hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01917
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NFKBIA | NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3) | UniProt NCBI |
| NFKBIB | NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9) | UniProt NCBI |
| NFKBIE | NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkB-E) (IkB-epsilon) (IkappaBepsilon) | UniProt NCBI |
| RELA | Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | UniProt NCBI |
| NFKB2 | Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit] | UniProt NCBI |
| RELB | Transcription factor RelB (I-Rel) | UniProt NCBI |
| NFKB1 | Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] | UniProt NCBI |
| REL | Proto-oncogene c-Rel | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5193 | 3.82294249055e-25 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| CORUM:5232 | 2.23470069303e-19 | 0.875 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| CORUM:5230 | 7.90274535478e-17 | 0.75 | NFKBIA RELA REL NFKB1 NFKB2 NFKBIE | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
| CORUM:2084 | 4.24766632997e-16 | 0.625 | NFKB2 RELA REL RELB NFKB1 | NFKB1-NFKB2-REL-RELA-RELB complex |
| WP:WP4562 | 2.59888124995e-14 | 0.625 | RELA REL NFKB1 NFKBIA NFKBIE | Canonical NF-KB pathway |
| WP:WP4329 | 5.53979662162e-14 | 0.75 | NFKBIA RELA REL RELB NFKB1 NFKB2 | miRNAs involvement in the immune response in sepsis |
| WP:WP2036 | 3.57700029933e-13 | 0.75 | NFKBIA RELA RELB NFKB1 NFKB2 NFKBIB | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| CORUM:2086 | 1.58119379133e-12 | 0.5 | NFKB2 RELA RELB NFKB1 | NFKB1-NFKB2-RELA-RELB complex |
| REAC:R-HSA-1810476 | 1.00461568417e-11 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | RIP-mediated NFkB activation via ZBP1 |
| KEGG:05169 | 1.4347079072e-11 | 0.875 | NFKBIA RELA RELB NFKB1 NFKB2 NFKBIB NFKBIE | Epstein-Barr virus infection |
| CORUM:5233 | 1.79967425227e-11 | 0.625 | NFKB2 RELA NFKBIB REL NFKB1 | TNF-alpha/NF-kappa B signaling complex 5 |
| REAC:R-HSA-1169091 | 2.95761754056e-11 | 0.75 | NFKBIA RELA REL NFKB1 NFKBIB NFKBIE | Activation of NF-kappaB in B cells |
| REAC:R-HSA-1606322 | 3.30142017002e-11 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | ZBP1(DAI) mediated induction of type I IFNs |
| REAC:R-HSA-933542 | 4.27170811658e-11 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | TRAF6 mediated NF-kB activation |
| WP:WP3858 | 4.54573412322e-11 | 0.625 | NFKB2 RELA REL RELB NFKB1 | Toll-like Receptor Signaling |
| WP:WP231 | 5.02234923621e-11 | 0.75 | NFKBIA REL NFKB1 NFKB2 NFKBIB NFKBIE | TNF alpha Signaling Pathway |
| WP:WP3617 | 6.58909843227e-11 | 0.625 | NFKB2 RELA REL RELB NFKB1 | Photodynamic therapy-induced NF-kB survival signaling |
| REAC:R-HSA-1168372 | 7.70802648053e-11 | 0.75 | NFKBIA RELA REL NFKB1 NFKBIB NFKBIE | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-5603029 | 2.11810627495e-10 | 0.5 | NFKB2 RELA NFKBIA NFKB1 | IkBA variant leads to EDA-ID |
| REAC:R-HSA-445989 | 2.30852101102e-10 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| WP:WP2203 | 3.45861239295e-10 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| REAC:R-HSA-983705 | 4.10875557283e-10 | 0.75 | NFKBIA RELA REL NFKB1 NFKBIB NFKBIE | Signaling by the B Cell Receptor (BCR) |
