hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_01967

Confidence: Medium

Genename	Protein Name	Links
CDK7	Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)	UniProt NCBI
MNAT1	CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)	UniProt NCBI
ERCC5	DNA repair protein complementing XP-G cells (EC 3.1.-.-) (DNA excision repair protein ERCC-5) (Xeroderma pigmentosum group G-complementing protein)	UniProt NCBI
ERCC2	General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)	UniProt NCBI
GTF2H5	General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit)	UniProt NCBI
CCNH	Cyclin-H (MO15-associated protein) (p34) (p37)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1009	1.53631870449e-14	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	TFIIH transcription factor complex
CORUM:1029	1.53631870449e-14	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	TFIIH transcription factor complex
KEGG:03420	2.15771692683e-14	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	Nucleotide excision repair
REAC:R-HSA-5696395	6.59856204746e-14	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	Formation of Incision Complex in GG-NER
CORUM:2660	4.54011687692e-13	0.666666666667	CCNH ERCC2 CDK7 MNAT1	CAK-ERCC2 complex
CORUM:1030	4.54011687692e-13	0.666666666667	CCNH ERCC2 CDK7 MNAT1	CAK-ERCC2 complex
REAC:R-HSA-6782135	8.94017792524e-13	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	Dual incision in TC-NER
GO:0006294	1.56813604737e-12	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	nucleotide-excision repair, preincision complex assembly
REAC:R-HSA-6781827	2.78006064935e-12	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
REAC:R-HSA-5696399	4.39959637066e-12	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	Global Genome Nucleotide Excision Repair (GG-NER)
REAC:R-HSA-167160	1.29938364124e-11	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
REAC:R-HSA-77075	1.29938364124e-11	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Pol II CTD phosphorylation and interaction with CE
REAC:R-HSA-72086	1.91119794167e-11	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	mRNA Capping
REAC:R-HSA-5696398	2.3182559747e-11	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	Nucleotide Excision Repair
REAC:R-HSA-73863	2.73417670054e-11	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase I Transcription Termination
REAC:R-HSA-113418	3.81873931614e-11	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Formation of the Early Elongation Complex
REAC:R-HSA-167158	3.81873931614e-11	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Formation of the HIV-1 Early Elongation Complex
KEGG:03022	3.86343321341e-11	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Basal transcription factors
GO:0005675	3.89127899416e-11	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	transcription factor TFIIH holo complex
CORUM:107	5.71747411144e-11	0.666666666667	CCNH ERCC2 CDK7 MNAT1	TFIIH transcription factor complex
CORUM:1036	5.71747411144e-11	0.666666666667	CCNH ERCC2 CDK7 MNAT1	TFIIH transcription factor complex
REAC:R-HSA-167246	1.7463107816e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167200	1.7463107816e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167169	1.7463107816e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	HIV Transcription Elongation
REAC:R-HSA-167152	2.20393767491e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Formation of HIV elongation complex in the absence of HIV Tat
REAC:R-HSA-167161	2.46617285137e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	HIV Transcription Initiation
