hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02004
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FCGR3A | Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a) | UniProt NCBI |
| FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b) | UniProt NCBI |
| PLAUR | Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87) | UniProt NCBI |
| RIOK3 | Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog) | UniProt NCBI |
| MAN2A1 | Alpha-mannosidase 2 (EC 3.2.1.114) (Golgi alpha-mannosidase II) (AMan II) (Man II) (Mannosidase alpha class 2A member 1) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05140 | 0.00680203716674 | 0.4 | FCGR3B FCGR3A | Leishmaniasis |
| KEGG:05150 | 0.00913076995809 | 0.4 | FCGR3B FCGR3A | Staphylococcus aureus infection |
| WP:WP2806 | 0.0104424923561 | 0.4 | FCGR3A PLAUR | Human Complement System |
| KEGG:04666 | 0.0162467151192 | 0.4 | FCGR3B FCGR3A | Fc gamma R-mediated phagocytosis |
| KEGG:04650 | 0.0205580217111 | 0.4 | FCGR3B FCGR3A | Natural killer cell mediated cytotoxicity |
| KEGG:04380 | 0.0222496587654 | 0.4 | FCGR3B FCGR3A | Osteoclast differentiation |
| REAC:R-HSA-163125 | 0.0229182830201 | 0.4 | FCGR3B PLAUR | Post-translational modification: synthesis of GPI-anchored proteins |
| KEGG:05322 | 0.0267668372004 | 0.4 | FCGR3B FCGR3A | Systemic lupus erythematosus |
| KEGG:04145 | 0.0381461453689 | 0.4 | FCGR3B FCGR3A | Phagosome |
| KEGG:05152 | 0.0470338525035 | 0.4 | FCGR3B FCGR3A | Tuberculosis |
| CORUM:7108 | 0.0499494897235 | 0.2 | PLAUR | IGF2R-PLAUR complex |
| CORUM:7112 | 0.0499494897235 | 0.2 | PLAUR | PLAUR-PLAU complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FCGR3A | FCGR3B | 0.351 | 0.537 | bioplex (FCGR3A) bioplex_WMM |
| FCGR3A | RIOK3 | 0.276 | 0.487 | bioplex (FCGR3A) bioplex_WMM |
| RIOK3 | PLAUR | 0.064 | 0.347 | bioplex (PLAUR) bioplex_WMM |
| PLAUR | MAN2A1 | 0.043 | 0.273 | bioplex (PLAUR) bioplex_WMM |
| RIOK3 | FCGR3B | 0.008 | 0.09 | bioplex_WMM WMM_only |
| RIOK3 | MAN2A1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| MAN2A1 | FCGR3B | 0.003 | 0.014 | bioplex (FCGR3B) bioplex_WMM |
Images
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Complex HuMAP2_02004 has an average edge precision of 0.25 which is ranked 5374 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FCGR3A | HuMAP2_00753 HuMAP2_02004 HuMAP2_05604 HuMAP2_05829 |
| FCGR3B | HuMAP2_00979 HuMAP2_02004 HuMAP2_05829 |
| PLAUR | HuMAP2_00753 HuMAP2_02004 HuMAP2_05604 HuMAP2_05829 |
| RIOK3 | HuMAP2_00753 HuMAP2_02004 HuMAP2_05604 HuMAP2_05829 |
| MAN2A1 | HuMAP2_00753 HuMAP2_01074 HuMAP2_02004 HuMAP2_05613 |