hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02054
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GRK2 | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | UniProt NCBI |
| GRK3 | Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3) | UniProt NCBI |
| UFD1 | Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04340 | 0.000422858026176 | 0.666666666667 | GRK3 GRK2 | Hedgehog signaling pathway |
| WP:WP4249 | 0.000673229988357 | 0.666666666667 | GRK3 GRK2 | Hedgehog Signaling Pathway |
| KEGG:05032 | 0.00144586300556 | 0.666666666667 | GRK3 GRK2 | Morphine addiction |
| KEGG:04724 | 0.00220707183162 | 0.666666666667 | GRK3 GRK2 | Glutamatergic synapse |
| KEGG:04740 | 0.00339655892893 | 0.666666666667 | GRK3 GRK2 | Olfactory transduction |
| KEGG:04062 | 0.00373360278335 | 0.666666666667 | GRK3 GRK2 | Chemokine signaling pathway |
| GO:0047696 | 0.00811409485621 | 0.666666666667 | GRK3 GRK2 | beta-adrenergic receptor kinase activity |
| KEGG:04144 | 0.0117748506163 | 0.666666666667 | GRK3 GRK2 | Endocytosis |
| REAC:R-HSA-8856825 | 0.0261170593829 | 0.666666666667 | GRK3 GRK2 | Cargo recognition for clathrin-mediated endocytosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRK3 | GRK2 | 1.0 | 0.949 | bioplex (GRK2) bioplex_WMM |
| GRK2 | UFD1 | 0.083 | 0.35 | youn_WMM fraction |
| GRK3 | UFD1 | 0.003 | 0.019 | fraction |
Images
Click to enlarge
Complex HuMAP2_02054 has an average edge precision of 0.439 which is ranked 2943 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GRK2 | HuMAP2_01849 HuMAP2_02054 HuMAP2_02691 HuMAP2_06904 |
| GRK3 | HuMAP2_01849 HuMAP2_02054 HuMAP2_02691 HuMAP2_06904 |
| UFD1 | HuMAP2_02054 HuMAP2_02799 HuMAP2_04063 HuMAP2_06192 |