| WP:WP195 | 1.08231238934e-09 | 0.625 | RELA REL NFKBIB NFKBIA NFKB1 | IL-1 signaling pathway |
| WP:WP2018 | 1.19725045286e-09 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| KEGG:04920 | 3.3299944007e-09 | 0.625 | RELA NFKBIB NFKB1 NFKBIA NFKBIE | Adipocytokine signaling pathway |
| KEGG:04662 | 4.21583246545e-09 | 0.625 | RELA NFKBIB NFKB1 NFKBIA NFKBIE | B cell receptor signaling pathway |
| CORUM:5466 | 4.70911134935e-09 | 0.375 | RELA NFKBIB REL | IKB(beta)-RELA-cREL complex |
| CORUM:5467 | 4.70911134935e-09 | 0.375 | RELA NFKBIA REL | IKB(alpha)-RELA-cREL complex |
| CORUM:5492 | 4.70911134935e-09 | 0.375 | RELA NFKBIA NFKB1 | IKBA-p50-p65 Nf(kappa)B complex |
| CORUM:5465 | 4.70911134935e-09 | 0.375 | RELA NFKBIE REL | IKB(epsilon)-RELA-cREL complex |
| CORUM:5464 | 4.70911134935e-09 | 0.375 | RELA NFKBIA NFKB1 | IKBA-p50-p65 Nf(kappa)B complex |
| KEGG:04658 | 5.67972393584e-09 | 0.625 | RELA NFKBIB NFKB1 NFKBIA NFKBIE | Th1 and Th2 cell differentiation |
| WP:WP254 | 6.89491462916e-09 | 0.625 | RELA NFKBIB NFKB1 NFKBIA NFKBIE | Apoptosis |
| KEGG:04064 | 9.8183776979e-09 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | NF-kappa B signaling pathway |
| WP:WP262 | 1.03069132677e-08 | 0.5 | NFKB2 RELA NFKBIA NFKB1 | EBV LMP1 signaling |
| KEGG:05235 | 1.0471170817e-08 | 0.625 | RELA NFKBIB NFKB1 NFKBIA NFKBIE | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| REAC:R-HSA-1834949 | 1.13232976593e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Cytosolic sensors of pathogen-associated DNA |
| KEGG:04659 | 1.51540420586e-08 | 0.625 | RELA NFKBIB NFKB1 NFKBIA NFKBIE | Th17 cell differentiation |
| KEGG:04625 | 1.70408785831e-08 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | C-type lectin receptor signaling pathway |
| KEGG:04660 | 1.91108403613e-08 | 0.625 | RELA NFKBIB NFKB1 NFKBIA NFKBIE | T cell receptor signaling pathway |
| REAC:R-HSA-168928 | 2.25058784481e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:04380 | 3.79829085586e-08 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | Osteoclast differentiation |
| REAC:R-HSA-168176 | 4.38154815861e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 4.38154815861e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 4.38154815861e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor 10 (TLR10) Cascade |
| KEGG:04722 | 4.60946484651e-08 | 0.625 | RELA NFKBIB NFKB1 NFKBIA NFKBIE | Neurotrophin signaling pathway |
| REAC:R-HSA-975138 | 4.95583477516e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 5.26468661015e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 5.26468661015e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-5260271 | 5.34040294723e-08 | 0.5 | NFKB2 RELA NFKBIA NFKB1 | Diseases of Immune System |
| REAC:R-HSA-5602358 | 5.34040294723e-08 | 0.5 | NFKB2 RELA NFKBIA NFKB1 | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-168138 | 6.65753847156e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168188 | 6.65753847156e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 6.65753847156e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168164 | 7.04796949494e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-168179 | 7.88368047942e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 7.88368047942e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-5607764 | 7.88368047942e-08 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | CLEC7A (Dectin-1) signaling |
