hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_01999
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GTF2H2C | General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein) | UniProt NCBI |
| ERCC3 | General transcription and DNA repair factor IIH helicase subunit XPB (TFIIH subunit XPB) (EC 3.6.4.12) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein) | UniProt NCBI |
| GTF2H5 | General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) | UniProt NCBI |
| GTF2H1 | General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit) | UniProt NCBI |
| GTF2H2 | General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit) | UniProt NCBI |
| GTF2H3 | General transcription factor IIH subunit 3 (Basic transcription factor 2 34 kDa subunit) (BTF2 p34) (General transcription factor IIH polypeptide 3) (TFIIH basal transcription factor complex p34 subunit) | UniProt NCBI |
| GTF2H4 | General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005675 | 1.22930232891e-18 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | transcription factor TFIIH holo complex |
| CORUM:1029 | 5.16132609016e-18 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | TFIIH transcription factor complex |
| CORUM:1009 | 5.16132609016e-18 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | TFIIH transcription factor complex |
| GO:0000439 | 2.31084003444e-17 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | transcription factor TFIIH core complex |
| GO:0032806 | 7.82097042285e-17 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | carboxy-terminal domain protein kinase complex |
| CORUM:1037 | 1.83011155706e-16 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | TFIIH transcription factor core complex |
| REAC:R-HSA-167160 | 2.28496570386e-14 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| REAC:R-HSA-77075 | 2.28496570386e-14 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Pol II CTD phosphorylation and interaction with CE |
| CORUM:1036 | 2.30490814807e-14 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | TFIIH transcription factor complex |
| CORUM:107 | 2.30490814807e-14 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | TFIIH transcription factor complex |
| REAC:R-HSA-72086 | 3.66636018365e-14 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | mRNA Capping |
| REAC:R-HSA-73863 | 5.68220306165e-14 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-167158 | 8.54660187695e-14 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-113418 | 8.54660187695e-14 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Formation of the Early Elongation Complex |
| KEGG:03022 | 1.26803434627e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Basal transcription factors |
| KEGG:03420 | 1.70614805227e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Nucleotide excision repair |
| REAC:R-HSA-5696400 | 3.46805893074e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 4.70164548084e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-167200 | 5.4436964611e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167246 | 5.4436964611e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167169 | 5.4436964611e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | HIV Transcription Elongation |
| REAC:R-HSA-167152 | 7.22253289646e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-167161 | 8.27901115701e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | HIV Transcription Initiation |
| REAC:R-HSA-73779 | 8.27901115701e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-76042 | 8.27901115701e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-75953 | 8.27901115701e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-73762 | 8.27901115701e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase I Transcription Initiation |
| REAC:R-HSA-167162 | 8.27901115701e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-73776 | 8.27901115701e-13 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase II Promoter Escape |
| GO:0006295 | 1.25287133269e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | nucleotide-excision repair, DNA incision, 3'-to lesion |
| GO:0006293 | 1.25287133269e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | nucleotide-excision repair, preincision complex stabilization |
