hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01908
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| YME1L1 | ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) | UniProt NCBI |
| CFAP410 | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | UniProt NCBI |
| NEK1 | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | UniProt NCBI |
| TTC25 | Tetratricopeptide repeat protein 25 (TPR repeat protein 25) | UniProt NCBI |
| ARMC4 | Armadillo repeat-containing protein 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0031815 | 6.68835069866e-05 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Abnormal oral physiology |
| HP:0012207 | 0.000115080494194 | 0.6 | TTC25 ARMC4 CFAP410 | Reduced sperm motility |
| HP:0012206 | 0.000115080494194 | 0.6 | TTC25 ARMC4 CFAP410 | Abnormal sperm motility |
| HP:0002094 | 0.000510409681764 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Dyspnea |
| HP:0002087 | 0.000563935221561 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Abnormality of the upper respiratory tract |
| HP:0002789 | 0.00128396303463 | 0.6 | NEK1 ARMC4 TTC25 | Tachypnea |
| HP:0000025 | 0.00422237396976 | 0.6 | TTC25 ARMC4 CFAP410 | Functional abnormality of male internal genitalia |
| HP:0002090 | 0.00431306699981 | 0.6 | TTC25 ARMC4 CFAP410 | Pneumonia |
| HP:0000750 | 0.00588417041727 | 0.8 | NEK1 ARMC4 YME1L1 TTC25 | Delayed speech and language development |
| HP:0012874 | 0.00689491832004 | 0.6 | TTC25 ARMC4 CFAP410 | Abnormal male reproductive system physiology |
| HP:0000765 | 0.00927785594799 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Abnormality of the thorax |
| HP:0012372 | 0.0107492437093 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormal eye morphology |
| HP:0002088 | 0.0138760898251 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Abnormal lung morphology |
| HP:0025142 | 0.0158705846075 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Constitutional symptom |
| HP:0009121 | 0.0166603503444 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormal axial skeleton morphology |
| HP:0002011 | 0.0222964274548 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Morphological abnormality of the central nervous system |
| HP:0012252 | 0.0256832651071 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Abnormal respiratory system morphology |
| HP:0000405 | 0.0261117985092 | 0.6 | NEK1 ARMC4 TTC25 | Conductive hearing impairment |
| HP:0000271 | 0.0264901379119 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormality of the face |
| HP:0011452 | 0.0270250488113 | 0.6 | NEK1 ARMC4 TTC25 | Functional abnormality of the middle ear |
| HP:0030195 | 0.0275312401623 | 0.4 | NEK1 CFAP410 | Fatigable weakness of swallowing muscles |
| HP:0025425 | 0.0291468055875 | 0.4 | NEK1 CFAP410 | Laryngospasm |
| HP:0012261 | 0.0308081945037 | 0.4 | TTC25 ARMC4 | Abnormal respiratory motile cilium physiology |
| HP:0040262 | 0.0308081945037 | 0.4 | TTC25 ARMC4 | Glue ear |
| HP:0012262 | 0.0308081945037 | 0.4 | TTC25 ARMC4 | Abnormal ciliary motility |
| HP:0031603 | 0.0308081945037 | 0.4 | TTC25 ARMC4 | Impaired nasal mucociliary clearance |
| HP:0031602 | 0.0308081945037 | 0.4 | TTC25 ARMC4 | Abnormal mucociliary clearance |
| HP:0031456 | 0.0308081945037 | 0.4 | TTC25 ARMC4 | Ectopic pregnancy |
| HP:0012263 | 0.0308081945037 | 0.4 | TTC25 ARMC4 | Immotile cilia |
| HP:0012639 | 0.0338634615703 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormality of nervous system morphology |
| HP:0000478 | 0.0345715487774 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormality of the eye |
| HP:0011842 | 0.0361875215647 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormality of skeletal morphology |
| HP:0000007 | 0.0363523847838 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Autosomal recessive inheritance |
| HP:0100812 | 0.0379116132621 | 0.4 | TTC25 ARMC4 | Halitosis |
| HP:0002793 | 0.0384968933304 | 0.6 | NEK1 ARMC4 TTC25 | Abnormal pattern of respiration |
| HP:0002012 | 0.038603375935 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Abnormality of the abdominal organs |
| HP:0002795 | 0.0390927093194 | 0.8 | CFAP410 NEK1 ARMC4 TTC25 | Functional respiratory abnormality |
| HP:0100582 | 0.0417377803311 | 0.4 | TTC25 ARMC4 | Nasal polyposis |
| HP:0007354 | 0.0417377803311 | 0.4 | NEK1 CFAP410 | Amyotrophic lateral sclerosis |
| HP:0025424 | 0.0417377803311 | 0.4 | NEK1 CFAP410 | Abnormal larynx physiology |
| HP:0011109 | 0.0417377803311 | 0.4 | TTC25 ARMC4 | Chronic sinusitis |
| HP:0000924 | 0.042794211029 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormality of the skeletal system |
| HP:0000234 | 0.043361765796 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormality of the head |
| HP:0004469 | 0.0437194132729 | 0.4 | TTC25 ARMC4 | Chronic bronchitis |
| HP:0000152 | 0.0448070321906 | 1.0 | CFAP410 NEK1 ARMC4 YME1L1 TTC25 | Abnormality of head or neck |
| HP:0000433 | 0.0478196851342 | 0.4 | TTC25 ARMC4 | Abnormality of the nasal mucosa |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NEK1 | CFAP410 | 0.998 | 0.943 | hein_WMM bioplex_WMM boldt (CFAP410,NEK1) hein (NEK1) gupta_WMM boldt_WMM |
| TTC25 | ARMC4 | 0.124 | 0.397 | bioplex (TTC25) bioplex_WMM |
| NEK1 | TTC25 | 0.102 | 0.366 | bioplex (TTC25) bioplex_WMM |
| TTC25 | CFAP410 | 0.068 | 0.348 | bioplex (TTC25) bioplex_WMM |
| TTC25 | YME1L1 | 0.026 | 0.218 | bioplex (TTC25) bioplex_WMM |
| NEK1 | ARMC4 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| CFAP410 | ARMC4 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| ARMC4 | YME1L1 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| NEK1 | YME1L1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| CFAP410 | YME1L1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01908 has an average edge precision of 0.24 which is ranked 5520 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| YME1L1 | HuMAP2_01908 HuMAP2_06049 |
| CFAP410 | HuMAP2_00805 HuMAP2_01908 HuMAP2_02878 HuMAP2_06049 |
| NEK1 | HuMAP2_00805 HuMAP2_01908 HuMAP2_02878 HuMAP2_06049 HuMAP2_06217 |
| TTC25 | HuMAP2_00805 HuMAP2_01908 HuMAP2_06049 |
| ARMC4 | HuMAP2_00805 HuMAP2_01908 HuMAP2_06049 |