hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01975
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| E2F1 | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | UniProt NCBI |
| TFDP2 | Transcription factor Dp-2 (E2F dimerization partner 2) | UniProt NCBI |
| E2F4 | Transcription factor E2F4 (E2F-4) | UniProt NCBI |
| E2F2 | Transcription factor E2F2 (E2F-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-69236 | 1.01509114577e-08 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | G1 Phase |
| REAC:R-HSA-69231 | 1.01509114577e-08 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | Cyclin D associated events in G1 |
| WP:WP179 | 1.08495774033e-07 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | Cell Cycle |
| KEGG:04110 | 1.48443738085e-07 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | Cell cycle |
| REAC:R-HSA-1362300 | 7.55763607906e-07 | 0.75 | TFDP2 E2F1 E2F4 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-1362277 | 1.30754323077e-06 | 0.75 | TFDP2 E2F1 E2F4 | Transcription of E2F targets under negative control by DREAM complex |
| REAC:R-HSA-453279 | 1.69335486182e-06 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | Mitotic G1-G1/S phases |
| REAC:R-HSA-1538133 | 3.94532681474e-06 | 0.75 | TFDP2 E2F1 E2F4 | G0 and Early G1 |
| REAC:R-HSA-69205 | 4.41854320762e-06 | 0.75 | TFDP2 E2F1 E2F4 | G1/S-Specific Transcription |
| REAC:R-HSA-2559585 | 6.68850838342e-06 | 0.75 | TFDP2 E2F1 E2F2 | Oncogene Induced Senescence |
| WP:WP45 | 8.93316220103e-06 | 0.75 | TFDP2 E2F1 E2F2 | G1 to S cell cycle control |
| REAC:R-HSA-6791312 | 2.33046531546e-05 | 0.75 | TFDP2 E2F1 E2F4 | TP53 Regulates Transcription of Cell Cycle Genes |
| WP:WP2446 | 2.38151267007e-05 | 0.75 | TFDP2 E2F1 E2F2 | Retinoblastoma Gene in Cancer |
| REAC:R-HSA-111448 | 0.000100528399861 | 0.5 | TFDP2 E2F1 | Activation of NOXA and translocation to mitochondria |
| REAC:R-HSA-69202 | 0.000119121057505 | 0.75 | TFDP2 E2F1 E2F4 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 0.00012815247216 | 0.75 | TFDP2 E2F1 E2F4 | Cyclin A:Cdk2-associated events at S phase entry |
| KEGG:04218 | 0.000132953253798 | 0.75 | E2F1 E2F2 E2F4 | Cellular senescence |
| REAC:R-HSA-69278 | 0.000264779714116 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | Cell Cycle, Mitotic |
| REAC:R-HSA-139915 | 0.000361772624521 | 0.5 | TFDP2 E2F1 | Activation of PUMA and translocation to mitochondria |
| REAC:R-HSA-2559580 | 0.000396320737366 | 0.75 | TFDP2 E2F1 E2F2 | Oxidative Stress Induced Senescence |
| GO:0090575 | 0.000443117561019 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | RNA polymerase II transcription factor complex |
| REAC:R-HSA-69206 | 0.000480050915503 | 0.75 | TFDP2 E2F1 E2F4 | G1/S Transition |
| REAC:R-HSA-1640170 | 0.000545854331888 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | Cell Cycle |
| REAC:R-HSA-68689 | 0.000552609179875 | 0.5 | E2F1 E2F2 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113501 | 0.000783559910601 | 0.5 | TFDP2 E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-69242 | 0.000880763368668 | 0.75 | TFDP2 E2F1 E2F4 | S Phase |
| GO:0044798 | 0.000921003798055 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | nuclear transcription factor complex |
| KEGG:05219 | 0.00133025918726 | 0.5 | E2F1 E2F2 | Bladder cancer |
