hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01854
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKT1 | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) | UniProt NCBI |
| CDK3 | Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3) | UniProt NCBI |
| AKT3 | RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) | UniProt NCBI |
| AKT2 | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta) | UniProt NCBI |
| HSP90AB4P | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-211163 | 5.40157631853e-09 | 0.75 | AKT2 AKT1 AKT3 | AKT-mediated inactivation of FOXO1A |
| REAC:R-HSA-8941332 | 4.72566509639e-08 | 0.75 | AKT2 AKT1 AKT3 | RUNX2 regulates genes involved in cell migration |
| REAC:R-HSA-198693 | 1.13404535396e-07 | 0.75 | AKT2 AKT1 AKT3 | AKT phosphorylates targets in the nucleus |
| REAC:R-HSA-210745 | 2.22736463084e-07 | 0.75 | AKT2 AKT1 AKT3 | Regulation of gene expression in beta cells |
| REAC:R-HSA-9614399 | 2.22736463084e-07 | 0.75 | AKT2 AKT1 AKT3 | Regulation of localization of FOXO transcription factors |
| REAC:R-HSA-1358803 | 2.96966986958e-07 | 0.75 | AKT2 AKT1 AKT3 | Downregulation of ERBB2:ERBB3 signaling |
| REAC:R-HSA-6804759 | 3.86037630079e-07 | 0.75 | AKT2 AKT1 AKT3 | Regulation of TP53 Activity through Association with Co-factors |
| REAC:R-HSA-198323 | 4.9129586178e-07 | 0.75 | AKT2 AKT1 AKT3 | AKT phosphorylates targets in the cytosol |
| WP:WP26 | 5.18388253329e-07 | 0.75 | AKT2 AKT1 AKT3 | Signal Transduction of S1P Receptor |
| WP:WP4561 | 5.18388253329e-07 | 0.75 | AKT2 AKT1 AKT3 | Cell migration and invasion through p75NTR |
| REAC:R-HSA-111447 | 6.14088879325e-07 | 0.75 | AKT2 AKT1 AKT3 | Activation of BAD and translocation to mitochondria |
| WP:WP3965 | 7.38253492454e-07 | 0.75 | AKT2 AKT1 AKT3 | Lipid Metabolism Pathway |
| WP:WP4481 | 9.14837263068e-07 | 0.75 | AKT2 AKT1 AKT3 | Resistin as a regulator of inflammation |
| REAC:R-HSA-389513 | 9.1766670065e-07 | 0.75 | AKT2 AKT1 AKT3 | CTLA4 inhibitory signaling |
| REAC:R-HSA-9634638 | 1.30754323077e-06 | 0.75 | AKT2 AKT1 AKT3 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
| REAC:R-HSA-389357 | 1.30754323077e-06 | 0.75 | AKT2 AKT1 AKT3 | CD28 dependent PI3K/Akt signaling |
| WP:WP4564 | 1.34809896275e-06 | 0.75 | AKT2 AKT1 AKT3 | Neural Crest Cell Migration during Development |
| WP:WP4565 | 1.75019113556e-06 | 0.75 | AKT2 AKT1 AKT3 | Neural Crest Cell Migration in Cancer |
| REAC:R-HSA-392451 | 1.7944862533e-06 | 0.75 | AKT2 AKT1 AKT3 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-8863795 | 2.38925919874e-06 | 0.75 | AKT2 AKT1 AKT3 | Downregulation of ERBB2 signaling |
