hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01833
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RABIF | Guanine nucleotide exchange factor MSS4 (Rab-interacting factor) | UniProt NCBI |
| DNM3 | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | UniProt NCBI |
| DNM2 | Dynamin-2 (EC 3.6.5.5) | UniProt NCBI |
| DNM1 | Dynamin-1 (EC 3.6.5.5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-177504 | 3.86037630079e-07 | 0.75 | DNM1 DNM3 DNM2 | Retrograde neurotrophin signalling |
| GO:0098844 | 1.45302402969e-06 | 0.75 | DNM1 DNM3 DNM2 | postsynaptic endocytic zone membrane |
| WP:WP2267 | 3.41773973111e-06 | 0.75 | DNM1 DNM3 DNM2 | Synaptic Vesicle Pathway |
| GO:0044327 | 3.6323771075e-06 | 0.75 | DNM1 DNM3 DNM2 | dendritic spine head |
| KEGG:04961 | 5.26171960509e-06 | 0.75 | DNM1 DNM3 DNM2 | Endocrine and other factor-regulated calcium reabsorption |
| GO:0016185 | 7.26438828159e-06 | 0.75 | DNM1 DNM3 DNM2 | synaptic vesicle budding from presynaptic endocytic zone membrane |
| GO:0140239 | 7.26438828159e-06 | 0.75 | DNM1 DNM3 DNM2 | postsynaptic endocytosis |
| GO:0098884 | 7.26438828159e-06 | 0.75 | DNM1 DNM3 DNM2 | postsynaptic neurotransmitter receptor internalization |
| GO:0098843 | 1.27120391093e-05 | 0.75 | DNM1 DNM3 DNM2 | postsynaptic endocytic zone |
| GO:0070142 | 1.27120391093e-05 | 0.75 | DNM1 DNM3 DNM2 | synaptic vesicle budding |
| KEGG:04721 | 1.28493032652e-05 | 0.75 | DNM1 DNM3 DNM2 | Synaptic vesicle cycle |
| KEGG:05100 | 1.66774444702e-05 | 0.75 | DNM1 DNM3 DNM2 | Bacterial invasion of epithelial cells |
| REAC:R-HSA-437239 | 1.91225201676e-05 | 0.75 | DNM1 DNM3 DNM2 | Recycling pathway of L1 |
| GO:0099590 | 4.35775472874e-05 | 0.75 | DNM1 DNM3 DNM2 | neurotransmitter receptor internalization |
| REAC:R-HSA-187037 | 8.36972120253e-05 | 0.75 | DNM1 DNM3 DNM2 | Signaling by NTRK1 (TRKA) |
| KEGG:04072 | 8.70468528245e-05 | 0.75 | DNM1 DNM3 DNM2 | Phospholipase D signaling pathway |
| REAC:R-HSA-166520 | 0.000163333735977 | 0.75 | DNM1 DNM3 DNM2 | Signaling by NTRKs |
| REAC:R-HSA-373760 | 0.000297923324705 | 0.75 | DNM1 DNM3 DNM2 | L1CAM interactions |
| REAC:R-HSA-2132295 | 0.000340340039133 | 0.75 | DNM1 DNM3 DNM2 | MHC class II antigen presentation |
| REAC:R-HSA-166016 | 0.000358372124957 | 0.75 | DNM1 DNM3 DNM2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-8856828 | 0.000468996589794 | 0.75 | DNM1 DNM3 DNM2 | Clathrin-mediated endocytosis |
| KEGG:04144 | 0.000539397470166 | 0.75 | DNM1 DNM3 DNM2 | Endocytosis |
| REAC:R-HSA-196025 | 0.000552609179875 | 0.5 | DNM1 DNM2 | Formation of annular gap junctions |
| REAC:R-HSA-168898 | 0.000600269105338 | 0.75 | DNM1 DNM3 DNM2 | Toll-like Receptor Cascades |
| REAC:R-HSA-190873 | 0.000663071622452 | 0.5 | DNM1 DNM2 | Gap junction degradation |
| GO:0099637 | 0.000943419049714 | 0.75 | DNM1 DNM3 DNM2 | neurotransmitter receptor transport |
| GO:0099072 | 0.00106129291317 | 0.75 | DNM1 DNM3 DNM2 | regulation of postsynaptic membrane neurotransmitter receptor levels |
| GO:0000266 | 0.00132566605022 | 0.75 | DNM1 DNM3 DNM2 | mitochondrial fission |
| GO:0048489 | 0.00217043933003 | 0.75 | DNM1 DNM3 DNM2 | synaptic vesicle transport |
| GO:0140238 | 0.00237379826551 | 0.75 | DNM1 DNM3 DNM2 | presynaptic endocytosis |
| GO:0048488 | 0.00237379826551 | 0.75 | DNM1 DNM3 DNM2 | synaptic vesicle endocytosis |
| GO:0097479 | 0.00358246159338 | 0.75 | DNM1 DNM3 DNM2 | synaptic vesicle localization |
| GO:0036465 | 0.00447413621813 | 0.75 | DNM1 DNM3 DNM2 | synaptic vesicle recycling |
| REAC:R-HSA-190828 | 0.00562500866147 | 0.5 | DNM1 DNM2 | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.00596538345738 | 0.5 | DNM1 DNM2 | Gap junction trafficking and regulation |
| WP:WP4549 | 0.0109018647515 | 0.5 | DNM1 DNM2 | Fragile X Syndrome |
| REAC:R-HSA-9006934 | 0.0147563350021 | 0.75 | DNM1 DNM3 DNM2 | Signaling by Receptor Tyrosine Kinases |
| GO:0043197 | 0.0206918321066 | 0.75 | DNM1 DNM3 DNM2 | dendritic spine |
| GO:0044309 | 0.0215903857674 | 0.75 | DNM1 DNM3 DNM2 | neuron spine |
| GO:0031623 | 0.0225145500348 | 0.75 | DNM1 DNM3 DNM2 | receptor internalization |
| REAC:R-HSA-422475 | 0.0294332368862 | 0.75 | DNM1 DNM3 DNM2 | Axon guidance |
| GO:0045211 | 0.0320435644688 | 0.75 | DNM1 DNM3 DNM2 | postsynaptic membrane |
| REAC:R-HSA-199991 | 0.0426366599823 | 0.75 | DNM1 DNM3 DNM2 | Membrane Trafficking |
| GO:0006900 | 0.0454154921687 | 0.75 | DNM1 DNM3 DNM2 | vesicle budding from membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DNM2 | DNM3 | 0.994 | 0.921 | bioplex (DNM3) bioplex_WMM |
| DNM1 | DNM3 | 0.955 | 0.862 | bioplex (DNM3) bioplex_WMM |
| RABIF | DNM1 | 0.024 | 0.214 | bioplex_WMM fraction |
| DNM2 | DNM1 | 0.011 | 0.148 | bioplex_WMM youn_WMM WMM_only |
| RABIF | DNM3 | 0.003 | 0.011 | bioplex_WMM fraction |
| DNM2 | RABIF | 0.0 | 0.007 | bioplex_WMM fraction |
Images
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Complex HuMAP2_01833 has an average edge precision of 0.36 which is ranked 3755 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RABIF | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 |
| DNM3 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |
| DNM2 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |
| DNM1 | HuMAP2_00829 HuMAP2_01833 HuMAP2_02944 HuMAP2_03916 |