| WP:WP4217 | 7.97074989941e-08 | 0.625 | NFKB2 RELA REL RELB NFKB1 | Ebola Virus Pathway on Host |
| REAC:R-HSA-937061 | 8.33021146523e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 8.33021146523e-08 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-9020702 | 1.03227550056e-07 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Interleukin-1 signaling |
| KEGG:05134 | 2.65540961466e-07 | 0.5 | NFKB2 RELA NFKBIA NFKB1 | Legionellosis |
| REAC:R-HSA-166016 | 2.79258897185e-07 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll Like Receptor 4 (TLR4) Cascade |
| WP:WP4479 | 2.8790343499e-07 | 0.375 | RELA NFKBIA NFKB1 | Supression of HMGB1 mediated inflammation by THBD |
| WP:WP2637 | 3.62684377336e-07 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Structural Pathway of Interleukin 1 (IL-1) |
| REAC:R-HSA-5621481 | 3.89276889356e-07 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | C-type lectin receptors (CLRs) |
| REAC:R-HSA-446652 | 3.89276889356e-07 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Interleukin-1 family signaling |
| CORUM:5194 | 3.94967983144e-07 | 0.375 | RELA REL NFKB2 | TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) |
| GO:0038061 | 4.27651079492e-07 | 0.75 | NFKBIA RELA REL RELB NFKB1 NFKB2 | NIK/NF-kappaB signaling |
| WP:WP4480 | 4.31746378335e-07 | 0.375 | RELA NFKBIA NFKB1 | Role Altered Glycolysation of MUC1 in Tumour Microenvironment |
| WP:WP3865 | 5.40768315846e-07 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| REAC:R-HSA-448706 | 6.3058567172e-07 | 0.375 | NFKB2 RELA NFKB1 | Interleukin-1 processing |
| REAC:R-HSA-3134963 | 6.3058567172e-07 | 0.375 | NFKB2 RELA NFKB1 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production |
| KEGG:05140 | 6.41254345961e-07 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Leishmaniasis |
| REAC:R-HSA-168898 | 6.63047934317e-07 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Toll-like Receptor Cascades |
| KEGG:04623 | 6.88606278574e-07 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Cytosolic DNA-sensing pathway |
| KEGG:05203 | 7.93325083367e-07 | 0.625 | NFKB2 RELA REL NFKBIA NFKB1 | Viral carcinogenesis |
| KEGG:05166 | 1.0032341149e-06 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | Human T-cell leukemia virus 1 infection |
| KEGG:04622 | 1.02990675309e-06 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | RIG-I-like receptor signaling pathway |
| KEGG:05131 | 1.02990675309e-06 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Shigellosis |
| CORUM:5196 | 1.03365844178e-06 | 0.375 | RELA REL NFKB2 | TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) |
| WP:WP4655 | 1.38834948115e-06 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Cytosolic DNA-sensing pathway |
| WP:WP2037 | 1.9590314161e-06 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Prolactin Signaling Pathway |
| WP:WP69 | 2.3025671643e-06 | 0.5 | RELA REL NFKBIA NFKB1 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| REAC:R-HSA-4755510 | 2.9697670258e-06 | 0.375 | RELA NFKBIA NFKB2 | SUMOylation of immune response proteins |
| REAC:R-HSA-209560 | 2.9697670258e-06 | 0.375 | RELA NFKBIA NFKB1 | NF-kB is activated and signals survival |
