hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02047

Confidence: Very High

Genename	Protein Name	Links
DNAJC7	DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)	UniProt NCBI
RNASEH2A	Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A)	UniProt NCBI
RNASEH2C	Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C)	UniProt NCBI
RNASEH2B	Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0200149	1.06823858061e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	CSF lymphocytic pleiocytosis
HP:0009704	1.06823858061e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Chronic CSF lymphocytosis
HP:0009709	1.06823858061e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Increased CSF interferon alpha
HP:0009710	1.06823858061e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Chilblains
HP:0030356	1.06823858061e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Increased serum interferon-gamma level
HP:0012229	1.06823858061e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	CSF pleocytosis
HP:0005550	1.709095627e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Chronic lymphatic leukemia
HP:0001955	1.709095627e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Unexplained fevers
HP:0040140	1.709095627e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Degeneration of the striatum
HP:0030355	2.56351428753e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal serum interferon-gamma level
HP:0030354	2.56351428753e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal serum interferon level
GO:0032299	3.63274304092e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	ribonuclease H2 complex
HP:0011834	3.66197876365e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Moyamoya phenomenon
HP:0007052	3.66197876365e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Multifocal cerebral white matter abnormalities
HP:0004809	6.71295121779e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Neonatal alloimmune thrombocytopenia
HP:0003683	8.72639684801e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Large beaked nose
HP:0007076	8.72639684801e-07	0.75	RNASEH2C RNASEH2A RNASEH2B	Extrapyramidal muscular rigidity
HP:0011112	1.11057635982e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of serum cytokine level
HP:0030038	1.38815049192e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Enchondroma
HP:0011111	1.38815049192e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of immune serum protein physiology
HP:0005558	1.70840681115e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Chronic leukemia
HP:0004963	1.70840681115e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Calcification of the aorta
KEGG:03030	1.91812405155e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	DNA replication
HP:0030880	2.48914185619e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Raynaud phenomenon
HP:0012490	3.47712703514e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Panniculitis
HP:0001063	4.05644371545e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Acrocyanosis
HP:0003207	6.17218075444e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Arterial calcification
HP:0004934	7.01348813327e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Vascular calcification
HP:0002132	7.01348813327e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Porencephalic cyst
HP:0000625	8.91842784173e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Eyelid coloboma
HP:0011915	8.91842784173e-06	0.75	RNASEH2C RNASEH2A RNASEH2B	Cardiovascular calcification
HP:0010994	1.11400508422e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal corpus striatum morphology
HP:0002139	1.11400508422e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Arrhinencephaly
HP:0100614	1.23772100297e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Myositis
HP:0025323	1.23772100297e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal arterial physiology
HP:0006579	1.37026485536e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Prolonged neonatal jaundice
HP:0011226	1.37026485536e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Aplasia/Hypoplasia of the eyelid
HP:0007108	1.66305025548e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Demyelinating peripheral neuropathy
HP:0002371	1.82389859666e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Loss of speech
HP:0001087	2.36790565399e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Developmental glaucoma
HP:0002313	2.57073928928e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Spastic paraparesis
HP:0002828	5.61131031658e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Multiple joint contractures
HP:0000961	6.34193111797e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Cyanosis
HP:0002385	7.13330500581e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Paraparesis
HP:0002323	9.39339580894e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Anencephaly
HP:0001357	9.89611360418e-05	0.75	RNASEH2C RNASEH2A RNASEH2B	Plagiocephaly
HP:0000965	0.00010416435544	0.75	RNASEH2C RNASEH2A RNASEH2B	Cutis marmorata
HP:0001433	0.000109546633338	0.75	RNASEH2C RNASEH2A RNASEH2B	Hepatosplenomegaly
HP:0001609	0.000109546633338	0.75	RNASEH2C RNASEH2A RNASEH2B	Hoarse voice
HP:0010622	0.000126797979354	0.75	RNASEH2C RNASEH2A RNASEH2B	Neoplasm of the skeletal system
HP:0002180	0.00014576940679	0.75	RNASEH2C RNASEH2A RNASEH2B	Neurodegeneration
HP:0003552	0.000152489520052	0.75	RNASEH2C RNASEH2A RNASEH2B	Muscle stiffness
HP:0001640	0.000166542276482	0.75	RNASEH2C RNASEH2A RNASEH2B	Cardiomegaly
HP:0002510	0.000189197899452	0.75	RNASEH2C RNASEH2A RNASEH2B	Spastic tetraplegia
HP:0100578	0.000205387753182	0.75	RNASEH2C RNASEH2A RNASEH2B	Lipoatrophy
HP:0004942	0.000322204655363	0.75	RNASEH2C RNASEH2A RNASEH2B	Aortic aneurysm
HP:0025454	0.000322204655363	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal CSF metabolite level
HP:0002415	0.0004073240164	0.75	RNASEH2C RNASEH2A RNASEH2B	Leukodystrophy
HP:0002187	0.000476501757358	0.75	RNASEH2C RNASEH2A RNASEH2B	Intellectual disability, profound
HP:0009125	0.000521539375712	0.75	RNASEH2C RNASEH2A RNASEH2B	Lipodystrophy
HP:0009145	0.000569323965231	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal cerebral artery morphology
HP:0002514	0.000585876554513	0.75	RNASEH2C RNASEH2A RNASEH2B	Cerebral calcification
