hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01942
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IKBKG | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | UniProt NCBI |
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | UniProt NCBI |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5844 | 2.25356268047e-10 | 1.0 | IKBKG CHUK IKBKB | I-kappa-B kinase complex |
| CORUM:2121 | 2.25356268047e-10 | 1.0 | IKBKG CHUK IKBKB | I-kappa-B kinase complex |
| REAC:R-HSA-5602636 | 4.49596911006e-10 | 1.0 | IKBKG CHUK IKBKB | IKBKB deficiency causes SCID |
| REAC:R-HSA-5603027 | 4.49596911006e-10 | 1.0 | IKBKG CHUK IKBKB | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) |
| CORUM:2118 | 9.0142507219e-10 | 1.0 | IKBKG CHUK IKBKB | CHUK-ERC1-IKBKB-IKBKG |
| WP:WP4562 | 3.60697890588e-09 | 1.0 | IKBKG CHUK IKBKB | Canonical NF-KB pathway |
| WP:WP288 | 3.60697890588e-09 | 1.0 | IKBKG CHUK IKBKB | NLR Proteins |
| WP:WP4479 | 3.60697890588e-09 | 1.0 | IKBKG CHUK IKBKB | Supression of HMGB1 mediated inflammation by THBD |
| WP:WP4480 | 5.41046835882e-09 | 1.0 | IKBKG CHUK IKBKB | Role Altered Glycolysation of MUC1 in Tumour Microenvironment |
| CORUM:2727 | 7.88746938166e-09 | 1.0 | IKBKG CHUK IKBKB | SRC-3 complex |
| WP:WP3849 | 1.41702742731e-08 | 1.0 | IKBKG CHUK IKBKB | MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ |
| REAC:R-HSA-5603029 | 1.57358918852e-08 | 1.0 | IKBKG CHUK IKBKB | IkBA variant leads to EDA-ID |
| CORUM:5194 | 1.8929926516e-08 | 1.0 | IKBKG CHUK IKBKB | TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) |
| KEGG:01523 | 7.81881780332e-08 | 1.0 | IKBKG CHUK IKBKB | Antifolate resistance |
| CORUM:5266 | 8.20296815693e-08 | 1.0 | IKBKG CHUK IKBKB | TNF-alpha/NF-kappa B signaling complex 6 |
| WP:WP4482 | 8.56657490147e-08 | 1.0 | IKBKG CHUK IKBKB | Vitamin D in inflammatory diseases |
| WP:WP712 | 8.56657490147e-08 | 1.0 | IKBKG CHUK IKBKB | Estrogen signaling pathway |
| WP:WP262 | 8.56657490147e-08 | 1.0 | IKBKG CHUK IKBKB | EBV LMP1 signaling |
| REAC:R-HSA-933543 | 9.89113204212e-08 | 1.0 | IKBKG CHUK IKBKB | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| CORUM:6344 | 1.02537101962e-07 | 1.0 | IKBKG CHUK IKBKB | TNF-R1-associated signaling complex |
| REAC:R-HSA-975144 | 1.63653275606e-07 | 1.0 | IKBKG CHUK IKBKB | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| REAC:R-HSA-937039 | 1.63653275606e-07 | 1.0 | IKBKG CHUK IKBKB | IRAK1 recruits IKK complex |
| WP:WP3851 | 1.67466877773e-07 | 1.0 | IKBKG CHUK IKBKB | TLR4 Signaling and Tolerance |
| WP:WP3858 | 2.11008265994e-07 | 1.0 | IKBKG CHUK IKBKB | Toll-like Receptor Signaling |
| REAC:R-HSA-5684264 | 2.51774270163e-07 | 1.0 | IKBKG CHUK IKBKB | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| WP:WP4481 | 2.61505970677e-07 | 1.0 | IKBKG CHUK IKBKB | Resistin as a regulator of inflammation |
