hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02045
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BCL2L1 | Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) | UniProt NCBI |
| BAD | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | UniProt NCBI |
| BCL2L15 | Bcl-2-like protein 15 (Bcl2-L-15) | UniProt NCBI |
| BAX | Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) | UniProt NCBI |
| BCL2 | Apoptosis regulator Bcl-2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3872 | 4.37388476407e-10 | 0.8 | BCL2L15 BCL2L1 BAX BCL2 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| WP:WP2447 | 6.65729208537e-09 | 0.8 | BCL2 BCL2L1 BAX BAD | Amyotrophic lateral sclerosis (ALS) |
| KEGG:05014 | 2.89574100843e-08 | 0.8 | BCL2 BCL2L1 BAX BAD | Amyotrophic lateral sclerosis (ALS) |
| REAC:R-HSA-109606 | 8.38983891617e-08 | 0.8 | BCL2 BCL2L1 BAX BAD | Intrinsic Pathway for Apoptosis |
| WP:WP254 | 9.79793498057e-08 | 0.8 | BCL2 BCL2L1 BAX BAD | Apoptosis |
| KEGG:01524 | 1.1907721613e-07 | 0.8 | BCL2 BCL2L1 BAX BAD | Platinum drug resistance |
| KEGG:01521 | 1.33164750997e-07 | 0.8 | BCL2 BCL2L1 BAX BAD | EGFR tyrosine kinase inhibitor resistance |
| WP:WP1772 | 1.49703551962e-07 | 0.8 | BCL2 BCL2L1 BAX BAD | Apoptosis Modulation and Signaling |
| REAC:R-HSA-111453 | 2.28267971382e-07 | 0.6 | BCL2 BCL2L1 BAD | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| KEGG:04210 | 1.11852153694e-06 | 0.8 | BCL2 BCL2L1 BAX BAD | Apoptosis |
| KEGG:05162 | 1.2310381019e-06 | 0.8 | BCL2 BCL2L1 BAX BAD | Measles |
| KEGG:04215 | 3.50210741481e-06 | 0.6 | BCL2 BCL2L1 BAX | Apoptosis - multiple species |
| GO:0051434 | 3.6323771075e-06 | 0.6 | BCL2 BCL2L1 BAX | BH3 domain binding |
| GO:0051400 | 3.6323771075e-06 | 0.6 | BCL2 BCL2L1 BAX | BH domain binding |
| KEGG:05170 | 7.28696714432e-06 | 0.8 | BCL2 BCL2L1 BAX BAD | Human immunodeficiency virus 1 infection |
| WP:WP286 | 7.69263363807e-06 | 0.6 | BCL2 BCL2L1 BAD | IL-3 Signaling Pathway |
| WP:WP1971 | 8.26874661986e-06 | 0.6 | BCL2 BAD BAX | Integrated Cancer Pathway |
| GO:2001244 | 1.00139303444e-05 | 0.8 | BCL2 BCL2L1 BAX BAD | positive regulation of intrinsic apoptotic signaling pathway |
| WP:WP3611 | 1.08600279875e-05 | 0.6 | BCL2 BCL2L1 BAX | Photodynamic therapy-induced AP-1 survival signaling. |
| REAC:R-HSA-109581 | 1.18707037161e-05 | 0.8 | BCL2 BCL2L1 BAX BAD | Apoptosis |
| REAC:R-HSA-5357801 | 1.27422309093e-05 | 0.8 | BCL2 BCL2L1 BAX BAD | Programmed Cell Death |
| GO:0051881 | 1.36251014669e-05 | 0.8 | BCL2 BCL2L1 BAX BAD | regulation of mitochondrial membrane potential |
| GO:0001836 | 1.50217389985e-05 | 0.8 | BCL2 BCL2L1 BAX BAD | release of cytochrome c from mitochondria |
| GO:0070513 | 1.81582264982e-05 | 0.6 | BCL2 BCL2L1 BAX | death domain binding |
| KEGG:04115 | 3.58157342459e-05 | 0.6 | BCL2 BCL2L1 BAX | p53 signaling pathway |
| WP:WP4216 | 3.81869950786e-05 | 0.6 | BCL2 BAD BAX | Chromosomal and microsatellite instability in colorectal cancer |
| REAC:R-HSA-844455 | 4.04876825444e-05 | 0.4 | BCL2 BCL2L1 | The NLRP1 inflammasome |
