hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01849
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GRK2 | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | UniProt NCBI |
| GRK3 | Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3) | UniProt NCBI |
| AHNAK | Neuroblast differentiation-associated protein AHNAK (Desmoyokin) | UniProt NCBI |
| ANXA3 | Annexin A3 (35-alpha calcimedin) (Annexin III) (Annexin-3) (Inositol 1,2-cyclic phosphate 2-phosphohydrolase) (Lipocortin III) (Placental anticoagulant protein III) (PAP-III) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4249 | 0.00117729775616 | 0.5 | GRK3 GRK2 | Hedgehog Signaling Pathway |
| KEGG:04340 | 0.00188834163584 | 0.5 | GRK3 GRK2 | Hedgehog signaling pathway |
| KEGG:05032 | 0.00644602944709 | 0.5 | GRK3 GRK2 | Morphine addiction |
| KEGG:04724 | 0.00983130325145 | 0.5 | GRK3 GRK2 | Glutamatergic synapse |
| KEGG:04740 | 0.0151135129134 | 0.5 | GRK3 GRK2 | Olfactory transduction |
| GO:0047696 | 0.0162267366884 | 0.5 | GRK3 GRK2 | beta-adrenergic receptor kinase activity |
| KEGG:04062 | 0.016608760826 | 0.5 | GRK3 GRK2 | Chemokine signaling pathway |
| REAC:R-HSA-8856825 | 0.0390714342086 | 0.5 | GRK3 GRK2 | Cargo recognition for clathrin-mediated endocytosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRK3 | GRK2 | 1.0 | 0.949 | bioplex (GRK2) bioplex_WMM |
| AHNAK | GRK2 | 0.025 | 0.211 | youn_WMM fraction |
| AHNAK | ANXA3 | 0.023 | 0.207 | fraction treiber_WMM |
Images
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Complex HuMAP2_01849 has an average edge precision of 0.456 which is ranked 2834 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GRK2 | HuMAP2_01849 HuMAP2_02054 HuMAP2_02691 HuMAP2_06904 |
| GRK3 | HuMAP2_01849 HuMAP2_02054 HuMAP2_02691 HuMAP2_06904 |
| AHNAK | HuMAP2_00229 HuMAP2_01849 |
| ANXA3 | HuMAP2_00351 HuMAP2_01849 |