| WP:WP4329 | 2.61505970677e-07 | 1.0 | IKBKG CHUK IKBKB | miRNAs involvement in the immune response in sepsis |
| REAC:R-HSA-1810476 | 3.05725899484e-07 | 1.0 | IKBKG CHUK IKBKB | RIP-mediated NFkB activation via ZBP1 |
| WP:WP4136 | 3.85431460229e-07 | 1.0 | IKBKG CHUK IKBKB | Fibrin Complement Receptor 3 Signaling Pathway |
| REAC:R-HSA-168927 | 4.35659406764e-07 | 1.0 | IKBKG CHUK IKBKB | TICAM1, RIP1-mediated IKK complex recruitment |
| CORUM:5233 | 4.56121086528e-07 | 1.0 | IKBKG CHUK IKBKB | TNF-alpha/NF-kappa B signaling complex 5 |
| WP:WP1433 | 5.43365608036e-07 | 1.0 | IKBKG CHUK IKBKB | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| REAC:R-HSA-937041 | 5.97963891637e-07 | 1.0 | IKBKG CHUK IKBKB | IKK complex recruitment mediated by RIP1 |
| REAC:R-HSA-1606322 | 5.97963891637e-07 | 1.0 | IKBKG CHUK IKBKB | ZBP1(DAI) mediated induction of type I IFNs |
| REAC:R-HSA-933542 | 6.92379242949e-07 | 1.0 | IKBKG CHUK IKBKB | TRAF6 mediated NF-kB activation |
| REAC:R-HSA-5260271 | 7.96236129391e-07 | 1.0 | IKBKG CHUK IKBKB | Diseases of Immune System |
| REAC:R-HSA-5602358 | 7.96236129391e-07 | 1.0 | IKBKG CHUK IKBKB | Diseases associated with the TLR signaling cascade |
| KEGG:04623 | 9.27913238996e-07 | 1.0 | IKBKG CHUK IKBKB | Cytosolic DNA-sensing pathway |
| KEGG:05221 | 1.02907671242e-06 | 1.0 | IKBKG CHUK IKBKB | Acute myeloid leukemia |
| KEGG:05120 | 1.08230481824e-06 | 1.0 | IKBKG CHUK IKBKB | Epithelial cell signaling in Helicobacter pylori infection |
| WP:WP2795 | 1.11404119922e-06 | 1.0 | IKBKG CHUK IKBKB | Cardiac Hypertrophic Response |
| KEGG:05131 | 1.25293548061e-06 | 1.0 | IKBKG CHUK IKBKB | Shigellosis |
| KEGG:04920 | 1.25293548061e-06 | 1.0 | IKBKG CHUK IKBKB | Adipocytokine signaling pathway |
| KEGG:04622 | 1.25293548061e-06 | 1.0 | IKBKG CHUK IKBKB | RIG-I-like receptor signaling pathway |
| WP:WP3863 | 1.26244261706e-06 | 1.0 | IKBKG CHUK IKBKB | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| WP:WP195 | 1.34134528063e-06 | 1.0 | IKBKG CHUK IKBKB | IL-1 signaling pathway |
| WP:WP2018 | 1.42346846107e-06 | 1.0 | IKBKG CHUK IKBKB | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| KEGG:04662 | 1.44061718026e-06 | 1.0 | IKBKG CHUK IKBKB | B cell receptor signaling pathway |
| WP:WP3865 | 1.59763401396e-06 | 1.0 | IKBKG CHUK IKBKB | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| REAC:R-HSA-5357956 | 1.64282711281e-06 | 1.0 | IKBKG CHUK IKBKB | TNFR1-induced NFkappaB signaling pathway |
| KEGG:04657 | 1.64616187136e-06 | 1.0 | IKBKG CHUK IKBKB | IL-17 signaling pathway |
| KEGG:05212 | 1.7187866598e-06 | 1.0 | IKBKG CHUK IKBKB | Pancreatic cancer |
| KEGG:04658 | 1.7187866598e-06 | 1.0 | IKBKG CHUK IKBKB | Th1 and Th2 cell differentiation |
| REAC:R-HSA-445989 | 1.82536345868e-06 | 1.0 | IKBKG CHUK IKBKB | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| REAC:R-HSA-5357905 | 1.82536345868e-06 | 1.0 | IKBKG CHUK IKBKB | Regulation of TNFR1 signaling |
