hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02024
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLR1C | DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40) | UniProt NCBI |
| POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8) | UniProt NCBI |
| POLR1D | Protein POLR1D, isoform 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03020 | 1.22093847236e-07 | 1.0 | POLR2H POLR1C POLR1D | RNA polymerase |
| REAC:R-HSA-73780 | 3.66871079381e-07 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase III Chain Elongation |
| REAC:R-HSA-73980 | 7.96236129391e-07 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase III Transcription Termination |
| KEGG:04623 | 9.27913238996e-07 | 1.0 | POLR2H POLR1C POLR1D | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-76066 | 1.31507096469e-06 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| REAC:R-HSA-76071 | 1.47287948045e-06 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| REAC:R-HSA-76061 | 1.47287948045e-06 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase III Transcription Initiation From Type 1 Promoter |
| REAC:R-HSA-73863 | 2.02093811497e-06 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-76046 | 3.21012194458e-06 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase III Transcription Initiation |
| WP:WP4655 | 3.22798847941e-06 | 1.0 | POLR2H POLR1C POLR1D | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-74158 | 4.79270307132e-06 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase III Transcription |
| REAC:R-HSA-749476 | 4.79270307132e-06 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase III Abortive And Retractive Initiation |
| WP:WP4022 | 5.09350508747e-06 | 1.0 | POLR2H POLR1C POLR1D | Pyrimidine metabolism |
| REAC:R-HSA-73762 | 7.29021391195e-06 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase I Transcription Initiation |
| REAC:R-HSA-1834949 | 1.78539429329e-05 | 1.0 | POLR2H POLR1C POLR1D | Cytosolic sensors of pathogen-associated DNA |
| GO:0001054 | 2.59741127426e-05 | 1.0 | POLR2H POLR1C POLR1D | RNA polymerase I activity |
| GO:0005736 | 2.59741127426e-05 | 1.0 | POLR2H POLR1C POLR1D | RNA polymerase I complex |
| GO:0001056 | 5.08584025729e-05 | 1.0 | POLR2H POLR1C POLR1D | RNA polymerase III activity |
| REAC:R-HSA-5250924 | 5.10580236014e-05 | 1.0 | POLR2H POLR1C POLR1D | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 5.28186451049e-05 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase I Promoter Escape |
| GO:0005666 | 7.41079580349e-05 | 1.0 | POLR2H POLR1C POLR1D | RNA polymerase III complex |
| REAC:R-HSA-5250913 | 8.18733958818e-05 | 1.0 | POLR2H POLR1C POLR1D | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 8.42814369371e-05 | 1.0 | POLR2H POLR1C POLR1D | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 9.17879069632e-05 | 1.0 | POLR2H POLR1C POLR1D | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 9.4385677915e-05 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 9.70320053332e-05 | 1.0 | POLR2H POLR1C POLR1D | RNA Polymerase I Transcription |
| HP:0011219 | 0.000132571377575 | 0.666666666667 | POLR1C POLR1D | Short face |
| REAC:R-HSA-212165 | 0.000228431198544 | 1.0 | POLR2H POLR1C POLR1D | Epigenetic regulation of gene expression |
| HP:0005701 | 0.00024744441095 | 0.666666666667 | POLR1C POLR1D | Multiple enchondromatosis |
| HP:0009795 | 0.00024744441095 | 0.666666666667 | POLR1C POLR1D | Branchial fistula |
| GO:0006362 | 0.000331851076788 | 1.0 | POLR2H POLR1C POLR1D | transcription elongation from RNA polymerase I promoter |