| WP:WP75 | 3.95825481308e-06 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Toll-like Receptor Signaling Pathway |
| WP:WP23 | 3.95825481308e-06 | 0.5 | RELA REL NFKBIA NFKB1 | B Cell Receptor Signaling Pathway |
| KEGG:05145 | 4.91117856912e-06 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Toxoplasmosis |
| GO:0033256 | 5.08584025729e-06 | 0.375 | NFKB1 NFKBIA NFKB2 | I-kappaB/NF-kappaB complex |
| WP:WP4658 | 5.39573475915e-06 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Small cell lung cancer |
| REAC:R-HSA-168256 | 6.52691464423e-06 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | Immune System |
| REAC:R-HSA-844456 | 6.54653606528e-06 | 0.375 | NFKB2 RELA NFKB1 | The NLRP3 inflammasome |
| REAC:R-HSA-193639 | 6.54653606528e-06 | 0.375 | RELA NFKBIA NFKB1 | p75NTR signals via NF-kB |
| WP:WP4482 | 6.81534609429e-06 | 0.375 | RELA NFKBIA NFKB1 | Vitamin D in inflammatory diseases |
| GO:0007249 | 1.121531372e-05 | 0.75 | NFKBIA RELA REL RELB NFKB1 NFKB2 | I-kappaB kinase/NF-kappaB signaling |
| CORUM:5460 | 1.16880143691e-05 | 0.25 | RELA NFKB1 | p50-p65 NF(kappa)B complex |
| WP:WP1449 | 1.29418037893e-05 | 0.5 | NFKB2 RELA NFKBIA NFKB1 | Regulation of toll-like receptor signaling pathway |
| WP:WP3929 | 1.58008323692e-05 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Chemokine signaling pathway |
| WP:WP2112 | 1.67576801968e-05 | 0.375 | RELA NFKBIB NFKB1 | IL17 signaling pathway |
| KEGG:05162 | 1.70549442425e-05 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Measles |
| REAC:R-HSA-622312 | 1.74055112733e-05 | 0.375 | NFKB2 RELA NFKB1 | Inflammasomes |
| KEGG:04062 | 1.8151604603e-05 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Chemokine signaling pathway |
| WP:WP4496 | 1.86865473155e-05 | 0.375 | RELA NFKBIA NFKB1 | Signal transduction through IL1R |
| WP:WP3414 | 2.07575966263e-05 | 0.375 | RELA NFKBIA NFKB1 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| WP:WP4481 | 2.07575966263e-05 | 0.375 | RELA NFKBIA NFKB1 | Resistin as a regulator of inflammation |
| REAC:R-HSA-5621575 | 2.3877879224e-05 | 0.375 | RELA RELB NFKB1 | CD209 (DC-SIGN) signaling |
| REAC:R-HSA-1280218 | 3.05433104477e-05 | 0.75 | NFKBIA RELA REL NFKB1 NFKBIB NFKBIE | Adaptive Immune System |
| KEGG:05164 | 3.05476150525e-05 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | Influenza A |
| CORUM:5461 | 3.50546248845e-05 | 0.25 | RELA NFKB1 | p50-p65 NF(kappa)B-SRC1 complex |
| CORUM:5475 | 3.50546248845e-05 | 0.25 | RELA NFKBIA | MURR1-NF(kappa)Bp65-IKBA complex |
| GO:0032479 | 3.75909855022e-05 | 0.625 | NFKB2 RELA REL RELB NFKB1 | regulation of type I interferon production |
| GO:0032606 | 3.95022249009e-05 | 0.625 | NFKB2 RELA REL RELB NFKB1 | type I interferon production |
| KEGG:04621 | 3.96963379957e-05 | 0.5 | RELA NFKBIB NFKBIA NFKB1 | NOD-like receptor signaling pathway |
| REAC:R-HSA-1280215 | 4.43602602217e-05 | 0.75 | NFKBIA RELA RELB NFKB1 NFKB2 NFKBIB | Cytokine Signaling in Immune system |
| WP:WP1533 | 5.85165564524e-05 | 0.375 | NFKB2 RELA NFKB1 | Vitamin B12 Metabolism |
| WP:WP4008 | 6.28894339249e-05 | 0.375 | RELA NFKBIA NFKB1 | NO/cGMP/PKG mediated Neuroprotection |
| WP:WP395 | 0.000112365649743 | 0.375 | RELA NFKBIA NFKB1 | IL-4 Signaling Pathway |