| KEGG:04973 | 2.65367525435e-06 | 0.75 | AKT2 AKT1 AKT3 | Carbohydrate digestion and absorption |
| REAC:R-HSA-5674400 | 3.10262114446e-06 | 0.75 | AKT2 AKT1 AKT3 | Constitutive Signaling by AKT1 E17K in Cancer |
| WP:WP4566 | 3.41773973111e-06 | 0.75 | AKT2 AKT1 AKT3 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-5218920 | 3.50713401381e-06 | 0.75 | AKT2 AKT1 AKT3 | VEGFR2 mediated vascular permeability |
| KEGG:04923 | 3.5564960873e-06 | 0.75 | AKT2 AKT1 AKT3 | Regulation of lipolysis in adipocytes |
| WP:WP4539 | 3.65058316643e-06 | 0.75 | AKT2 AKT1 AKT3 | Synaptic signaling pathways associated with autism spectrum disorder |
| REAC:R-HSA-397795 | 4.41854320762e-06 | 0.75 | AKT2 AKT1 AKT3 | G-protein beta:gamma signalling |
| REAC:R-HSA-389356 | 4.41854320762e-06 | 0.75 | AKT2 AKT1 AKT3 | CD28 co-stimulation |
| REAC:R-HSA-186712 | 4.92812658075e-06 | 0.75 | AKT2 AKT1 AKT3 | Regulation of beta-cell development |
| REAC:R-HSA-6804758 | 5.47542005033e-06 | 0.75 | AKT2 AKT1 AKT3 | Regulation of TP53 Activity through Acetylation |
| REAC:R-HSA-114452 | 5.47542005033e-06 | 0.75 | AKT2 AKT1 AKT3 | Activation of BH3-only proteins |
| WP:WP4205 | 6.58415941968e-06 | 0.75 | AKT2 AKT1 AKT3 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04929 | 6.65741516792e-06 | 0.75 | AKT2 AKT1 AKT3 | GnRH secretion |
| KEGG:04664 | 7.04114124692e-06 | 0.75 | AKT2 AKT1 AKT3 | Fc epsilon RI signaling pathway |
| KEGG:04370 | 7.04114124692e-06 | 0.75 | AKT2 AKT1 AKT3 | VEGF signaling pathway |
| KEGG:04213 | 7.43932072019e-06 | 0.75 | AKT2 AKT1 AKT3 | Longevity regulating pathway - multiple species |
| KEGG:05213 | 7.85221975235e-06 | 0.75 | AKT2 AKT1 AKT3 | Endometrial cancer |
| WP:WP4155 | 8.50820332609e-06 | 0.75 | AKT2 AKT1 AKT3 | Endometrial cancer |
| REAC:R-HSA-6804757 | 8.82452886806e-06 | 0.75 | AKT2 AKT1 AKT3 | Regulation of TP53 Degradation |
| KEGG:05221 | 9.18189503509e-06 | 0.75 | AKT2 AKT1 AKT3 | Acute myeloid leukemia |
| REAC:R-HSA-6806003 | 9.62627312117e-06 | 0.75 | AKT2 AKT1 AKT3 | Regulation of TP53 Expression and Degradation |
| KEGG:04917 | 1.0146820263e-05 | 0.75 | AKT2 AKT1 AKT3 | Prolactin signaling pathway |
| KEGG:05218 | 1.0146820263e-05 | 0.75 | AKT2 AKT1 AKT3 | Melanoma |
| KEGG:05211 | 1.06536230694e-05 | 0.75 | AKT2 AKT1 AKT3 | Renal cell carcinoma |
| KEGG:04920 | 1.1177007069e-05 | 0.75 | AKT2 AKT1 AKT3 | Adipocytokine signaling pathway |
| KEGG:05223 | 1.1177007069e-05 | 0.75 | AKT2 AKT1 AKT3 | Non-small cell lung cancer |
| WP:WP4255 | 1.23096465226e-05 | 0.75 | AKT2 AKT1 AKT3 | Non-small cell lung cancer |
