hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01876
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DNAJA1 | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | UniProt NCBI |
| TUBB4B | Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain) | UniProt NCBI |
| TUBA1C | Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | UniProt NCBI |
| TUBB6 | Tubulin beta-6 chain (Tubulin beta class V) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371497 | 2.455200129e-08 | 1.0 | TUBB6 DNAJA1 TUBA1C TUBB4B | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| REAC:R-HSA-190840 | 9.1766670065e-07 | 0.75 | TUBB6 TUBA1C TUBB4B | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 1.10114453861e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Transport of connexons to the plasma membrane |
| REAC:R-HSA-389977 | 1.7944862533e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Post-chaperonin tubulin folding pathway |
| REAC:R-HSA-190861 | 2.38925919874e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Gap junction assembly |
| REAC:R-HSA-389960 | 2.73044427427e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-9619483 | 2.73044427427e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389957 | 3.94532681474e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-5626467 | 4.41854320762e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | RHO GTPases activate IQGAPs |
| WP:WP2272 | 4.97425382323e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-389958 | 6.06176646053e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-190828 | 8.06854769528e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Gap junction trafficking |
| REAC:R-HSA-157858 | 8.82452886806e-06 | 0.75 | TUBB6 TUBA1C TUBB4B | Gap junction trafficking and regulation |
| WP:WP2359 | 1.02923509617e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-8955332 | 1.04751216664e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 1.13724154433e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-437239 | 1.91225201676e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Recycling pathway of L1 |
| KEGG:04540 | 2.55355666749e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Gap junction |
| REAC:R-HSA-6811436 | 2.64063995051e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-5620924 | 2.80553830126e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Intraflagellar transport |
| REAC:R-HSA-983189 | 3.94070508018e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Kinesins |
| REAC:R-HSA-1445148 | 6.7458189168e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-438064 | 8.36972120253e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | Post NMDA receptor activation events |
| REAC:R-HSA-8852276 | 9.45884271068e-05 | 0.75 | TUBB6 TUBA1C TUBB4B | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-2262752 | 0.00010216546718 | 1.0 | TUBB6 DNAJA1 TUBA1C TUBB4B | Cellular responses to stress |
| KEGG:04145 | 0.000107187194263 | 0.75 | TUBB6 TUBA1C TUBB4B | Phagosome |
| REAC:R-HSA-442755 | 0.00012815247216 | 0.75 | TUBB6 TUBA1C TUBB4B | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-380320 | 0.000157957097998 | 0.75 | TUBB6 TUBA1C TUBB4B | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-390466 | 0.000157957097998 | 0.75 | TUBB6 TUBA1C TUBB4B | Chaperonin-mediated protein folding |
| REAC:R-HSA-6811434 | 0.000192050220564 | 0.75 | TUBB6 TUBA1C TUBB4B | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-391251 | 0.000192050220564 | 0.75 | TUBB6 TUBA1C TUBB4B | Protein folding |
| REAC:R-HSA-6807878 | 0.000198169454442 | 0.75 | TUBB6 TUBA1C TUBB4B | COPI-mediated anterograde transport |
| REAC:R-HSA-8953897 | 0.00021167720149 | 1.0 | TUBB6 DNAJA1 TUBA1C TUBB4B | Cellular responses to external stimuli |
| KEGG:05130 | 0.000242354366577 | 0.75 | TUBB6 TUBA1C TUBB4B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-5610787 | 0.000297923324705 | 0.75 | TUBB6 TUBA1C TUBB4B | Hedgehog 'off' state |
| REAC:R-HSA-373760 | 0.000297923324705 | 0.75 | TUBB6 TUBA1C TUBB4B | L1CAM interactions |
