hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02016
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ELAVL3 | ELAV-like protein 3 (Hu-antigen C) (HuC) (Paraneoplastic cerebellar degeneration-associated antigen) (Paraneoplastic limbic encephalitis antigen 21) | UniProt NCBI |
| SUGP2 | SURP and G-patch domain-containing protein 2 (Arginine/serine-rich-splicing factor 14) (Splicing factor, arginine/serine-rich 14) | UniProt NCBI |
| YTHDC1 | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) | UniProt NCBI |
| RO60 | 60 kDa SS-A/Ro ribonucleoprotein (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (Ro60) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2) | UniProt NCBI |
| PUM2 | Pumilio homolog 2 (Pumilio-2) | UniProt NCBI |
| ELAVL2 | ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Hel-N1) | UniProt NCBI |
| HNRNPCL1 | Heterogeneous nuclear ribonucleoprotein C-like 1 (hnRNP C-like-1) (hnRNP core protein C-like 1) | UniProt NCBI |
| SAFB2 | Scaffold attachment factor B2 (SAF-B2) | UniProt NCBI |
| RBMS2 | RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3) | UniProt NCBI |
| PPIL4 | Peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) (EC 5.2.1.8) (Cyclophilin-like protein PPIL4) (Rotamase PPIL4) | UniProt NCBI |
| APOBEC3B | DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0003723 | 3.06229754191e-07 | 1.0 | SUGP2 YTHDC1 ELAVL3 PPIL4 APOBEC3B HNRNPCL1 RO60 ELAVL2 SAFB2 RBMS2 PUM2 | RNA binding |
| GO:0003676 | 0.000163963366639 | 1.0 | SUGP2 YTHDC1 ELAVL3 PPIL4 APOBEC3B HNRNPCL1 RO60 ELAVL2 SAFB2 RBMS2 PUM2 | nucleic acid binding |
| GO:1901363 | 0.00188066327196 | 1.0 | SUGP2 YTHDC1 ELAVL3 PPIL4 APOBEC3B HNRNPCL1 RO60 ELAVL2 SAFB2 RBMS2 PUM2 | heterocyclic compound binding |
| GO:0097159 | 0.00227552471421 | 1.0 | SUGP2 YTHDC1 ELAVL3 PPIL4 APOBEC3B HNRNPCL1 RO60 ELAVL2 SAFB2 RBMS2 PUM2 | organic cyclic compound binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ELAVL2 | ELAVL3 | 0.988 | 0.901 | bioplex (ELAVL2) bioplex_WMM |
| APOBEC3B | ELAVL2 | 0.159 | 0.416 | bioplex (ELAVL2) bioplex_WMM |
| ELAVL2 | YTHDC1 | 0.05 | 0.297 | bioplex (ELAVL2) bioplex_WMM youn_WMM |
| HNRNPCL1 | ELAVL2 | 0.046 | 0.293 | bioplex (ELAVL2) bioplex_WMM |
| ELAVL2 | PUM2 | 0.039 | 0.264 | bioplex (ELAVL2) bioplex_WMM youn_WMM |
| PPIL4 | SAFB2 | 0.035 | 0.26 | hein_WMM youn_WMM gupta_WMM fraction bioplex_WMM |
| ELAVL2 | SAFB2 | 0.035 | 0.262 | bioplex (ELAVL2) bioplex_WMM youn_WMM |
| RBMS2 | ELAVL2 | 0.028 | 0.23 | bioplex (ELAVL2) bioplex_WMM youn_WMM treiber_WMM |
| ELAVL2 | RO60 | 0.028 | 0.231 | bioplex (ELAVL2) bioplex_WMM youn_WMM |
| ELAVL2 | SUGP2 | 0.022 | 0.21 | bioplex (ELAVL2) bioplex_WMM youn_WMM |
| RBMS2 | PUM2 | 0.01 | 0.134 | bioplex_WMM youn_WMM WMM_only |
| APOBEC3B | ELAVL3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| RBMS2 | ELAVL3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| YTHDC1 | SAFB2 | 0.008 | 0.089 | bioplex_WMM youn_WMM WMM_only |
| RBMS2 | APOBEC3B | 0.008 | 0.083 | bioplex_WMM WMM_only treiber_WMM |
| HNRNPCL1 | ELAVL3 | 0.008 | 0.068 | bioplex_WMM WMM_only |
| SUGP2 | PUM2 | 0.008 | 0.062 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| ELAVL3 | PUM2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| ELAVL3 | SAFB2 | 0.008 | 0.059 | bioplex_WMM WMM_only |
| APOBEC3B | HNRNPCL1 | 0.008 | 0.045 | bioplex_WMM WMM_only |
| RBMS2 | HNRNPCL1 | 0.008 | 0.045 | bioplex_WMM WMM_only |
| ELAVL3 | YTHDC1 | 0.008 | 0.039 | bioplex_WMM WMM_only |
| APOBEC3B | SAFB2 | 0.008 | 0.037 | hein_WMM bioplex_WMM WMM_only treiber_WMM |
| HNRNPCL1 | YTHDC1 | 0.008 | 0.032 | bioplex_WMM youn_WMM WMM_only |
| RBMS2 | SAFB2 | 0.008 | 0.029 | bioplex_WMM youn_WMM WMM_only |
| APOBEC3B | PUM2 | 0.008 | 0.029 | bioplex_WMM WMM_only treiber_WMM |
| YTHDC1 | PUM2 | 0.008 | 0.02 | bioplex_WMM youn_WMM WMM_only |
| SUGP2 | SAFB2 | 0.008 | 0.026 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RBMS2 | YTHDC1 | 0.008 | 0.01 | bioplex_WMM youn_WMM WMM_only |
| APOBEC3B | YTHDC1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| RBMS2 | SUGP2 | 0.007 | 0.012 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| ELAVL3 | SUGP2 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| HNRNPCL1 | PUM2 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| HNRNPCL1 | SAFB2 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| ELAVL3 | RO60 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| PUM2 | SAFB2 | 0.007 | 0.007 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| PPIL4 | SUGP2 | 0.007 | 0.005 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RBMS2 | RO60 | 0.007 | 0.007 | bioplex_WMM youn_WMM WMM_only |
| APOBEC3B | SUGP2 | 0.007 | 0.006 | hein_WMM bioplex_WMM WMM_only |
| YTHDC1 | SUGP2 | 0.007 | 0.007 | bioplex_WMM youn_WMM WMM_only |
| PPIL4 | ELAVL2 | 0.007 | 0.002 | youn_WMM WMM_only |
| APOBEC3B | RO60 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| PPIL4 | YTHDC1 | 0.007 | 0.002 | youn_WMM WMM_only |
| PPIL4 | PUM2 | 0.007 | 0.001 | youn_WMM WMM_only |
| RBMS2 | PPIL4 | 0.007 | 0.001 | youn_WMM WMM_only |
| HNRNPCL1 | SUGP2 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| HNRNPCL1 | RO60 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| RO60 | PUM2 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| PPIL4 | RO60 | 0.006 | 0.004 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| YTHDC1 | RO60 | 0.006 | 0.006 | bioplex_WMM youn_WMM WMM_only |
| SUGP2 | RO60 | 0.006 | 0.007 | bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| RO60 | SAFB2 | 0.0 | 0.01 | bioplex_WMM youn_WMM fraction |
Images
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Complex HuMAP2_02016 has an average edge precision of 0.088 which is ranked 6955 out of all 6965 complexes.
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