hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02018
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KIRREL2 | Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3) | UniProt NCBI |
| CUL2 | Cullin-2 (CUL-2) | UniProt NCBI |
| VHL | von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:622 | 2.01342304124e-05 | 0.666666666667 | CUL2 VHL | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) |
| CORUM:205 | 3.35555483123e-05 | 0.666666666667 | CUL2 VHL | Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) |
| WP:WP4241 | 0.000416728443271 | 0.666666666667 | CUL2 VHL | Type 2 papillary renal cell carcinoma |
| KEGG:05211 | 0.00087223886567 | 0.666666666667 | CUL2 VHL | Renal cell carcinoma |
| KEGG:04066 | 0.00220707183162 | 0.666666666667 | CUL2 VHL | HIF-1 signaling pathway |
| KEGG:04120 | 0.00373360278335 | 0.666666666667 | CUL2 VHL | Ubiquitin mediated proteolysis |
| REAC:R-HSA-1234176 | 0.0138871493871 | 0.666666666667 | CUL2 VHL | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-1234174 | 0.0180259784934 | 0.666666666667 | CUL2 VHL | Cellular response to hypoxia |
| KEGG:05200 | 0.0473113658041 | 0.666666666667 | CUL2 VHL | Pathways in cancer |
| CORUM:6736 | 0.0499776345577 | 0.333333333333 | CUL2 | PRAME-Cullin2 ubiquitin ligase complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CUL2 | VHL | 0.134 | 0.405 | bioplex (VHL) bioplex_WMM boldt (VHL) boldt_WMM |
| KIRREL2 | VHL | 0.061 | 0.335 | bioplex (KIRREL2) bioplex_WMM |
| CUL2 | KIRREL2 | 0.003 | 0.019 | bioplex (KIRREL2) |
Images
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Complex HuMAP2_02018 has an average edge precision of 0.253 which is ranked 5335 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KIRREL2 | HuMAP2_00567 HuMAP2_01263 HuMAP2_02018 HuMAP2_02716 |
| CUL2 | HuMAP2_00567 HuMAP2_00652 HuMAP2_02018 HuMAP2_02341 |
| VHL | HuMAP2_00567 HuMAP2_01263 HuMAP2_02018 HuMAP2_02716 |