| REAC:R-HSA-2132295 | 0.000340340039133 | 0.75 | TUBB6 TUBA1C TUBB4B | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 0.000377028841718 | 0.75 | TUBB6 TUBA1C TUBB4B | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 0.000480050915503 | 0.75 | TUBB6 TUBA1C TUBB4B | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.000514250934249 | 0.75 | TUBB6 TUBA1C TUBB4B | RHO GTPases Activate Formins |
| REAC:R-HSA-5358351 | 0.000626491969508 | 0.75 | TUBB6 TUBA1C TUBB4B | Signaling by Hedgehog |
| REAC:R-HSA-199977 | 0.000653465752726 | 0.75 | TUBB6 TUBA1C TUBB4B | ER to Golgi Anterograde Transport |
| REAC:R-HSA-983231 | 0.000880763368668 | 0.75 | TUBB6 TUBA1C TUBB4B | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-948021 | 0.00105827201724 | 0.75 | TUBB6 TUBA1C TUBB4B | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-112314 | 0.00117540054179 | 0.75 | TUBB6 TUBA1C TUBB4B | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2467813 | 0.00134455008537 | 0.75 | TUBB6 TUBA1C TUBB4B | Separation of Sister Chromatids |
| REAC:R-HSA-69275 | 0.00150520149981 | 0.75 | TUBB6 TUBA1C TUBB4B | G2/M Transition |
| REAC:R-HSA-5617833 | 0.00152914291965 | 0.75 | TUBB6 TUBA1C TUBB4B | Cilium Assembly |
| REAC:R-HSA-68877 | 0.00152914291965 | 0.75 | TUBB6 TUBA1C TUBB4B | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.00152914291965 | 0.75 | TUBB6 TUBA1C TUBB4B | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.00155333604228 | 0.75 | TUBB6 TUBA1C TUBB4B | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-453274 | 0.00155333604228 | 0.75 | TUBB6 TUBA1C TUBB4B | Mitotic G2-G2/M phases |
| REAC:R-HSA-6811442 | 0.00167812264469 | 0.75 | TUBB6 TUBA1C TUBB4B | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-112315 | 0.00256874155841 | 0.75 | TUBB6 TUBA1C TUBB4B | Transmission across Chemical Synapses |
| REAC:R-HSA-1852241 | 0.00476848509584 | 0.75 | TUBB6 TUBA1C TUBB4B | Organelle biogenesis and maintenance |
| REAC:R-HSA-446203 | 0.00508239229975 | 0.75 | TUBB6 TUBA1C TUBB4B | Asparagine N-linked glycosylation |
| REAC:R-HSA-195258 | 0.0064749029242 | 0.75 | TUBB6 TUBA1C TUBB4B | RHO GTPase Effectors |
| REAC:R-HSA-112316 | 0.00869575285043 | 0.75 | TUBB6 TUBA1C TUBB4B | Neuronal System |
| REAC:R-HSA-68886 | 0.0117390466083 | 0.75 | TUBB6 TUBA1C TUBB4B | M Phase |
| REAC:R-HSA-194315 | 0.0173883634433 | 0.75 | TUBB6 TUBA1C TUBB4B | Signaling by Rho GTPases |
| REAC:R-HSA-422475 | 0.0294332368862 | 0.75 | TUBB6 TUBA1C TUBB4B | Axon guidance |
| REAC:R-HSA-69278 | 0.0299490115235 | 0.75 | TUBB6 TUBA1C TUBB4B | Cell Cycle, Mitotic |
| REAC:R-HSA-109582 | 0.033540764945 | 0.75 | TUBB6 TUBA1C TUBB4B | Hemostasis |
| GO:0005200 | 0.0424904593616 | 0.75 | TUBB6 TUBA1C TUBB4B | structural constituent of cytoskeleton |
| REAC:R-HSA-199991 | 0.0426366599823 | 0.75 | TUBB6 TUBA1C TUBB4B | Membrane Trafficking |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBA1C | TUBB4B | 0.988 | 0.901 | hein_WMM bioplex (TUBA1C) bioplex_WMM boldt (TUBB4B) youn_WMM hein (TUBA1C) boldt_WMM treiber_WMM |
| TUBA1C | TUBB6 | 0.729 | 0.735 | hein_WMM bioplex (TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM treiber_WMM |
| TUBA1C | DNAJA1 | 0.555 | 0.647 | hein_WMM bioplex (DNAJA1,TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM fraction boldt_WMM treiber_WMM |
| DNAJA1 | TUBB4B | 0.009 | 0.108 | hein_WMM bioplex (DNAJA1) bioplex_WMM boldt (TUBB4B) youn_WMM boldt_WMM treiber_WMM |
| DNAJA1 | TUBB6 | 0.009 | 0.099 | hein_WMM bioplex (DNAJA1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| TUBB6 | TUBB4B | 0.0 | 0.008 | hein_WMM bioplex_WMM boldt (TUBB4B) youn_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_01876 has an average edge precision of 0.416 which is ranked 3144 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DNAJA1 | HuMAP2_00105 HuMAP2_01876 HuMAP2_02513 HuMAP2_02619 HuMAP2_02732 HuMAP2_05358 HuMAP2_06642 |
| TUBB4B | HuMAP2_00341 HuMAP2_01876 HuMAP2_05358 |
| TUBA1C | HuMAP2_00105 HuMAP2_00284 HuMAP2_01876 HuMAP2_02619 HuMAP2_02732 HuMAP2_05358 |
| TUBB6 | HuMAP2_00284 HuMAP2_00602 HuMAP2_01876 HuMAP2_02732 HuMAP2_05358 HuMAP2_06702 |