| GO:0000717 | 1.72259881629e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | nucleotide-excision repair, DNA duplex unwinding |
| REAC:R-HSA-6781823 | 1.76948200735e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Formation of TC-NER Pre-Incision Complex |
| GO:0016591 | 2.28648635084e-12 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | RNA polymerase II, holoenzyme |
| GO:1902554 | 2.79321557377e-12 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | serine/threonine protein kinase complex |
| REAC:R-HSA-112382 | 3.47166909111e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 3.47166909111e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-6796648 | 4.7357784261e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | TP53 Regulates Transcription of DNA Repair Genes |
| GO:0070911 | 5.31412098802e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | global genome nucleotide-excision repair |
| REAC:R-HSA-6782210 | 5.77509160286e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 6.36202152662e-12 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Dual incision in TC-NER |
| CORUM:103 | 7.76217059492e-12 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | RNA polymerase II holoenzyme complex |
| GO:1902911 | 9.85356801999e-12 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | protein kinase complex |
| GO:0006362 | 1.09624169491e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | transcription elongation from RNA polymerase I promoter |
| GO:0006294 | 1.09624169491e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | nucleotide-excision repair, preincision complex assembly |
| REAC:R-HSA-167172 | 1.10273472623e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Transcription of the HIV genome |
| CORUM:2825 | 1.20101909287e-11 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | BRCA1-RNA polymerase II complex |
| GO:0006363 | 1.69897871543e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | termination of RNA polymerase I transcription |
| GO:0055029 | 1.85003675181e-11 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | nuclear DNA-directed RNA polymerase complex |
| REAC:R-HSA-6781827 | 1.97686479115e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| GO:0000428 | 1.99392849918e-11 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | DNA-directed RNA polymerase complex |
| GO:0006370 | 2.09093016566e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | 7-methylguanosine mRNA capping |
| GO:0009452 | 2.09093016566e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | 7-methylguanosine RNA capping |
| GO:0006361 | 2.09093016566e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | transcription initiation from RNA polymerase I promoter |
| GO:0030880 | 2.48461259742e-11 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | RNA polymerase complex |
| GO:0036260 | 2.55543396121e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA capping |
| REAC:R-HSA-674695 | 2.69440600988e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase II Pre-transcription Events |
| REAC:R-HSA-5696399 | 3.12741027993e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0006289 | 3.53280437526e-11 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | nucleotide-excision repair |
| REAC:R-HSA-73772 | 4.78864481055e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase I Promoter Escape |
| GO:0006296 | 5.36261587218e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| GO:0033683 | 7.52507573836e-11 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | nucleotide-excision repair, DNA incision |
| REAC:R-HSA-427413 | 1.23670232415e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | NoRC negatively regulates rRNA expression |
| WP:WP405 | 1.36596068277e-10 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | Eukaryotic Transcription Initiation |
| REAC:R-HSA-5250941 | 1.47021748274e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 1.55577111529e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 1.64543183853e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase I Transcription |
| REAC:R-HSA-5696398 | 1.64543183853e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Nucleotide Excision Repair |
| GO:0090575 | 3.76320490958e-10 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | RNA polymerase II transcription factor complex |