| KEGG:04662 | 1.28493032652e-05 | 0.75 | AKT2 AKT1 AKT3 | B cell receptor signaling pathway |
| KEGG:05230 | 1.28493032652e-05 | 0.75 | AKT2 AKT1 AKT3 | Central carbon metabolism in cancer |
| WP:WP4216 | 1.28520696315e-05 | 0.75 | AKT2 AKT1 AKT3 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:05214 | 1.34416688046e-05 | 0.75 | AKT2 AKT1 AKT3 | Glioma |
| KEGG:05212 | 1.5327283042e-05 | 0.75 | AKT2 AKT1 AKT3 | Pancreatic cancer |
| REAC:R-HSA-1227986 | 1.54728521392e-05 | 0.75 | AKT2 AKT1 AKT3 | Signaling by ERBB2 |
| KEGG:01524 | 1.59928783462e-05 | 0.75 | AKT2 AKT1 AKT3 | Platinum drug resistance |
| KEGG:01521 | 1.7381246657e-05 | 0.75 | AKT2 AKT1 AKT3 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 1.7381246657e-05 | 0.75 | AKT2 AKT1 AKT3 | Chronic myeloid leukemia |
| WP:WP2261 | 1.99028350738e-05 | 0.75 | AKT2 AKT1 AKT3 | Signaling Pathways in Glioblastoma |
| WP:WP4263 | 2.06481472174e-05 | 0.75 | AKT2 AKT1 AKT3 | Pancreatic adenocarcinoma pathway |
| KEGG:04012 | 2.11980782425e-05 | 0.75 | AKT2 AKT1 AKT3 | ErbB signaling pathway |
| KEGG:05235 | 2.20228638729e-05 | 0.75 | AKT2 AKT1 AKT3 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP673 | 2.2194047028e-05 | 0.75 | AKT2 AKT1 AKT3 | ErbB Signaling Pathway |
| KEGG:04914 | 2.28687407492e-05 | 0.75 | AKT2 AKT1 AKT3 | Progesterone-mediated oocyte maturation |
| KEGG:05210 | 2.37359736806e-05 | 0.75 | AKT2 AKT1 AKT3 | Colorectal cancer |
| KEGG:04211 | 2.37359736806e-05 | 0.75 | AKT2 AKT1 AKT3 | Longevity regulating pathway |
| WP:WP75 | 2.46544135014e-05 | 0.75 | AKT2 AKT1 AKT3 | Toll-like Receptor Signaling Pathway |
| REAC:R-HSA-109606 | 2.64063995051e-05 | 0.75 | AKT2 AKT1 AKT3 | Intrinsic Pathway for Apoptosis |
| KEGG:04620 | 2.74237602459e-05 | 0.75 | AKT2 AKT1 AKT3 | Toll-like receptor signaling pathway |
| WP:WP185 | 2.91471848583e-05 | 0.75 | AKT2 AKT1 AKT3 | Integrin-mediated Cell Adhesion |
| KEGG:05142 | 2.94026709165e-05 | 0.75 | AKT2 AKT1 AKT3 | Chagas disease (American trypanosomiasis) |
| KEGG:04666 | 2.94026709165e-05 | 0.75 | AKT2 AKT1 AKT3 | Fc gamma R-mediated phagocytosis |
| KEGG:04625 | 2.94026709165e-05 | 0.75 | AKT2 AKT1 AKT3 | C-type lectin receptor signaling pathway |
| KEGG:05231 | 3.04268063402e-05 | 0.75 | AKT2 AKT1 AKT3 | Choline metabolism in cancer |
| WP:WP4658 | 3.10867203099e-05 | 0.75 | AKT2 AKT1 AKT3 | Small cell lung cancer |
| KEGG:05215 | 3.14744143419e-05 | 0.75 | AKT2 AKT1 AKT3 | Prostate cancer |
| KEGG:04660 | 3.14744143419e-05 | 0.75 | AKT2 AKT1 AKT3 | T cell receptor signaling pathway |
| KEGG:01522 | 3.14744143419e-05 | 0.75 | AKT2 AKT1 AKT3 | Endocrine resistance |
