hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01822
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAPK14 | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | UniProt NCBI |
| MAPKAPK3 | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-171007 | 0.000110610948517 | 1.0 | MAPKAPK3 MAPK14 | p38MAPK events |
| KEGG:04370 | 0.000216657853041 | 1.0 | MAPKAPK3 MAPK14 | VEGF signaling pathway |
| REAC:R-HSA-167044 | 0.000227925590883 | 1.0 | MAPKAPK3 MAPK14 | Signalling to RAS |
| REAC:R-HSA-450302 | 0.000424008635981 | 1.0 | MAPKAPK3 MAPK14 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-187687 | 0.000680424925724 | 1.0 | MAPKAPK3 MAPK14 | Signalling to ERKs |
| REAC:R-HSA-450294 | 0.00327307852202 | 1.0 | MAPKAPK3 MAPK14 | MAP kinase activation |
| REAC:R-HSA-448424 | 0.00393171644273 | 1.0 | MAPKAPK3 MAPK14 | Interleukin-17 signaling |
| REAC:R-HSA-187037 | 0.00440432685912 | 1.0 | MAPKAPK3 MAPK14 | Signaling by NTRK1 (TRKA) |
| KEGG:04010 | 0.00476209584058 | 1.0 | MAPKAPK3 MAPK14 | MAPK signaling pathway |
| REAC:R-HSA-168176 | 0.00556574181855 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.00556574181855 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.00556574181855 | 1.0 | MAPKAPK3 MAPK14 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 0.00584226918984 | 1.0 | MAPKAPK3 MAPK14 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.00598304676068 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.00598304676068 | 1.0 | MAPKAPK3 MAPK14 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168138 | 0.00656291627866 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168188 | 0.00656291627866 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00656291627866 | 1.0 | MAPKAPK3 MAPK14 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168164 | 0.00671207346681 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.00686290657842 | 1.0 | MAPKAPK3 MAPK14 | Signaling by NTRKs |
| REAC:R-HSA-4420097 | 0.00686290657842 | 1.0 | MAPKAPK3 MAPK14 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-181438 | 0.0070154156135 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.0070154156135 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-937061 | 0.00716960057204 | 1.0 | MAPKAPK3 MAPK14 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.00716960057204 | 1.0 | MAPKAPK3 MAPK14 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-194138 | 0.00812990471598 | 1.0 | MAPKAPK3 MAPK14 | Signaling by VEGF |
| WP:WP382 | 0.00889388896944 | 1.0 | MAPKAPK3 MAPK14 | MAPK Signaling Pathway |
| REAC:R-HSA-166016 | 0.0115688996608 | 1.0 | MAPKAPK3 MAPK14 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-2559580 | 0.0123699910758 | 1.0 | MAPKAPK3 MAPK14 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-168898 | 0.0163067352889 | 1.0 | MAPKAPK3 MAPK14 | Toll-like Receptor Cascades |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | MAPKAPK3 MAPK14 | Cellular Senescence |
| GO:0004708 | 0.0473364581948 | 1.0 | MAPKAPK3 MAPK14 | MAP kinase kinase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAPK14 | MAPKAPK3 | 1.0 | 0.949 | hein_WMM bioplex (MAPK14,MAPKAPK3) bioplex_WMM hein (MAPK14) |
Images
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Complex HuMAP2_01822 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAPK14 | HuMAP2_01116 HuMAP2_01822 HuMAP2_04988 |
| MAPKAPK3 | HuMAP2_01116 HuMAP2_01822 HuMAP2_05115 |