| WP:WP2034 | 4.32977577664e-05 | 0.6 | BAX BCL2L1 BAD | Leptin signaling pathway |
| WP:WP4298 | 4.50972726e-05 | 0.6 | BCL2 BCL2L1 BAX | Viral Acute Myocarditis |
| KEGG:05212 | 4.90975651011e-05 | 0.6 | BAX BCL2L1 BAD | Pancreatic cancer |
| GO:0046902 | 5.1601378618e-05 | 0.8 | BCL2 BCL2L1 BAX BAD | regulation of mitochondrial membrane permeability |
| KEGG:05220 | 5.56685456996e-05 | 0.6 | BAX BCL2L1 BAD | Chronic myeloid leukemia |
| WP:WP4263 | 6.13140713704e-05 | 0.6 | BAX BCL2L1 BAD | Pancreatic adenocarcinoma pathway |
| WP:WP231 | 7.31920604822e-05 | 0.6 | BAX BCL2L1 BAD | TNF alpha Signaling Pathway |
| KEGG:05210 | 7.59906976524e-05 | 0.6 | BCL2 BAD BAX | Colorectal cancer |
| GO:0090559 | 8.23131966602e-05 | 0.8 | BCL2 BCL2L1 BAX BAD | regulation of membrane permeability |
| WP:WP4658 | 9.22551217476e-05 | 0.6 | BCL2 BCL2L1 BAX | Small cell lung cancer |
| KEGG:05168 | 9.63165855874e-05 | 0.8 | BCL2 BCL2L1 BAX BAD | Herpes simplex virus 1 infection |
| KEGG:01522 | 0.000100724565592 | 0.6 | BCL2 BAD BAX | Endocrine resistance |
| KEGG:05222 | 0.00010764753353 | 0.6 | BCL2 BCL2L1 BAX | Small cell lung cancer |
| KEGG:05145 | 0.000114879653041 | 0.6 | BCL2 BCL2L1 BAD | Toxoplasmosis |
| WP:WP710 | 0.00012126383097 | 0.6 | BCL2 BAD BAX | DNA Damage Response (only ATM dependent) |
| KEGG:04722 | 0.000169883843985 | 0.6 | BCL2 BAD BAX | Neurotrophin signaling pathway |
| KEGG:05200 | 0.000217862252065 | 0.8 | BCL2 BCL2L1 BAX BAD | Pathways in cancer |
| WP:WP1984 | 0.000323211998967 | 0.6 | BCL2 BAD BAX | Integrated Breast Cancer Pathway |
| GO:0008637 | 0.000324482580121 | 0.8 | BCL2 BCL2L1 BAX BAD | apoptotic mitochondrial changes |
| KEGG:04140 | 0.000327209764734 | 0.6 | BCL2 BCL2L1 BAD | Autophagy - animal |
| WP:WP4666 | 0.000330006954152 | 0.6 | BCL2 BAD BAX | Hepatitis B infection |
| WP:WP1742 | 0.00045324857597 | 0.4 | BCL2 BAX | TP53 Network |
| WP:WP3287 | 0.00045324857597 | 0.4 | BCL2 BAX | Overview of nanoparticle effects |
| KEGG:05152 | 0.00046980759615 | 0.6 | BCL2 BAD BAX | Tuberculosis |
| WP:WP3657 | 0.000509836133129 | 0.4 | BCL2 BCL2L1 | Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex |
| KEGG:05161 | 0.000518446983019 | 0.6 | BCL2 BAD BAX | Hepatitis B |
| KEGG:05225 | 0.000559677819772 | 0.6 | BAX BCL2L1 BAD | Hepatocellular carcinoma |
| WP:WP2507 | 0.000569740286986 | 0.4 | BCL2 BAX | Nanomaterial induced apoptosis |
| GO:2001235 | 0.000650038064497 | 0.8 | BCL2 BCL2L1 BAX BAD | positive regulation of apoptotic signaling pathway |
| GO:0007006 | 0.000674764960334 | 0.8 | BCL2 BCL2L1 BAX BAD | mitochondrial membrane organization |
| GO:2001242 | 0.000700189954213 | 0.8 | BCL2 BCL2L1 BAX BAD | regulation of intrinsic apoptotic signaling pathway |
| WP:WP205 | 0.000769338921543 | 0.4 | BCL2L1 BAD | IL-7 Signaling Pathway |
| GO:0005741 | 0.00106458629457 | 0.8 | BCL2 BCL2L1 BAX BAD | mitochondrial outer membrane |
| REAC:R-HSA-111447 | 0.00141478632427 | 0.4 | BCL2 BAD | Activation of BAD and translocation to mitochondria |
| GO:0031968 | 0.00146369592834 | 0.8 | BCL2 BCL2L1 BAX BAD | organelle outer membrane |