| KEGG:05220 | 1.94941171262e-06 | 1.0 | IKBKG CHUK IKBKB | Chronic myeloid leukemia |
| KEGG:04064 | 2.37809343488e-06 | 1.0 | IKBKG CHUK IKBKB | NF-kappa B signaling pathway |
| KEGG:05235 | 2.47074642585e-06 | 1.0 | IKBKG CHUK IKBKB | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP3303 | 2.81344354659e-06 | 1.0 | IKBKG CHUK IKBKB | RAC1/PAK1/p38/MMP2 Pathway |
| REAC:R-HSA-168638 | 2.94261178253e-06 | 1.0 | IKBKG CHUK IKBKB | NOD1/2 Signaling Pathway |
| KEGG:04659 | 3.07760697689e-06 | 1.0 | IKBKG CHUK IKBKB | Th17 cell differentiation |
| KEGG:04620 | 3.07760697689e-06 | 1.0 | IKBKG CHUK IKBKB | Toll-like receptor signaling pathway |
| WP:WP4655 | 3.22798847941e-06 | 1.0 | IKBKG CHUK IKBKB | Cytosolic DNA-sensing pathway |
| KEGG:04625 | 3.30002227102e-06 | 1.0 | IKBKG CHUK IKBKB | C-type lectin receptor signaling pathway |
| KEGG:05142 | 3.30002227102e-06 | 1.0 | IKBKG CHUK IKBKB | Chagas disease (American trypanosomiasis) |
| CORUM:5829 | 3.35600554376e-06 | 0.666666666667 | IKBKG CHUK | IKBKG-CHUK complex |
| CORUM:2101 | 3.35600554376e-06 | 0.666666666667 | CHUK IKBKB | IKKA-IKKB complex |
| CORUM:5828 | 3.35600554376e-06 | 0.666666666667 | IKBKG IKBKB | IKBKG-IKBKB complex |
| CORUM:6152 | 3.35600554376e-06 | 0.666666666667 | IKBKG CHUK | IKBKG-CHUK complex |
| KEGG:04660 | 3.53290275205e-06 | 1.0 | IKBKG CHUK IKBKB | T cell receptor signaling pathway |
| KEGG:05215 | 3.53290275205e-06 | 1.0 | IKBKG CHUK IKBKB | Prostate cancer |
| KEGG:05222 | 3.776488999e-06 | 1.0 | IKBKG CHUK IKBKB | Small cell lung cancer |
| KEGG:04668 | 3.90237196563e-06 | 1.0 | IKBKG CHUK IKBKB | TNF signaling pathway |
| WP:WP254 | 4.00606535768e-06 | 1.0 | IKBKG CHUK IKBKB | Apoptosis |
| KEGG:05145 | 4.03102159088e-06 | 1.0 | IKBKG CHUK IKBKB | Toxoplasmosis |
| WP:WP2034 | 4.17533572491e-06 | 1.0 | IKBKG CHUK IKBKB | Leptin signaling pathway |
| REAC:R-HSA-75893 | 4.44201748073e-06 | 1.0 | IKBKG CHUK IKBKB | TNF signaling |
| WP:WP1544 | 4.52804673364e-06 | 1.0 | IKBKG CHUK IKBKB | MicroRNAs in cardiomyocyte hypertrophy |
| WP:WP69 | 4.71161619581e-06 | 1.0 | IKBKG CHUK IKBKB | T-Cell antigen Receptor (TCR) Signaling Pathway |
| KEGG:04380 | 5.31832979744e-06 | 1.0 | IKBKG CHUK IKBKB | Osteoclast differentiation |
| WP:WP4263 | 5.91808622949e-06 | 1.0 | IKBKG CHUK IKBKB | Pancreatic adenocarcinoma pathway |
| KEGG:05135 | 6.85409597589e-06 | 1.0 | IKBKG CHUK IKBKB | Yersinia infection |
| WP:WP75 | 7.06813280743e-06 | 1.0 | IKBKG CHUK IKBKB | Toll-like Receptor Signaling Pathway |
| WP:WP23 | 7.06813280743e-06 | 1.0 | IKBKG CHUK IKBKB | B Cell Receptor Signaling Pathway |
| WP:WP231 | 7.06813280743e-06 | 1.0 | IKBKG CHUK IKBKB | TNF alpha Signaling Pathway |
| GO:0008385 | 7.62876038594e-06 | 1.0 | IKBKG CHUK IKBKB | IkappaB kinase complex |
| WP:WP4658 | 8.9153568796e-06 | 1.0 | IKBKG CHUK IKBKB | Small cell lung cancer |