REAC:R-HSA-73762	2.46617285137e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase I Transcription Initiation
REAC:R-HSA-167162	2.46617285137e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase II HIV Promoter Escape
REAC:R-HSA-73776	2.46617285137e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase II Promoter Escape
REAC:R-HSA-75953	2.46617285137e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase II Transcription Initiation
REAC:R-HSA-73779	2.46617285137e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REAC:R-HSA-76042	2.46617285137e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase II Transcription Initiation And Promoter Clearance
REAC:R-HSA-6781823	4.61215016079e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Formation of TC-NER Pre-Incision Complex
GO:0006283	5.61964776518e-10	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	transcription-coupled nucleotide-excision repair
GO:0032806	5.7108658647e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	carboxy-terminal domain protein kinase complex
REAC:R-HSA-75955	8.04354101299e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	8.04354101299e-10	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Formation of RNA Pol II elongation complex
REAC:R-HSA-6796648	1.03949243731e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	TP53 Regulates Transcription of DNA Repair Genes
REAC:R-HSA-6782210	1.22465308044e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-167172	2.09044250377e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Transcription of the HIV genome
CORUM:1010	2.25356268047e-09	0.5	CCNH CDK7 MNAT1	CAK complex (Cdk-activating kinase complex)
CORUM:1008	2.25356268047e-09	0.5	CCNH CDK7 MNAT1	CAK complex (Cdk-activating kinase complex)
REAC:R-HSA-674695	4.37815496425e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase II Pre-transcription Events
GO:0006289	5.3127668221e-09	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	nucleotide-excision repair
GO:0006362	5.82915372209e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	transcription elongation from RNA polymerase I promoter
REAC:R-HSA-73772	7.04884766188e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase I Promoter Escape
GO:0006363	8.33923893666e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	termination of RNA polymerase I transcription
GO:0006361	9.88298845806e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	transcription initiation from RNA polymerase I promoter
GO:0006370	9.88298845806e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	7-methylguanosine mRNA capping
GO:0009452	9.88298845806e-09	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	7-methylguanosine RNA capping
GO:0036260	1.16471549142e-08	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA capping
REAC:R-HSA-427413	1.54739123893e-08	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	NoRC negatively regulates rRNA expression
REAC:R-HSA-73894	1.56912906071e-08	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	DNA Repair
REAC:R-HSA-5250941	1.78599987084e-08	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Negative epigenetic regulation of rRNA expression
REAC:R-HSA-73854	1.87175987397e-08	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	1.9607809034e-08	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase I Transcription
WP:WP405	3.05048674057e-08	0.666666666667	CCNH ERCC2 CDK7 MNAT1	Eukaryotic Transcription Initiation
CORUM:2657	4.50508252789e-08	0.5	CCNH CDK7 MNAT1	ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex
REAC:R-HSA-162599	5.14237423466e-08	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	8.24751451013e-08	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	HIV Life Cycle
REAC:R-HSA-212165	8.24751451013e-08	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Epigenetic regulation of gene expression
GO:0065004	1.92887063772e-07	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	protein-DNA complex assembly
GO:0006360	2.45328000896e-07	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	transcription by RNA polymerase I
GO:0016591	6.85127440347e-07	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA polymerase II, holoenzyme
REAC:R-HSA-162906	6.99264691977e-07	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	HIV Infection
GO:0006353	7.3546313708e-07	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	DNA-templated transcription, termination
GO:0071824	7.43003663183e-07	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	protein-DNA complex subunit organization
GO:1902554	7.88713252093e-07	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	serine/threonine protein kinase complex
GO:0006368	1.10316613839e-06	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	transcription elongation from RNA polymerase II promoter
GO:0008353	1.11807235637e-06	0.666666666667	CCNH ERCC2 CDK7 MNAT1	RNA polymerase II CTD heptapeptide repeat kinase activity
HP:0007587	1.12933306268e-06	0.5	ERCC2 ERCC5 GTF2H5	Numerous pigmented freckles
GO:0019907	1.81637152046e-06	0.5	CCNH CDK7 MNAT1	cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:1902911	1.91660450295e-06	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	protein kinase complex
GO:0055029	2.98904170003e-06	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	nuclear DNA-directed RNA polymerase complex
GO:0000428	3.15131232749e-06	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	DNA-directed RNA polymerase complex
GO:0030880	3.68082360643e-06	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA polymerase complex
HP:0003079	4.43398396567e-06	0.5	ERCC2 ERCC5 GTF2H5	Defective DNA repair after ultraviolet radiation damage
GO:0006354	4.71954327875e-06	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	DNA-templated transcription, elongation
REAC:R-HSA-3700989	6.53130785078e-06	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Transcriptional Regulation by TP53
GO:0150005	7.26438828159e-06	0.5	CCNH CDK7 MNAT1	enzyme activator complex
REAC:R-HSA-5663205	7.5270145098e-06	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Infectious disease
CORUM:1007	8.39001385941e-06	0.333333333333	CCNH CDK7	CAK core complex (Cdk-activating kinase core complex)
HP:0003254	9.16612699891e-06	0.5	ERCC2 ERCC5 GTF2H5	Abnormality of DNA repair
REAC:R-HSA-69273	1.36517474966e-05	0.5	CCNH CDK7 MNAT1	Cyclin A/B1/B2 associated events during G2/M transition
GO:0090575	2.51549192559e-05	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA polymerase II transcription factor complex
GO:0006281	3.93579335792e-05	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	DNA repair
GO:0006367	5.42995521166e-05	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	transcription initiation from RNA polymerase II promoter
WP:WP45	5.90727924684e-05	0.5	CCNH CDK7 MNAT1	G1 to S cell cycle control
GO:0044798	6.28582159941e-05	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	nuclear transcription factor complex
REAC:R-HSA-5696400	6.31198919075e-05	0.5	ERCC2 ERCC5 GTF2H5	Dual Incision in GG-NER
REAC:R-HSA-69236	6.79649802247e-05	0.5	CCNH CDK7 MNAT1	G1 Phase
REAC:R-HSA-69231	6.79649802247e-05	0.5	CCNH CDK7 MNAT1	Cyclin D associated events in G1