| KEGG:04933 | 3.25457592428e-05 | 0.75 | AKT2 AKT1 AKT3 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-388841 | 3.34108196159e-05 | 0.75 | AKT2 AKT1 AKT3 | Costimulation by the CD28 family |
| KEGG:05222 | 3.36411053102e-05 | 0.75 | AKT2 AKT1 AKT3 | Small cell lung cancer |
| WP:WP3931 | 3.41541600995e-05 | 0.75 | AKT2 AKT1 AKT3 | ESC Pluripotency Pathways |
| KEGG:04668 | 3.4760716757e-05 | 0.75 | AKT2 AKT1 AKT3 | TNF signaling pathway |
| WP:WP1559 | 3.52660392509e-05 | 0.5 | AKT2 AKT1 | TFs Regulate miRNAs related to cardiac hypertrophy |
| KEGG:05145 | 3.59048577419e-05 | 0.75 | AKT2 AKT1 AKT3 | Toxoplasmosis |
| KEGG:04922 | 3.82677846902e-05 | 0.75 | AKT2 AKT1 AKT3 | Glucagon signaling pathway |
| KEGG:04725 | 3.82677846902e-05 | 0.75 | AKT2 AKT1 AKT3 | Cholinergic synapse |
| WP:WP710 | 4.08802374395e-05 | 0.75 | AKT2 AKT1 AKT3 | DNA Damage Response (only ATM dependent) |
| REAC:R-HSA-9614085 | 4.15544275563e-05 | 0.75 | AKT2 AKT1 AKT3 | FOXO-mediated transcription |
| KEGG:04066 | 4.32996100123e-05 | 0.75 | AKT2 AKT1 AKT3 | HIF-1 signaling pathway |
| KEGG:04931 | 4.59727301554e-05 | 0.75 | AKT2 AKT1 AKT3 | Insulin resistance |
| KEGG:04380 | 4.73495151826e-05 | 0.75 | AKT2 AKT1 AKT3 | Osteoclast differentiation |
| KEGG:04722 | 5.31309720846e-05 | 0.75 | AKT2 AKT1 AKT3 | Neurotrophin signaling pathway |
| KEGG:04071 | 5.61899791571e-05 | 0.75 | AKT2 AKT1 AKT3 | Sphingolipid signaling pathway |
| KEGG:04611 | 5.93639809967e-05 | 0.75 | AKT2 AKT1 AKT3 | Platelet activation |
| WP:WP1449 | 5.98770817475e-05 | 0.75 | AKT2 AKT1 AKT3 | Regulation of toll-like receptor signaling pathway |
| KEGG:04152 | 6.09947630131e-05 | 0.75 | AKT2 AKT1 AKT3 | AMPK signaling pathway |
| KEGG:05135 | 6.09947630131e-05 | 0.75 | AKT2 AKT1 AKT3 | Yersinia infection |
| REAC:R-HSA-9009391 | 6.16010596593e-05 | 0.75 | AKT2 AKT1 AKT3 | Extra-nuclear estrogen signaling |
| KEGG:04919 | 6.26550832836e-05 | 0.75 | AKT2 AKT1 AKT3 | Thyroid hormone signaling pathway |
| KEGG:04068 | 6.43452048828e-05 | 0.75 | AKT2 AKT1 AKT3 | FoxO signaling pathway |
| REAC:R-HSA-8948751 | 6.7458189168e-05 | 0.75 | AKT2 AKT1 AKT3 | Regulation of PTEN stability and activity |
| WP:WP3929 | 6.95487562915e-05 | 0.75 | AKT2 AKT1 AKT3 | Chemokine signaling pathway |
| KEGG:04926 | 7.51264877201e-05 | 0.75 | AKT2 AKT1 AKT3 | Relaxin signaling pathway |
| REAC:R-HSA-2219528 | 7.69213089466e-05 | 0.75 | AKT2 AKT1 AKT3 | PI3K/AKT Signaling in Cancer |
| KEGG:04728 | 7.70325801518e-05 | 0.75 | AKT2 AKT1 AKT3 | Dopaminergic synapse |
| KEGG:04630 | 7.70325801518e-05 | 0.75 | AKT2 AKT1 AKT3 | JAK-STAT signaling pathway |
