hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01868
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTNNB1 | Catenin beta-1 (Beta-catenin) | UniProt NCBI |
| CDH1 | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | UniProt NCBI |
| CTNNA2 | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | UniProt NCBI |
| CTNNA1 | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05213 | 7.13814125159e-09 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | Endometrial cancer |
| WP:WP4155 | 8.45275895801e-09 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | Endometrial cancer |
| KEGG:04520 | 1.56222127292e-08 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | Adherens junction |
| KEGG:05100 | 1.96687858091e-08 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | Bacterial invasion of epithelial cells |
| KEGG:05226 | 2.11728896266e-07 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | Gastric cancer |
| KEGG:04390 | 2.93370268701e-07 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | Hippo signaling pathway |
| WP:WP4534 | 2.40067855039e-06 | 0.75 | CTNNB1 CDH1 CTNNA1 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| REAC:R-HSA-525793 | 3.10262114446e-06 | 0.75 | CTNNB1 CTNNA1 CTNNA2 | Myogenesis |
| GO:0071680 | 3.6323771075e-06 | 0.75 | CTNNB1 CDH1 CTNNA1 | response to indole-3-methanol |
| GO:0071681 | 3.6323771075e-06 | 0.75 | CTNNB1 CDH1 CTNNA1 | cellular response to indole-3-methanol |
| REAC:R-HSA-418990 | 3.94532681474e-06 | 0.75 | CTNNB1 CDH1 CTNNA1 | Adherens junctions interactions |
| REAC:R-HSA-5626467 | 4.41854320762e-06 | 0.75 | CTNNB1 CDH1 CTNNA1 | RHO GTPases activate IQGAPs |
| CORUM:5281 | 5.02777038712e-06 | 0.5 | CTNNB1 CDH1 | Cell-cell junction complex (CDH1-CTNNB1) |
| CORUM:4096 | 5.02777038712e-06 | 0.5 | CTNNB1 CTNNA1 | CTNNA1-CTNNB1 complex |
| WP:WP2118 | 1.1782685669e-05 | 0.75 | CTNNB1 CTNNA1 CTNNA2 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| CORUM:521 | 1.50819606993e-05 | 0.5 | CTNNB1 CDH1 | Polycystin-1-E-cadherin-beta-catenin complex |
| CORUM:6362 | 1.50819606993e-05 | 0.5 | CTNNB1 CDH1 | PDLIM1-E-cadherin-beta-catenin complex |
| KEGG:05412 | 1.59928783462e-05 | 0.75 | CTNNB1 CTNNA1 CTNNA2 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| REAC:R-HSA-421270 | 1.78485863117e-05 | 0.75 | CTNNB1 CDH1 CTNNA1 | Cell-cell junction organization |
| KEGG:04670 | 2.94026709165e-05 | 0.75 | CTNNB1 CTNNA1 CTNNA2 | Leukocyte transendothelial migration |
| CORUM:522 | 3.01612206104e-05 | 0.5 | CTNNB1 CDH1 | Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex |
| KEGG:05200 | 3.47503918145e-05 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | Pathways in cancer |
| WP:WP4541 | 3.85485625527e-05 | 0.75 | CTNNB1 CDH1 CTNNA1 | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-446728 | 7.69213089466e-05 | 0.75 | CTNNB1 CDH1 CTNNA1 | Cell junction organization |