| GO:0019867 | 0.00150900020821 | 0.8 | BCL2 BCL2L1 BAX BAD | outer membrane |
| GO:0097191 | 0.0016027516158 | 0.8 | BCL2 BCL2L1 BAX BAD | extrinsic apoptotic signaling pathway |
| GO:0010821 | 0.00170079952717 | 0.8 | BCL2 BCL2L1 BAX BAD | regulation of mitochondrion organization |
| WP:WP3981 | 0.00175589070762 | 0.4 | BCL2 BAD | miRNA regulation of prostate cancer signaling pathways |
| WP:WP3614 | 0.00175589070762 | 0.4 | BAX BCL2L1 | Photodynamic therapy-induced HIF-1 survival signaling |
| WP:WP3941 | 0.0022136258273 | 0.4 | BCL2 BAD | Oxidative Damage |
| REAC:R-HSA-622312 | 0.00230284247734 | 0.4 | BCL2 BCL2L1 | Inflammasomes |
| WP:WP4172 | 0.00254843909372 | 0.6 | BCL2 BCL2L1 BAD | PI3K-Akt Signaling Pathway |
| WP:WP364 | 0.00285983596887 | 0.4 | BCL2L1 BAD | IL-6 signaling pathway |
| WP:WP4008 | 0.00299893680898 | 0.4 | BCL2 BAD | NO/cGMP/PKG mediated Neuroprotection |
| GO:0001844 | 0.00330982532021 | 0.6 | BCL2 BAD BAX | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| KEGG:04151 | 0.00373902224905 | 0.6 | BCL2 BCL2L1 BAD | PI3K-Akt signaling pathway |
| GO:1901030 | 0.0049400991777 | 0.6 | BCL2 BAD BAX | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| WP:WP304 | 0.00510552962608 | 0.4 | BCL2 BAD | Kit receptor signaling pathway |
| GO:0090199 | 0.00541762673764 | 0.6 | BAX BCL2L1 BAD | regulation of release of cytochrome c from mitochondria |
| REAC:R-HSA-114452 | 0.00584945327803 | 0.4 | BCL2 BAD | Activation of BH3-only proteins |
| WP:WP4155 | 0.0062641329336 | 0.4 | BAX BAD | Endometrial cancer |
| KEGG:05213 | 0.00680203716674 | 0.4 | BAX BAD | Endometrial cancer |
| WP:WP3303 | 0.00688743357746 | 0.4 | BAX BAD | RAC1/PAK1/p38/MMP2 Pathway |
| GO:0038034 | 0.00703245670927 | 0.6 | BCL2 BCL2L1 BAX | signal transduction in absence of ligand |
| GO:0097192 | 0.00703245670927 | 0.6 | BCL2 BCL2L1 BAX | extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0097193 | 0.00780704088192 | 0.8 | BCL2 BCL2L1 BAX BAD | intrinsic apoptotic signaling pathway |
| WP:WP4255 | 0.00799132765459 | 0.4 | BAX BAD | Non-small cell lung cancer |
| KEGG:05218 | 0.00805388520034 | 0.4 | BAX BAD | Melanoma |
| GO:1901028 | 0.00826983957236 | 0.6 | BCL2 BAD BAX | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| KEGG:05223 | 0.00858395707223 | 0.4 | BAX BAD | Non-small cell lung cancer |
| GO:0070059 | 0.0111628079368 | 0.6 | BCL2 BCL2L1 BAX | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| GO:0051204 | 0.0119783897598 | 0.6 | BCL2 BAD BAX | protein insertion into mitochondrial membrane |
| GO:0006839 | 0.0123084612281 | 0.8 | BCL2 BCL2L1 BAX BAD | mitochondrial transport |
| WP:WP1438 | 0.0124335427142 | 0.2 | BCL2 | Influenza A virus infection |
| KEGG:04064 | 0.0130921728933 | 0.4 | BCL2 BCL2L1 | NF-kappa B signaling pathway |
| GO:0097345 | 0.0156368617465 | 0.6 | BCL2 BAD BAX | mitochondrial outer membrane permeabilization |
| KEGG:05215 | 0.0169933560846 | 0.4 | BCL2 BAD | Prostate cancer |
| KEGG:04933 | 0.0173728888545 | 0.4 | BCL2 BAX | AGE-RAGE signaling pathway in diabetic complications |