| KEGG:04915 | 7.89705765566e-05 | 0.75 | AKT2 AKT1 AKT3 | Estrogen signaling pathway |
| KEGG:04550 | 8.0940739521e-05 | 0.75 | AKT2 AKT1 AKT3 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04371 | 8.29433315773e-05 | 0.75 | AKT2 AKT1 AKT3 | Apelin signaling pathway |
| KEGG:04210 | 8.49786152038e-05 | 0.75 | AKT2 AKT1 AKT3 | Apoptosis |
| KEGG:05418 | 8.49786152038e-05 | 0.75 | AKT2 AKT1 AKT3 | Fluid shear stress and atherosclerosis |
| KEGG:04910 | 8.49786152038e-05 | 0.75 | AKT2 AKT1 AKT3 | Insulin signaling pathway |
| KEGG:04072 | 8.70468528245e-05 | 0.75 | AKT2 AKT1 AKT3 | Phospholipase D signaling pathway |
| WP:WP4239 | 8.98774610281e-05 | 0.75 | AKT2 AKT1 AKT3 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:05162 | 9.12832394729e-05 | 0.75 | AKT2 AKT1 AKT3 | Measles |
| KEGG:04261 | 9.34519130775e-05 | 0.75 | AKT2 AKT1 AKT3 | Adrenergic signaling in cardiomyocytes |
| WP:WP4396 | 9.39528133447e-05 | 0.75 | AKT2 AKT1 AKT3 | Nonalcoholic fatty liver disease |
| REAC:R-HSA-199418 | 9.45884271068e-05 | 0.75 | AKT2 AKT1 AKT3 | Negative regulation of the PI3K/AKT network |
| KEGG:05224 | 9.56545898299e-05 | 0.75 | AKT2 AKT1 AKT3 | Breast cancer |
| KEGG:04062 | 9.56545898299e-05 | 0.75 | AKT2 AKT1 AKT3 | Chemokine signaling pathway |
| KEGG:05226 | 9.7891531883e-05 | 0.75 | AKT2 AKT1 AKT3 | Gastric cancer |
| WP:WP4262 | 9.81492425143e-05 | 0.75 | AKT2 AKT1 AKT3 | Breast cancer pathway |
| KEGG:04932 | 0.000102469260232 | 0.75 | AKT2 AKT1 AKT3 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:04140 | 0.000102469260232 | 0.75 | AKT2 AKT1 AKT3 | Autophagy - animal |
| KEGG:05160 | 0.000109599393216 | 0.75 | AKT2 AKT1 AKT3 | Hepatitis C |
| REAC:R-HSA-5628897 | 0.000110523666277 | 0.75 | AKT2 AKT1 AKT3 | TP53 Regulates Metabolic Genes |
| WP:WP4666 | 0.000111482542004 | 0.75 | AKT2 AKT1 AKT3 | Hepatitis B infection |
| REAC:R-HSA-69202 | 0.000119121057505 | 0.75 | AKT2 AKT1 AKT3 | Cyclin E associated events during G1/S transition |
| KEGG:04022 | 0.000122203178829 | 0.75 | AKT2 AKT1 AKT3 | cGMP-PKG signaling pathway |
| REAC:R-HSA-69656 | 0.00012815247216 | 0.75 | AKT2 AKT1 AKT3 | Cyclin A:Cdk2-associated events at S phase entry |
| KEGG:04150 | 0.00013020910184 | 0.75 | AKT2 AKT1 AKT3 | mTOR signaling pathway |
| REAC:R-HSA-8876198 | 0.000132834259164 | 0.75 | AKT2 AKT1 AKT3 | RAB GEFs exchange GTP for GDP on RABs |
| KEGG:04218 | 0.000132953253798 | 0.75 | AKT2 AKT1 AKT3 | Cellular senescence |
| WP:WP4223 | 0.000136289943844 | 0.75 | AKT2 AKT1 AKT3 | Ras Signaling |
| KEGG:05164 | 0.000141415901292 | 0.75 | AKT2 AKT1 AKT3 | Influenza A |
| KEGG:05152 | 0.000147252104815 | 0.75 | AKT2 AKT1 AKT3 | Tuberculosis |