| WP:WP3969 | 0.00015272372185 | 0.5 | CTNNB1 CDH1 | H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity |
| REAC:R-HSA-1500931 | 0.000237627678426 | 0.75 | CTNNB1 CDH1 CTNNA1 | Cell-Cell communication |
| CORUM:5177 | 0.000276304589937 | 0.5 | CTNNB1 CDH1 | Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) |
| REAC:R-HSA-8876493 | 0.000361772624521 | 0.5 | CTNNB1 CDH1 | InlA-mediated entry of Listeria monocytogenes into host cells |
| HP:0006774 | 0.000477128766336 | 0.5 | CTNNB1 CDH1 | Ovarian papillary adenocarcinoma |
| REAC:R-HSA-351906 | 0.000552609179875 | 0.5 | CTNNB1 CDH1 | Apoptotic cleavage of cell adhesion proteins |
| GO:0016342 | 0.000558907067709 | 0.75 | CTNNB1 CDH1 CTNNA1 | catenin complex |
| HP:0100621 | 0.000636114718594 | 0.5 | CTNNB1 CDH1 | Dysgerminoma |
| KEGG:05216 | 0.00133025918726 | 0.5 | CTNNB1 CDH1 | Thyroid cancer |
| HP:0100620 | 0.00149887618857 | 0.5 | CTNNB1 CDH1 | Germinoma |
| REAC:R-HSA-8876384 | 0.00171688133139 | 0.5 | CTNNB1 CDH1 | Listeria monocytogenes entry into host cells |
| WP:WP2272 | 0.00221783487587 | 0.5 | CTNNB1 CDH1 | Pathogenic Escherichia coli infection |
| GO:0097327 | 0.00237379826551 | 0.75 | CTNNB1 CDH1 CTNNA1 | response to antineoplastic agent |
| REAC:R-HSA-5218920 | 0.00326103241616 | 0.5 | CTNNB1 CTNNA1 | VEGFR2 mediated vascular permeability |
| GO:0097306 | 0.00416219722544 | 0.75 | CTNNB1 CDH1 CTNNA1 | cellular response to alcohol |
| WP:WP2064 | 0.00475658252429 | 0.5 | CTNNB1 CDH1 | Neural Crest Differentiation |
| GO:0051149 | 0.00480126971785 | 0.75 | CTNNB1 CTNNA1 CTNNA2 | positive regulation of muscle cell differentiation |
| WP:WP4540 | 0.00623747495525 | 0.5 | CTNNB1 CDH1 | Pathways Regulating Hippo Signaling |
| REAC:R-HSA-195258 | 0.0064749029242 | 0.75 | CTNNB1 CDH1 CTNNA1 | RHO GTPase Effectors |
| REAC:R-HSA-111465 | 0.00667602194349 | 0.5 | CTNNB1 CDH1 | Apoptotic cleavage of cellular proteins |
| GO:0045296 | 0.0101996106268 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | cadherin binding |
| HP:0100728 | 0.011244112798 | 0.5 | CTNNB1 CDH1 | Germ cell neoplasia |
| REAC:R-HSA-75153 | 0.012764635731 | 0.5 | CTNNB1 CDH1 | Apoptotic execution phase |
| WP:WP2858 | 0.0132924049077 | 0.5 | CTNNB1 CTNNA2 | Ectoderm Differentiation |
| WP:WP4239 | 0.015016032698 | 0.5 | CTNNB1 CDH1 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP1984 | 0.017079034299 | 0.5 | CTNNB1 CDH1 | Integrated Breast Cancer Pathway |
| REAC:R-HSA-194315 | 0.0173883634433 | 0.75 | CTNNB1 CDH1 CTNNA1 | Signaling by Rho GTPases |
| HP:0010784 | 0.0176695962482 | 0.5 | CTNNB1 CDH1 | Uterine neoplasm |
| GO:0097305 | 0.0189701239271 | 0.75 | CTNNB1 CDH1 CTNNA1 | response to alcohol |
| CORUM:6680 | 0.0249595281251 | 0.25 | CTNNB1 | CTNNB1-GLIS2 complex |
| KEGG:04015 | 0.0293559966201 | 0.5 | CTNNB1 CDH1 | Rap1 signaling pathway |