| GO:0006363 | 0.000408229499224 | 1.0 | POLR2H POLR1C POLR1D | termination of RNA polymerase I transcription |
| GO:0006361 | 0.000450460137075 | 1.0 | POLR2H POLR1C POLR1D | transcription initiation from RNA polymerase I promoter |
| HP:0009794 | 0.000485986227107 | 0.666666666667 | POLR1C POLR1D | Branchial anomaly |
| HP:0005990 | 0.000485986227107 | 0.666666666667 | POLR1C POLR1D | Thyroid hypoplasia |
| HP:0011386 | 0.000583157354768 | 0.666666666667 | POLR1C POLR1D | Narrow internal auditory canal |
| HP:0002006 | 0.000689155098282 | 0.666666666667 | POLR1C POLR1D | Facial cleft |
| GO:0003899 | 0.0007056603357 | 1.0 | POLR2H POLR1C POLR1D | DNA-directed 5'-3' RNA polymerase activity |
| WP:WP405 | 0.000785169744646 | 0.666666666667 | POLR2H POLR1D | Eukaryotic Transcription Initiation |
| HP:0008188 | 0.000803978270478 | 0.666666666667 | POLR1C POLR1D | Thyroid dysgenesis |
| GO:0097747 | 0.000897287531108 | 1.0 | POLR2H POLR1C POLR1D | RNA polymerase activity |
| GO:0034062 | 0.000897287531108 | 1.0 | POLR2H POLR1C POLR1D | 5'-3' RNA polymerase activity |
| HP:0030038 | 0.000927625684184 | 0.666666666667 | POLR1C POLR1D | Enchondroma |
| HP:0011384 | 0.000927625684184 | 0.666666666667 | POLR1C POLR1D | Abnormality of the internal auditory canal |
| HP:0002763 | 0.00120138848745 | 0.666666666667 | POLR1C POLR1D | Abnormal cartilage morphology |
| HP:0000143 | 0.00120138848745 | 0.666666666667 | POLR1C POLR1D | Rectovaginal fistula |
| HP:0100590 | 0.00135150150266 | 0.666666666667 | POLR1C POLR1D | Rectal fistula |
| HP:0000561 | 0.0015104340107 | 0.666666666667 | POLR1C POLR1D | Absent eyelashes |
| HP:0100819 | 0.00185475275658 | 0.666666666667 | POLR1C POLR1D | Intestinal fistula |
| HP:0000162 | 0.00185475275658 | 0.666666666667 | POLR1C POLR1D | Glossoptosis |
| HP:0002550 | 0.00204013662007 | 0.666666666667 | POLR1C POLR1D | Absent facial hair |
| HP:0004320 | 0.00223433522771 | 0.666666666667 | POLR1C POLR1D | Vaginal fistula |
| HP:0000778 | 0.00286980764378 | 0.666666666667 | POLR1C POLR1D | Hypoplasia of the thymus |
| GO:0006360 | 0.00295242108794 | 1.0 | POLR2H POLR1C POLR1D | transcription by RNA polymerase I |
| GO:0045815 | 0.00295242108794 | 1.0 | POLR2H POLR1C POLR1D | positive regulation of gene expression, epigenetic |
| HP:0000625 | 0.00309925335629 | 0.666666666667 | POLR1C POLR1D | Eyelid coloboma |
| HP:0010669 | 0.00333750787708 | 0.666666666667 | POLR1C POLR1D | Hypoplasia of the zygomatic bone |
| HP:0000643 | 0.00358457001899 | 0.666666666667 | POLR1C POLR1D | Blepharospasm |
| GO:0032481 | 0.00378386515143 | 1.0 | POLR2H POLR1C POLR1D | positive regulation of type I interferon production |
| HP:0010515 | 0.00384043859485 | 0.666666666667 | POLR1C POLR1D | Aplasia/Hypoplasia of the thymus |
| HP:0011226 | 0.00410511241748 | 0.666666666667 | POLR1C POLR1D | Aplasia/Hypoplasia of the eyelid |
| HP:0031879 | 0.00437859029972 | 0.666666666667 | POLR1C POLR1D | Abnormal eyelid physiology |
| HP:0032040 | 0.00437859029972 | 0.666666666667 | POLR1C POLR1D | Abnormal ocular adnexa physiology |
| HP:0002298 | 0.00495195349433 | 0.666666666667 | POLR1C POLR1D | Absent hair |
| HP:0100589 | 0.00525183643236 | 0.666666666667 | POLR1C POLR1D | Urogenital fistula |
| GO:0006353 | 0.00564855215433 | 1.0 | POLR2H POLR1C POLR1D | DNA-templated transcription, termination |
| HP:0010807 | 0.00587799905401 | 0.666666666667 | POLR1C POLR1D | Open bite |
| HP:0002692 | 0.00587799905401 | 0.666666666667 | POLR1C POLR1D | Hypoplastic facial bones |
| HP:0000777 | 0.00759733122278 | 0.666666666667 | POLR1C POLR1D | Abnormality of the thymus |
| HP:0000046 | 0.0079675754074 | 0.666666666667 | POLR1C POLR1D | Scrotal hypoplasia |