HP:0000958	0.000831010499476	0.75	RNASEH2C RNASEH2A RNASEH2B	Dry skin
HP:0001909	0.000873899018529	0.75	RNASEH2C RNASEH2A RNASEH2B	Leukemia
HP:0008936	0.000940953761592	0.75	RNASEH2C RNASEH2A RNASEH2B	Muscular hypotonia of the trunk
HP:0002960	0.000940953761592	0.75	RNASEH2C RNASEH2A RNASEH2B	Autoimmunity
HP:0000737	0.00101134633775	0.75	RNASEH2C RNASEH2A RNASEH2B	Irritability
HP:0002617	0.00124335446085	0.75	RNASEH2C RNASEH2A RNASEH2B	Dilatation
HP:0030163	0.00141618772939	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal vascular physiology
HP:0000952	0.00157185823159	0.75	RNASEH2C RNASEH2A RNASEH2B	Jaundice
HP:0002063	0.00160429803987	0.75	RNASEH2C RNASEH2A RNASEH2B	Rigidity
HP:0002061	0.00202891029227	0.75	RNASEH2C RNASEH2A RNASEH2B	Lower limb spasticity
HP:0001369	0.00210622821499	0.75	RNASEH2C RNASEH2A RNASEH2B	Arthritis
HP:0002134	0.00210622821499	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of the basal ganglia
HP:0010766	0.0023922283415	0.75	RNASEH2C RNASEH2A RNASEH2B	Ectopic calcification
HP:0004374	0.00247843647398	0.75	RNASEH2C RNASEH2A RNASEH2B	Hemiplegia/hemiparesis
HP:0009124	0.00256668512029	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal adipose tissue morphology
HP:0000054	0.0028439099223	0.75	RNASEH2C RNASEH2A RNASEH2B	Micropenis
HP:0011119	0.00289196481854	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of the nasal dorsum
HP:0010551	0.0029405563548	0.75	RNASEH2C RNASEH2A RNASEH2B	Paraplegia/paraparesis
HP:0002355	0.00298968747372	0.75	RNASEH2C RNASEH2A RNASEH2B	Difficulty walking
HP:0011400	0.00298968747372	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal CNS myelination
HP:0002910	0.00340251431469	0.75	RNASEH2C RNASEH2A RNASEH2B	Elevated hepatic transaminase
HP:0001396	0.00345663399483	0.75	RNASEH2C RNASEH2A RNASEH2B	Cholestasis
HP:0001005	0.00367883182322	0.75	RNASEH2C RNASEH2A RNASEH2B	Dermatological manifestations of systemic disorders
HP:0001679	0.00409014842826	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal aortic morphology
HP:0002071	0.00433834919234	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of extrapyramidal motor function
HP:0000821	0.00433834919234	0.75	RNASEH2C RNASEH2A RNASEH2B	Hypothyroidism
HP:0007700	0.00446611555555	0.75	RNASEH2C RNASEH2A RNASEH2B	Ocular anterior segment dysgenesis
HP:0004377	0.00459635712378	0.75	RNASEH2C RNASEH2A RNASEH2B	Hematological neoplasm
HP:0002926	0.00479641167228	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of thyroid physiology
HP:0001639	0.00514254331689	0.75	RNASEH2C RNASEH2A RNASEH2B	Hypertrophic cardiomyopathy
HP:0100659	0.00528551172659	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of the cerebral vasculature
HP:0001945	0.00543109559899	0.75	RNASEH2C RNASEH2A RNASEH2B	Fever
HP:0003819	0.00574003251223	0.5	RNASEH2C RNASEH2A	Death in childhood
HP:0002315	0.00652537513546	0.75	RNASEH2C RNASEH2A RNASEH2B	Headache
HP:0000501	0.00775694691432	0.75	RNASEH2C RNASEH2A RNASEH2B	Glaucoma
HP:0001873	0.00852541144013	0.75	RNASEH2C RNASEH2A RNASEH2B	Thrombocytopenia
HP:0002376	0.00862487853069	0.75	RNASEH2C RNASEH2A RNASEH2B	Developmental regression
HP:0004297	0.00934279216777	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of the biliary system
HP:0011873	0.0102105700644	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal platelet count
HP:0004370	0.0113684155376	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of temperature regulation
HP:0000820	0.0121032286381	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of the thyroid gland
HP:0007256	0.0133967549828	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal pyramidal sign
HP:0001872	0.0139387949708	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal thrombocyte morphology
HP:0000819	0.0146365452656	0.75	RNASEH2C RNASEH2A RNASEH2B	Diabetes mellitus
HP:0004302	0.0152111292306	0.75	RNASEH2C RNASEH2A RNASEH2B	Functional motor deficit
HP:0001952	0.0158004749793	0.75	RNASEH2C RNASEH2A RNASEH2B	Glucose intolerance
HP:0002079	0.0161007407271	0.75	RNASEH2C RNASEH2A RNASEH2B	Hypoplasia of the corpus callosum
HP:0011004	0.016867901027	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal systemic arterial morphology
HP:0001608	0.0173396229329	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of the voice
HP:0008736	0.0201786179727	0.75	RNASEH2C RNASEH2A RNASEH2B	Hypoplasia of penis
HP:0100851	0.0203545802465	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal emotion/affect behavior
HP:0001332	0.0219842049556	0.75	RNASEH2C RNASEH2A RNASEH2B	Dystonia
HP:0010549	0.0233097913112	0.75	RNASEH2C RNASEH2A RNASEH2B	Weakness due to upper motor neuron dysfunction
HP:0012447	0.0257035156736	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal myelination
HP:0030962	0.0286954928674	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal morphology of the great vessels
HP:0025408	0.0289176088458	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal spleen morphology
HP:0002921	0.0295907808511	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of the cerebrospinal fluid
HP:0000050	0.0307356499029	0.75	RNASEH2C RNASEH2A RNASEH2B	Hypoplastic male external genitalia
HP:0001638	0.0319094681526	0.75	RNASEH2C RNASEH2A RNASEH2B	Cardiomyopathy
HP:0011276	0.0326278007787	0.75	RNASEH2C RNASEH2A RNASEH2B	Vascular skin abnormality
HP:0001743	0.0331125866707	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormality of the spleen
HP:0001337	0.0338486678119	0.75	RNASEH2C RNASEH2A RNASEH2B	Tremor
HP:0003241	0.0353531558248	0.75	RNASEH2C RNASEH2A RNASEH2B	External genital hypoplasia
HP:0001637	0.0369012487759	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal myocardium morphology
HP:0010987	0.037691835903	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal cellular immune system morphology
HP:0001881	0.037691835903	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal leukocyte morphology
GO:0004523	0.0405595771497	0.5	RNASEH2B RNASEH2A	RNA-DNA hybrid ribonuclease activity
HP:0032251	0.0406864321028	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal immune system morphology
HP:0000253	0.0427529847392	0.5	RNASEH2C RNASEH2A	Progressive microcephaly
HP:0011014	0.0477573380446	0.75	RNASEH2C RNASEH2A RNASEH2B	Abnormal glucose homeostasis

