hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01955
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TNRC6A | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | UniProt NCBI |
| TNRC6B | Trinucleotide repeat-containing gene 6B protein | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 1.57358918852e-08 | 1.0 | TNRC6B TNRC6A AGO3 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 2.51774270163e-08 | 1.0 | TNRC6B TNRC6A AGO3 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-8943723 | 3.77661405245e-08 | 1.0 | TNRC6B TNRC6A AGO3 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-8934593 | 3.05725899484e-07 | 1.0 | TNRC6B TNRC6A AGO3 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9022692 | 1.64282711281e-06 | 1.0 | TNRC6B TNRC6A AGO3 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-2559585 | 2.23000067859e-06 | 1.0 | TNRC6B TNRC6A AGO3 | Oncogene Induced Senescence |
| REAC:R-HSA-8986944 | 1.05322572372e-05 | 1.0 | TNRC6B TNRC6A AGO3 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-4086398 | 1.05322572372e-05 | 1.0 | TNRC6B TNRC6A AGO3 | Ca2+ pathway |
| REAC:R-HSA-5628897 | 3.69388822082e-05 | 1.0 | TNRC6B TNRC6A AGO3 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-5687128 | 4.7655024582e-05 | 1.0 | TNRC6B TNRC6A AGO3 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912408 | 5.46192807335e-05 | 1.0 | TNRC6B TNRC6A AGO3 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-8936459 | 5.64603800841e-05 | 1.0 | TNRC6B TNRC6A AGO3 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| REAC:R-HSA-1912422 | 8.92382428809e-05 | 1.0 | TNRC6B TNRC6A AGO3 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-2559580 | 0.000132738992005 | 1.0 | TNRC6B TNRC6A AGO3 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-211000 | 0.000168445978677 | 1.0 | TNRC6B TNRC6A AGO3 | Gene Silencing by RNA |
| REAC:R-HSA-6807070 | 0.000180286113329 | 1.0 | TNRC6B TNRC6A AGO3 | PTEN Regulation |
| REAC:R-HSA-3858494 | 0.000188480017032 | 1.0 | TNRC6B TNRC6A AGO3 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-9018519 | 0.000205605163372 | 1.0 | TNRC6B TNRC6A AGO3 | Estrogen-dependent gene expression |
| MIRNA:hsa-miR-152-3p | 0.000351525498008 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-152-3p |
| REAC:R-HSA-2559583 | 0.000489986899103 | 1.0 | TNRC6B TNRC6A AGO3 | Cellular Senescence |
| GO:0007223 | 0.000495506150782 | 1.0 | TNRC6B TNRC6A AGO3 | Wnt signaling pathway, calcium modulating pathway |
| REAC:R-HSA-8939211 | 0.000626829811712 | 1.0 | TNRC6B TNRC6A AGO3 | ESR-mediated signaling |
| REAC:R-HSA-8878171 | 0.000776305048729 | 1.0 | TNRC6B TNRC6A AGO3 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-157118 | 0.000787037376592 | 1.0 | TNRC6B TNRC6A AGO3 | Signaling by NOTCH |
| REAC:R-HSA-1257604 | 0.000842184933696 | 1.0 | TNRC6B TNRC6A AGO3 | PIP3 activates AKT signaling |
| MIRNA:hsa-miR-148a-3p | 0.000863587061898 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-148a-3p |
| REAC:R-HSA-5683057 | 0.00097245114269 | 1.0 | TNRC6B TNRC6A AGO3 | MAPK family signaling cascades |
| REAC:R-HSA-9006931 | 0.00107518583524 | 1.0 | TNRC6B TNRC6A AGO3 | Signaling by Nuclear Receptors |
