hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01946
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ZACN | Zinc-activated ligand-gated ion channel (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2) | UniProt NCBI |
| PLPPR3 | Phospholipid phosphatase-related protein type 3 (EC 3.1.3.4) (Lipid phosphate phosphatase-related protein type 3) (PAP-2-like protein 2) (Plasticity-related gene 2 protein) (PRG-2) | UniProt NCBI |
| PLPPR1 | Phospholipid phosphatase-related protein type 1 (Lipid phosphate phosphatase-related protein type 1) (Plasticity-related gene 3 protein) (PRG-3) | UniProt NCBI |
| PLPP3 | Phospholipid phosphatase 3 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 3) (PAP2-beta) (Phosphatidate phosphohydrolase type 2b) (Phosphatidic acid phosphatase 2b) (PAP-2b) (PAP2b) (Vascular endothelial growth factor and type I collagen-inducible protein) (VCIP) | UniProt NCBI |
| PLPP2 | Phospholipid phosphatase 2 (EC 3.1.3.4) (Lipid phosphate phosphohydrolase 2) (PAP2-gamma) (PAP2-G) (Phosphatidate phosphohydrolase type 2c) (Phosphatidic acid phosphatase 2c) (PAP-2c) (PAP2c) | UniProt NCBI |
| EDEM1 | ER degradation-enhancing alpha-mannosidase-like protein 1 | UniProt NCBI |
| STXBP3 | Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008195 | 1.07497741607e-07 | 0.571428571429 | PLPPR3 PLPPR1 PLPP2 PLPP3 | phosphatidate phosphatase activity |
| GO:0042577 | 1.07497741607e-07 | 0.571428571429 | PLPPR3 PLPPR1 PLPP2 PLPP3 | lipid phosphatase activity |
| GO:0046839 | 1.07646157797e-05 | 0.571428571429 | PLPPR3 PLPPR1 PLPP2 PLPP3 | phospholipid dephosphorylation |
| REAC:R-HSA-419408 | 0.00173796966748 | 0.285714285714 | PLPPR3 PLPPR1 | Lysosphingolipid and LPA receptors |
| WP:WP325 | 0.00253615815428 | 0.285714285714 | PLPP3 PLPP2 | Triacylglyceride Synthesis |
| KEGG:04975 | 0.00428986512 | 0.285714285714 | PLPP3 PLPP2 | Fat digestion and absorption |
| KEGG:00565 | 0.00552749174707 | 0.285714285714 | PLPP3 PLPP2 | Ether lipid metabolism |
| KEGG:00600 | 0.00806673921792 | 0.285714285714 | PLPP3 PLPP2 | Sphingolipid metabolism |
| KEGG:00561 | 0.0145629093746 | 0.285714285714 | PLPP3 PLPP2 | Glycerolipid metabolism |
| REAC:R-HSA-1660661 | 0.0176362111261 | 0.285714285714 | PLPP3 PLPP2 | Sphingolipid de novo biosynthesis |
| GO:0030258 | 0.0299438047992 | 0.571428571429 | PLPPR3 PLPPR1 PLPP2 PLPP3 | lipid modification |
| KEGG:00564 | 0.030052232514 | 0.285714285714 | PLPP3 PLPP2 | Glycerophospholipid metabolism |
| KEGG:04666 | 0.0372632222286 | 0.285714285714 | PLPP3 PLPP2 | Fc gamma R-mediated phagocytosis |
| KEGG:05231 | 0.0381112991793 | 0.285714285714 | PLPP3 PLPP2 | Choline metabolism in cancer |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PLPPR3 | PLPPR1 | 0.401 | 0.561 | bioplex (PLPPR1) bioplex_WMM |
| PLPPR1 | PLPP3 | 0.29 | 0.492 | bioplex (PLPPR1) bioplex_WMM |
| PLPP3 | PLPP2 | 0.246 | 0.47 | bioplex (PLPP2) bioplex_WMM |
| ZACN | EDEM1 | 0.047 | 0.294 | bioplex (ZACN) bioplex_WMM |
| PLPPR3 | ZACN | 0.036 | 0.265 | bioplex (ZACN) bioplex_WMM |
| STXBP3 | PLPPR1 | 0.027 | 0.227 | bioplex (PLPPR1) bioplex_WMM |
| PLPPR3 | PLPP3 | 0.008 | 0.079 | bioplex_WMM WMM_only |
| PLPPR3 | EDEM1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| STXBP3 | PLPP3 | 0.007 | 0.007 | bioplex_WMM gupta_WMM WMM_only |
| STXBP3 | PLPPR3 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_01946 has an average edge precision of 0.244 which is ranked 5474 out of all 6965 complexes.
Related Complexes