| KEGG:04210 | 9.55549752694e-06 | 1.0 | IKBKG CHUK IKBKB | Apoptosis |
| KEGG:05418 | 9.55549752694e-06 | 1.0 | IKBKG CHUK IKBKB | Fluid shear stress and atherosclerosis |
| CORUM:2100 | 1.00675659188e-05 | 0.666666666667 | CHUK IKBKB | CHUK-IKBKB-MAP3K14 complex |
| KEGG:05162 | 1.02659874862e-05 | 1.0 | IKBKG CHUK IKBKB | Measles |
| REAC:R-HSA-168643 | 1.05322572372e-05 | 1.0 | IKBKG CHUK IKBKB | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:04062 | 1.07586932974e-05 | 1.0 | IKBKG CHUK IKBKB | Chemokine signaling pathway |
| KEGG:05160 | 1.23308771234e-05 | 1.0 | IKBKG CHUK IKBKB | Hepatitis C |
| KEGG:05164 | 1.59201956531e-05 | 1.0 | IKBKG CHUK IKBKB | Influenza A |
| WP:WP1449 | 1.71921496722e-05 | 1.0 | IKBKG CHUK IKBKB | Regulation of toll-like receptor signaling pathway |
| REAC:R-HSA-450294 | 1.78539429329e-05 | 1.0 | IKBKG CHUK IKBKB | MAP kinase activation |
| REAC:R-HSA-1834949 | 1.78539429329e-05 | 1.0 | IKBKG CHUK IKBKB | Cytosolic sensors of pathogen-associated DNA |
| KEGG:05161 | 1.8304604287e-05 | 1.0 | IKBKG CHUK IKBKB | Hepatitis B |
| KEGG:04621 | 1.93953594429e-05 | 1.0 | IKBKG CHUK IKBKB | NOD-like receptor signaling pathway |
| WP:WP3929 | 1.99751915394e-05 | 1.0 | IKBKG CHUK IKBKB | Chemokine signaling pathway |
| REAC:R-HSA-1169091 | 2.05735546476e-05 | 1.0 | IKBKG CHUK IKBKB | Activation of NF-kappaB in B cells |
| KEGG:05167 | 2.21071058913e-05 | 1.0 | IKBKG CHUK IKBKB | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-448424 | 2.35561805552e-05 | 1.0 | IKBKG CHUK IKBKB | Interleukin-17 signaling |
| WP:WP2380 | 2.64108148316e-05 | 1.0 | IKBKG CHUK IKBKB | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-168928 | 2.68139597724e-05 | 1.0 | IKBKG CHUK IKBKB | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:05130 | 2.7323760985e-05 | 1.0 | IKBKG CHUK IKBKB | Pathogenic Escherichia coli infection |
| KEGG:05169 | 3.02146485782e-05 | 1.0 | IKBKG CHUK IKBKB | Epstein-Barr virus infection |
| KEGG:04014 | 3.07154438585e-05 | 1.0 | IKBKG CHUK IKBKB | Ras signaling pathway |
| REAC:R-HSA-2871837 | 3.16066628437e-05 | 1.0 | IKBKG CHUK IKBKB | FCERI mediated NF-kB activation |
| WP:WP4666 | 3.20531604058e-05 | 1.0 | IKBKG CHUK IKBKB | Hepatitis B infection |
| REAC:R-HSA-1168372 | 3.28880140401e-05 | 1.0 | IKBKG CHUK IKBKB | Downstream signaling events of B Cell Receptor (BCR) |
| CORUM:2055 | 3.35555483123e-05 | 0.666666666667 | CHUK IKBKB | CASP8-CHUK-IKBKB-MALT1-BCL10 complex |
| KEGG:05166 | 3.77375241277e-05 | 1.0 | IKBKG CHUK IKBKB | Human T-cell leukemia virus 1 infection |
| KEGG:05170 | 3.89046029743e-05 | 1.0 | IKBKG CHUK IKBKB | Human immunodeficiency virus 1 infection |
| WP:WP4223 | 3.92056063451e-05 | 1.0 | IKBKG CHUK IKBKB | Ras Signaling |
