hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01885
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAMTOR3 | Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1) | UniProt NCBI |
| LAMTOR1 | Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho) | UniProt NCBI |
| LAMTOR5 | Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6888 | 8.20296815693e-08 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | v-ATPase-Ragulator-AXIN/LKB1-AMPK complex |
| REAC:R-HSA-166208 | 6.92379242949e-07 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | mTORC1-mediated signalling |
| REAC:R-HSA-380972 | 1.47287948045e-06 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | Energy dependent regulation of mTOR by LKB1-AMPK |
| GO:0071986 | 1.81637152046e-06 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | Ragulator complex |
| REAC:R-HSA-165159 | 4.10886616968e-06 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | mTOR signalling |
| REAC:R-HSA-8943724 | 1.3155205616e-05 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | Regulation of PTEN gene transcription |
| KEGG:04150 | 1.46555920905e-05 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | mTOR signaling pathway |
| REAC:R-HSA-5628897 | 3.69388822082e-05 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-1632852 | 4.7655024582e-05 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | Macroautophagy |
| REAC:R-HSA-9612973 | 7.95116633082e-05 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | Autophagy |
| REAC:R-HSA-6807070 | 0.000180286113329 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | PTEN Regulation |
| GO:0071230 | 0.000495506150782 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | cellular response to amino acid stimulus |
| GO:0032008 | 0.000543458358922 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | positive regulation of TOR signaling |
| GO:0043200 | 0.000829990966275 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | response to amino acid |
| REAC:R-HSA-1257604 | 0.000842184933696 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 0.00134762672661 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | Intracellular signaling by second messengers |
| GO:0031902 | 0.00238262534197 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | late endosome membrane |
| REAC:R-HSA-3700989 | 0.00313081125109 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | Transcriptional Regulation by TP53 |
| GO:0032006 | 0.00746165420606 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | regulation of TOR signaling |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | Cellular responses to external stimuli |
| GO:0031929 | 0.0117851633362 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | TOR signaling |
| GO:0071229 | 0.0138131421388 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | cellular response to acid chemical |
| GO:0001101 | 0.0302766427817 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | response to acid chemical |
| GO:0016241 | 0.0442598881134 | 1.0 | LAMTOR5 LAMTOR3 LAMTOR1 | regulation of macroautophagy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAMTOR1 | LAMTOR3 | 0.193 | 0.446 | bioplex_WMM fraction |
| LAMTOR5 | LAMTOR1 | 0.048 | 0.294 | hein_WMM bioplex_WMM fraction |
| LAMTOR5 | LAMTOR3 | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01885 has an average edge precision of 0.249 which is ranked 5392 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LAMTOR3 | HuMAP2_01885 HuMAP2_02685 HuMAP2_03784 |
| LAMTOR1 | HuMAP2_01018 HuMAP2_01885 HuMAP2_02685 HuMAP2_03784 |
| LAMTOR5 | HuMAP2_01018 HuMAP2_01885 HuMAP2_02685 HuMAP2_03784 |