| GO:1902110 | 0.0177162705742 | 0.6 | BCL2 BAD BAX | positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| REAC:R-HSA-168643 | 0.0184727645209 | 0.4 | BCL2 BCL2L1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| GO:2001233 | 0.0188190633636 | 0.8 | BCL2 BCL2L1 BAX BAD | regulation of apoptotic signaling pathway |
| GO:0042391 | 0.0191240231491 | 0.8 | BCL2 BCL2L1 BAX BAD | regulation of membrane potential |
| GO:1902686 | 0.0199719657189 | 0.6 | BCL2 BAD BAX | mitochondrial outer membrane permeabilization involved in programmed cell death |
| GO:0035794 | 0.0211681462149 | 0.6 | BCL2 BAD BAX | positive regulation of mitochondrial membrane permeability |
| GO:1902108 | 0.0211681462149 | 0.6 | BCL2 BAD BAX | regulation of mitochondrial membrane permeability involved in apoptotic process |
| GO:0051205 | 0.0211681462149 | 0.6 | BCL2 BAD BAX | protein insertion into membrane |
| GO:1905710 | 0.022411068229 | 0.6 | BCL2 BAD BAX | positive regulation of membrane permeability |
| KEGG:04071 | 0.0249106474345 | 0.4 | BCL2 BAX | Sphingolipid signaling pathway |
| CORUM:2000 | 0.0249780992026 | 0.2 | BAX | BAX homo-oligomer complex |
| CORUM:3492 | 0.0249780992026 | 0.2 | BAX | BAX homo-oligomer complex |
| GO:0008625 | 0.0264291737868 | 0.6 | BCL2 BCL2L1 BAX | extrinsic apoptotic signaling pathway via death domain receptors |
| MIRNA:hsa-miR-184 | 0.0270575118475 | 0.4 | BCL2 BCL2L1 | hsa-miR-184 |
| KEGG:04630 | 0.030676003082 | 0.4 | BCL2 BCL2L1 | JAK-STAT signaling pathway |
| KEGG:05226 | 0.0359303198923 | 0.4 | BCL2 BAX | Gastric cancer |
| KEGG:05160 | 0.038710268063 | 0.4 | BAX BAD | Hepatitis C |
| WP:WP4223 | 0.0390434201563 | 0.4 | BCL2L1 BAD | Ras Signaling |
| KEGG:04217 | 0.0482876775804 | 0.4 | BCL2 BAX | Necroptosis |
| GO:0008630 | 0.0493791608738 | 0.6 | BCL2 BCL2L1 BAX | intrinsic apoptotic signaling pathway in response to DNA damage |
| WP:WP4399 | 0.0497141369515 | 0.2 | BCL2 | MicroRNA network associated with chronic lymphocytic leukemia |
| CORUM:5811 | 0.0499494897235 | 0.2 | BCL2 | p53-BCL2 complex |
| CORUM:5526 | 0.0499494897235 | 0.2 | BCL2 | CALM1-FKBP38-BCL2 complex |
| CORUM:1062 | 0.0499494897235 | 0.2 | BCL2 | BAR-BCL2-CASP8 complex |
| CORUM:7275 | 0.0499494897235 | 0.2 | BCL2 | BCL2-CISD2 complex |
| CORUM:5812 | 0.0499494897235 | 0.2 | BCL2L1 | p53-BCL2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BAD | BCL2L1 | 0.976 | 0.892 | bioplex (BCL2L1) bioplex_WMM |
| BAX | BCL2L1 | 0.939 | 0.85 | hein_WMM bioplex (BCL2L1) bioplex_WMM hein (BAX) |
| BCL2 | BCL2L1 | 0.831 | 0.778 | bioplex (BCL2L1) bioplex_WMM |
| BCL2L1 | BCL2L15 | 0.024 | 0.213 | bioplex (BCL2L15) bioplex_WMM |
| BAX | BCL2L15 | 0.016 | 0.162 | bioplex (BCL2L15) bioplex_WMM |
| BAX | BCL2 | 0.01 | 0.132 | bioplex_WMM WMM_only |
| BAD | BCL2 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| BAX | BAD | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02045 has an average edge precision of 0.401 which is ranked 3306 out of all 6965 complexes.
Related Complexes