Edges

Protein 1	Protein 2	Score	Precision	Evidence
RNASEH2C	RNASEH2A	1.0	0.949	hein_WMM hein (RNASEH2A) fraction
RNASEH2B	RNASEH2A	1.0	0.949	hein_WMM hein (RNASEH2A,RNASEH2B) fraction
RNASEH2C	RNASEH2B	1.0	0.949	hein_WMM hein (RNASEH2B) fraction
RNASEH2C	DNAJC7	0.725	0.735	fraction
RNASEH2B	DNAJC7	0.01	0.137	fraction
RNASEH2A	DNAJC7	0.004	0.008	bioplex_WMM youn_WMM fraction

Images

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Complex HuMAP2_02047 has an average edge precision of 0.621 which is ranked 1823 out of all 6965 complexes.

Related Complexes

Genename	Complexes
DNAJC7	HuMAP2_00457 HuMAP2_02047 HuMAP2_02091 HuMAP2_02851
RNASEH2A	HuMAP2_00183 HuMAP2_01100 HuMAP2_01825 HuMAP2_02047 HuMAP2_03593 HuMAP2_04588 HuMAP2_05586
RNASEH2C	HuMAP2_00183 HuMAP2_00457 HuMAP2_01100 HuMAP2_01825 HuMAP2_02047 HuMAP2_03593 HuMAP2_04588
RNASEH2B	HuMAP2_00183 HuMAP2_01100 HuMAP2_01825 HuMAP2_02047 HuMAP2_03593 HuMAP2_05586

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_02047