hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01825
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SPAST | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | UniProt NCBI |
| CMTR1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | UniProt NCBI |
| CHID1 | Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP) | UniProt NCBI |
| RNASEH2A | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | UniProt NCBI |
| FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | UniProt NCBI |
| PRMT7 | Protein arginine N-methyltransferase 7 (EC 2.1.1.321) (Histone-arginine N-methyltransferase PRMT7) ([Myelin basic protein]-arginine N-methyltransferase PRMT7) | UniProt NCBI |
| RNASEH2B | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) | UniProt NCBI |
| RNASEH2C | Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C) | UniProt NCBI |
| SETD3 | Actin-histidine N-methyltransferase (EC 2.1.1.85) (SET domain-containing protein 3) (hSETD3) | UniProt NCBI |
| EHBP1L1 | EH domain-binding protein 1-like protein 1 | UniProt NCBI |
| NHLRC2 | NHL repeat-containing protein 2 | UniProt NCBI |
| VAT1 | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0200149 | 1.10799348151e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | CSF lymphocytic pleiocytosis |
| HP:0030356 | 1.10799348151e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Increased serum interferon-gamma level |
| HP:0012229 | 1.10799348151e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | CSF pleocytosis |
| HP:0009710 | 1.10799348151e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Chilblains |
| HP:0009709 | 1.10799348151e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Increased CSF interferon alpha |
| HP:0009704 | 1.10799348151e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Chronic CSF lymphocytosis |
| HP:0040140 | 1.77198590019e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Degeneration of the striatum |
| HP:0005550 | 1.77198590019e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Chronic lymphatic leukemia |
| HP:0001955 | 1.77198590019e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Unexplained fevers |
| GO:0032299 | 1.99800867251e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | ribonuclease H2 complex |
| HP:0030355 | 2.65677386317e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Abnormal serum interferon-gamma level |
| HP:0030354 | 2.65677386317e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Abnormal serum interferon level |
| HP:0011834 | 3.79367056296e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Moyamoya phenomenon |
| HP:0007052 | 3.79367056296e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Multifocal cerebral white matter abnormalities |
| HP:0004809 | 6.94875764301e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Neonatal alloimmune thrombocytopenia |
| HP:0007076 | 9.02928929254e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Extrapyramidal muscular rigidity |
| HP:0003683 | 9.02928929254e-05 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Large beaked nose |
| HP:0011112 | 0.000114866123402 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Abnormality of serum cytokine level |
| KEGG:03030 | 0.000127762236376 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | DNA replication |
| HP:0030038 | 0.00014351755231 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Enchondroma |
| HP:0011111 | 0.00014351755231 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Abnormality of immune serum protein physiology |
| HP:0003552 | 0.000151859371401 | 0.333333333333 | RNASEH2C SPAST RNASEH2A RNASEH2B | Muscle stiffness |
| HP:0001640 | 0.000170827232113 | 0.333333333333 | NHLRC2 RNASEH2C RNASEH2A RNASEH2B | Cardiomegaly |
| HP:0005558 | 0.000176556896445 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Chronic leukemia |
| HP:0004963 | 0.000176556896445 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Calcification of the aorta |
| HP:0030880 | 0.00025703536297 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Raynaud phenomenon |
| HP:0012490 | 0.000358767927482 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Panniculitis |
| HP:0001063 | 0.000418372774563 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Acrocyanosis |
| HP:0003207 | 0.000635815771206 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Arterial calcification |
| HP:0002132 | 0.000722190247657 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Porencephalic cyst |
| HP:0004934 | 0.000722190247657 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Vascular calcification |
| HP:0000625 | 0.000917604703139 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Eyelid coloboma |
| HP:0011915 | 0.000917604703139 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Cardiovascular calcification |
| HP:0002139 | 0.00114526044683 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Arrhinencephaly |
| HP:0010994 | 0.00114526044683 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Abnormal corpus striatum morphology |
| HP:0100614 | 0.00127193443454 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Myositis |
| HP:0025323 | 0.00127193443454 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Abnormal arterial physiology |
| HP:0011226 | 0.00140757438586 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Aplasia/Hypoplasia of the eyelid |
| HP:0006579 | 0.00140757438586 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Prolonged neonatal jaundice |
