hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01941
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GFM1 | Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1) | UniProt NCBI |
| MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta) | UniProt NCBI |
| MCCC1 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7190 | 3.35600554376e-06 | 0.666666666667 | MCCC2 MCCC1 | 3-methylcrotonyl-CoA carboxylase |
| HP:0004357 | 8.83967473292e-06 | 0.666666666667 | MCCC2 MCCC1 | Abnormal circulating leucine concentration |
| HP:0008281 | 5.30332997138e-05 | 0.666666666667 | MCCC2 MCCC1 | Acute hyperammonemia |
| HP:0001942 | 6.29170912782e-05 | 1.0 | MCCC2 MCCC1 GFM1 | Metabolic acidosis |
| REAC:R-HSA-3371599 | 0.000140571869389 | 0.666666666667 | MCCC2 MCCC1 | Defective HLCS causes multiple carboxylase deficiency |
| HP:0010892 | 0.000185591618409 | 0.666666666667 | MCCC2 MCCC1 | Abnormal circulating branched chain amino acid concentration |
| REAC:R-HSA-3323169 | 0.000187420766709 | 0.666666666667 | MCCC2 MCCC1 | Defects in biotin (Btn) metabolism |
| REAC:R-HSA-196780 | 0.000368098478948 | 0.666666666667 | MCCC2 MCCC1 | Biotin transport and metabolism |
| KEGG:00280 | 0.00048313744261 | 0.666666666667 | MCCC2 MCCC1 | Valine, leucine and isoleucine degradation |
| REAC:R-HSA-70895 | 0.00114404160216 | 0.666666666667 | MCCC2 MCCC1 | Branched-chain amino acid catabolism |
| GO:1905202 | 0.00135247023414 | 0.666666666667 | MCCC2 MCCC1 | methylcrotonoyl-CoA carboxylase complex |
| GO:0002169 | 0.00135247023414 | 0.666666666667 | MCCC2 MCCC1 | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial |
| GO:0004485 | 0.00135247023414 | 0.666666666667 | MCCC2 MCCC1 | methylcrotonoyl-CoA carboxylase activity |
| REAC:R-HSA-3296482 | 0.00140483748394 | 0.666666666667 | MCCC2 MCCC1 | Defects in vitamin and cofactor metabolism |
| HP:0002919 | 0.0015104340107 | 0.666666666667 | MCCC2 MCCC1 | Ketonuria |
| HP:0001941 | 0.00226611341913 | 1.0 | MCCC2 MCCC1 GFM1 | Acidosis |
| HP:0004360 | 0.0029472200921 | 1.0 | MCCC2 MCCC1 GFM1 | Abnormality of acid-base homeostasis |
| HP:0002179 | 0.00358457001899 | 0.666666666667 | MCCC2 MCCC1 | Opisthotonus |
| HP:0001987 | 0.00913104209388 | 0.666666666667 | MCCC2 MCCC1 | Hyperammonemia |
| GO:0006552 | 0.0135228859698 | 0.666666666667 | MCCC2 MCCC1 | leucine catabolic process |
| HP:0001347 | 0.0171883112328 | 1.0 | MCCC2 MCCC1 GFM1 | Hyperreflexia |
| HP:0001992 | 0.0172167410086 | 0.666666666667 | MCCC2 MCCC1 | Organic aciduria |
| HP:0001531 | 0.0189067773604 | 0.666666666667 | MCCC2 MCCC1 | Failure to thrive in infancy |
| GO:0016421 | 0.020283420769 | 0.666666666667 | MCCC2 MCCC1 | CoA carboxylase activity |
| HP:0001259 | 0.023156827915 | 0.666666666667 | MCCC2 MCCC1 | Coma |
| REAC:R-HSA-5668914 | 0.0255313065434 | 0.666666666667 | MCCC2 MCCC1 | Diseases of metabolism |
| HP:0001257 | 0.0255710895815 | 1.0 | MCCC2 MCCC1 GFM1 | Spasticity |
| GO:0006551 | 0.0283955176165 | 0.666666666667 | MCCC2 MCCC1 | leucine metabolic process |
| GO:0016885 | 0.0283955176165 | 0.666666666667 | MCCC2 MCCC1 | ligase activity, forming carbon-carbon bonds |
| HP:0025356 | 0.0307019877242 | 0.666666666667 | MCCC2 MCCC1 | Psychomotor retardation |
| HP:0011968 | 0.0323585280482 | 1.0 | MCCC2 MCCC1 GFM1 | Feeding difficulties |
| HP:0002157 | 0.0352634284647 | 0.666666666667 | MCCC2 MCCC1 | Azotemia |
| HP:0004364 | 0.0368537935068 | 0.666666666667 | MCCC2 MCCC1 | Abnormal circulating nitrogen compound concentration |
| REAC:R-HSA-196849 | 0.0399448421955 | 0.666666666667 | MCCC2 MCCC1 | Metabolism of water-soluble vitamins and cofactors |
| HP:0003112 | 0.041834410056 | 0.666666666667 | MCCC2 MCCC1 | Abnormality of serum amino acid level |
| HP:0001276 | 0.0448141259844 | 1.0 | MCCC2 MCCC1 GFM1 | Hypertonia |
| GO:0006768 | 0.0486736709081 | 0.666666666667 | MCCC2 MCCC1 | biotin metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MCCC2 | MCCC1 | 1.0 | 0.949 | bioplex_WMM Guru boldt Malo fraction boldt_WMM treiber_WMM |
| GFM1 | MCCC2 | 0.032 | 0.241 | bioplex_WMM fraction |
| GFM1 | MCCC1 | 0.003 | 0.011 | bioplex_WMM fraction |
Images
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Complex HuMAP2_01941 has an average edge precision of 0.4 which is ranked 3318 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GFM1 | HuMAP2_00182 HuMAP2_01941 HuMAP2_04067 HuMAP2_05526 |
| MCCC2 | HuMAP2_01941 HuMAP2_04067 HuMAP2_04599 HuMAP2_05526 |
| MCCC1 | HuMAP2_01941 HuMAP2_02020 HuMAP2_03882 HuMAP2_04067 HuMAP2_04599 HuMAP2_05526 |