REAC:R-HSA-8953854	0.000150175559311	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Metabolism of RNA
GO:0006352	0.000153875667585	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	DNA-templated transcription, initiation
GO:0061695	0.000213275731053	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	transferase complex, transferring phosphorus-containing groups
GO:0019908	0.00039905855691	0.5	CCNH CDK7 MNAT1	nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0005667	0.00040236464741	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	transcription factor complex
HP:0000656	0.000417247653264	0.5	ERCC2 ERCC5 GTF2H5	Ectropion
REAC:R-HSA-69202	0.000521133699904	0.5	CCNH CDK7 MNAT1	Cyclin E associated events during G1/S transition
HP:0002860	0.000525323572597	0.5	ERCC2 ERCC5 GTF2H5	Squamous cell carcinoma
REAC:R-HSA-69656	0.000560531240275	0.5	CCNH CDK7 MNAT1	Cyclin A:Cdk2-associated events at S phase entry
GO:0006259	0.000579923761468	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	DNA metabolic process
GO:0006974	0.000584852292019	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	cellular response to DNA damage stimulus
HP:0000491	0.000684694628873	0.5	ERCC2 ERCC5 GTF2H5	Keratitis
REAC:R-HSA-1643685	0.000968789017735	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Disease
GO:0008094	0.00101282970404	0.666666666667	CCNH ERCC2 CDK7 MNAT1	DNA-dependent ATPase activity
HP:0004337	0.00112625143517	0.333333333333	ERCC2 ERCC5	Abnormality of amino acid metabolism
HP:0410219	0.00112625143517	0.333333333333	ERCC2 GTF2H5	Hypoplasia of mandible relative to maxilla
HP:0007381	0.00112625143517	0.333333333333	ERCC2 GTF2H5	Congenital exfoliative erythroderma
HP:0012760	0.00112625143517	0.333333333333	ERCC2 GTF2H5	Impaired social reciprocity
HP:0045055	0.00112625143517	0.333333333333	ERCC2 GTF2H5	Tiger tail banding
HP:0000992	0.00134801387668	0.5	ERCC2 ERCC5 GTF2H5	Cutaneous photosensitivity
REAC:R-HSA-212436	0.00148146469319	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Generic Transcription Pathway
HP:0002562	0.0015764696333	0.333333333333	ERCC2 GTF2H5	Low-set nipples
GO:0034622	0.00167500343618	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	cellular protein-containing complex assembly
HP:0011495	0.00189957809204	0.5	ERCC2 ERCC5 GTF2H5	Abnormal corneal epithelium morphology
REAC:R-HSA-8939236	0.00190266482243	0.5	CCNH CDK7 MNAT1	RUNX1 regulates transcription of genes involved in differentiation of HSCs
REAC:R-HSA-69206	0.00208996561591	0.5	CCNH CDK7 MNAT1	G1/S Transition
HP:0010649	0.00210158306671	0.333333333333	ERCC2 ERCC5	Flat nasal alae
HP:0001809	0.00210158306671	0.333333333333	ERCC2 GTF2H5	Split nail
GO:0006295	0.00240920978697	0.5	ERCC2 ERCC5 GTF2H5	nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006293	0.00240920978697	0.5	ERCC2 ERCC5 GTF2H5	nucleotide-excision repair, preincision complex stabilization
REAC:R-HSA-73857	0.00253857262834	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	RNA Polymerase II Transcription
HP:0006538	0.00270155144475	0.333333333333	ERCC2 GTF2H5	Recurrent bronchopulmonary infections
HP:0007034	0.00270155144475	0.333333333333	ERCC2 GTF2H5	Generalized hyperreflexia
HP:0025428	0.00270155144475	0.333333333333	ERCC2 GTF2H5	Bronchospasm
REAC:R-HSA-453279	0.00302212243809	0.5	CCNH CDK7 MNAT1	Mitotic G1-G1/S phases
HP:0007495	0.0032158301853	0.5	ERCC2 ERCC5 GTF2H5	Prematurely aged appearance
HP:0025427	0.00337633448894	0.333333333333	ERCC2 GTF2H5	Abnormal bronchus physiology
REAC:R-HSA-69242	0.00382327070463	0.5	CCNH CDK7 MNAT1	S Phase