| GO:0032508 | 4.69206908828e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | DNA duplex unwinding |
| REAC:R-HSA-162599 | 5.26040261796e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 9.29347995061e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | HIV Life Cycle |
| REAC:R-HSA-212165 | 9.29347995061e-10 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Epigenetic regulation of gene expression |
| GO:0006360 | 1.03802905824e-09 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | transcription by RNA polymerase I |
| GO:0044798 | 1.37087093836e-09 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | nuclear transcription factor complex |
| GO:0032392 | 1.4159977494e-09 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | DNA geometric change |
| GO:0008353 | 1.47181302638e-09 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| GO:0006283 | 3.91857948075e-09 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | transcription-coupled nucleotide-excision repair |
| GO:0006353 | 3.91857948075e-09 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | DNA-templated transcription, termination |
| GO:0006368 | 6.39627721266e-09 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | transcription elongation from RNA polymerase II promoter |
| GO:0061695 | 7.67955615914e-09 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-162906 | 1.21809078273e-08 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | HIV Infection |
| GO:0005667 | 1.87925519573e-08 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | transcription factor complex |
| GO:0006354 | 3.69773994922e-08 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | DNA-templated transcription, elongation |
| GO:0005669 | 4.77132473629e-08 | 0.714285714286 | ERCC3 GTF2H2 GTF2H5 GTF2H3 GTF2H4 | transcription factor TFIID complex |
| REAC:R-HSA-73894 | 1.10011213226e-07 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | DNA Repair |
| GO:0090305 | 1.24450669981e-07 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | nucleic acid phosphodiester bond hydrolysis |
| REAC:R-HSA-3700989 | 1.78972441078e-07 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Transcriptional Regulation by TP53 |
| REAC:R-HSA-5663205 | 2.12266820846e-07 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Infectious disease |
| GO:0070816 | 2.81450928027e-07 | 0.571428571429 | GTF2H1 GTF2H5 GTF2H3 GTF2H4 | phosphorylation of RNA polymerase II C-terminal domain |
| GO:0006367 | 7.01892721448e-07 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | transcription initiation from RNA polymerase II promoter |
| GO:0031334 | 1.17327993584e-06 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | positive regulation of protein complex assembly |
| GO:0006281 | 1.18697690603e-06 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | DNA repair |
| GO:0065004 | 1.33598389589e-06 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | protein-DNA complex assembly |
| GO:0006352 | 2.45902527963e-06 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | DNA-templated transcription, initiation |
| GO:0000438 | 3.17865016081e-06 | 0.428571428571 | GTF2H2 GTF2H3 GTF2H4 | core TFIIH complex portion of holo TFIIH complex |
| GO:0071103 | 4.87454292006e-06 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | DNA conformation change |
| GO:0071824 | 5.13215507167e-06 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | protein-DNA complex subunit organization |
| REAC:R-HSA-8953854 | 7.75839378739e-06 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Metabolism of RNA |
| GO:0008094 | 8.37777986794e-06 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | DNA-dependent ATPase activity |
| GO:1990234 | 2.43643658467e-05 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | transferase complex |
| GO:0006259 | 2.74614623747e-05 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | DNA metabolic process |
| GO:0006974 | 2.7734129377e-05 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | cellular response to DNA damage stimulus |
| GO:0043254 | 2.82502873256e-05 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | regulation of protein complex assembly |
| KEGG:05203 | 4.37888853972e-05 | 0.571428571429 | GTF2H4 GTF2H1 GTF2H3 GTF2H2 | Viral carcinogenesis |
