hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02057
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UMAD1 | UBAP1-MVB12-associated (UMA)-domain containing protein 1 (RPA3 antisense RNA 1) (RPA3 opposite strand) | UniProt NCBI |
| MVB12A | Multivesicular body subunit 12A (CIN85/CD2AP family-binding protein) (ESCRT-I complex subunit MVB12A) (Protein FAM125A) | UniProt NCBI |
| MVB12B | Multivesicular body subunit 12B (ESCRT-I complex subunit MVB12B) (Protein FAM125B) | UniProt NCBI |
| VPS37C | Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C) | UniProt NCBI |
| UBAP1 | Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein) | UniProt NCBI |
| VPS37A | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) | UniProt NCBI |
| VPS28 | Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28) | UniProt NCBI |
| VPS37B | Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B) | UniProt NCBI |
| TSG101 | Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101) | UniProt NCBI |
| SEC24B | Protein transport protein Sec24B (SEC24-related protein B) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000813 | 3.37768756831e-22 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | ESCRT I complex |
| REAC:R-HSA-174495 | 4.71275654511e-22 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Synthesis And Processing Of GAG, GAGPOL Polyproteins |
| REAC:R-HSA-174490 | 4.71275654511e-22 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Membrane binding and targetting of GAG proteins |
| REAC:R-HSA-175474 | 2.01927022627e-21 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Assembly Of The HIV Virion |
| REAC:R-HSA-9615710 | 3.47866447427e-19 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Microautophagy |
| REAC:R-HSA-162588 | 4.86954799069e-19 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 1.2355035129e-18 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Endosomal Sorting Complex Required For Transport (ESCRT) |
| GO:0043162 | 4.72142757303e-18 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| GO:0036452 | 4.05138282324e-17 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | ESCRT complex |
| REAC:R-HSA-9612973 | 3.69174874118e-14 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Autophagy |
| GO:0075733 | 3.88389504302e-14 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | intracellular transport of virus |
| GO:0046794 | 6.16597616917e-14 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | transport of virus |
| GO:0046755 | 8.92503012063e-14 | 0.7 | MVB12B VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | viral budding |
| REAC:R-HSA-162599 | 3.03121753439e-13 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Late Phase of HIV Life Cycle |
| GO:0044766 | 3.11559494175e-13 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | multi-organism transport |
| GO:1902579 | 3.11559494175e-13 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | multi-organism localization |
| REAC:R-HSA-162587 | 6.50718374228e-13 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | HIV Life Cycle |
| GO:0019068 | 2.84868659565e-12 | 0.7 | MVB12B VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | virion assembly |
| REAC:R-HSA-162906 | 2.04444041428e-11 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | HIV Infection |
| GO:0039702 | 3.74888389692e-11 | 0.6 | VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | viral budding via host ESCRT complex |
| REAC:R-HSA-199991 | 3.97902840722e-10 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Membrane Trafficking |
| GO:0036258 | 4.09365218449e-10 | 0.6 | VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | multivesicular body assembly |
| GO:0036257 | 5.07495820633e-10 | 0.6 | VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | multivesicular body organization |
| REAC:R-HSA-5653656 | 6.45480454488e-10 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Vesicle-mediated transport |
| REAC:R-HSA-5663205 | 9.3115963706e-10 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Infectious disease |
| KEGG:04144 | 1.09348545882e-09 | 0.7 | MVB12B VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | Endocytosis |
| GO:0016197 | 2.02095725161e-09 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | endosomal transport |
| GO:0019058 | 7.73067111851e-09 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | viral life cycle |
| CORUM:1192 | 1.62176028613e-08 | 0.3 | VPS28 TSG101 VPS37C | ESCRT-I complex |