| CORUM:5228 | 0.00011678598518 | 0.25 | RELA REL | REL-MAP3K8-RELA-TNIP2-PAPOLA complex |
| CORUM:3045 | 0.00011678598518 | 0.25 | RELA NFKB1 | hs4 enhancer complex (faster migrating complex) |
| WP:WP176 | 0.00011907753957 | 0.375 | NFKB2 RELA NFKB1 | Folate Metabolism |
| GO:0006954 | 0.000149781875216 | 0.75 | NFKBIA RELA REL RELB NFKB1 NFKB2 | inflammatory response |
| WP:WP382 | 0.000153845331631 | 0.5 | NFKB2 RELA RELB NFKB1 | MAPK Signaling Pathway |
| KEGG:05120 | 0.000173444438443 | 0.375 | RELA NFKBIA NFKB1 | Epithelial cell signaling in Helicobacter pylori infection |
| CORUM:2105 | 0.000175131922226 | 0.25 | RELA NFKBIA | IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) |
| WP:WP4341 | 0.000201347625851 | 0.375 | NFKB1 RELB NFKB2 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| REAC:R-HSA-168249 | 0.00020989927665 | 0.75 | NFKBIA RELA RELB NFKB1 NFKB2 NFKBIB | Innate Immune System |
| WP:WP2374 | 0.000211196651104 | 0.375 | RELA NFKBIA NFKB1 | Oncostatin M Signaling Pathway |
| WP:WP3303 | 0.000221359959089 | 0.375 | RELA NFKBIA NFKB1 | RAC1/PAK1/p38/MMP2 Pathway |
| WP:WP2324 | 0.000221359959089 | 0.375 | RELA NFKBIA NFKB1 | AGE/RAGE pathway |
| WP:WP15 | 0.000253783817803 | 0.375 | NFKB2 RELA NFKB1 | Selenium Micronutrient Network |
| KEGG:04657 | 0.000263206512291 | 0.375 | RELA NFKBIA NFKB1 | IL-17 signaling pathway |
| WP:WP3926 | 0.000267943660265 | 0.25 | RELA NFKB2 | ApoE and miR-146 in inflammation and atherosclerosis |
| KEGG:04010 | 0.000271791789208 | 0.5 | NFKB2 RELA RELB NFKB1 | MAPK signaling pathway |
| KEGG:05220 | 0.000311378790393 | 0.375 | RELA NFKBIA NFKB1 | Chronic myeloid leukemia |
| WP:WP2034 | 0.000327767147782 | 0.375 | RELA REL NFKB1 | Leptin signaling pathway |
| CORUM:0000000 | 0.000356401437906 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | CORUM root |
| REAC:R-HSA-168643 | 0.000417193649275 | 0.375 | NFKB2 RELA NFKB1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| REAC:R-HSA-449147 | 0.000420849920465 | 0.625 | NFKB2 RELA NFKBIB NFKBIA NFKB1 | Signaling by Interleukins |
| REAC:R-HSA-5660668 | 0.000447265475157 | 0.25 | RELA NFKB1 | CLEC7A/inflammasome pathway |
| WP:WP2355 | 0.000480565625947 | 0.375 | RELA NFKBIA NFKB1 | Corticotropin-releasing hormone signaling pathway |
| KEGG:04620 | 0.000490097308558 | 0.375 | RELA NFKBIA NFKB1 | Toll-like receptor signaling pathway |
| KEGG:05142 | 0.000525250641096 | 0.375 | RELA NFKBIA NFKB1 | Chagas disease (American trypanosomiasis) |
| KEGG:05215 | 0.000562033170489 | 0.375 | RELA NFKBIA NFKB1 | Prostate cancer |
| KEGG:05222 | 0.000600480649738 | 0.375 | RELA NFKBIA NFKB1 | Small cell lung cancer |
| REAC:R-HSA-5607761 | 0.000608348414674 | 0.375 | RELA RELB NFKB2 | Dectin-1 mediated noncanonical NF-kB signaling |
| KEGG:04668 | 0.000620339897821 | 0.375 | RELA NFKBIA NFKB1 | TNF signaling pathway |
| WP:WP4337 | 0.000701003457493 | 0.25 | RELA NFKB1 | ncRNAs involved in STAT3 signaling in hepatocellular carcinoma |
| KEGG:04931 | 0.000818938393318 | 0.375 | RELA NFKBIA NFKB1 | Insulin resistance |
| WP:WP3849 | 0.000840978166984 | 0.25 | NFKB1 NFKBIA | MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ |
| WP:WP1434 | 0.000993616285887 | 0.25 | RELA NFKB1 | Osteopontin Signaling |
| REAC:R-HSA-3214841 | 0.00101325940726 | 0.375 | NFKB2 RELA NFKB1 | PKMTs methylate histone lysines |