| KEGG:05161 | 0.000162538377473 | 0.75 | AKT2 AKT1 AKT3 | Hepatitis B |
| REAC:R-HSA-4420097 | 0.000163333735977 | 0.75 | AKT2 AKT1 AKT3 | VEGFA-VEGFR2 Pathway |
| KEGG:05225 | 0.000175500256423 | 0.75 | AKT2 AKT1 AKT3 | Hepatocellular carcinoma |
| KEGG:05167 | 0.000196203606831 | 0.75 | AKT2 AKT1 AKT3 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-194138 | 0.000210794457716 | 0.75 | AKT2 AKT1 AKT3 | Signaling by VEGF |
| KEGG:04024 | 0.000214647688386 | 0.75 | AKT2 AKT1 AKT3 | cAMP signaling pathway |
| KEGG:04015 | 0.000226248540233 | 0.75 | AKT2 AKT1 AKT3 | Rap1 signaling pathway |
| WP:WP306 | 0.00024361518378 | 0.75 | AKT2 AKT1 AKT3 | Focal Adhesion |
| REAC:R-HSA-8878166 | 0.000244673540066 | 0.75 | AKT2 AKT1 AKT3 | Transcriptional regulation by RUNX2 |
| KEGG:05169 | 0.000267914054047 | 0.75 | AKT2 AKT1 AKT3 | Epstein-Barr virus infection |
| KEGG:04014 | 0.00027234077557 | 0.75 | AKT2 AKT1 AKT3 | Ras signaling pathway |
| KEGG:05205 | 0.000290533663619 | 0.75 | AKT2 AKT1 AKT3 | Proteoglycans in cancer |
| KEGG:04510 | 0.000295204681571 | 0.75 | AKT2 AKT1 AKT3 | Focal adhesion |
| KEGG:05166 | 0.000334381475127 | 0.75 | AKT2 AKT1 AKT3 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-9007101 | 0.000340340039133 | 0.75 | AKT2 AKT1 AKT3 | Rab regulation of trafficking |
| KEGG:05170 | 0.000344687561831 | 0.75 | AKT2 AKT1 AKT3 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.000360539009602 | 0.75 | AKT2 AKT1 AKT3 | Human cytomegalovirus infection |
| WP:WP382 | 0.000385360586168 | 0.75 | AKT2 AKT1 AKT3 | MAPK Signaling Pathway |
| REAC:R-HSA-69206 | 0.000480050915503 | 0.75 | AKT2 AKT1 AKT3 | G1/S Transition |
| REAC:R-HSA-6807070 | 0.000537928298347 | 0.75 | AKT2 AKT1 AKT3 | PTEN Regulation |
| WP:WP3932 | 0.000615604541072 | 0.75 | AKT2 AKT1 AKT3 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| HP:0001528 | 0.000636114718594 | 0.5 | AKT2 AKT1 | Hemihypertrophy |
| REAC:R-HSA-453279 | 0.000695357358954 | 0.75 | AKT2 AKT1 AKT3 | Mitotic G1-G1/S phases |
| KEGG:04010 | 0.000734165415649 | 0.75 | AKT2 AKT1 AKT3 | MAPK signaling pathway |
| REAC:R-HSA-5633007 | 0.000847823442334 | 0.75 | AKT2 AKT1 AKT3 | Regulation of TP53 Activity |
| WP:WP4172 | 0.000867148271367 | 0.75 | AKT2 AKT1 AKT3 | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-69242 | 0.000880763368668 | 0.75 | AKT2 AKT1 AKT3 | S Phase |
| REAC:R-HSA-109581 | 0.00105827201724 | 0.75 | AKT2 AKT1 AKT3 | Apoptosis |
| REAC:R-HSA-5357801 | 0.00111581489513 | 0.75 | AKT2 AKT1 AKT3 | Programmed Cell Death |
| KEGG:04151 | 0.00118089914293 | 0.75 | AKT2 AKT1 AKT3 | PI3K-Akt signaling pathway |