| CORUM:1863 | 1.62176028613e-08 | 0.3 | VPS28 VPS37B TSG101 | TSG101-VPS37B-VPS28 complex |
| GO:0010008 | 2.66062956692e-08 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | endosome membrane |
| GO:0044440 | 7.74979322964e-08 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | endosomal part |
| GO:0007032 | 8.95641551469e-08 | 0.6 | VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | endosome organization |
| GO:0016032 | 1.06236728618e-06 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | viral process |
| REAC:R-HSA-1643685 | 2.21604873229e-06 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | Disease |
| GO:0044403 | 2.29771881129e-06 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | symbiotic process |
| GO:0006511 | 2.49674331732e-06 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | ubiquitin-dependent protein catabolic process |
| GO:0019941 | 2.66663868299e-06 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | modification-dependent protein catabolic process |
| GO:0043632 | 3.18696685484e-06 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | modification-dependent macromolecule catabolic process |
| GO:0016050 | 3.23728339391e-06 | 0.7 | VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B | vesicle organization |
| GO:0098796 | 3.4622441018e-06 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | membrane protein complex |
| GO:0044419 | 3.56240964627e-06 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | interspecies interaction between organisms |
| GO:0051603 | 9.48359726968e-06 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | proteolysis involved in cellular protein catabolic process |
| GO:0005768 | 1.5633583498e-05 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | endosome |
| GO:0044433 | 1.82251961266e-05 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | cytoplasmic vesicle part |
| GO:0044257 | 1.9222722912e-05 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | cellular protein catabolic process |
| GO:0098805 | 2.93781815133e-05 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | whole membrane |
| GO:0030163 | 6.54298289246e-05 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | protein catabolic process |
| GO:0098588 | 0.000174432418885 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | bounding membrane of organelle |
| GO:0016236 | 0.000241096802095 | 0.6 | VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | macroautophagy |
| GO:0007034 | 0.00026875022533 | 0.5 | VPS37A VPS28 MVB12A VPS37B VPS37C | vacuolar transport |
| GO:0046907 | 0.000302069878376 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | intracellular transport |
| GO:0072666 | 0.000462790237267 | 0.4 | VPS37A VPS28 VPS37B VPS37C | establishment of protein localization to vacuole |
| GO:0044265 | 0.000619525578897 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | cellular macromolecule catabolic process |
| GO:0016192 | 0.000624908324856 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | vesicle-mediated transport |
| GO:0031410 | 0.000654331066808 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | cytoplasmic vesicle |
| GO:0097708 | 0.000658093879649 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | intracellular vesicle |
| GO:1901565 | 0.000866643202871 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | organonitrogen compound catabolic process |
| GO:0010256 | 0.00116292943911 | 0.6 | VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | endomembrane system organization |
| GO:0072665 | 0.00159423941993 | 0.4 | VPS37A VPS28 VPS37B VPS37C | protein localization to vacuole |
| GO:0051649 | 0.00190382571183 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | establishment of localization in cell |
| GO:0009057 | 0.00219111309354 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | macromolecule catabolic process |
| GO:0006914 | 0.00321550558502 | 0.6 | VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | autophagy |
| GO:0061919 | 0.00321550558502 | 0.6 | VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B | process utilizing autophagic mechanism |
| GO:0006508 | 0.00407084340517 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | proteolysis |
| GO:0043130 | 0.00433692274445 | 0.4 | VPS28 MVB12A TSG101 UBAP1 | ubiquitin binding |
| GO:0032182 | 0.0111017782004 | 0.4 | VPS28 MVB12A TSG101 UBAP1 | ubiquitin-like protein binding |