| REAC:R-HSA-168142 | 3.98163024387e-05 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 3.98163024387e-05 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975871 | 3.98163024387e-05 | 1.0 | IKBKG CHUK IKBKB | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-1236974 | 3.98163024387e-05 | 1.0 | IKBKG CHUK IKBKB | ER-Phagosome pathway |
| KEGG:05163 | 4.06999539039e-05 | 1.0 | IKBKG CHUK IKBKB | Human cytomegalovirus infection |
| REAC:R-HSA-975138 | 4.28393920683e-05 | 1.0 | IKBKG CHUK IKBKB | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 4.44066869e-05 | 1.0 | IKBKG CHUK IKBKB | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 4.44066869e-05 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| CORUM:2105 | 5.03310689057e-05 | 0.666666666667 | CHUK IKBKB | IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) |
| REAC:R-HSA-168188 | 5.10580236014e-05 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168138 | 5.10580236014e-05 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-166058 | 5.10580236014e-05 | 1.0 | IKBKG CHUK IKBKB | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-202424 | 5.10580236014e-05 | 1.0 | IKBKG CHUK IKBKB | Downstream TCR signaling |
| REAC:R-HSA-168164 | 5.28186451049e-05 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-5607764 | 5.64603800841e-05 | 1.0 | IKBKG CHUK IKBKB | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-168179 | 5.64603800841e-05 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 5.64603800841e-05 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-937061 | 5.83423927535e-05 | 1.0 | IKBKG CHUK IKBKB | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 5.83423927535e-05 | 1.0 | IKBKG CHUK IKBKB | MyD88-independent TLR4 cascade |
| REAC:R-HSA-1236975 | 6.02657683388e-05 | 1.0 | IKBKG CHUK IKBKB | Antigen processing-Cross presentation |
| REAC:R-HSA-9020702 | 6.62885685587e-05 | 1.0 | IKBKG CHUK IKBKB | Interleukin-1 signaling |
| WP:WP1434 | 7.47806596008e-05 | 0.666666666667 | CHUK IKBKB | Osteopontin Signaling |
| REAC:R-HSA-983705 | 7.49253252191e-05 | 1.0 | IKBKG CHUK IKBKB | Signaling by the B Cell Receptor (BCR) |
| KEGG:04010 | 8.31056129839e-05 | 1.0 | IKBKG CHUK IKBKB | MAPK signaling pathway |
| REAC:R-HSA-202403 | 8.92382428809e-05 | 1.0 | IKBKG CHUK IKBKB | TCR signaling |
| WP:WP382 | 0.000111215333222 | 1.0 | IKBKG CHUK IKBKB | MAPK Signaling Pathway |
| REAC:R-HSA-166016 | 0.000120004609098 | 1.0 | IKBKG CHUK IKBKB | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-2454202 | 0.000126264796487 | 1.0 | IKBKG CHUK IKBKB | Fc epsilon receptor (FCERI) signaling |
| KEGG:04151 | 0.00013397544306 | 1.0 | IKBKG CHUK IKBKB | PI3K-Akt signaling pathway |
| REAC:R-HSA-446652 | 0.000146343794532 | 1.0 | IKBKG CHUK IKBKB | Interleukin-1 family signaling |
| REAC:R-HSA-73887 | 0.000146343794532 | 1.0 | IKBKG CHUK IKBKB | Death Receptor Signalling |
| REAC:R-HSA-5621481 | 0.000146343794532 | 1.0 | IKBKG CHUK IKBKB | C-type lectin receptors (CLRs) |