| REAC:R-HSA-2559583 | 0.00145806857207 | 0.75 | TFDP2 E2F1 E2F2 | Cellular Senescence |
| REAC:R-HSA-6804114 | 0.00153629461685 | 0.5 | TFDP2 E2F4 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| REAC:R-HSA-113510 | 0.00231867248578 | 0.5 | TFDP2 E2F1 | E2F mediated regulation of DNA replication |
| KEGG:05218 | 0.00376859643257 | 0.5 | E2F1 E2F2 | Melanoma |
| KEGG:05223 | 0.00401698930658 | 0.5 | E2F1 E2F2 | Non-small cell lung cancer |
| WP:WP4255 | 0.00403274972955 | 0.5 | E2F1 E2F2 | Non-small cell lung cancer |
| GO:0005667 | 0.00406662724791 | 1.0 | TFDP2 E2F1 E2F2 E2F4 | transcription factor complex |
| REAC:R-HSA-114452 | 0.00436320194063 | 0.5 | TFDP2 E2F1 | Activation of BH3-only proteins |
| KEGG:05214 | 0.00453740909542 | 0.5 | E2F1 E2F2 | Glioma |
| REAC:R-HSA-2173796 | 0.00466369436644 | 0.5 | TFDP2 E2F4 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| KEGG:05212 | 0.00494838688052 | 0.5 | E2F1 E2F2 | Pancreatic cancer |
| KEGG:05220 | 0.00537705972469 | 0.5 | E2F1 E2F2 | Chronic myeloid leukemia |
| REAC:R-HSA-8953750 | 0.00562500866147 | 0.5 | TFDP2 E2F1 | Transcriptional Regulation by E2F6 |
| WP:WP4263 | 0.00567595707464 | 0.5 | E2F1 E2F2 | Pancreatic adenocarcinoma pathway |
| WP:WP4658 | 0.00743927140269 | 0.5 | E2F1 E2F2 | Small cell lung cancer |
| KEGG:05215 | 0.00796156937098 | 0.5 | E2F1 E2F2 | Prostate cancer |
| KEGG:01522 | 0.00796156937098 | 0.5 | E2F1 E2F2 | Endocrine resistance |
| KEGG:05222 | 0.0083198854229 | 0.5 | E2F1 E2F2 | Small cell lung cancer |
| GO:0006977 | 0.00898751047669 | 0.75 | TFDP2 E2F1 E2F4 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| REAC:R-HSA-2173793 | 0.00904685478976 | 0.5 | TFDP2 E2F4 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| REAC:R-HSA-3700989 | 0.00924066477779 | 0.75 | TFDP2 E2F1 E2F4 | Transcriptional Regulation by TP53 |
| GO:1902400 | 0.00950554068334 | 0.75 | TFDP2 E2F1 E2F4 | intracellular signal transduction involved in G1 DNA damage checkpoint |
| GO:0072431 | 0.00950554068334 | 0.75 | TFDP2 E2F1 E2F4 | signal transduction involved in mitotic G1 DNA damage checkpoint |
| WP:WP236 | 0.00997499186767 | 0.5 | E2F1 E2F4 | Adipogenesis |
| GO:1902403 | 0.0100430829723 | 0.75 | TFDP2 E2F1 E2F4 | signal transduction involved in mitotic DNA integrity checkpoint |
| GO:1902402 | 0.0100430829723 | 0.75 | TFDP2 E2F1 E2F4 | signal transduction involved in mitotic DNA damage checkpoint |
| GO:0072413 | 0.0100430829723 | 0.75 | TFDP2 E2F1 E2F4 | signal transduction involved in mitotic cell cycle checkpoint |
| REAC:R-HSA-109606 | 0.0122651619918 | 0.5 | TFDP2 E2F1 | Intrinsic Pathway for Apoptosis |
| GO:0031571 | 0.0123955582974 | 0.75 | TFDP2 E2F1 E2F4 | mitotic G1 DNA damage checkpoint |
| GO:0044819 | 0.0123955582974 | 0.75 | TFDP2 E2F1 E2F4 | mitotic G1/S transition checkpoint |
| GO:0044783 | 0.0130360493673 | 0.75 | TFDP2 E2F1 E2F4 | G1 DNA damage checkpoint |
| REAC:R-HSA-2262752 | 0.0147563350021 | 0.75 | TFDP2 E2F1 E2F2 | Cellular responses to stress |
| WP:WP4262 | 0.0159167413674 | 0.5 | E2F1 E2F2 | Breast cancer pathway |
| KEGG:05224 | 0.016608760826 | 0.5 | E2F1 E2F2 | Breast cancer |
| KEGG:05226 | 0.0168647432957 | 0.5 | E2F1 E2F2 | Gastric cancer |
| KEGG:05160 | 0.0181736572757 | 0.5 | E2F1 E2F2 | Hepatitis C |
| GO:0072422 | 0.0189701239271 | 0.75 | TFDP2 E2F1 E2F4 | signal transduction involved in DNA damage checkpoint |