| HP:0000384 | 0.0108053329976 | 0.666666666667 | POLR1C POLR1D | Preauricular skin tag |
| HP:0011390 | 0.0126201279551 | 0.666666666667 | POLR1C POLR1D | Morphological abnormality of the inner ear |
| GO:0055029 | 0.0129761581422 | 1.0 | POLR2H POLR1C POLR1D | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.0133902908488 | 1.0 | POLR2H POLR1C POLR1D | DNA-directed RNA polymerase complex |
| HP:0002357 | 0.0135801907106 | 0.666666666667 | POLR1C POLR1D | Dysphasia |
| HP:0000294 | 0.0145753509873 | 0.666666666667 | POLR1C POLR1D | Low anterior hairline |
| GO:0030880 | 0.0146853637429 | 1.0 | POLR2H POLR1C POLR1D | RNA polymerase complex |
| GO:0032479 | 0.0155935495032 | 1.0 | POLR2H POLR1C POLR1D | regulation of type I interferon production |
| GO:0032606 | 0.0160613559883 | 1.0 | POLR2H POLR1C POLR1D | type I interferon production |
| HP:0012179 | 0.0161338784795 | 0.666666666667 | POLR1C POLR1D | Craniofacial dystonia |
| GO:0006354 | 0.0170248502613 | 1.0 | POLR2H POLR1C POLR1D | DNA-templated transcription, elongation |
| HP:0010622 | 0.017771321972 | 0.666666666667 | POLR1C POLR1D | Neoplasm of the skeletal system |
| HP:0002575 | 0.017771321972 | 0.666666666667 | POLR1C POLR1D | Tracheoesophageal fistula |
| HP:0200102 | 0.0183346678183 | 0.666666666667 | POLR1C POLR1D | Sparse or absent eyelashes |
| HP:0010609 | 0.0183346678183 | 0.666666666667 | POLR1C POLR1D | Skin tags |
| HP:0000383 | 0.0200772827833 | 0.666666666667 | POLR1C POLR1D | Abnormality of periauricular region |
| GO:0016779 | 0.0201449224406 | 1.0 | POLR2H POLR1C POLR1D | nucleotidyltransferase activity |
| HP:0004373 | 0.0225234057432 | 0.666666666667 | POLR1C POLR1D | Focal dystonia |
| HP:0000142 | 0.023156827915 | 0.666666666667 | POLR1C POLR1D | Abnormal vagina morphology |
| HP:0002034 | 0.0271411575623 | 0.666666666667 | POLR1C POLR1D | Abnormality of the rectum |
| HP:0011815 | 0.0314403819239 | 0.666666666667 | POLR1C POLR1D | Cephalocele |
| HP:0002084 | 0.0314403819239 | 0.666666666667 | POLR1C POLR1D | Encephalocele |
| HP:0000599 | 0.0344813463748 | 0.666666666667 | POLR1C POLR1D | Abnormality of the frontal hairline |
| HP:0000274 | 0.0352634284647 | 0.666666666667 | POLR1C POLR1D | Small face |
| HP:0000045 | 0.0368537935068 | 0.666666666667 | POLR1C POLR1D | Abnormality of the scrotum |
| HP:0000453 | 0.0376620740847 | 0.666666666667 | POLR1C POLR1D | Choanal atresia |
| HP:0008551 | 0.0393048254184 | 0.666666666667 | POLR1C POLR1D | Microtia |
| HP:0000415 | 0.041834410056 | 0.666666666667 | POLR1C POLR1D | Abnormality of the choanae |
| HP:0000327 | 0.0426950555564 | 0.666666666667 | POLR1C POLR1D | Hypoplasia of the maxilla |
| HP:0008772 | 0.0426950555564 | 0.666666666667 | POLR1C POLR1D | Aplasia/Hypoplasia of the external ear |
| HP:0008771 | 0.0462248590062 | 0.666666666667 | POLR1C POLR1D | Aplasia/Hypoplasia of the ear |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLR1C | POLR1D | 1.0 | 0.949 | hein_WMM bioplex (POLR1C) bioplex_WMM Malo fraction |
| POLR1C | POLR2H | 0.923 | 0.844 | hein_WMM bioplex (POLR1C) bioplex_WMM youn_WMM gupta_WMM fraction |
| POLR1D | POLR2H | 0.004 | 0.013 | hein_WMM bioplex_WMM youn_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_02024 has an average edge precision of 0.602 which is ranked 1935 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| POLR1C | HuMAP2_00232 HuMAP2_02024 HuMAP2_02071 HuMAP2_02439 HuMAP2_02562 HuMAP2_04738 |
| POLR2H | HuMAP2_02024 HuMAP2_05090 HuMAP2_05703 HuMAP2_05762 HuMAP2_05766 |
| POLR1D | HuMAP2_00232 HuMAP2_01570 HuMAP2_02024 HuMAP2_02071 HuMAP2_02562 HuMAP2_03631 HuMAP2_04738 |