| KEGG:05165 | 0.000150762444884 | 1.0 | IKBKG CHUK IKBKB | Human papillomavirus infection |
| CORUM:5286 | 0.000150966163965 | 0.666666666667 | IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex 10 |
| REAC:R-HSA-168898 | 0.000201230585428 | 1.0 | IKBKG CHUK IKBKB | Toll-like Receptor Cascades |
| CORUM:5193 | 0.00022139720913 | 0.666666666667 | IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| CORUM:5230 | 0.00022139720913 | 0.666666666667 | IKBKG CHUK | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
| WP:WP4172 | 0.000251129143237 | 1.0 | IKBKG CHUK IKBKB | PI3K-Akt Signaling Pathway |
| GO:0035666 | 0.000265644334868 | 1.0 | IKBKG CHUK IKBKB | TRIF-dependent toll-like receptor signaling pathway |
| KEGG:05168 | 0.0002707003734 | 1.0 | IKBKG CHUK IKBKB | Herpes simplex virus 1 infection |
| WP:WP2112 | 0.000362155110066 | 0.666666666667 | IKBKG IKBKB | IL17 signaling pathway |
| WP:WP4496 | 0.000388963980784 | 0.666666666667 | CHUK IKBKB | Signal transduction through IL1R |
| GO:0002756 | 0.000408229499224 | 1.0 | IKBKG CHUK IKBKB | MyD88-independent toll-like receptor signaling pathway |
| WP:WP3617 | 0.000416728443271 | 0.666666666667 | CHUK IKBKB | Photodynamic therapy-induced NF-kB survival signaling |
| CORUM:5232 | 0.000456110269427 | 0.666666666667 | IKBKG CHUK | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| KEGG:05200 | 0.000500689425538 | 1.0 | IKBKG CHUK IKBKB | Pathways in cancer |
| WP:WP2332 | 0.000709588979832 | 0.666666666667 | CHUK IKBKB | Interleukin-11 Signaling Pathway |
| WP:WP2036 | 0.000746902274868 | 0.666666666667 | CHUK IKBKB | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| WP:WP2637 | 0.00112564433507 | 0.666666666667 | CHUK IKBKB | Structural Pathway of Interleukin 1 (IL-1) |
| WP:WP395 | 0.00126905060241 | 0.666666666667 | CHUK IKBKB | IL-4 Signaling Pathway |
| GO:0008384 | 0.00135247023414 | 0.666666666667 | CHUK IKBKB | IkappaB kinase activity |
| GO:0010803 | 0.00147262321021 | 1.0 | IKBKG CHUK IKBKB | regulation of tumor necrosis factor-mediated signaling pathway |
| WP:WP2324 | 0.00198950650794 | 0.666666666667 | CHUK IKBKB | AGE/RAGE pathway |
| KEGG:04068 | 0.00287006078872 | 0.666666666667 | CHUK IKBKB | FoxO signaling pathway |
| REAC:R-HSA-983169 | 0.00315795701338 | 1.0 | IKBKG CHUK IKBKB | Class I MHC mediated antigen processing & presentation |
| KEGG:04150 | 0.00458162707101 | 0.666666666667 | CHUK IKBKB | mTOR signaling pathway |
| GO:0002479 | 0.00541641987402 | 1.0 | IKBKG CHUK IKBKB | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| GO:1902554 | 0.00588722337212 | 1.0 | IKBKG CHUK IKBKB | serine/threonine protein kinase complex |
| GO:0042590 | 0.00613252434596 | 1.0 | IKBKG CHUK IKBKB | antigen processing and presentation of exogenous peptide antigen via MHC class I |
| REAC:R-HSA-449147 | 0.00988151966016 | 1.0 | IKBKG CHUK IKBKB | Signaling by Interleukins |