| WP:WP2036 | 0.00130601363574 | 0.5 | AKT2 AKT1 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| KEGG:05165 | 0.00132804938561 | 0.75 | AKT2 AKT1 AKT3 | Human papillomavirus infection |
| REAC:R-HSA-8939211 | 0.00186375881111 | 0.75 | AKT2 AKT1 AKT3 | ESR-mediated signaling |
| WP:WP2795 | 0.00188734205227 | 0.5 | AKT2 AKT1 | Cardiac Hypertrophic Response |
| WP:WP2018 | 0.00221783487587 | 0.5 | AKT2 AKT1 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| KEGG:05168 | 0.00237639508828 | 0.75 | AKT2 AKT1 AKT3 | Herpes simplex virus 1 infection |
| REAC:R-HSA-1257604 | 0.00250140055192 | 0.75 | AKT2 AKT1 AKT3 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006931 | 0.00319035348708 | 0.75 | AKT2 AKT1 AKT3 | Signaling by Nuclear Receptors |
| WP:WP1403 | 0.00336828295894 | 0.5 | AKT2 AKT1 | AMP-activated Protein Kinase (AMPK) Signaling |
| REAC:R-HSA-9006925 | 0.00399488218563 | 0.75 | AKT2 AKT1 AKT3 | Intracellular signaling by second messengers |
| KEGG:05200 | 0.00437599198048 | 0.75 | AKT2 AKT1 AKT3 | Pathways in cancer |
| WP:WP1544 | 0.00475658252429 | 0.5 | AKT2 AKT1 | MicroRNAs in cardiomyocyte hypertrophy |
| REAC:R-HSA-3769402 | 0.00742649434549 | 0.5 | AKT2 AKT1 | Deactivation of the beta-catenin transactivating complex |
| REAC:R-HSA-165159 | 0.00742649434549 | 0.5 | AKT2 AKT1 | mTOR signalling |
| REAC:R-HSA-5663202 | 0.00839415877685 | 0.75 | AKT2 AKT1 AKT3 | Diseases of signal transduction |
| REAC:R-HSA-3700989 | 0.00924066477779 | 0.75 | AKT2 AKT1 AKT3 | Transcriptional Regulation by TP53 |
| WP:WP3915 | 0.012672821387 | 0.5 | AKT2 AKT1 | Angiopoietin Like Protein 8 Regulatory Pathway |
| HP:0100555 | 0.0134847743701 | 0.5 | AKT2 AKT1 | Asymmetric growth |
| REAC:R-HSA-9006934 | 0.0147563350021 | 0.75 | AKT2 AKT1 AKT3 | Signaling by Receptor Tyrosine Kinases |
| GO:0010748 | 0.0162267366884 | 0.5 | AKT2 AKT1 | negative regulation of long-chain fatty acid import across plasma membrane |
| GO:0010746 | 0.0162267366884 | 0.5 | AKT2 AKT1 | regulation of long-chain fatty acid import across plasma membrane |
| GO:0140213 | 0.0162267366884 | 0.5 | AKT2 AKT1 | negative regulation of long-chain fatty acid import into cell |
| WP:WP2366 | 0.0166793461628 | 0.25 | AKT1 | Butyrate-induced histone acetylation |
| GO:0004674 | 0.0181401540934 | 1.0 | AKT1 AKT2 CDK3 AKT3 | protein serine/threonine kinase activity |
| MIRNA:hsa-miR-184 | 0.0187858608682 | 0.5 | AKT2 AKT1 | hsa-miR-184 |
| WP:WP481 | 0.0195247658454 | 0.5 | AKT2 AKT1 | Insulin Signaling |
| HP:0000147 | 0.0224167415402 | 0.5 | AKT2 AKT1 | Polycystic ovaries |
