hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02034
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ATP6V0A1 | V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) | UniProt NCBI |
| ATP6V0D1 | V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1) | UniProt NCBI |
| ATP6V0A2 | V-type proton ATPase 116 kDa subunit a isoform 2 (V-ATPase 116 kDa isoform a2) (Lysosomal H(+)-transporting ATPase V0 subunit a2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 6.91664651832e-08 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Collecting duct acid secretion |
| KEGG:05110 | 5.20131818177e-07 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Vibrio cholerae infection |
| KEGG:05323 | 8.33606267338e-07 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Rheumatoid arthritis |
| REAC:R-HSA-77387 | 9.09984147875e-07 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Insulin receptor recycling |
| KEGG:05120 | 1.08230481824e-06 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:04721 | 1.44061718026e-06 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Synaptic vesicle cycle |
| REAC:R-HSA-917977 | 1.64282711281e-06 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Transferrin endocytosis and recycling |
| REAC:R-HSA-1222556 | 2.23000067859e-06 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | ROS and RNS production in phagocytes |
| KEGG:00190 | 8.02679835688e-06 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Oxidative phosphorylation |
| KEGG:04142 | 8.02679835688e-06 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Lysosome |
| REAC:R-HSA-917937 | 1.11518017806e-05 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Iron uptake and transport |
| KEGG:04145 | 1.20588724809e-05 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Phagosome |
| REAC:R-HSA-74752 | 1.46159459799e-05 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Signaling by Insulin receptor |
| KEGG:05152 | 1.65789009806e-05 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Tuberculosis |
| GO:0046961 | 4.13224520905e-05 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | proton-transporting ATPase activity, rotational mechanism |
| GO:0016471 | 6.17566316957e-05 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | vacuolar proton-transporting V-type ATPase complex |
| GO:0007035 | 8.80032001664e-05 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | vacuolar acidification |
| GO:0033176 | 8.80032001664e-05 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | proton-transporting V-type ATPase complex |
| KEGG:05165 | 0.000150762444884 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Human papillomavirus infection |
| GO:0044769 | 0.000208882724853 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism |
| GO:0090383 | 0.000265644334868 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | phagosome acidification |
| REAC:R-HSA-983712 | 0.000301193962621 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Ion channel transport |
| GO:0033572 | 0.000495506150782 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | transferrin transport |
| GO:0009678 | 0.000594407580071 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity |
| GO:0090382 | 0.000648444632805 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | phagosome maturation |
| GO:0030670 | 0.000829990966275 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | phagocytic vesicle membrane |
| GO:0051452 | 0.000968126020406 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | intracellular pH reduction |
| GO:0016469 | 0.000968126020406 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | proton-transporting two-sector ATPase complex |
| GO:0045851 | 0.00104259725275 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | pH reduction |
| GO:0019829 | 0.00225266395968 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | ATPase-coupled cation transmembrane transporter activity |
| GO:0006826 | 0.00238262534197 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | iron ion transport |
| GO:0042625 | 0.00280229798177 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | ATPase-coupled ion transmembrane transporter activity |
| GO:0051453 | 0.00435066388439 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | regulation of intracellular pH |
| GO:0030641 | 0.00475834847216 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | regulation of cellular pH |
| REAC:R-HSA-9006934 | 0.00501472976187 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Signaling by Receptor Tyrosine Kinases |
| GO:0006885 | 0.00541641987402 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | regulation of pH |
| GO:0045335 | 0.00774864090629 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | phagocytic vesicle |
| GO:0030004 | 0.00774864090629 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | cellular monovalent inorganic cation homeostasis |
| GO:0000041 | 0.00865355719779 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | transition metal ion transport |
| KEGG:01100 | 0.0105851300972 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Metabolic pathways |
| GO:0008286 | 0.0121736852044 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | insulin receptor signaling pathway |
| GO:0015078 | 0.0129761581422 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | proton transmembrane transporter activity |
| GO:0042626 | 0.0133902908488 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | ATPase-coupled transmembrane transporter activity |
| GO:0015399 | 0.0151349156943 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | primary active transmembrane transporter activity |
| REAC:R-HSA-382551 | 0.0162665061596 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | Transport of small molecules |
| GO:0055067 | 0.0170248502613 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | monovalent inorganic cation homeostasis |
| GO:0030666 | 0.0212638981157 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | endocytic vesicle membrane |
| GO:0032869 | 0.0415322430011 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | cellular response to insulin stimulus |
| GO:0016241 | 0.0442598881134 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | regulation of macroautophagy |
| GO:0032868 | 0.0480789908723 | 1.0 | ATP6V0A1 ATP6V0A2 ATP6V0D1 | response to insulin |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP6V0D1 | ATP6V0A1 | 1.0 | 0.949 | hein_WMM bioplex (ATP6V0D1) bioplex_WMM Guru fraction |
| ATP6V0D1 | ATP6V0A2 | 0.533 | 0.637 | bioplex (ATP6V0A2,ATP6V0D1) bioplex_WMM |
| ATP6V0A1 | ATP6V0A2 | 0.324 | 0.512 | bioplex (ATP6V0A2) bioplex_WMM gupta_WMM |
Images
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Complex HuMAP2_02034 has an average edge precision of 0.699 which is ranked 1373 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ATP6V0A1 | HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_02034 HuMAP2_02651 HuMAP2_04677 |
| ATP6V0D1 | HuMAP2_00515 HuMAP2_00772 HuMAP2_01018 HuMAP2_01065 HuMAP2_01270 HuMAP2_02034 HuMAP2_02651 HuMAP2_04677 HuMAP2_06925 |
| ATP6V0A2 | HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_02034 HuMAP2_04677 |