| KEGG:05135 | 0.0010843397219 | 0.375 | RELA NFKBIA NFKB1 | Yersinia infection |
| REAC:R-HSA-2871837 | 0.0012447250077 | 0.375 | RELA NFKBIA NFKB1 | FCERI mediated NF-kB activation |
| GO:0000980 | 0.00129128001412 | 0.5 | RELA REL RELB NFKB1 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| KEGG:04926 | 0.00133340843894 | 0.375 | RELA NFKBIA NFKB1 | Relaxin signaling pathway |
| KEGG:04210 | 0.00150674749359 | 0.375 | RELA NFKBIA NFKB1 | Apoptosis |
| WP:WP4559 | 0.00152740874202 | 0.25 | NFKB1 NFKB2 | Interactions between immune cells and microRNAs in tumor microenvironment |
| REAC:R-HSA-193692 | 0.00160842632192 | 0.25 | RELA NFKB1 | Regulated proteolysis of p75NTR |
| REAC:R-HSA-193704 | 0.00180745106702 | 0.375 | RELA NFKBIA NFKB1 | p75 NTR receptor-mediated signalling |
| KEGG:05160 | 0.00193897536269 | 0.375 | RELA NFKBIA NFKB1 | Hepatitis C |
| REAC:R-HSA-202424 | 0.002004161208 | 0.375 | RELA NFKBIA NFKB1 | Downstream TCR signaling |
| WP:WP2380 | 0.00204102669757 | 0.375 | RELA NFKBIA NFKB1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| GO:0001158 | 0.00227493635833 | 0.5 | RELA REL RELB NFKB1 | enhancer sequence-specific DNA binding |
| KEGG:05200 | 0.00285664338154 | 0.5 | NFKB2 RELA NFKBIA NFKB1 | Pathways in cancer |
| KEGG:05161 | 0.00286450440117 | 0.375 | RELA NFKBIA NFKB1 | Hepatitis B |
| KEGG:05202 | 0.00297605939997 | 0.375 | RELA REL NFKB1 | Transcriptional misregulation in cancer |
| WP:WP4223 | 0.0030152677907 | 0.375 | RELA REL NFKB1 | Ras Signaling |
| WP:WP2583 | 0.00321423512458 | 0.25 | NFKB1 NFKBIA | T-Cell Receptor and Co-stimulatory Signaling |
| KEGG:05167 | 0.00345080874318 | 0.375 | RELA NFKBIA NFKB1 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-202403 | 0.00348693544502 | 0.375 | RELA NFKBIA NFKB1 | TCR signaling |
| GO:0035326 | 0.00373379969889 | 0.5 | RELA REL RELB NFKB1 | enhancer binding |
| KEGG:04024 | 0.00377137895638 | 0.375 | RELA NFKBIA NFKB1 | cAMP signaling pathway |
| KEGG:01523 | 0.00391934917642 | 0.25 | RELA NFKB1 | Antifolate resistance |
| WP:WP3851 | 0.00412563071202 | 0.25 | NFKB1 NFKBIA | TLR4 Signaling and Tolerance |
| KEGG:05130 | 0.00425215180026 | 0.375 | RELA NFKBIA NFKB1 | Pathogenic Escherichia coli infection |
| KEGG:04014 | 0.00477149410271 | 0.375 | RELA REL NFKB1 | Ras signaling pathway |
| REAC:R-HSA-2454202 | 0.00491753466842 | 0.375 | RELA NFKBIA NFKB1 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-73887 | 0.00569089099284 | 0.375 | RELA NFKBIA NFKB1 | Death Receptor Signalling |
| KEGG:05170 | 0.0060206924582 | 0.375 | RELA NFKBIA NFKB1 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.00629374055323 | 0.375 | RELA NFKBIA NFKB1 | Human cytomegalovirus infection |
| WP:WP3981 | 0.00668996541081 | 0.25 | NFKB1 NFKBIA | miRNA regulation of prostate cancer signaling pathways |
| HP:0006783 | 0.00745813121128 | 0.25 | NFKB1 NFKB2 | Posterior pharyngeal cleft |
| WP:WP3888 | 0.00841578083452 | 0.375 | RELA NFKBIA NFKB1 | VEGFA-VEGFR2 Signaling Pathway |
| WP:WP3941 | 0.00842941151014 | 0.25 | NFKB1 NFKBIE | Oxidative Damage |
| HP:0002088 | 0.00884430713945 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | Abnormal lung morphology |