| GO:0051704 | 0.0181527324061 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | multi-organism process |
| GO:0019075 | 0.020287053512 | 0.2 | MVB12A MVB12B | virus maturation |
| GO:0031090 | 0.0212278717661 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | organelle membrane |
| GO:0051641 | 0.021391870384 | 0.9 | UBAP1 VPS28 SEC24B TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | cellular localization |
| GO:1901575 | 0.047518621896 | 0.8 | UBAP1 VPS28 TSG101 MVB12A VPS37C VPS37A VPS37B MVB12B | organic substance catabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS37B | VPS28 | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM Guru youn_WMM hein (VPS28) Malo fraction |
| VPS28 | VPS37A | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM hein (VPS28) |
| MVB12A | VPS28 | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM hein (VPS28) Malo fraction |
| TSG101 | VPS28 | 1.0 | 0.949 | hein_WMM bioplex (VPS28) bioplex_WMM Guru youn_WMM hein (TSG101,VPS28) Malo gupta_WMM fraction |
| VPS37B | TSG101 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (TSG101) Malo fraction |
| TSG101 | UBAP1 | 1.0 | 0.949 | hein_WMM bioplex (UBAP1) bioplex_WMM youn_WMM hein (TSG101) Malo fraction |
| VPS28 | UBAP1 | 1.0 | 0.949 | hein_WMM bioplex (UBAP1,VPS28) bioplex_WMM hein (VPS28) |
| MVB12A | TSG101 | 0.996 | 0.927 | hein_WMM bioplex_WMM hein (TSG101) Malo fraction |
| TSG101 | VPS37C | 0.987 | 0.902 | hein_WMM bioplex_WMM Guru youn_WMM hein (TSG101) fraction |
| UBAP1 | VPS37A | 0.919 | 0.841 | hein_WMM bioplex (UBAP1) bioplex_WMM youn_WMM |
| MVB12A | VPS37B | 0.509 | 0.629 | hein_WMM bioplex_WMM Malo fraction |
| VPS37C | VPS28 | 0.404 | 0.564 | hein_WMM bioplex (VPS28) bioplex_WMM youn_WMM hein (VPS28) |
| TSG101 | VPS37A | 0.211 | 0.459 | hein_WMM bioplex_WMM youn_WMM hein (TSG101) |
| VPS37B | UBAP1 | 0.152 | 0.409 | hein_WMM bioplex (UBAP1) bioplex_WMM |
| VPS28 | UMAD1 | 0.086 | 0.352 | hein_WMM hein (VPS28) |
| SEC24B | VPS37B | 0.066 | 0.348 | youn_WMM fraction |
| MVB12B | VPS28 | 0.056 | 0.315 | bioplex (VPS28) bioplex_WMM |
| SEC24B | TSG101 | 0.051 | 0.296 | bioplex_WMM youn_WMM fraction |
| VPS37B | VPS37A | 0.015 | 0.14 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MVB12A | VPS37C | 0.012 | 0.147 | hein_WMM bioplex_WMM WMM_only |
| MVB12A | UBAP1 | 0.01 | 0.105 | hein_WMM bioplex_WMM WMM_only |
| MVB12A | VPS37A | 0.009 | 0.11 | hein_WMM bioplex_WMM WMM_only |
| TSG101 | UMAD1 | 0.009 | 0.107 | hein_WMM WMM_only |
| VPS37C | UBAP1 | 0.009 | 0.107 | hein_WMM bioplex_WMM WMM_only |
| VPS37B | VPS37C | 0.009 | 0.101 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| VPS37C | VPS37A | 0.009 | 0.09 | hein_WMM bioplex_WMM WMM_only |
| MVB12A | MVB12B | 0.009 | 0.096 | bioplex_WMM WMM_only |
| MVB12B | UBAP1 | 0.008 | 0.09 | bioplex_WMM WMM_only |
| MVB12B | VPS37A | 0.008 | 0.066 | bioplex_WMM WMM_only |
| VPS37C | MVB12B | 0.008 | 0.055 | bioplex_WMM WMM_only |
| VPS37A | UMAD1 | 0.007 | 0.002 | hein_WMM WMM_only |
| UBAP1 | UMAD1 | 0.007 | 0.002 | hein_WMM WMM_only |
| VPS37B | UMAD1 | 0.007 | 0.002 | hein_WMM WMM_only |
| MVB12A | UMAD1 | 0.007 | 0.01 | hein_WMM WMM_only |
| VPS37C | UMAD1 | 0.007 | 0.006 | hein_WMM WMM_only |
| SEC24B | VPS37A | 0.007 | 0.004 | youn_WMM WMM_only |
| SEC24B | VPS28 | 0.007 | 0.004 | youn_WMM gupta_WMM WMM_only |
| SEC24B | UBAP1 | 0.007 | 0.003 | youn_WMM WMM_only |
| SEC24B | MVB12A | 0.007 | 0.005 | hein_WMM bioplex_WMM WMM_only |
| SEC24B | VPS37C | 0.004 | 0.008 | youn_WMM fraction |
| VPS37B | MVB12B | 0.0 | 0.002 | bioplex_WMM fraction |
| TSG101 | MVB12B | 0.0 | 0.0 | bioplex_WMM fraction |
Images
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Complex HuMAP2_02057 has an average edge precision of 0.332 which is ranked 4210 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UMAD1 | HuMAP2_02057 HuMAP2_03969 |
| MVB12A | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_05381 HuMAP2_05909 HuMAP2_06430 |
| MVB12B | HuMAP2_01232 HuMAP2_02057 HuMAP2_02606 |
| VPS37C | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 HuMAP2_06935 |
| UBAP1 | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| VPS37A | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| VPS28 | HuMAP2_01745 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| VPS37B | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| TSG101 | HuMAP2_01179 HuMAP2_02057 HuMAP2_03969 HuMAP2_06430 |
| SEC24B | HuMAP2_00758 HuMAP2_02057 HuMAP2_05176 HuMAP2_06134 HuMAP2_06430 |