hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01970
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KRT6A | Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5) | UniProt NCBI |
| KRT77 | Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) | UniProt NCBI |
| KRT1 | Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1) | UniProt NCBI |
| DSP | Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) | UniProt NCBI |
| KRT17 | Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) | UniProt NCBI |
| KRT5 | Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6809371 | 1.13931274999e-11 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 5.87030346239e-11 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | Keratinization |
| HP:0010765 | 1.2941283238e-10 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Palmar hyperkeratosis |
| HP:0007556 | 3.13838957909e-10 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Plantar hyperkeratosis |
| GO:0070268 | 2.51632482928e-09 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | cornification |
| HP:0100872 | 6.11568703447e-09 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the plantar skin of foot |
| HP:0008066 | 7.08427737387e-09 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormal blistering of the skin |
| GO:0031424 | 1.47414278611e-08 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | keratinization |
| HP:0008404 | 3.32115744447e-08 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Nail dystrophy |
| HP:0000972 | 9.63105818758e-08 | 0.666666666667 | KRT1 KRT17 DSP KRT5 | Palmoplantar hyperkeratosis |
| GO:0030216 | 9.76534709514e-08 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | keratinocyte differentiation |
| HP:0000982 | 1.67727324635e-07 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Palmoplantar keratoderma |
| GO:0009913 | 2.33249753624e-07 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | epidermal cell differentiation |
| GO:0043588 | 3.76606909308e-07 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | skin development |
| GO:0008544 | 7.62302459629e-07 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | epidermis development |
| HP:0040211 | 1.30202884778e-06 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the skin of the palm |
| HP:0000962 | 1.88101184226e-06 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Hyperkeratosis |
| HP:0100871 | 6.19822959836e-06 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the palm |
| HP:0011356 | 6.92149242855e-06 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Regional abnormality of skin |
| REAC:R-HSA-1266738 | 9.02630421648e-06 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | Developmental Biology |
| HP:0100643 | 1.12796815876e-05 | 0.5 | KRT17 DSP KRT6A | Abnormality of nail color |
| HP:0011368 | 1.4537931865e-05 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Epidermal thickening |
| HP:0001597 | 1.6706451294e-05 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the nail |
| GO:0030855 | 1.8360536653e-05 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | epithelial cell differentiation |
| HP:0002745 | 1.95090261981e-05 | 0.5 | KRT6A KRT17 KRT5 | Oral leukoplakia |
| HP:0025125 | 1.95090261981e-05 | 0.5 | KRT6A KRT17 KRT5 | White lesion of the oral mucosa |
| HP:0001805 | 1.95090261981e-05 | 0.5 | KRT6A KRT17 KRT5 | Onychogryposis |
| HP:0000975 | 2.15468843809e-05 | 0.666666666667 | KRT6A KRT17 KRT1 KRT5 | Hyperhidrosis |
| HP:0001072 | 2.41124975651e-05 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Thickened skin |
| HP:0008064 | 3.7653275253e-05 | 0.666666666667 | KRT1 KRT17 DSP KRT6A | Ichthyosis |
| HP:0007550 | 8.3287186125e-05 | 0.666666666667 | KRT6A KRT17 KRT1 KRT5 | Hypohidrosis or hyperhidrosis |
| HP:0025276 | 9.74218743439e-05 | 0.666666666667 | KRT6A KRT17 KRT1 KRT5 | Abnormality of skin adnexa physiology |
| GO:0060429 | 0.000373822345987 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | epithelium development |
| HP:0011830 | 0.000420118841457 | 0.666666666667 | KRT6A KRT17 DSP KRT5 | Abnormal oral mucosa morphology |
| HP:0007475 | 0.00045066196833 | 0.333333333333 | KRT1 DSP | Congenital bullous ichthyosiform erythroderma |
| HP:0011355 | 0.000467596504172 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Localized skin lesion |
| HP:0001798 | 0.000469218904624 | 0.5 | KRT17 DSP KRT6A | Anonychia |