| GO:0044089 | 7.01476815555e-05 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | positive regulation of cellular component biogenesis |
| REAC:R-HSA-1643685 | 7.29866025129e-05 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Disease |
| GO:0006397 | 0.000120054472817 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | mRNA processing |
| REAC:R-HSA-212436 | 0.00012164166601 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Generic Transcription Pathway |
| GO:0044451 | 0.000166634167312 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | nucleoplasm part |
| REAC:R-HSA-73857 | 0.00023249479605 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.000444522787502 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | Gene expression (Transcription) |
| GO:0042623 | 0.000558514532351 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | ATPase activity, coupled |
| CORUM:3066 | 0.000783651479317 | 0.285714285714 | GTF2H3 ERCC3 | RNA polymerase II complex, chromatin structure modifying |
| GO:0016251 | 0.000907263777246 | 0.428571428571 | GTF2H2 GTF2H3 GTF2H4 | RNA polymerase II general transcription initiation factor activity |
| GO:1902494 | 0.00105300999874 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | catalytic complex |
| CORUM:1141 | 0.00105444313284 | 0.285714285714 | GTF2H4 ERCC3 | CF IIAm complex (Cleavage factor IIAm complex) |
| HP:0045055 | 0.00173027154874 | 0.285714285714 | ERCC3 GTF2H5 | Tiger tail banding |
| HP:0012760 | 0.00173027154874 | 0.285714285714 | ERCC3 GTF2H5 | Impaired social reciprocity |
| HP:0410219 | 0.00173027154874 | 0.285714285714 | ERCC3 GTF2H5 | Hypoplasia of mandible relative to maxilla |
| HP:0007381 | 0.00173027154874 | 0.285714285714 | ERCC3 GTF2H5 | Congenital exfoliative erythroderma |
| HP:0002562 | 0.0024218379091 | 0.285714285714 | ERCC3 GTF2H5 | Low-set nipples |
| GO:0044087 | 0.00251807816964 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | regulation of cellular component biogenesis |
| GO:0140223 | 0.00258594907681 | 0.428571428571 | GTF2H2 GTF2H3 GTF2H4 | general transcription initiation factor activity |
| GO:0006357 | 0.00307195999035 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | regulation of transcription by RNA polymerase II |
| HP:0007587 | 0.00322839434563 | 0.285714285714 | ERCC3 GTF2H5 | Numerous pigmented freckles |
| HP:0001809 | 0.00322839434563 | 0.285714285714 | ERCC3 GTF2H5 | Split nail |
| GO:0016071 | 0.00396065506267 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | mRNA metabolic process |
| GO:0016887 | 0.00409284107934 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | ATPase activity |
| HP:0007034 | 0.00414986351758 | 0.285714285714 | ERCC3 GTF2H5 | Generalized hyperreflexia |
| HP:0006538 | 0.00414986351758 | 0.285714285714 | ERCC3 GTF2H5 | Recurrent bronchopulmonary infections |
| HP:0025428 | 0.00414986351758 | 0.285714285714 | ERCC3 GTF2H5 | Bronchospasm |
| HP:0025427 | 0.0051861681154 | 0.285714285714 | ERCC3 GTF2H5 | Abnormal bronchus physiology |
| HP:0001598 | 0.0063372308607 | 0.285714285714 | ERCC3 GTF2H5 | Concave nail |
| HP:0007485 | 0.0063372308607 | 0.285714285714 | ERCC3 GTF2H5 | Absence of subcutaneous fat |
| GO:0006396 | 0.00636934613966 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | RNA processing |
| GO:0006366 | 0.0065302926108 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | transcription by RNA polymerase II |
| GO:0033554 | 0.00695537920525 | 1.0 | ERCC3 GTF2H2 GTF2H5 GTF2H4 GTF2H1 GTF2H2C GTF2H3 | cellular response to stress |
| HP:0100275 | 0.00760297450628 | 0.285714285714 | ERCC3 GTF2H5 | Diffuse cerebellar atrophy |
| HP:0007266 | 0.00760297450628 | 0.285714285714 | ERCC3 GTF2H5 | Cerebral dysmyelination |
| HP:0003079 | 0.00760297450628 | 0.285714285714 | ERCC3 GTF2H5 | Defective DNA repair after ultraviolet radiation damage |
| HP:0000320 | 0.00760297450628 | 0.285714285714 | ERCC3 GTF2H5 | Bird-like facies |
| GO:0004674 | 0.00891451540705 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | protein serine/threonine kinase activity |
| HP:0025548 | 0.00898332183607 | 0.285714285714 | ERCC3 GTF2H5 | Increased mean corpuscular hemoglobin concentration |
| HP:0007479 | 0.00898332183607 | 0.285714285714 | ERCC3 GTF2H5 | Congenital nonbullous ichthyosiform erythroderma |