| GO:1902911 | 0.00996606725847 | 1.0 | IKBKG CHUK IKBKB | protein kinase complex |
| GO:0002474 | 0.0110330947082 | 1.0 | IKBKG CHUK IKBKB | antigen processing and presentation of peptide antigen via MHC class I |
| GO:0070498 | 0.0125706532002 | 1.0 | IKBKG CHUK IKBKB | interleukin-1-mediated signaling pathway |
| GO:0038095 | 0.0155935495032 | 1.0 | IKBKG CHUK IKBKB | Fc-epsilon receptor signaling pathway |
| GO:0002223 | 0.0155935495032 | 1.0 | IKBKG CHUK IKBKB | stimulatory C-type lectin receptor signaling pathway |
| GO:0002220 | 0.0160613559883 | 1.0 | IKBKG CHUK IKBKB | innate immune response activating cell surface receptor signaling pathway |
| REAC:R-HSA-1280218 | 0.0202947578047 | 1.0 | IKBKG CHUK IKBKB | Adaptive Immune System |
| GO:0001959 | 0.0212638981157 | 1.0 | IKBKG CHUK IKBKB | regulation of cytokine-mediated signaling pathway |
| GO:0002224 | 0.0230188762788 | 1.0 | IKBKG CHUK IKBKB | toll-like receptor signaling pathway |
| GO:0051092 | 0.0242409310378 | 1.0 | IKBKG CHUK IKBKB | positive regulation of NF-kappaB transcription factor activity |
| REAC:R-HSA-1280215 | 0.0245091821355 | 1.0 | IKBKG CHUK IKBKB | Cytokine Signaling in Immune system |
| CORUM:5730 | 0.0249904952816 | 0.333333333333 | IKBKG | IKBKG homotrimer complex |
| CORUM:5827 | 0.0249904952816 | 0.333333333333 | IKBKG | IKBKG homotetramer complex |
| CORUM:2123 | 0.0249904952816 | 0.333333333333 | IKBKG | IKBKG homodimer complex |
| GO:0060759 | 0.0274836082947 | 1.0 | IKBKG CHUK IKBKB | regulation of response to cytokine stimulus |
| WP:WP3932 | 0.0309522486098 | 0.666666666667 | IKBKG IKBKB | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0071347 | 0.033252767518 | 1.0 | IKBKG CHUK IKBKB | cellular response to interleukin-1 |
| GO:0033209 | 0.033252767518 | 1.0 | IKBKG CHUK IKBKB | tumor necrosis factor-mediated signaling pathway |
| GO:0070555 | 0.0442598881134 | 1.0 | IKBKG CHUK IKBKB | response to interleukin-1 |
| GO:0043123 | 0.0490669153423 | 1.0 | IKBKG CHUK IKBKB | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| CORUM:4043 | 0.0499776345577 | 0.333333333333 | IKBKG | NEMO-HIF2(alpha)-ARNT complex |
| CORUM:2104 | 0.0499776345577 | 0.333333333333 | IKBKB | IKKB-NIK complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IKBKG | IKBKB | 0.998 | 0.943 | hein_WMM bioplex (IKBKG) bioplex_WMM hein (IKBKG) |
| IKBKG | CHUK | 0.989 | 0.905 | hein_WMM bioplex (IKBKG) bioplex_WMM hein (IKBKG) |
| CHUK | IKBKB | 0.068 | 0.346 | hein_WMM bioplex (IKBKB) bioplex_WMM youn_WMM |
Images
Click to enlarge
Complex HuMAP2_01942 has an average edge precision of 0.731 which is ranked 1256 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IKBKG | HuMAP2_01443 HuMAP2_01942 HuMAP2_04318 HuMAP2_05843 HuMAP2_06238 |
| CHUK | HuMAP2_01942 HuMAP2_05843 HuMAP2_06238 |
| IKBKB | HuMAP2_01942 HuMAP2_05843 HuMAP2_06238 |