hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_01954
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| COG1 | Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1) | UniProt NCBI |
| COG5 | Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1) | UniProt NCBI |
| COG2 | Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein) | UniProt NCBI |
| COG7 | Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7) | UniProt NCBI |
| COG3 | Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94) | UniProt NCBI |
| COG6 | Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6) | UniProt NCBI |
| COG8 | Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8) | UniProt NCBI |
| COG4 | Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3522 | 7.72311614252e-28 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | COG complex |
| CORUM:162 | 7.72311614252e-28 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | COG complex |
| CORUM:3556 | 7.72311614252e-28 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | COG complex |
| GO:0017119 | 4.12877788979e-22 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Golgi transport complex |
| REAC:R-HSA-6811438 | 5.2421674311e-19 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Intra-Golgi traffic |
| REAC:R-HSA-6811440 | 9.30098970296e-19 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Retrograde transport at the Trans-Golgi-Network |
| CORUM:3552 | 4.24766632997e-16 | 0.625 | COG8 COG7 COG6 COG1 COG5 | COG1-COG8-COG5-COG6-COG7 subcomplex |
| CORUM:3551 | 4.24766632997e-16 | 0.625 | COG3 COG2 COG1 COG4 COG8 | COG1-COG8-COG2-COG3-COG4 subcomplex |
| REAC:R-HSA-6807878 | 4.27460307188e-16 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | COPI-mediated anterograde transport |
| GO:0099023 | 1.18482919787e-15 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | vesicle tethering complex |
| REAC:R-HSA-199977 | 1.11274375542e-14 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | ER to Golgi Anterograde Transport |
| GO:0032588 | 2.97284270535e-14 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | trans-Golgi network membrane |
| REAC:R-HSA-948021 | 4.12570001246e-14 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-6811442 | 1.4409563805e-13 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| HP:0012345 | 1.34287448791e-12 | 0.75 | COG2 COG4 COG5 COG8 COG6 COG1 | Abnormal glycosylation |
| CORUM:3525 | 1.58119379133e-12 | 0.5 | COG8 COG7 COG6 COG5 | Tetrameric COG subcomplex |
| REAC:R-HSA-446203 | 2.89173694772e-12 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Asparagine N-linked glycosylation |
| GO:0006888 | 2.22806739407e-11 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0005802 | 3.89848188668e-11 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | trans-Golgi network |
| GO:0006891 | 5.47331906216e-11 | 0.75 | COG2 COG3 COG5 COG8 COG6 COG1 | intra-Golgi vesicle-mediated transport |
| GO:0098791 | 1.59141755874e-10 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Golgi subcompartment |
| GO:0031984 | 3.10537232584e-10 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | organelle subcompartment |
| HP:0003160 | 3.19625248114e-10 | 0.625 | COG6 COG5 COG1 COG4 COG8 | Abnormal isoelectric focusing of serum transferrin |
| HP:0012346 | 4.85501080138e-10 | 0.625 | COG6 COG5 COG1 COG4 COG8 | Abnormal protein glycosylation |
| HP:0012347 | 4.85501080138e-10 | 0.625 | COG6 COG5 COG1 COG4 COG8 | Abnormal protein N-linked glycosylation |
| HP:0032245 | 8.02781083348e-10 | 0.75 | COG2 COG4 COG5 COG8 COG6 COG1 | Abnormal metabolism |
| REAC:R-HSA-199991 | 9.0747621596e-10 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 1.39704957882e-09 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Vesicle-mediated transport |
| GO:0048193 | 2.73716638126e-09 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Golgi vesicle transport |
| CORUM:3545 | 4.70911134935e-09 | 0.375 | COG7 COG6 COG5 | COG5-COG6-COG7 subcomplex |
| CORUM:3544 | 4.70911134935e-09 | 0.375 | COG2 COG3 COG4 | COG2-COG3-COG4 subcomplex |
| CORUM:3529 | 4.70911134935e-09 | 0.375 | COG7 COG6 COG5 | COG5-COG6-COG7 subcomplex |
| GO:0000139 | 1.51205364498e-08 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Golgi membrane |
| HP:0012301 | 2.67608394228e-07 | 0.375 | COG8 COG6 COG4 | Type II transferrin isoform profile |
| GO:0044431 | 3.3155360142e-07 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Golgi apparatus part |