| WP:WP1433 | 0.0088953208221 | 0.25 | RELA NFKBIA | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| WP:WP28 | 0.0088953208221 | 0.25 | RELA NFKB1 | Selenium Metabolism and Selenoproteins |
| WP:WP2526 | 0.00986432600459 | 0.25 | NFKB1 NFKBIA | PDGF Pathway |
| TF:M03563_1 | 0.0101367647888 | 0.75 | NFKBIA REL RELB NFKB1 NFKB2 NFKBIB | Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 |
| GO:0051090 | 0.0102250427997 | 0.625 | NFKB2 RELA NFKB1 NFKBIA NFKBIE | regulation of DNA-binding transcription factor activity |
| WP:WP2586 | 0.0108828459268 | 0.25 | RELA NFKB1 | Aryl Hydrocarbon Receptor |
| KEGG:05321 | 0.0113532598614 | 0.25 | RELA NFKB1 | Inflammatory bowel disease (IBD) |
| KEGG:05030 | 0.0124147017773 | 0.25 | RELA NFKB1 | Cocaine addiction |
| HP:0100723 | 0.0129170117165 | 0.25 | NFKB1 NFKB2 | Gastrointestinal stroma tumor |
| REAC:R-HSA-3108232 | 0.012957331413 | 0.375 | RELA NFKBIA NFKB2 | SUMO E3 ligases SUMOylate target proteins |
| WP:000000 | 0.0134045376724 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | WIKIPATHWAYS |
| REAC:R-HSA-2990846 | 0.0144010068221 | 0.375 | RELA NFKBIA NFKB2 | SUMOylation |
| GO:0006351 | 0.0145078913523 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | transcription, DNA-templated |
| GO:0097659 | 0.0148177261561 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | nucleic acid-templated transcription |
| GO:0032774 | 0.0151333353827 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | RNA biosynthetic process |
| WP:WP3863 | 0.0154504595488 | 0.25 | NFKB1 NFKBIA | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| HP:0002205 | 0.0156099723254 | 0.5 | NFKB2 NFKB1 NFKBIA RELB | Recurrent respiratory infections |
| GO:0034097 | 0.0171970371657 | 0.75 | NFKBIA RELA REL RELB NFKB1 NFKB2 | response to cytokine |
| GO:0003682 | 0.017380915583 | 0.625 | NFKB2 RELA REL RELB NFKB1 | chromatin binding |
| HP:0012252 | 0.018860152253 | 0.625 | NFKB2 RELA NFKB1 NFKBIA RELB | Abnormal respiratory system morphology |
| KEGG:05133 | 0.0211511745665 | 0.25 | RELA NFKB1 | Pertussis |
| KEGG:05221 | 0.0211511745665 | 0.25 | RELA NFKB1 | Acute myeloid leukemia |
| KEGG:04917 | 0.0225849529429 | 0.25 | RELA NFKB1 | Prolactin signaling pathway |
| HP:0011947 | 0.0227491492119 | 0.5 | NFKB2 NFKB1 NFKBIA RELB | Respiratory tract infection |
| GO:0045944 | 0.0262849659974 | 0.75 | NFKBIA RELA REL RELB NFKB1 NFKB2 | positive regulation of transcription by RNA polymerase II |
| KEGG:05132 | 0.0263713562019 | 0.25 | RELA NFKB1 | Salmonella infection |
| TF:M00774 | 0.026551757697 | 0.875 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB | Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN |
| TF:M00774_0 | 0.026551757697 | 0.875 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB | Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN; match class: 0 |
| KEGG:05212 | 0.029607581241 | 0.25 | RELA NFKB1 | Pancreatic cancer |
| WP:WP2064 | 0.0356955243477 | 0.25 | NFKB1 NFKB2 | Neural Crest Differentiation |
| KEGG:04211 | 0.0394512249973 | 0.25 | RELA NFKB1 | Longevity regulating pathway |
| KEGG:05168 | 0.0400163527282 | 0.375 | RELA NFKBIA NFKB1 | Herpes simplex virus 1 infection |
| WP:WP1772 | 0.0405256363219 | 0.25 | NFKB1 NFKBIA | Apoptosis Modulation and Signaling |
| KEGG:05146 | 0.042374965807 | 0.25 | RELA NFKB1 | Amoebiasis |
