hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01963
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MGA | MAX gene-associated protein (MAX dimerization protein 5) | UniProt NCBI |
| PCGF6 | Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134) | UniProt NCBI |
| TFDP1 | Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) | UniProt NCBI |
| E2F6 | Transcription factor E2F6 (E2F-6) | UniProt NCBI |
| L3MBTL2 | Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1194 | 9.65477219389e-15 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | E2F-6 complex |
| REAC:R-HSA-8953750 | 6.82470986793e-12 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | Transcriptional Regulation by E2F6 |
| GO:0070317 | 3.57083680546e-09 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | negative regulation of G0 to G1 transition |
| GO:0070316 | 4.11187268507e-09 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | regulation of G0 to G1 transition |
| GO:0045023 | 5.39035410816e-09 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | G0 to G1 transition |
| GO:0010948 | 0.000126115844807 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | negative regulation of cell cycle process |
| REAC:R-HSA-212436 | 0.000239251603487 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.000412889072144 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.000713316403356 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | Gene expression (Transcription) |
| GO:0045786 | 0.00194806448895 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | negative regulation of cell cycle |
| REAC:R-HSA-69205 | 0.00508433997358 | 0.4 | TFDP1 E2F6 | G1/S-Specific Transcription |
| GO:0010564 | 0.00544233743161 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | regulation of cell cycle process |
| GO:0051726 | 0.0398642747089 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | regulation of cell cycle |
| CORUM:0000000 | 0.0474603483533 | 1.0 | PCGF6 TFDP1 MGA E2F6 L3MBTL2 | CORUM root |
| CORUM:6588 | 0.0499494897235 | 0.2 | TFDP1 | E2F-1-DP-1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| L3MBTL2 | E2F6 | 0.997 | 0.934 | hein_WMM bioplex (E2F6,L3MBTL2) bioplex_WMM youn_WMM hein (L3MBTL2) |
| L3MBTL2 | MGA | 0.996 | 0.928 | hein_WMM bioplex (L3MBTL2) bioplex_WMM youn_WMM hein (L3MBTL2) |
| PCGF6 | MGA | 0.988 | 0.902 | hein_WMM bioplex (PCGF6) bioplex_WMM youn_WMM |
| PCGF6 | L3MBTL2 | 0.978 | 0.893 | hein_WMM bioplex (L3MBTL2,PCGF6) bioplex_WMM youn_WMM hein (L3MBTL2) |
| E2F6 | MGA | 0.912 | 0.835 | hein_WMM bioplex (E2F6) bioplex_WMM youn_WMM |
| L3MBTL2 | TFDP1 | 0.785 | 0.756 | hein_WMM bioplex (L3MBTL2) bioplex_WMM youn_WMM hein (L3MBTL2) |
| PCGF6 | E2F6 | 0.706 | 0.727 | hein_WMM bioplex (E2F6,PCGF6) bioplex_WMM youn_WMM |
| E2F6 | TFDP1 | 0.558 | 0.649 | hein_WMM bioplex (E2F6) bioplex_WMM youn_WMM |
| PCGF6 | TFDP1 | 0.256 | 0.479 | hein_WMM bioplex (PCGF6) bioplex_WMM youn_WMM gupta_WMM |
| TFDP1 | MGA | 0.013 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_01963 has an average edge precision of 0.724 which is ranked 1297 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MGA | HuMAP2_01696 HuMAP2_01963 |
| PCGF6 | HuMAP2_00900 HuMAP2_01696 HuMAP2_01963 HuMAP2_02200 HuMAP2_02290 HuMAP2_02596 HuMAP2_06770 |
| TFDP1 | HuMAP2_01696 HuMAP2_01963 HuMAP2_05987 |
| E2F6 | HuMAP2_01696 HuMAP2_01963 HuMAP2_05987 |
| L3MBTL2 | HuMAP2_01696 HuMAP2_01963 HuMAP2_03231 HuMAP2_05847 |