hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01989
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMN1 | Survival motor neuron protein (Component of gems 1) (Gemin-1) | UniProt NCBI |
| DDX20 | Probable ATP-dependent RNA helicase DDX20 (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3) | UniProt NCBI |
| GEMIN8 | Gem-associated protein 8 (Gemin-8) (Protein FAM51A1) | UniProt NCBI |
| GEMIN7 | Gem-associated protein 7 (Gemin-7) (SIP3) | UniProt NCBI |
| GEMIN6 | Gem-associated protein 6 (Gemin-6) (SIP2) | UniProt NCBI |
| GEMIN4 | Gem-associated protein 4 (Gemin-4) (Component of gems 4) (p97) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1143 | 3.66076779018e-14 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | SMN complex |
| CORUM:1752 | 2.72242633204e-12 | 0.8 | DDX20 GEMIN4 GEMIN7 GEMIN6 | SMN complex |
| GO:0032797 | 3.78467070001e-12 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | SMN complex |
| CORUM:1751 | 2.28646948215e-11 | 0.8 | DDX20 GEMIN4 GEMIN7 GEMIN6 | SMN complex |
| GO:0034719 | 5.06916499819e-11 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | SMN-Sm protein complex |
| REAC:R-HSA-191859 | 5.19662551024e-11 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | snRNP Assembly |
| REAC:R-HSA-194441 | 5.19662551024e-11 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | Metabolism of non-coding RNA |
| CORUM:1745 | 2.4762098927e-10 | 0.8 | DDX20 GEMIN4 GEMIN7 GEMIN6 | SMN complex |
| GO:0000387 | 4.11187268507e-09 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | spliceosomal snRNP assembly |
| KEGG:03013 | 5.10275915838e-09 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | RNA transport |
| GO:0120114 | 1.31961833602e-07 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | Sm-like protein family complex |
| GO:0051170 | 1.4961513763e-06 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | import into nucleus |
| GO:0022618 | 1.87566738499e-05 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | ribonucleoprotein complex assembly |
| CORUM:3297 | 2.0123342217e-05 | 0.4 | GEMIN7 GEMIN6 | SMN complex (GEMIN6,7, UNRIP), SMN-independent intermediate |
| CORUM:3296 | 2.0123342217e-05 | 0.4 | GEMIN4 DDX20 | SMN complex (GEMIN5,4,3), SMN-independent intermediate |
| REAC:R-HSA-8953854 | 2.37148320446e-05 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | Metabolism of RNA |
| GO:0071826 | 2.6574882809e-05 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | ribonucleoprotein complex subunit organization |
| CORUM:3284 | 4.0241279111e-05 | 0.4 | GEMIN4 DDX20 | SMN complex (GEMIN2, GEMIN3, GEMIN4, GEMIN5, SMN) |
| CORUM:1750 | 4.0241279111e-05 | 0.4 | GEMIN4 DDX20 | PPP4C-PPP4R2-Gemin3-Gemin4 complex |
| CORUM:824 | 4.0241279111e-05 | 0.4 | GEMIN4 DDX20 | Anti-SMN protein complex |
| GO:0006913 | 9.09038692953e-05 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | nucleocytoplasmic transport |
| GO:0051169 | 9.61471171118e-05 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | nuclear transport |
| CORUM:832 | 0.000100576175246 | 0.4 | GEMIN4 DDX20 | Anti-Sm protein complex |
| GO:0000377 | 0.000195429782732 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.000195429782732 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.000205071070663 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | RNA splicing, via transesterification reactions |
| CORUM:1749 | 0.000301566439547 | 0.4 | GEMIN4 DDX20 | SMN-PolII-RHA complex |
| GO:0022613 | 0.000460710313953 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | ribonucleoprotein complex biogenesis |
| GO:0008380 | 0.000460710313953 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | RNA splicing |
| GO:0006397 | 0.00066476318296 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | mRNA processing |
| GO:0016071 | 0.0124036237668 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | mRNA metabolic process |
| GO:0006396 | 0.0184779947673 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | RNA processing |
| GO:0034622 | 0.0295837795507 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | cellular protein-containing complex assembly |
| CORUM:0000000 | 0.0474603483533 | 1.0 | GEMIN4 GEMIN6 DDX20 GEMIN7 GEMIN8 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GEMIN4 | DDX20 | 0.997 | 0.93 | hein_WMM youn (DDX20) bioplex (DDX20) bioplex_WMM youn_WMM treiber_WMM |
| DDX20 | GEMIN7 | 0.99 | 0.909 | hein_WMM youn (DDX20) bioplex (DDX20) bioplex_WMM youn_WMM hein (GEMIN7) |
| GEMIN7 | GEMIN8 | 0.968 | 0.88 | hein_WMM bioplex (GEMIN8) bioplex_WMM youn_WMM hein (GEMIN7) |
| GEMIN8 | GEMIN6 | 0.883 | 0.818 | hein_WMM bioplex (GEMIN6,GEMIN8) bioplex_WMM youn_WMM |
| SMN1 | GEMIN6 | 0.834 | 0.78 | hein_WMM bioplex (SMN1) bioplex_WMM youn_WMM hein (SMN1) |
| SMN1 | DDX20 | 0.797 | 0.764 | hein_WMM youn (DDX20) bioplex_WMM youn_WMM hein (SMN1) gupta_WMM treiber_WMM |
| DDX20 | GEMIN8 | 0.683 | 0.711 | hein_WMM youn (DDX20) bioplex (DDX20,GEMIN8) bioplex_WMM youn_WMM |
| DDX20 | GEMIN6 | 0.598 | 0.668 | hein_WMM youn (DDX20) bioplex (DDX20,GEMIN6) bioplex_WMM youn_WMM |
| GEMIN4 | GEMIN6 | 0.127 | 0.4 | hein_WMM bioplex (GEMIN6) bioplex_WMM youn_WMM |
| GEMIN4 | GEMIN8 | 0.114 | 0.384 | hein_WMM bioplex (GEMIN8) bioplex_WMM youn_WMM |
| SMN1 | GEMIN7 | 0.059 | 0.328 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN7,SMN1) |
| GEMIN7 | GEMIN6 | 0.029 | 0.232 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN7) |
| GEMIN4 | GEMIN7 | 0.026 | 0.224 | hein_WMM bioplex_WMM youn_WMM hein (GEMIN7) |
| SMN1 | GEMIN8 | 0.02 | 0.187 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) treiber_WMM |
| GEMIN4 | SMN1 | 0.013 | 0.148 | hein_WMM bioplex_WMM youn_WMM hein (SMN1) gupta_WMM |
Images
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Complex HuMAP2_01989 has an average edge precision of 0.558 which is ranked 2149 out of all 6965 complexes.
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