| GO:0051147 | 0.0320435644688 | 0.75 | CTNNB1 CTNNA1 CTNNA2 | regulation of muscle cell differentiation |
| HP:0003002 | 0.0335949626331 | 0.5 | CTNNB1 CDH1 | Breast carcinoma |
| HP:0100615 | 0.0360996225593 | 0.5 | CTNNB1 CDH1 | Ovarian neoplasm |
| HP:0006753 | 0.0360996225593 | 0.5 | CTNNB1 CDH1 | Neoplasm of the stomach |
| GO:0050839 | 0.0382716890733 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | cell adhesion molecule binding |
| WP:WP3888 | 0.0393304030404 | 0.5 | CTNNB1 CTNNA1 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-4420097 | 0.0408500448467 | 0.5 | CTNNB1 CTNNA1 | VEGFA-VEGFR2 Pathway |
| GO:0005912 | 0.0433740392707 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | adherens junction |
| GO:0070161 | 0.0477280075644 | 1.0 | CTNNB1 CTNNA2 CDH1 CTNNA1 | anchoring junction |
| REAC:R-HSA-194138 | 0.0483568152087 | 0.5 | CTNNB1 CTNNA1 | Signaling by VEGF |
| CORUM:6961 | 0.0499140284799 | 0.25 | CTNNB1 | CTNNB1-GID8 complex |
| CORUM:5262 | 0.0499140284799 | 0.25 | CTNNB1 | TCF4-CTNNB1 complex |
| CORUM:5274 | 0.0499140284799 | 0.25 | CTNNA1 | Cell-cell junction complex (ARHGAP10-CTNNA1) |
| CORUM:5319 | 0.0499140284799 | 0.25 | CDH1 | CDH1-CKS1B complex |
| CORUM:5320 | 0.0499140284799 | 0.25 | CDH1 | CDH1-SKP2 complex |
| CORUM:6269 | 0.0499140284799 | 0.25 | CTNNB1 | DLL1-CTNNB1-CDH2 complex |
| CORUM:6334 | 0.0499140284799 | 0.25 | CTNNB1 | Afadin-beta-catenin complex |
| CORUM:6336 | 0.0499140284799 | 0.25 | CTNNB1 | CTNNB1-DNMT1 complex |
| CORUM:6339 | 0.0499140284799 | 0.25 | CTNNB1 | beta-catenin-B-cell lymphoma 9 protein complex |
| CORUM:6359 | 0.0499140284799 | 0.25 | CTNNB1 | RHAMM-beta-catenin complex |
| CORUM:6364 | 0.0499140284799 | 0.25 | CTNNB1 | OVOL2-beta-catenin-TCF4 complex |
| CORUM:4095 | 0.0499140284799 | 0.25 | CTNNB1 | CTNNAL1-CTNNB1 complex |
| CORUM:7312 | 0.0499140284799 | 0.25 | CTNNB1 | CTNNB1-ESR1 complex |
| CORUM:3155 | 0.0499140284799 | 0.25 | CTNNB1 | TFC4-CTNNB1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CTNNA1 | CTNNA2 | 0.632 | 0.681 | bioplex_WMM fraction |
| CTNNB1 | CTNNA1 | 0.25 | 0.474 | hein_WMM bioplex_WMM Guru boldt hein (CTNNB1) gupta_WMM fraction boldt_WMM treiber_WMM |
| CTNNA1 | CDH1 | 0.122 | 0.394 | hein_WMM bioplex_WMM hein (CDH1) fraction treiber_WMM |
| CTNNB1 | CDH1 | 0.102 | 0.364 | hein_WMM bioplex_WMM hein (CDH1) treiber_WMM |
| CTNNB1 | CTNNA2 | 0.009 | 0.109 | bioplex_WMM Guru fraction |
| CTNNA2 | CDH1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01868 has an average edge precision of 0.338 which is ranked 4150 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CTNNB1 | HuMAP2_00343 HuMAP2_01868 HuMAP2_02943 HuMAP2_05814 |
| CDH1 | HuMAP2_01324 HuMAP2_01868 HuMAP2_02274 HuMAP2_02710 HuMAP2_04643 HuMAP2_04810 HuMAP2_05168 HuMAP2_06022 |
| CTNNA2 | HuMAP2_00343 HuMAP2_01868 HuMAP2_06526 |
| CTNNA1 | HuMAP2_00343 HuMAP2_01868 HuMAP2_02943 HuMAP2_06526 |