| REAC:R-HSA-1445148 | 0.0227713839361 | 0.5 | AKT2 AKT1 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| CORUM:3848 | 0.0249595281251 | 0.25 | AKT2 | TCL1(trimer)-AKT2 complex |
| CORUM:3847 | 0.0249595281251 | 0.25 | AKT1 | TCL1(trimer)-AKT1 complex |
| MIRNA:hsa-miR-126-3p | 0.0261296427357 | 0.5 | AKT2 AKT1 | hsa-miR-126-3p |
| HP:0000138 | 0.0266188198793 | 0.5 | AKT2 AKT1 | Ovarian cyst |
| GO:2000192 | 0.0270421395626 | 0.5 | AKT2 AKT1 | negative regulation of fatty acid transport |
| GO:0015911 | 0.0270421395626 | 0.5 | AKT2 AKT1 | long-chain fatty acid import across plasma membrane |
| GO:0010918 | 0.0270421395626 | 0.5 | AKT2 AKT1 | positive regulation of mitochondrial membrane potential |
| REAC:R-HSA-69278 | 0.0299490115235 | 0.75 | AKT2 AKT1 AKT3 | Cell Cycle, Mitotic |
| REAC:R-HSA-388396 | 0.0339148209768 | 0.75 | AKT2 AKT1 AKT3 | GPCR downstream signalling |
| GO:0140212 | 0.0405595771497 | 0.5 | AKT2 AKT1 | regulation of long-chain fatty acid import into cell |
| GO:0060644 | 0.0405595771497 | 0.5 | AKT2 AKT1 | mammary gland epithelial cell differentiation |
| REAC:R-HSA-199991 | 0.0426366599823 | 0.75 | AKT2 AKT1 AKT3 | Membrane Trafficking |
| REAC:R-HSA-372790 | 0.0432949536543 | 0.75 | AKT2 AKT1 AKT3 | Signaling by GPCR |
| HP:0000771 | 0.0470133620262 | 0.5 | AKT2 AKT1 | Gynecomastia |
| CORUM:2628 | 0.0499140284799 | 0.25 | CDK3 | CCNC-CDK3 complex |
| CORUM:2156 | 0.0499140284799 | 0.25 | AKT1 | YBX1-AKT1 complex |
| CORUM:3138 | 0.0499140284799 | 0.25 | AKT2 | POSH-AKT2 complex |
| CORUM:7266 | 0.0499140284799 | 0.25 | AKT1 | AKT1-NQO2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKT2 | AKT1 | 0.999 | 0.949 | bioplex (AKT1) bioplex_WMM youn_WMM |
| AKT3 | AKT1 | 0.283 | 0.488 | bioplex (AKT1,AKT3) bioplex_WMM |
| HSP90AB4P | AKT3 | 0.088 | 0.353 | bioplex (AKT3) bioplex_WMM |
| HSP90AB4P | CDK3 | 0.07 | 0.348 | bioplex (CDK3) bioplex_WMM |
| AKT2 | AKT3 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| HSP90AB4P | AKT1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| HSP90AB4P | AKT2 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| CDK3 | AKT1 | 0.007 | 0.001 | youn_WMM WMM_only |
| AKT2 | CDK3 | 0.0 | 0.017 | bioplex (CDK3) bioplex_WMM youn_WMM |
Images
Click to enlarge
Complex HuMAP2_01854 has an average edge precision of 0.25 which is ranked 5382 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AKT1 | HuMAP2_01854 HuMAP2_04755 |
| CDK3 | HuMAP2_01854 HuMAP2_05212 |
| AKT3 | HuMAP2_01854 HuMAP2_03159 HuMAP2_04784 |
| AKT2 | HuMAP2_01854 HuMAP2_04755 |
| HSP90AB4P | HuMAP2_00682 HuMAP2_01854 HuMAP2_04784 HuMAP2_06154 HuMAP2_06166 |