hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01957
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CYTH2 | Cytohesin-2 (ARF exchange factor) (ARF nucleotide-binding site opener) (Protein ARNO) (PH, SEC7 and coiled-coil domain-containing protein 2) | UniProt NCBI |
| CYTH3 | Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3) | UniProt NCBI |
| CYTH1 | Cytohesin-1 (PH, SEC7 and coiled-coil domain-containing protein 1) (SEC7 homolog B2-1) | UniProt NCBI |
| CCDC120 | Coiled-coil domain-containing protein 120 | UniProt NCBI |
| CYTIP | Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein) | UniProt NCBI |
| IPCEF1 | Interactor protein for cytohesin exchange factors 1 (Phosphoinositide-binding protein PIP3-E) | UniProt NCBI |
| CNKSR1 | Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6811438 | 0.00013963689386 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Intra-Golgi traffic |
| GO:0005086 | 0.000698035893352 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | ARF guanyl-nucleotide exchange factor activity |
| KEGG:04072 | 0.00105792752643 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Phospholipase D signaling pathway |
| KEGG:05130 | 0.00292272717057 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Pathogenic Escherichia coli infection |
| KEGG:04144 | 0.00645172813212 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Endocytosis |
| REAC:R-HSA-6811442 | 0.0128273022096 | 0.428571428571 | CYTH1 CYTH3 CYTH2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| CORUM:1063 | 0.0249993571594 | 0.142857142857 | CYTH3 | GRASP-GRP1 complex |
| CORUM:5926 | 0.0249993571594 | 0.142857142857 | CNKSR1 | CNK1 homodimer complex |
| CORUM:5924 | 0.0499886427319 | 0.142857142857 | CNKSR1 | RAF1-CNK1 complex, RAS stimulated |
| CORUM:5925 | 0.0499886427319 | 0.142857142857 | CNKSR1 | BRAF-CNK1 complex, not RAS stimulated |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CYTH1 | CYTIP | 1.0 | 0.949 | bioplex (CYTIP) bioplex_WMM |
| CYTH2 | CYTIP | 0.997 | 0.93 | bioplex (CYTIP) bioplex_WMM |
| CYTH3 | CYTIP | 0.778 | 0.752 | bioplex (CYTIP) bioplex_WMM |
| CYTH2 | CNKSR1 | 0.762 | 0.749 | bioplex (CNKSR1) |
| CYTH1 | CNKSR1 | 0.645 | 0.687 | bioplex (CNKSR1) |
| IPCEF1 | CYTH1 | 0.632 | 0.681 | bioplex (IPCEF1) bioplex_WMM |
| IPCEF1 | CYTH2 | 0.601 | 0.671 | bioplex (IPCEF1) bioplex_WMM |
| CYTH3 | CNKSR1 | 0.306 | 0.501 | bioplex (CNKSR1) |
| IPCEF1 | CYTH3 | 0.192 | 0.446 | bioplex (IPCEF1) bioplex_WMM |
| CCDC120 | CYTH2 | 0.066 | 0.348 | bioplex (CCDC120) bioplex_WMM |
| CCDC120 | CYTH1 | 0.052 | 0.3 | bioplex (CCDC120) bioplex_WMM |
| CYTH1 | CYTH2 | 0.019 | 0.181 | bioplex_WMM WMM_only |
| CYTH2 | CYTH3 | 0.017 | 0.174 | bioplex_WMM WMM_only |
| CYTH1 | CYTH3 | 0.016 | 0.161 | bioplex_WMM WMM_only |
| CCDC120 | CYTH3 | 0.013 | 0.144 | bioplex (CCDC120) bioplex_WMM |
Images
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Complex HuMAP2_01957 has an average edge precision of 0.512 which is ranked 2442 out of all 6965 complexes.
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