| WP:WP4263 | 0.0425415333003 | 0.25 | RELA NFKB1 | Pancreatic adenocarcinoma pathway |
| KEGG:00000 | 0.045111549543 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | KEGG root term |
| GO:0034654 | 0.0465658023825 | 1.0 | NFKBIA RELA REL RELB NFKB1 NFKB2 NFKBIB NFKBIE | nucleobase-containing compound biosynthetic process |
| KEGG:04933 | 0.0485281855609 | 0.25 | RELA NFKB1 | AGE-RAGE signaling pathway in diabetic complications |
| CORUM:3046 | 0.0497224828424 | 0.125 | RELB | hs4 enhancer complex (slow migrating complex) |
| CORUM:7317 | 0.0497224828424 | 0.125 | RELA | RELA-STAT3 complex |
| CORUM:7316 | 0.0497224828424 | 0.125 | NFKB1 | NFKB1-STAT3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NFKBIA | RELA | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA) bioplex_WMM hein (NFKBIA) |
| NFKBIA | REL | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA,REL) bioplex_WMM hein (NFKBIA) |
| NFKBIA | NFKB2 | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA) bioplex_WMM hein (NFKBIA) |
| RELA | NFKBIB | 1.0 | 0.949 | bioplex (NFKBIB) bioplex_WMM |
| NFKBIA | NFKB1 | 1.0 | 0.949 | hein_WMM bioplex (NFKBIA) bioplex_WMM hein (NFKBIA) |
| REL | NFKBIB | 0.998 | 0.937 | bioplex (NFKBIB,REL) bioplex_WMM |
| RELB | NFKB2 | 0.997 | 0.933 | bioplex (RELB) bioplex_WMM |
| NFKB1 | NFKBIB | 0.957 | 0.863 | bioplex (NFKBIB) bioplex_WMM |
| NFKBIA | RELB | 0.902 | 0.826 | bioplex (NFKBIA,RELB) bioplex_WMM |
| NFKB2 | NFKBIB | 0.887 | 0.818 | bioplex (NFKBIB) bioplex_WMM |
| RELB | NFKB1 | 0.831 | 0.778 | bioplex (RELB) bioplex_WMM |
| NFKB2 | REL | 0.755 | 0.747 | hein_WMM bioplex (REL) bioplex_WMM |
| NFKB1 | REL | 0.656 | 0.695 | hein_WMM bioplex (REL) bioplex_WMM |
| NFKBIE | RELB | 0.528 | 0.633 | bioplex (RELB) bioplex_WMM |
| NFKBIE | REL | 0.415 | 0.571 | hein_WMM bioplex (REL) bioplex_WMM |
| RELA | REL | 0.375 | 0.547 | hein_WMM bioplex (REL) bioplex_WMM youn_WMM |
| RELB | REL | 0.241 | 0.468 | bioplex (REL,RELB) bioplex_WMM |
| RELB | RELA | 0.139 | 0.406 | bioplex (RELB) bioplex_WMM |
| NFKBIA | NFKBIB | 0.028 | 0.228 | bioplex (NFKBIA) bioplex_WMM |
| RELA | NFKB1 | 0.017 | 0.173 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RELA | NFKB2 | 0.017 | 0.171 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NFKB1 | NFKB2 | 0.015 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| NFKBIE | RELA | 0.01 | 0.12 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NFKBIE | NFKB2 | 0.01 | 0.101 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RELB | NFKBIB | 0.01 | 0.1 | bioplex_WMM WMM_only |
| NFKBIE | NFKB1 | 0.01 | 0.104 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NFKBIE | NFKBIB | 0.008 | 0.028 | bioplex_WMM WMM_only |
| NFKBIA | NFKBIE | 0.003 | 0.008 | hein_WMM bioplex_WMM hein (NFKBIA) |
Images
Click to enlarge
Complex HuMAP2_01917 has an average edge precision of 0.541 which is ranked 2263 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NFKBIA | HuMAP2_01917 HuMAP2_02654 HuMAP2_03076 HuMAP2_03080 HuMAP2_06875 |
| NFKBIB | HuMAP2_01917 HuMAP2_03076 HuMAP2_06426 |
| NFKBIE | HuMAP2_01917 HuMAP2_03076 |
| RELA | HuMAP2_01917 HuMAP2_03076 HuMAP2_06875 |
| NFKB2 | HuMAP2_01917 HuMAP2_03076 HuMAP2_03896 |
| RELB | HuMAP2_01917 HuMAP2_03076 HuMAP2_03080 |
| NFKB1 | HuMAP2_01917 HuMAP2_03076 |
| REL | HuMAP2_01917 HuMAP2_03076 HuMAP2_03896 |