hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02002
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC30A5 | Zinc transporter 5 (ZnT-5) (Solute carrier family 30 member 5) (ZnT-like transporter 1) (hZTL1) | UniProt NCBI |
| GLG1 | Golgi apparatus protein 1 (CFR-1) (Cysteine-rich fibroblast growth factor receptor) (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) | UniProt NCBI |
| SPPL2B | Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1) | UniProt NCBI |
| SLC52A2 | Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3) | UniProt NCBI |
| MTCH1 | Mitochondrial carrier homolog 1 (Presenilin-associated protein) | UniProt NCBI |
| PIGN | GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) | UniProt NCBI |
| FXYD6 | FXYD domain-containing ion transport regulator 6 (Phosphohippolin) | UniProt NCBI |
| COX14 | Cytochrome c oxidase assembly protein COX14 | UniProt NCBI |
| SLC30A6 | Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-435368 | 0.000968683784969 | 0.222222222222 | SLC30A5 SLC30A6 | Zinc efflux and compartmentalization by the SLC30 family |
| WP:WP3529 | 0.00488522165191 | 0.222222222222 | SLC30A5 SLC30A6 | Zinc homeostasis |
| REAC:R-HSA-435354 | 0.00676168485278 | 0.222222222222 | SLC30A5 SLC30A6 | Zinc transporters |
| REAC:R-HSA-425410 | 0.0134979585429 | 0.222222222222 | SLC30A5 SLC30A6 | Metal ion SLC transporters |
| REAC:R-HSA-264876 | 0.0177234980319 | 0.222222222222 | SLC30A5 SLC30A6 | Insulin processing |
| HP:0006254 | 0.0343154638255 | 0.222222222222 | PIGN SLC52A2 | Elevated alpha-fetoprotein |
| HP:0045056 | 0.0383405566315 | 0.222222222222 | PIGN SLC52A2 | Abnormal levels of alpha-fetoprotein |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SPPL2B | SLC30A5 | 0.08 | 0.35 | bioplex (SPPL2B) bioplex_WMM |
| SPPL2B | COX14 | 0.045 | 0.283 | bioplex (SPPL2B) bioplex_WMM |
| GLG1 | SPPL2B | 0.044 | 0.278 | bioplex (SPPL2B) bioplex_WMM |
| SPPL2B | PIGN | 0.043 | 0.269 | bioplex (SPPL2B) bioplex_WMM |
| SPPL2B | SLC30A6 | 0.041 | 0.269 | bioplex (SPPL2B) bioplex_WMM |
| SPPL2B | MTCH1 | 0.034 | 0.261 | bioplex (SPPL2B) bioplex_WMM |
| SLC30A5 | SLC30A6 | 0.026 | 0.218 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| SPPL2B | FXYD6 | 0.021 | 0.188 | bioplex (SPPL2B) bioplex_WMM |
| SPPL2B | SLC52A2 | 0.02 | 0.186 | bioplex (SPPL2B) bioplex_WMM |
| FXYD6 | COX14 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| COX14 | SLC52A2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FXYD6 | SLC52A2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PIGN | COX14 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| COX14 | SLC30A6 | 0.008 | 0.028 | bioplex_WMM WMM_only |
| COX14 | SLC30A5 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| PIGN | SLC52A2 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| PIGN | FXYD6 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| FXYD6 | SLC30A6 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| SLC30A6 | SLC52A2 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| FXYD6 | SLC30A5 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| SLC30A5 | SLC52A2 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| MTCH1 | COX14 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| PIGN | SLC30A6 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| GLG1 | COX14 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| PIGN | SLC30A5 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| MTCH1 | SLC52A2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| FXYD6 | MTCH1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| GLG1 | SLC52A2 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| GLG1 | FXYD6 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| PIGN | MTCH1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| GLG1 | PIGN | 0.007 | 0.005 | bioplex_WMM WMM_only |
| MTCH1 | SLC30A6 | 0.006 | 0.002 | bioplex_WMM WMM_only |
| GLG1 | SLC30A6 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| MTCH1 | SLC30A5 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| GLG1 | MTCH1 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| GLG1 | SLC30A5 | 0.006 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02002 has an average edge precision of 0.078 which is ranked 6964 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SLC30A5 | HuMAP2_00807 HuMAP2_00856 HuMAP2_02002 HuMAP2_05608 |
| GLG1 | HuMAP2_00807 HuMAP2_02002 |
| SPPL2B | HuMAP2_00807 HuMAP2_02002 |
| SLC52A2 | HuMAP2_02002 HuMAP2_04291 |
| MTCH1 | HuMAP2_00807 HuMAP2_02002 HuMAP2_03665 HuMAP2_05177 |
| PIGN | HuMAP2_00807 HuMAP2_02002 HuMAP2_05430 |
| FXYD6 | HuMAP2_00807 HuMAP2_02002 |
| COX14 | HuMAP2_00807 HuMAP2_02002 |
| SLC30A6 | HuMAP2_00807 HuMAP2_00856 HuMAP2_02002 HuMAP2_05608 |