GO:0006397	0.00390084589509	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	mRNA processing
HP:0001598	0.00412589193299	0.333333333333	ERCC2 GTF2H5	Concave nail
HP:0007485	0.00412589193299	0.333333333333	ERCC2 GTF2H5	Absence of subcutaneous fat
REAC:R-HSA-74160	0.00435080618405	0.833333333333	CCNH ERCC2 GTF2H5 CDK7 MNAT1	Gene expression (Transcription)
HP:0000502	0.00452454045934	0.5	ERCC2 ERCC5 GTF2H5	Abnormal conjunctiva morphology
HP:0100275	0.00495018352279	0.333333333333	ERCC2 GTF2H5	Diffuse cerebellar atrophy
HP:0009755	0.00495018352279	0.333333333333	ERCC2 ERCC5	Ankyloblepharon
HP:0000320	0.00495018352279	0.333333333333	ERCC2 GTF2H5	Bird-like facies
HP:0007266	0.00495018352279	0.333333333333	ERCC2 GTF2H5	Cerebral dysmyelination
HP:0000958	0.00542992690819	0.5	ERCC2 ERCC5 GTF2H5	Dry skin
HP:0007479	0.00584916901642	0.333333333333	ERCC2 GTF2H5	Congenital nonbullous ichthyosiform erythroderma
HP:0025548	0.00584916901642	0.333333333333	ERCC2 GTF2H5	Increased mean corpuscular hemoglobin concentration
REAC:R-HSA-69275	0.00651335516082	0.5	CCNH CDK7 MNAT1	G2/M Transition
REAC:R-HSA-453274	0.00672028001895	0.5	CCNH CDK7 MNAT1	Mitotic G2-G2/M phases
GO:0070985	0.00676235117068	0.333333333333	CCNH CDK7	transcription factor TFIIK complex
HP:0001029	0.00682280818411	0.333333333333	ERCC2 ERCC5	Poikiloderma
HP:0025546	0.00899388668352	0.333333333333	ERCC2 GTF2H5	Abnormal mean corpuscular hemoglobin concentration
HP:0007633	0.00899388668352	0.333333333333	ERCC2 GTF2H5	Bilateral microphthalmos
REAC:R-HSA-8878171	0.00995111812887	0.5	CCNH CDK7 MNAT1	Transcriptional regulation by RUNX1
HP:0003139	0.0101912456166	0.333333333333	ERCC2 GTF2H5	Panhypogammaglobulinemia
HP:0100533	0.0113217289996	0.5	ERCC2 ERCC5 GTF2H5	Inflammatory abnormality of the eye
HP:0008069	0.0113217289996	0.5	ERCC2 ERCC5 GTF2H5	Neoplasm of the skin
HP:0006970	0.0114630974264	0.333333333333	ERCC2 GTF2H5	Periventricular leukomalacia
HP:0001596	0.0115464072696	0.5	ERCC2 ERCC5 GTF2H5	Alopecia
GO:0000307	0.0118307664632	0.5	CCNH CDK7 MNAT1	cyclin-dependent protein kinase holoenzyme complex
HP:0000621	0.0128094019441	0.333333333333	ERCC2 ERCC5	Entropion
HP:0000524	0.0128094019441	0.333333333333	ERCC2 ERCC5	Conjunctival telangiectasia
GO:0006296	0.0140408309691	0.5	ERCC2 ERCC5 GTF2H5	nucleotide-excision repair, DNA incision, 5'-to lesion
HP:0001807	0.0157252084881	0.333333333333	ERCC2 GTF2H5	Ridged nail
HP:0006739	0.0157252084881	0.333333333333	ERCC2 ERCC5	Squamous cell carcinoma of the skin
GO:0033683	0.0165096938447	0.5	ERCC2 ERCC5 GTF2H5	nucleotide-excision repair, DNA incision
HP:0001808	0.0172946302375	0.333333333333	ERCC2 GTF2H5	Fragile nails
HP:0008054	0.0172946302375	0.333333333333	ERCC2 ERCC5	Abnormal morphology of the conjunctival vasculature
HP:0000613	0.0187800119955	0.5	ERCC2 ERCC5 GTF2H5	Photophobia
HP:0007431	0.0206563100896	0.333333333333	ERCC2 GTF2H5	Congenital ichthyosiform erythroderma
HP:0002293	0.0206563100896	0.333333333333	ERCC2 GTF2H5	Alopecia of scalp
HP:0008391	0.0224484879882	0.333333333333	ERCC2 GTF2H5	Dystrophic fingernails
HP:0008887	0.0224484879882	0.333333333333	ERCC2 GTF2H5	Adipose tissue loss
HP:0004493	0.0243148377528	0.333333333333	ERCC2 ERCC5	Craniofacial hyperostosis
HP:0009473	0.0253441504586	0.5	ERCC2 ERCC5 GTF2H5	Joint contracture of the hand
HP:0000568	0.0253441504586	0.5	ERCC2 ERCC5 GTF2H5	Microphthalmia
HP:0000133	0.0262553193116	0.333333333333	ERCC2 GTF2H5	Gonadal dysgenesis
HP:0002942	0.0262553193116	0.333333333333	ERCC2 GTF2H5	Thoracic kyphosis
HP:0003328	0.0262553193116	0.333333333333	ERCC2 GTF2H5	Abnormal hair laboratory examination