| REAC:R-HSA-597592 | 4.52871134533e-07 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Post-translational protein modification |
| REAC:R-HSA-392499 | 8.28368992499e-06 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Metabolism of proteins |
| HP:0002910 | 1.14485241658e-05 | 0.625 | COG8 COG2 COG6 COG4 COG7 | Elevated hepatic transaminase |
| CORUM:3530 | 1.16880143691e-05 | 0.25 | COG7 COG5 | Binary COG subcomplex |
| CORUM:3532 | 1.16880143691e-05 | 0.25 | COG8 COG1 | COG1-COG8 subcomplex |
| GO:0005794 | 3.21102464069e-05 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | Golgi apparatus |
| GO:0007030 | 7.87510090062e-05 | 0.625 | COG3 COG2 COG1 COG4 COG7 | Golgi organization |
| HP:0007367 | 8.22458895817e-05 | 0.75 | COG2 COG7 COG5 COG4 COG6 COG1 | Atrophy/Degeneration affecting the central nervous system |
| GO:0098588 | 0.000211856125423 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | bounding membrane of organelle |
| GO:0046907 | 0.000346824278428 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | intracellular transport |
| CORUM:0000000 | 0.000356401437906 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | CORUM root |
| HP:0003808 | 0.000533742642632 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Abnormal muscle tone |
| GO:0016192 | 0.00066641542434 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | vesicle-mediated transport |
| HP:0000252 | 0.00079958068487 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Microcephaly |
| HP:0040195 | 0.000820779377682 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Decreased head circumference |
| HP:0002059 | 0.00120621572236 | 0.625 | COG6 COG2 COG1 COG4 COG7 | Cerebral atrophy |
| HP:0007369 | 0.00126899722283 | 0.625 | COG6 COG2 COG1 COG4 COG7 | Atrophy/Degeneration affecting the cerebrum |
| HP:0001939 | 0.00157509357623 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Abnormality of metabolism/homeostasis |
| HP:0011804 | 0.0018093622786 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Abnormal muscle physiology |
| GO:0051649 | 0.00181553402649 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | establishment of localization in cell |
| HP:0012443 | 0.00193721416068 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Abnormality of brain morphology |
| HP:0012444 | 0.00199527165215 | 0.625 | COG6 COG2 COG1 COG4 COG7 | Brain atrophy |
| HP:0007364 | 0.00230169233087 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Aplasia/Hypoplasia of the cerebrum |
| HP:0000240 | 0.00295800074077 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Abnormality of skull size |
| HP:0001531 | 0.00301395088993 | 0.375 | COG8 COG1 COG4 | Failure to thrive in infancy |
| HP:0012759 | 0.0035386953444 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Neurodevelopmental abnormality |
| HP:0002011 | 0.00360020661695 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Morphological abnormality of the central nervous system |
| HP:0001272 | 0.00413934167929 | 0.5 | COG8 COG7 COG1 COG5 | Cerebellar atrophy |
| HP:0003011 | 0.00439765632744 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Abnormality of the musculature |
| HP:0410042 | 0.00510876434535 | 0.625 | COG8 COG2 COG6 COG4 COG7 | Abnormal liver morphology |
| HP:0002977 | 0.00599505683605 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Aplasia/Hypoplasia involving the central nervous system |
| HP:0001252 | 0.00602276773411 | 0.75 | COG4 COG7 COG5 COG8 COG6 COG1 | Muscular hypotonia |
| HP:0000277 | 0.0063748778182 | 0.625 | COG6 COG7 COG1 COG4 COG8 | Abnormality of the mandible |
| HP:0012639 | 0.0063897617932 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Abnormality of nervous system morphology |
| HP:0000007 | 0.00704237215587 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Autosomal recessive inheritance |
| HP:0001263 | 0.00728580236648 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Global developmental delay |
| HP:0002715 | 0.00778657006761 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Abnormality of the immune system |
| HP:0030791 | 0.00815229971493 | 0.625 | COG6 COG7 COG1 COG4 COG8 | Abnormal jaw morphology |
| HP:0001508 | 0.00832114594098 | 0.625 | COG6 COG7 COG1 COG4 COG8 | Failure to thrive |
| HP:0002060 | 0.010513709487 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Abnormality of the cerebrum |