| HP:0007108 | 0.00170695449098 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Demyelinating peripheral neuropathy |
| HP:0008936 | 0.00170757799982 | 0.333333333333 | NHLRC2 RNASEH2C RNASEH2A RNASEH2B | Muscular hypotonia of the trunk |
| HP:0002371 | 0.0018712944079 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Loss of speech |
| HP:0000737 | 0.00187867569123 | 0.333333333333 | NHLRC2 RNASEH2C RNASEH2A RNASEH2B | Irritability |
| HP:0001087 | 0.00242650051659 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Developmental glaucoma |
| HP:0002313 | 0.00263329112839 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Spastic paraparesis |
| HP:0100851 | 0.00356222402025 | 0.416666666667 | NHLRC2 RNASEH2C SPAST RNASEH2A RNASEH2B | Abnormal emotion/affect behavior |
| HP:0002061 | 0.00471222227292 | 0.333333333333 | RNASEH2C SPAST RNASEH2A RNASEH2B | Lower limb spasticity |
| HP:0002828 | 0.00572240009027 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Multiple joint contractures |
| HP:0000961 | 0.00646226942427 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Cyanosis |
| HP:0002385 | 0.0072627973726 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Paraparesis |
| HP:0010551 | 0.00768122384406 | 0.333333333333 | RNASEH2C SPAST RNASEH2A RNASEH2B | Paraplegia/paraparesis |
| HP:0002323 | 0.00954464281024 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Anencephaly |
| HP:0001357 | 0.0100513988009 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Plagiocephaly |
| HP:0000965 | 0.0105756174809 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Cutis marmorata |
| HP:0001433 | 0.0111175836489 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Hepatosplenomegaly |
| HP:0001609 | 0.0111175836489 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Hoarse voice |
| HP:0010622 | 0.0128528069703 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Neoplasm of the skeletal system |
| HP:0002180 | 0.014757958661 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Neurodegeneration |
| HP:0002510 | 0.0191084130978 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Spastic tetraplegia |
| HP:0100578 | 0.0207268019196 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Lipoatrophy |
| HP:0025454 | 0.0323583170486 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Abnormal CSF metabolite level |
| HP:0004942 | 0.0323583170486 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Aortic aneurysm |
| HP:0002415 | 0.0407912282172 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Leukodystrophy |
| HP:0002187 | 0.0476227521362 | 0.25 | RNASEH2C RNASEH2A RNASEH2B | Intellectual disability, profound |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RNASEH2C | RNASEH2A | 1.0 | 0.949 | hein_WMM hein (RNASEH2A) fraction |
| RNASEH2B | RNASEH2A | 1.0 | 0.949 | hein_WMM hein (RNASEH2A,RNASEH2B) fraction |
| RNASEH2C | RNASEH2B | 1.0 | 0.949 | hein_WMM hein (RNASEH2B) fraction |
| CMTR1 | SETD3 | 0.148 | 0.409 | fraction |
| SETD3 | RNASEH2A | 0.108 | 0.373 | fraction |
| RNASEH2B | FKBP4 | 0.103 | 0.366 | youn_WMM fraction |
| FKBP4 | NHLRC2 | 0.076 | 0.357 | bioplex_WMM youn_WMM gupta_WMM fraction |
| RNASEH2C | FKBP4 | 0.067 | 0.351 | fraction |
| RNASEH2B | SETD3 | 0.064 | 0.349 | fraction |
| PRMT7 | RNASEH2B | 0.048 | 0.296 | fraction |
| SPAST | RNASEH2B | 0.043 | 0.269 | fraction |
| CMTR1 | RNASEH2A | 0.041 | 0.27 | youn_WMM fraction |
| RNASEH2A | NHLRC2 | 0.04 | 0.267 | bioplex_WMM fraction |
| RNASEH2C | NHLRC2 | 0.039 | 0.264 | fraction |
| PRMT7 | RNASEH2C | 0.038 | 0.261 | fraction |
| RNASEH2A | CHID1 | 0.037 | 0.265 | bioplex_WMM fraction |
| RNASEH2C | EHBP1L1 | 0.029 | 0.23 | fraction |
| CMTR1 | FKBP4 | 0.028 | 0.233 | bioplex_WMM youn_WMM gupta_WMM fraction |
| RNASEH2A | VAT1 | 0.026 | 0.22 | bioplex_WMM fraction |
| RNASEH2A | FKBP4 | 0.026 | 0.215 | bioplex_WMM youn_WMM fraction |
| RNASEH2B | CHID1 | 0.023 | 0.206 | fraction |
| RNASEH2C | CMTR1 | 0.017 | 0.172 | fraction |
| RNASEH2C | CHID1 | 0.014 | 0.145 | fraction |
| RNASEH2C | SETD3 | 0.013 | 0.142 | fraction |
| SPAST | RNASEH2C | 0.012 | 0.15 | fraction |
| RNASEH2C | VAT1 | 0.011 | 0.144 | fraction |
| RNASEH2B | VAT1 | 0.008 | 0.085 | fraction |
| FKBP4 | VAT1 | 0.008 | 0.029 | bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM |
| CHID1 | FKBP4 | 0.007 | 0.005 | gupta_WMM fraction |
| CMTR1 | NHLRC2 | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only |
| PRMT7 | CMTR1 | 0.007 | 0.003 | youn_WMM WMM_only |
| SPAST | CMTR1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CMTR1 | VAT1 | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only |
| PRMT7 | NHLRC2 | 0.007 | 0.005 | bioplex_WMM youn_WMM WMM_only |
| SPAST | RNASEH2A | 0.005 | 0.007 | fraction |
| NHLRC2 | VAT1 | 0.005 | 0.017 | bioplex_WMM gupta_WMM WMM_only |
| RNASEH2B | CMTR1 | 0.004 | 0.013 | fraction |
| SPAST | SETD3 | 0.004 | 0.012 | fraction |
| SPAST | FKBP4 | 0.003 | 0.012 | youn_WMM fraction |
| PRMT7 | FKBP4 | 0.0 | 0.017 | bioplex_WMM youn_WMM fraction |
| SPAST | CHID1 | 0.0 | 0.011 | fraction |
| SETD3 | FKBP4 | 0.0 | 0.01 | bioplex (SETD3) bioplex_WMM fraction |
| PRMT7 | SETD3 | 0.0 | 0.007 | fraction |
| SETD3 | VAT1 | 0.0 | 0.0 | fraction |
Images
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Complex HuMAP2_01825 has an average edge precision of 0.206 which is ranked 6098 out of all 6965 complexes.
Related Complexes