| GO:0072401 | 0.0189701239271 | 0.75 | TFDP2 E2F1 E2F4 | signal transduction involved in DNA integrity checkpoint |
| KEGG:04934 | 0.0195308586359 | 0.5 | E2F1 E2F2 | Cushing syndrome |
| GO:0072395 | 0.0198185309013 | 0.75 | TFDP2 E2F1 E2F4 | signal transduction involved in cell cycle checkpoint |
| GO:0071158 | 0.0225145500348 | 0.75 | TFDP2 E2F1 E2F4 | positive regulation of cell cycle arrest |
| REAC:R-HSA-170834 | 0.0227713839361 | 0.5 | TFDP2 E2F4 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-68867 | 0.0227713839361 | 0.5 | E2F1 E2F2 | Assembly of the pre-replicative complex |
| KEGG:05161 | 0.0235873467107 | 0.5 | E2F1 E2F2 | Hepatitis B |
| KEGG:05206 | 0.0241976216174 | 0.5 | E2F1 E2F2 | MicroRNAs in cancer |
| KEGG:05225 | 0.0248155779574 | 0.5 | E2F1 E2F2 | Hepatocellular carcinoma |
| REAC:R-HSA-8953897 | 0.0253615474256 | 0.75 | TFDP2 E2F1 E2F2 | Cellular responses to external stimuli |
| KEGG:05167 | 0.0267154932054 | 0.5 | E2F1 E2F2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05169 | 0.0328286642151 | 0.5 | E2F1 E2F2 | Epstein-Barr virus infection |
| REAC:R-HSA-9616222 | 0.0339713415992 | 0.5 | TFDP2 E2F1 | Transcriptional regulation of granulopoiesis |
| REAC:R-HSA-69002 | 0.0356320611636 | 0.5 | E2F1 E2F2 | DNA Replication Pre-Initiation |
| KEGG:05166 | 0.0380105899241 | 0.5 | E2F1 E2F2 | Human T-cell leukemia virus 1 infection |
| GO:2000134 | 0.0383423539882 | 0.75 | TFDP2 E2F1 E2F4 | negative regulation of G1/S transition of mitotic cell cycle |
| REAC:R-HSA-9006936 | 0.0390714342086 | 0.5 | TFDP2 E2F4 | Signaling by TGF-beta family members |
| GO:1902807 | 0.0396936057372 | 0.75 | TFDP2 E2F1 E2F4 | negative regulation of cell cycle G1/S phase transition |
| GO:0044773 | 0.0396936057372 | 0.75 | TFDP2 E2F1 E2F4 | mitotic DNA damage checkpoint |
| KEGG:05163 | 0.0399515654372 | 0.5 | E2F1 E2F2 | Human cytomegalovirus infection |
| REAC:R-HSA-1912408 | 0.0408500448467 | 0.5 | TFDP2 E2F1 | Pre-NOTCH Transcription and Translation |
| GO:0030330 | 0.0484715579516 | 0.75 | TFDP2 E2F1 E2F4 | DNA damage response, signal transduction by p53 class mediator |
| GO:0071156 | 0.0484715579516 | 0.75 | TFDP2 E2F1 E2F4 | regulation of cell cycle arrest |
| CORUM:5143 | 0.0499140284799 | 0.25 | E2F1 | RB-E2F1 complex |
| CORUM:5099 | 0.0499140284799 | 0.25 | E2F4 | RB1(hypophosphorylated)-E2F4 complex |
| CORUM:1250 | 0.0499140284799 | 0.25 | E2F1 | RB-E2F1 complex |
| CORUM:6588 | 0.0499140284799 | 0.25 | E2F1 | E2F-1-DP-1 complex |
| CORUM:5160 | 0.0499140284799 | 0.25 | E2F4 | E2F4-p130 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TFDP2 | E2F2 | 0.999 | 0.946 | bioplex (TFDP2) bioplex_WMM |
| E2F1 | TFDP2 | 0.996 | 0.926 | bioplex (TFDP2) bioplex_WMM |
| TFDP2 | E2F4 | 0.753 | 0.747 | bioplex (TFDP2) bioplex_WMM boldt_WMM |
| E2F1 | E2F2 | 0.01 | 0.105 | bioplex_WMM WMM_only |
| E2F2 | E2F4 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| E2F1 | E2F4 | 0.009 | 0.096 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_01975 has an average edge precision of 0.486 which is ranked 2584 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| E2F1 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |
| TFDP2 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |
| E2F4 | HuMAP2_01975 HuMAP2_02343 HuMAP2_04984 HuMAP2_06111 |
| E2F2 | HuMAP2_00571 HuMAP2_01975 HuMAP2_02343 HuMAP2_06111 |