hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01881
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MOB1B | MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) | UniProt NCBI |
| LATS1 | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) | UniProt NCBI |
| LATS2 | Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 7.81881780332e-08 | 1.0 | LATS2 LATS1 MOB1B | Hippo signaling pathway - multiple species |
| REAC:R-HSA-2028269 | 4.35659406764e-07 | 1.0 | LATS2 LATS1 MOB1B | Signaling by Hippo |
| KEGG:04390 | 1.40492126975e-05 | 1.0 | LATS2 LATS1 MOB1B | Hippo signaling pathway |
| WP:WP4533 | 0.000146652290714 | 0.666666666667 | LATS1 LATS2 | Transcription co-factors SKI and SKIL protein partners |
| WP:WP4537 | 0.000182100906477 | 0.666666666667 | LATS1 LATS2 | Hippo-Yap signaling pathway |
| WP:WP4542 | 0.000416728443271 | 0.666666666667 | LATS1 LATS2 | Overview of leukocyte-intrinsic Hippo pathway functions |
| GO:0035329 | 0.0007056603357 | 1.0 | LATS2 LATS1 MOB1B | hippo signaling |
| WP:WP4540 | 0.00357470816736 | 0.666666666667 | LATS1 LATS2 | Pathways Regulating Hippo Signaling |
| WP:WP4541 | 0.00491871423903 | 0.666666666667 | LATS1 LATS2 | Hippo-Merlin Signaling Dysregulation |
| CORUM:6660 | 0.0499776345577 | 0.333333333333 | LATS1 | LATS1-NPHP4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MOB1B | LATS2 | 1.0 | 0.949 | bioplex (MOB1B) bioplex_WMM |
| MOB1B | LATS1 | 0.927 | 0.844 | bioplex (MOB1B) bioplex_WMM |
| LATS1 | LATS2 | 0.009 | 0.108 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_01881 has an average edge precision of 0.634 which is ranked 1757 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MOB1B | HuMAP2_01510 HuMAP2_01598 HuMAP2_01793 HuMAP2_01881 |
| LATS1 | HuMAP2_01598 HuMAP2_01793 HuMAP2_01881 |
| LATS2 | HuMAP2_01598 HuMAP2_01793 HuMAP2_01881 |