HP:0001059	0.0262553193116	0.333333333333	ERCC2 ERCC5	Pterygium
HP:0001097	0.0282698926051	0.333333333333	ERCC2 GTF2H5	Keratoconjunctivitis sicca
GO:0042623	0.0287203705471	0.666666666667	CCNH ERCC2 CDK7 MNAT1	ATPase activity, coupled
GO:0065003	0.0297226505367	1.0	ERCC2 MNAT1 ERCC5 CDK7 GTF2H5 CCNH	protein-containing complex assembly
HP:0005487	0.030358517586	0.333333333333	ERCC2 ERCC5	Prominent metopic ridge
HP:0100887	0.0341842384581	0.5	ERCC2 ERCC5 GTF2H5	Abnormality of globe size
WP:WP179	0.0365222779269	0.333333333333	CCNH CDK7	Cell Cycle
HP:0100360	0.0370377024816	0.5	ERCC2 ERCC5 GTF2H5	Contractures of the joints of the upper limbs
HP:0100579	0.0370683023611	0.333333333333	ERCC2 ERCC5	Mucosal telangiectasiae
HP:0011329	0.0380225871731	0.5	ERCC2 ERCC5 GTF2H5	Abnormality of cranial sutures
HP:0007108	0.0394527338604	0.333333333333	ERCC2 ERCC5	Demyelinating peripheral neuropathy
GO:0032508	0.0398453744123	0.5	ERCC2 MNAT1 GTF2H5	DNA duplex unwinding
HP:0001838	0.0419110169922	0.333333333333	ERCC2 ERCC5	Rocker bottom foot
HP:0001096	0.0419110169922	0.333333333333	ERCC2 GTF2H5	Keratoconjunctivitis
HP:0001338	0.0419110169922	0.333333333333	ERCC2 GTF2H5	Partial agenesis of the corpus callosum
HP:0002120	0.0421345110279	0.5	ERCC2 ERCC5 GTF2H5	Cerebral cortical atrophy
KEGG:04110	0.0437703225478	0.333333333333	CCNH CDK7	Cell cycle
HP:0001019	0.044443111782	0.333333333333	ERCC2 GTF2H5	Erythroderma
HP:0008365	0.044443111782	0.333333333333	ERCC2 ERCC5	Abnormality of the talus
HP:0002750	0.0465289476346	0.5	ERCC2 ERCC5 GTF2H5	Delayed skeletal maturation
HP:0100012	0.0470489782673	0.333333333333	ERCC2 ERCC5	Neoplasm of the eye
HP:0040063	0.0497285764978	0.333333333333	ERCC2 GTF2H5	Decreased adipose tissue
HP:0005556	0.0497285764978	0.333333333333	ERCC2 ERCC5	Abnormality of the metopic suture
HP:0012740	0.0497285764978	0.333333333333	ERCC2 ERCC5	Papilloma
CORUM:7222	0.0499726005494	0.166666666667	ERCC2	MMS19-XPD complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CCNH	MNAT1	1.0	0.949	hein_WMM bioplex (CCNH,MNAT1) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction
CCNH	CDK7	0.948	0.857	hein_WMM bioplex (CCNH,CDK7) bioplex_WMM youn_WMM Malo fraction
CCNH	ERCC5	0.82	0.773	hein_WMM bioplex (CCNH) bioplex_WMM
MNAT1	CDK7	0.779	0.753	hein_WMM bioplex (CDK7,MNAT1) bioplex_WMM youn_WMM Malo fraction
CCNH	ERCC2	0.219	0.466	hein_WMM bioplex (CCNH) bioplex_WMM
CDK7	ERCC2	0.07	0.348	hein_WMM bioplex (CDK7) bioplex_WMM
CDK7	GTF2H5	0.038	0.264	hein_WMM bioplex_WMM hein (GTF2H5)
ERCC2	GTF2H5	0.029	0.232	hein_WMM bioplex_WMM hein (GTF2H5)
MNAT1	ERCC2	0.027	0.23	hein_WMM bioplex (MNAT1) bioplex_WMM
CCNH	GTF2H5	0.022	0.2	hein_WMM bioplex_WMM hein (GTF2H5)
MNAT1	GTF2H5	0.016	0.156	hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5)
ERCC5	CDK7	0.012	0.148	hein_WMM bioplex_WMM youn_WMM WMM_only
ERCC5	GTF2H5	0.011	0.146	hein_WMM bioplex_WMM hein (GTF2H5)
ERCC5	MNAT1	0.011	0.145	hein_WMM bioplex_WMM youn_WMM WMM_only
ERCC5	ERCC2	0.009	0.11	hein_WMM bioplex_WMM WMM_only

Images

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Complex HuMAP2_01967 has an average edge precision of 0.385 which is ranked 3469 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CDK7	HuMAP2_01125 HuMAP2_01967 HuMAP2_04709 HuMAP2_04784
MNAT1	HuMAP2_01125 HuMAP2_01967 HuMAP2_04709
ERCC5	HuMAP2_01125 HuMAP2_01967 HuMAP2_04709 HuMAP2_06407
ERCC2	HuMAP2_01967 HuMAP2_04709
GTF2H5	HuMAP2_01967 HuMAP2_01999 HuMAP2_04213 HuMAP2_06159
CCNH	HuMAP2_01125 HuMAP2_01967 HuMAP2_04709

hu.MAP 2.0: Complex View

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Complex: HuMAP2_01967