| GO:0051130 | 0.00974557774339 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | positive regulation of cellular component organization |
| GO:0034622 | 0.0111566389539 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | cellular protein-containing complex assembly |
| HP:0003254 | 0.0120875188399 | 0.285714285714 | ERCC3 GTF2H5 | Abnormality of DNA repair |
| HP:0007633 | 0.0138112142376 | 0.285714285714 | ERCC3 GTF2H5 | Bilateral microphthalmos |
| HP:0025546 | 0.0138112142376 | 0.285714285714 | ERCC3 GTF2H5 | Abnormal mean corpuscular hemoglobin concentration |
| HP:0003139 | 0.0156492047667 | 0.285714285714 | ERCC3 GTF2H5 | Panhypogammaglobulinemia |
| HP:0006970 | 0.017601413367 | 0.285714285714 | ERCC3 GTF2H5 | Periventricular leukomalacia |
| GO:0051276 | 0.0190987011465 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | chromosome organization |
| HP:0001807 | 0.0241425774578 | 0.285714285714 | ERCC3 GTF2H5 | Ridged nail |
| HP:0001808 | 0.0265508883611 | 0.285714285714 | ERCC3 GTF2H5 | Fragile nails |
| HP:0002293 | 0.0317089330016 | 0.285714285714 | ERCC3 GTF2H5 | Alopecia of scalp |
| HP:0007431 | 0.0317089330016 | 0.285714285714 | ERCC3 GTF2H5 | Congenital ichthyosiform erythroderma |
| HP:0008391 | 0.0344585130221 | 0.285714285714 | ERCC3 GTF2H5 | Dystrophic fingernails |
| HP:0008887 | 0.0344585130221 | 0.285714285714 | ERCC3 GTF2H5 | Adipose tissue loss |
| HP:0002942 | 0.0402984044053 | 0.285714285714 | ERCC3 GTF2H5 | Thoracic kyphosis |
| HP:0000133 | 0.0402984044053 | 0.285714285714 | ERCC3 GTF2H5 | Gonadal dysgenesis |
| HP:0003328 | 0.0402984044053 | 0.285714285714 | ERCC3 GTF2H5 | Abnormal hair laboratory examination |
| GO:0004672 | 0.0406938796461 | 0.714285714286 | GTF2H4 GTF2H1 GTF2H3 ERCC3 GTF2H2 | protein kinase activity |
| HP:0001097 | 0.0433885622377 | 0.285714285714 | ERCC3 GTF2H5 | Keratoconjunctivitis sicca |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | ERCC3 GTF2H5 GTF2H2 GTF2H4 GTF2H1 GTF2H3 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GTF2H2C | GTF2H1 | 1.0 | 0.949 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H1 | ERCC3 | 1.0 | 0.949 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H1 | GTF2H3 | 1.0 | 0.949 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H2C | ERCC3 | 1.0 | 0.949 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H4 | ERCC3 | 1.0 | 0.949 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H2C | GTF2H3 | 0.998 | 0.939 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
| GTF2H1 | GTF2H4 | 0.998 | 0.936 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H2 | ERCC3 | 0.989 | 0.905 | hein_WMM bioplex (ERCC3) bioplex_WMM Malo fraction |
| GTF2H5 | GTF2H3 | 0.986 | 0.901 | hein_WMM bioplex (GTF2H3,GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H5 | GTF2H4 | 0.983 | 0.898 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H5 | GTF2H1 | 0.98 | 0.896 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H1 | GTF2H2 | 0.964 | 0.872 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H3 | GTF2H2 | 0.962 | 0.87 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H5 | ERCC3 | 0.951 | 0.858 | hein_WMM bioplex (ERCC3,GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H3 | ERCC3 | 0.945 | 0.856 | hein_WMM bioplex (ERCC3,GTF2H3) bioplex_WMM Malo fraction |
| GTF2H3 | GTF2H4 | 0.93 | 0.846 | hein_WMM bioplex (GTF2H3) bioplex_WMM Malo fraction |
| GTF2H2 | GTF2H4 | 0.823 | 0.774 | hein_WMM bioplex_WMM Malo fraction |
| GTF2H5 | GTF2H2 | 0.747 | 0.741 | hein_WMM bioplex (GTF2H5) bioplex_WMM hein (GTF2H5) |
| GTF2H2C | GTF2H5 | 0.529 | 0.634 | bioplex (GTF2H2C;) bioplex_WMM |
| GTF2H2C | GTF2H4 | 0.213 | 0.464 | bioplex (GTF2H2C;) bioplex_WMM Malo fraction |
Images
Click to enlarge
Complex HuMAP2_01999 has an average edge precision of 0.857 which is ranked 733 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GTF2H2C | HuMAP2_01329 HuMAP2_01999 HuMAP2_04213 HuMAP2_05362 HuMAP2_06159 |
| ERCC3 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 HuMAP2_06407 |
| GTF2H5 | HuMAP2_01967 HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H1 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H2 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H3 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |
| GTF2H4 | HuMAP2_01999 HuMAP2_04213 HuMAP2_06159 |