hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01890
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CAPN8 | Calpain-8 (EC 3.4.22.53) (New calpain 2) (nCL-2) (Stomach-specific M-type calpain) | UniProt NCBI |
| CAST | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | UniProt NCBI |
| CAPNS2 | Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) | UniProt NCBI |
| LIX1L | LIX1-like protein | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1474228 | 0.000458112911853 | 0.75 | CAPNS2 CAST CAPN8 | Degradation of the extracellular matrix |
| REAC:R-HSA-8862803 | 0.00210807296175 | 0.5 | CAPNS2 CAST | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00210807296175 | 0.5 | CAPNS2 CAST | Neurodegenerative Diseases |
| REAC:R-HSA-1474244 | 0.0041798099551 | 0.75 | CAPNS2 CAST CAPN8 | Extracellular matrix organization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAPNS2 | LIX1L | 1.0 | 0.949 | bioplex (CAPNS2) bioplex_WMM |
| CAST | CAPNS2 | 0.991 | 0.909 | bioplex (CAPNS2) bioplex_WMM |
| CAST | CAPN8 | 0.131 | 0.403 | bioplex (CAPN8) bioplex_WMM |
| CAST | LIX1L | 0.009 | 0.098 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01890 has an average edge precision of 0.59 which is ranked 1991 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CAPN8 | HuMAP2_01890 HuMAP2_02830 |
| CAST | HuMAP2_01189 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 HuMAP2_05777 |
| CAPNS2 | HuMAP2_01189 HuMAP2_01317 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 HuMAP2_05777 |
| LIX1L | HuMAP2_01317 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 |