| REAC:R-HSA-9006925 | 0.00134762672661 | 1.0 | TNRC6B TNRC6A AGO3 | Intracellular signaling by second messengers |
| REAC:R-HSA-195721 | 0.00221076692273 | 1.0 | TNRC6B TNRC6A AGO3 | Signaling by WNT |
| REAC:R-HSA-3700989 | 0.00313081125109 | 1.0 | TNRC6B TNRC6A AGO3 | Transcriptional Regulation by TP53 |
| MIRNA:hsa-miR-3666 | 0.0038776143209 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-3666 |
| MIRNA:hsa-miR-4295 | 0.00391351815721 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-4295 |
| MIRNA:hsa-miR-148b-3p | 0.00424667661484 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-148b-3p |
| MIRNA:hsa-miR-301b-3p | 0.00428482041677 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-301b-3p |
| MIRNA:hsa-miR-130a-3p | 0.0050110064284 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-130a-3p |
| REAC:R-HSA-2262752 | 0.00501472976187 | 1.0 | TNRC6B TNRC6A AGO3 | Cellular responses to stress |
| MIRNA:hsa-miR-454-3p | 0.0050535928853 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-454-3p |
| MIRNA:hsa-miR-301a-3p | 0.0050535928853 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-301a-3p |
| GO:0045652 | 0.0051907357126 | 1.0 | TNRC6B TNRC6A AGO3 | regulation of megakaryocyte differentiation |
| GO:0030219 | 0.00588722337212 | 1.0 | TNRC6B TNRC6A AGO3 | megakaryocyte differentiation |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | TNRC6B TNRC6A AGO3 | Cellular responses to external stimuli |
| MIRNA:hsa-miR-130b-3p | 0.0153393286541 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-130b-3p |
| MIRNA:hsa-miR-299-5p | 0.016068864109 | 0.666666666667 | TNRC6B TNRC6A | hsa-miR-299-5p |
| MIRNA:hsa-miR-19a-3p | 0.0166271896044 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-19a-3p |
| MIRNA:hsa-miR-4528 | 0.0257170229754 | 0.666666666667 | AGO3 TNRC6A | hsa-miR-4528 |
| MIRNA:hsa-miR-382-3p | 0.0264402587388 | 0.666666666667 | AGO3 TNRC6A | hsa-miR-382-3p |
| MIRNA:hsa-miR-19b-3p | 0.0329198794828 | 1.0 | TNRC6B TNRC6A AGO3 | hsa-miR-19b-3p |
| GO:0035567 | 0.033252767518 | 1.0 | TNRC6B TNRC6A AGO3 | non-canonical Wnt signaling pathway |
| MIRNA:hsa-miR-1825 | 0.0358983465251 | 0.666666666667 | TNRC6B AGO3 | hsa-miR-1825 |
| GO:0035195 | 0.0397775372938 | 1.0 | TNRC6B TNRC6A AGO3 | gene silencing by miRNA |
| GO:0035194 | 0.0480789908723 | 1.0 | TNRC6B TNRC6A AGO3 | posttranscriptional gene silencing by RNA |
| GO:0016441 | 0.0490669153423 | 1.0 | TNRC6B TNRC6A AGO3 | posttranscriptional gene silencing |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TNRC6A | AGO3 | 0.665 | 0.7 | hein_WMM youn (TNRC6A) bioplex_WMM youn_WMM hein (AGO3) |
| TNRC6B | AGO3 | 0.23 | 0.467 | hein_WMM youn (TNRC6B) bioplex_WMM youn_WMM hein (AGO3) |
| TNRC6A | TNRC6B | 0.01 | 0.1 | hein_WMM youn (TNRC6A,TNRC6B) bioplex_WMM youn_WMM gupta_WMM |
Images
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Complex HuMAP2_01955 has an average edge precision of 0.422 which is ranked 3089 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TNRC6A | HuMAP2_00153 HuMAP2_00478 HuMAP2_01955 HuMAP2_06245 |
| TNRC6B | HuMAP2_00153 HuMAP2_00478 HuMAP2_01955 |
| AGO3 | HuMAP2_00153 HuMAP2_00288 HuMAP2_00478 HuMAP2_01955 HuMAP2_04784 HuMAP2_06154 HuMAP2_06245 |