| GO:0005200 | 0.000926409268263 | 0.666666666667 | KRT6A KRT17 DSP KRT5 | structural constituent of cytoskeleton |
| HP:0011122 | 0.00190430644258 | 0.666666666667 | KRT1 KRT17 DSP KRT5 | Abnormality of skin physiology |
| HP:0200040 | 0.00270155144475 | 0.333333333333 | KRT17 KRT6A | Epidermoid cyst |
| HP:0010783 | 0.0028432701083 | 0.5 | KRT5 DSP KRT1 | Erythema |
| HP:0011138 | 0.00365909991853 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of skin adnexa morphology |
| HP:0001760 | 0.00388883454292 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the foot |
| HP:0200097 | 0.00495018352279 | 0.333333333333 | KRT5 DSP | Oral mucosal blisters |
| HP:0001155 | 0.00536595932357 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the hand |
| HP:0002164 | 0.00556831003761 | 0.5 | KRT17 DSP KRT5 | Nail dysplasia |
| HP:0025245 | 0.00682280818411 | 0.333333333333 | KRT17 KRT6A | Cutaneous cyst |
| HP:0200035 | 0.00682280818411 | 0.333333333333 | KRT17 KRT6A | Skin plaque |
| GO:0009888 | 0.00725557716859 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | tissue development |
| HP:0002817 | 0.00802906529576 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the upper limb |
| HP:0002814 | 0.00928699225478 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the lower limb |
| HP:0001231 | 0.0094284178221 | 0.5 | KRT1 KRT17 KRT6A | Abnormal fingernail morphology |
| GO:0005198 | 0.00994910152236 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | structural molecule activity |
| HP:0008069 | 0.0113217289996 | 0.5 | KRT1 KRT17 KRT5 | Neoplasm of the skin |
| HP:0001596 | 0.0115464072696 | 0.5 | KRT17 DSP KRT6A | Alopecia |
| HP:0008386 | 0.0120045707958 | 0.5 | KRT17 DSP KRT6A | Aplasia/Hypoplasia of the nails |
| HP:0000695 | 0.0157252084881 | 0.333333333333 | KRT17 DSP | Natal tooth |
| GO:0012501 | 0.0169516363243 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | programmed cell death |
| HP:0007431 | 0.0206563100896 | 0.333333333333 | KRT1 DSP | Congenital ichthyosiform erythroderma |
| HP:0011121 | 0.0218588319821 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of skin morphology |
| GO:0008219 | 0.0263661961424 | 1.0 | KRT6A KRT77 KRT5 KRT17 DSP KRT1 | cell death |
| HP:0006288 | 0.030358517586 | 0.333333333333 | KRT17 DSP | Advanced eruption of teeth |
| HP:0000164 | 0.0310897526003 | 0.666666666667 | KRT6A KRT17 DSP KRT5 | Abnormality of the dentition |
| HP:0000951 | 0.0311492674319 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of the skin |
| HP:0040064 | 0.0417522324256 | 0.833333333333 | KRT6A KRT17 KRT1 DSP KRT5 | Abnormality of limbs |
| HP:0011061 | 0.0459638888097 | 0.5 | KRT6A KRT17 KRT5 | Abnormality of dental structure |
| HP:0025092 | 0.0470489782673 | 0.333333333333 | KRT1 DSP | Epidermal acanthosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DSP | KRT1 | 0.645 | 0.687 | youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| DSP | KRT5 | 0.4 | 0.56 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT77 | KRT1 | 0.04 | 0.268 | youn_WMM fraction boldt_WMM |
| KRT17 | KRT5 | 0.037 | 0.263 | youn_WMM gupta_WMM fraction boldt_WMM |
| DSP | KRT17 | 0.034 | 0.256 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT17 | KRT6A | 0.022 | 0.206 | youn_WMM gupta_WMM fraction boldt_WMM |
| DSP | KRT77 | 0.009 | 0.099 | youn_WMM fraction boldt_WMM |
| KRT17 | KRT77 | 0.009 | 0.092 | fraction boldt_WMM |
| DSP | KRT6A | 0.006 | 0.005 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT6A | KRT1 | 0.005 | 0.008 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT6A | KRT5 | 0.005 | 0.017 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT77 | KRT5 | 0.0 | 0.007 | youn_WMM fraction boldt_WMM |
| KRT17 | KRT1 | 0.0 | 0.001 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT1 | KRT5 | 0.0 | 0.001 | youn_WMM gupta_WMM fraction boldt_WMM |
| KRT77 | KRT6A | 0.0 | 0.0 | youn_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_01970 has an average edge precision of 0.165 which is ranked 6581 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KRT6A | HuMAP2_00172 HuMAP2_01048 HuMAP2_01970 |
| KRT77 | HuMAP2_00172 HuMAP2_01970 HuMAP2_04038 |
| KRT1 | HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_04038 |
| DSP | HuMAP2_00172 HuMAP2_00512 HuMAP2_01725 HuMAP2_01970 HuMAP2_03046 HuMAP2_04038 |
| KRT17 | HuMAP2_00172 HuMAP2_01048 HuMAP2_01970 |
| KRT5 | HuMAP2_00172 HuMAP2_00512 HuMAP2_01048 HuMAP2_01970 HuMAP2_04038 |