hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01845
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SINHCAF | SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein homolog) | UniProt NCBI |
| ARID4A | AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1) | UniProt NCBI |
| BRMS1 | Breast cancer metastasis-suppressor 1 | UniProt NCBI |
| SIN3A | Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a) | UniProt NCBI |
| ING1 | Inhibitor of growth protein 1 | UniProt NCBI |
| BRMS1L | Breast cancer metastasis-suppressor 1-like protein (BRMS1-homolog protein p40) (BRMS1-like protein p40) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2851 | 3.24304491165e-10 | 0.666666666667 | BRMS1 ARID4A BRMS1L SIN3A | ING2 complex |
| GO:0070822 | 6.65140313081e-07 | 0.666666666667 | SINHCAF SIN3A BRMS1L BRMS1 | Sin3-type complex |
| GO:0000118 | 0.000216594058417 | 0.666666666667 | SINHCAF SIN3A BRMS1L BRMS1 | histone deacetylase complex |
| CORUM:696 | 0.000234668084372 | 0.333333333333 | BRMS1 SIN3A | BRMS1-SIN3-HDAC complex |
| CORUM:738 | 0.000301662071994 | 0.333333333333 | SIN3A ING1 | SIN3-ING1b complex I |
| CORUM:739 | 0.00100428015077 | 0.333333333333 | SIN3A ING1 | SIN3-ING1b complex II |
| GO:0004407 | 0.00366468326223 | 0.5 | BRMS1 BRMS1L SIN3A | histone deacetylase activity |
| GO:0033558 | 0.00416378298645 | 0.5 | BRMS1 BRMS1L SIN3A | protein deacetylase activity |
| GO:0019213 | 0.0129043378459 | 0.5 | BRMS1 BRMS1L SIN3A | deacetylase activity |
| GO:0016811 | 0.0472791215337 | 0.5 | BRMS1 BRMS1L SIN3A | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| GO:0016575 | 0.0499477329172 | 0.5 | BRMS1 BRMS1L SIN3A | histone deacetylation |
| CORUM:1163 | 0.0499726005494 | 0.166666666667 | ING1 | ING1-PCNA complex |
| CORUM:720 | 0.0499726005494 | 0.166666666667 | SIN3A | PU.1-SIN3A-HDAC complex |
| CORUM:1040 | 0.0499726005494 | 0.166666666667 | ING1 | p33ING1b-PCNA complex |
| CORUM:1158 | 0.0499726005494 | 0.166666666667 | ING1 | p33ING1b-p300 complex |
| CORUM:1159 | 0.0499726005494 | 0.166666666667 | ING1 | p33ING1b-HDAC1 complex |
| CORUM:697 | 0.0499726005494 | 0.166666666667 | BRMS1 | BRMS1-RBP1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SIN3A | ARID4A | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru hein (SIN3A) Malo gupta_WMM fraction |
| SINHCAF | SIN3A | 0.993 | 0.918 | hein_WMM bioplex (SINHCAF) bioplex_WMM youn_WMM hein (SIN3A,SINHCAF) |
| SINHCAF | ARID4A | 0.992 | 0.913 | hein_WMM bioplex (SINHCAF) bioplex_WMM hein (SINHCAF) |
| SINHCAF | BRMS1 | 0.972 | 0.886 | hein_WMM bioplex (SINHCAF) bioplex_WMM hein (SINHCAF) |
| SINHCAF | ING1 | 0.838 | 0.782 | hein_WMM bioplex (SINHCAF) bioplex_WMM hein (SINHCAF) |
| SINHCAF | BRMS1L | 0.631 | 0.681 | hein_WMM bioplex (SINHCAF) bioplex_WMM youn_WMM |
| SIN3A | BRMS1L | 0.216 | 0.464 | hein_WMM bioplex_WMM youn_WMM hein (SIN3A) |
| BRMS1 | SIN3A | 0.126 | 0.4 | hein_WMM bioplex_WMM hein (SIN3A) |
| SIN3A | ING1 | 0.047 | 0.293 | hein_WMM bioplex_WMM youn_WMM hein (SIN3A) |
| ARID4A | BRMS1L | 0.027 | 0.227 | hein_WMM bioplex_WMM WMM_only |
| BRMS1 | ARID4A | 0.023 | 0.206 | hein_WMM bioplex_WMM WMM_only |
| BRMS1 | BRMS1L | 0.021 | 0.184 | hein_WMM bioplex_WMM WMM_only |
| ING1 | ARID4A | 0.018 | 0.178 | hein_WMM bioplex_WMM WMM_only |
| BRMS1 | ING1 | 0.017 | 0.169 | hein_WMM bioplex_WMM WMM_only |
| ING1 | BRMS1L | 0.015 | 0.139 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01845 has an average edge precision of 0.493 which is ranked 2540 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SINHCAF | HuMAP2_01845 HuMAP2_03416 |
| ARID4A | HuMAP2_01845 HuMAP2_03416 |
| BRMS1 | HuMAP2_01845 HuMAP2_03416 |
| SIN3A | HuMAP2_01845 HuMAP2_02992 HuMAP2_03416 |
| ING1 | HuMAP2_01845 HuMAP2_03416 |
| BRMS1L | HuMAP2_01845 HuMAP2_03416 |