hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01916
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TLE5 | TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator) | UniProt NCBI |
| TLE4 | Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4) | UniProt NCBI |
| TLE1 | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-4641265 | 9.89113204212e-08 | 1.0 | TLE5 TLE1 TLE4 | Repression of WNT target genes |
| REAC:R-HSA-195253 | 3.98163024387e-05 | 1.0 | TLE5 TLE1 TLE4 | Degradation of beta-catenin by the destruction complex |
| REAC:R-HSA-195721 | 0.00221076692273 | 1.0 | TLE5 TLE1 TLE4 | Signaling by WNT |
| GO:0070491 | 0.00326856055107 | 1.0 | TLE5 TLE1 TLE4 | repressing transcription factor binding |
| REAC:R-HSA-3769402 | 0.00495307159189 | 0.666666666667 | TLE4 TLE1 | Deactivation of the beta-catenin transactivating complex |
| REAC:R-HSA-2122947 | 0.00603484671946 | 0.666666666667 | TLE4 TLE1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-1980143 | 0.0134604567412 | 0.666666666667 | TLE4 TLE1 | Signaling by NOTCH1 |
| CORUM:3125 | 0.0249904952816 | 0.333333333333 | TLE1 | TLE1 homodimer complex |
| CORUM:3127 | 0.0249904952816 | 0.333333333333 | TLE1 | TLE-Histone H3 complex |
| REAC:R-HSA-201722 | 0.0261170593829 | 0.666666666667 | TLE4 TLE1 | Formation of the beta-catenin:TCF transactivating complex |
| GO:0090090 | 0.0424286223465 | 1.0 | TLE5 TLE1 TLE4 | negative regulation of canonical Wnt signaling pathway |
| CORUM:3121 | 0.0499776345577 | 0.333333333333 | TLE4 | OCT2-TLE4 complex |
| CORUM:3124 | 0.0499776345577 | 0.333333333333 | TLE1 | TLE1-TLE2 complex |
| CORUM:3150 | 0.0499776345577 | 0.333333333333 | TLE1 | NK-3-Groucho complex |
| CORUM:3164 | 0.0499776345577 | 0.333333333333 | TLE1 | HESX1-TLE1 complex |
| CORUM:6769 | 0.0499776345577 | 0.333333333333 | TLE1 | TBX20-TLE1 repressor complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TLE5 | TLE4 | 0.994 | 0.923 | bioplex (TLE4) bioplex_WMM youn_WMM |
| TLE1 | TLE4 | 0.98 | 0.896 | bioplex (TLE4) bioplex_WMM youn_WMM |
| TLE1 | TLE5 | 0.012 | 0.146 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01916 has an average edge precision of 0.655 which is ranked 1616 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TLE5 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| TLE4 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |
| TLE1 | HuMAP2_01916 HuMAP2_05545 HuMAP2_06707 HuMAP2_06880 |