| HP:0100547 | 0.0112825532122 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Abnormality of forebrain morphology |
| HP:0001392 | 0.0140303519042 | 0.625 | COG8 COG2 COG6 COG4 COG7 | Abnormality of the liver |
| GO:0010256 | 0.0143675921258 | 0.625 | COG3 COG2 COG1 COG4 COG7 | endomembrane system organization |
| GO:0031090 | 0.0160038940184 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | organelle membrane |
| GO:0051641 | 0.0161157357033 | 1.0 | COG2 COG3 COG4 COG7 COG5 COG8 COG6 COG1 | cellular localization |
| HP:0032180 | 0.0179063560995 | 0.625 | COG8 COG2 COG6 COG4 COG7 | Abnormal circulating metabolite concentration |
| HP:0011821 | 0.0189685496946 | 0.625 | COG6 COG7 COG1 COG4 COG8 | Abnormality of facial skeleton |
| HP:0001511 | 0.0192222805697 | 0.5 | COG7 COG1 COG4 COG6 | Intrauterine growth retardation |
| HP:0025408 | 0.0192222805697 | 0.5 | COG2 COG6 COG4 COG7 | Abnormal spleen morphology |
| HP:0005484 | 0.0201288940439 | 0.375 | COG2 COG1 COG7 | Postnatal microcephaly |
| HP:0012758 | 0.0214525833514 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Neurodevelopmental delay |
| HP:0001743 | 0.022970476799 | 0.5 | COG2 COG6 COG4 COG7 | Abnormality of the spleen |
| HP:0012638 | 0.0237360835757 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Abnormality of nervous system physiology |
| HP:0000929 | 0.0254359106874 | 0.75 | COG2 COG7 COG4 COG8 COG6 COG1 | Abnormal skull morphology |
| HP:0002012 | 0.0310935229292 | 0.625 | COG8 COG2 COG6 COG4 COG7 | Abnormality of the abdominal organs |
| HP:0000707 | 0.0371785348004 | 0.875 | COG2 COG4 COG7 COG5 COG8 COG6 COG1 | Abnormality of the nervous system |
| HP:0004325 | 0.0407442770475 | 0.625 | COG6 COG7 COG1 COG4 COG8 | Decreased body weight |
| HP:0001410 | 0.0472215933278 | 0.375 | COG2 COG4 COG7 | Decreased liver function |
| HP:0025155 | 0.0498228947447 | 0.375 | COG2 COG4 COG7 | Abnormality of hepatobiliary system physiology |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| COG5 | COG3 | 1.0 | 0.949 | bioplex (COG3,COG5) bioplex_WMM fraction |
| COG8 | COG3 | 1.0 | 0.949 | bioplex (COG3) bioplex_WMM fraction |
| COG1 | COG3 | 1.0 | 0.949 | bioplex (COG3) bioplex_WMM fraction |
| COG2 | COG3 | 0.999 | 0.949 | bioplex (COG3) bioplex_WMM gupta_WMM fraction |
| COG5 | COG8 | 0.999 | 0.949 | bioplex (COG5) bioplex_WMM fraction |
| COG1 | COG5 | 0.999 | 0.949 | bioplex (COG5) bioplex_WMM Malo fraction |
| COG7 | COG5 | 0.999 | 0.948 | bioplex (COG5) bioplex_WMM Malo gupta_WMM fraction |
| COG7 | COG3 | 0.998 | 0.943 | bioplex (COG3) bioplex_WMM fraction |
| COG5 | COG4 | 0.998 | 0.937 | bioplex (COG5) bioplex_WMM Malo fraction |
| COG3 | COG4 | 0.997 | 0.934 | bioplex (COG3) bioplex_WMM fraction |
| COG5 | COG6 | 0.997 | 0.934 | bioplex (COG5,COG6) bioplex_WMM Malo fraction |
| COG7 | COG6 | 0.996 | 0.926 | bioplex (COG6) bioplex_WMM Malo fraction |
| COG6 | COG4 | 0.965 | 0.875 | bioplex (COG6) bioplex_WMM Malo fraction |
| COG7 | COG4 | 0.949 | 0.856 | bioplex_WMM Malo fraction |
| COG2 | COG5 | 0.942 | 0.855 | bioplex (COG5) bioplex_WMM fraction |
| COG1 | COG4 | 0.94 | 0.853 | bioplex_WMM Malo fraction |
| COG1 | COG6 | 0.938 | 0.85 | bioplex (COG6) bioplex_WMM Malo fraction |
| COG3 | COG6 | 0.935 | 0.85 | bioplex (COG3,COG6) bioplex_WMM fraction |
| COG2 | COG6 | 0.617 | 0.674 | bioplex (COG6) bioplex_WMM fraction |
| COG8 | COG4 | 0.611 | 0.674 | bioplex_WMM fraction |
| COG2 | COG4 | 0.594 | 0.666 | bioplex_WMM fraction |
| COG8 | COG6 | 0.526 | 0.634 | bioplex (COG6) bioplex_WMM fraction |
| COG2 | COG8 | 0.476 | 0.609 | bioplex_WMM fraction |
| COG1 | COG7 | 0.402 | 0.561 | bioplex_WMM youn_WMM Malo fraction |
| COG2 | COG7 | 0.344 | 0.534 | bioplex_WMM fraction |
| COG1 | COG2 | 0.338 | 0.527 | bioplex_WMM fraction |
| COG1 | COG8 | 0.267 | 0.483 | bioplex_WMM fraction |
| COG7 | COG8 | 0.033 | 0.251 | bioplex_WMM fraction |
Images
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Complex HuMAP2_01954 has an average edge precision of 0.788 which is ranked 970 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| COG1 | HuMAP2_01954 HuMAP2_05817 |
| COG5 | HuMAP2_01954 HuMAP2_05817 |
| COG2 | HuMAP2_01954 HuMAP2_05817 |
| COG7 | HuMAP2_01954 HuMAP2_05817 |
| COG3 | HuMAP2_01954 HuMAP2_05817 |
| COG6 | HuMAP2_01954 HuMAP2_02575 HuMAP2_03618 HuMAP2_05817 |
| COG8 | HuMAP2_01954 HuMAP2_05817 |
| COG4 | HuMAP2_01954 HuMAP2_05817 |