0.000160265071398	0.333333333333	NEFL NEFM NEFH	Amyotrophic lateral sclerosis (ALS)
GO:0045110	0.000266683990267	0.333333333333	NEFL NEFM NEFH	intermediate filament bundle assembly
WP:WP4352	0.000284698080609	0.444444444444	NEFL NEFM XPNPEP3 VIM	Ciliary landscape
WP:WP3680	0.000356282764137	0.333333333333	NEFL NEFM NEFH	Association Between Physico-Chemical Features and Toxicity Associated Pathways
GO:0005198	0.00420157703102	0.666666666667	NEFL NEFH INA NEFM DES VIM	structural molecule activity
WP:WP383	0.0128035909147	0.222222222222	DES VIM	Striated Muscle Contraction Pathway
GO:0044430	0.0316875099411	0.777777777778	NEFL NEFH INA VIM NES DES NEFM	cytoskeletal part
REAC:R-HSA-390522	0.0380767270881	0.222222222222	DES VIM	Striated Muscle Contraction

Edges

Protein 1	Protein 2	Score	Precision	Evidence
DES	VIM	0.97	0.881	bioplex (VIM) bioplex_WMM boldt_WMM treiber_WMM
DES	NEFM	0.74	0.739	bioplex (NEFM) bioplex_WMM boldt_WMM
INA	NEFM	0.707	0.729	bioplex (NEFM) bioplex_WMM boldt_WMM
NEFM	NEFL	0.447	0.591	bioplex (NEFL,NEFM) bioplex_WMM boldt boldt_WMM
VIM	NEFM	0.358	0.54	bioplex (NEFM,VIM) bioplex_WMM boldt (VIM) boldt_WMM
VIM	NES	0.216	0.464	hein_WMM bioplex (VIM) bioplex_WMM hein (NES) treiber_WMM
NEFM	NES	0.163	0.42	bioplex (NEFM) bioplex_WMM
VIM	INA	0.123	0.394	bioplex (VIM) bioplex_WMM boldt_WMM
VIM	NEFL	0.103	0.366	bioplex (NEFL,VIM) bioplex_WMM boldt (VIM) boldt_WMM
DES	SPATA22	0.042	0.27	bioplex (SPATA22) bioplex_WMM
NEFL	NEFH	0.033	0.247	bioplex (NEFH) bioplex_WMM
XPNPEP3	VIM	0.028	0.233	hein_WMM bioplex (VIM) bioplex_WMM boldt (VIM) hein (VIM) boldt_WMM
INA	NEFH	0.022	0.196	bioplex (NEFH) bioplex_WMM
INA	NEFL	0.014	0.14	bioplex_WMM youn_WMM WMM_only boldt_WMM
NEFM	NEFH	0.014	0.141	bioplex (NEFH) bioplex_WMM
DES	INA	0.011	0.143	bioplex_WMM WMM_only boldt_WMM
DES	NES	0.011	0.142	bioplex_WMM WMM_only treiber_WMM
DES	NEFL	0.01	0.14	bioplex_WMM WMM_only boldt_WMM
NEFL	NES	0.01	0.126	bioplex_WMM WMM_only
INA	NES	0.01	0.099	bioplex_WMM WMM_only
XPNPEP3	NEFM	0.009	0.108	bioplex (NEFM) bioplex_WMM boldt boldt_WMM
XPNPEP3	DES	0.008	0.045	bioplex_WMM WMM_only boldt_WMM
XPNPEP3	NEFL	0.007	0.01	bioplex (NEFL) bioplex_WMM boldt boldt_WMM
VIM	NEFH	0.007	0.006	bioplex (NEFH) bioplex_WMM
XPNPEP3	INA	0.007	0.003	bioplex_WMM WMM_only boldt_WMM
DES	NEFH	0.007	0.003	bioplex_WMM WMM_only
SPATA22	VIM	0.007	0.001	bioplex (SPATA22)
XPNPEP3	SPATA22	0.007	0.001	bioplex (SPATA22)
XPNPEP3	NES	0.006	0.004	bioplex_WMM WMM_only
XPNPEP3	NEFH	0.006	0.001	bioplex (NEFH) bioplex_WMM
SPATA22	NEFH	0.005	0.012	bioplex (SPATA22) bioplex_WMM

Images

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Complex HuMAP2_01819 has an average edge precision of 0.232 which is ranked 5656 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NEFM	HuMAP2_01819 HuMAP2_03169 HuMAP2_03286 HuMAP2_04023 HuMAP2_05486 HuMAP2_05674
NEFL	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_04987
NEFH	HuMAP2_01819 HuMAP2_04023 HuMAP2_04987
INA	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_05486
NES	HuMAP2_01819 HuMAP2_03169 HuMAP2_04023
SPATA22	HuMAP2_01489 HuMAP2_01819 HuMAP2_03169 HuMAP2_04023 HuMAP2_06460
DES	HuMAP2_01489 HuMAP2_01819 HuMAP2_03169 HuMAP2_03286 HuMAP2_03392 HuMAP2_04023 HuMAP2_05674 HuMAP2_06460
VIM	HuMAP2_01705 HuMAP2_01819 HuMAP2_03169 HuMAP2_03392 HuMAP2_04023 HuMAP2_04747 HuMAP2_05674
XPNPEP3	HuMAP2_00392 HuMAP2_01437 HuMAP2_01819 HuMAP2_03984 HuMAP2_04023 HuMAP2_05879

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01819