hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02063
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TOMM40 | Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5) | UniProt NCBI |
| MYOF | Myoferlin (Fer-1-like protein 3) | UniProt NCBI |
| ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) | UniProt NCBI |
| ABCB7 | ATP-binding cassette sub-family B member 7, mitochondrial (ATP-binding cassette transporter 7) (ABC transporter 7 protein) | UniProt NCBI |
| ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04964 | 0.00081380532431 | 0.4 | ATP1A1 ATP1B1 | Proximal tubule bicarbonate reclamation |
| KEGG:04960 | 0.00198873883948 | 0.4 | ATP1A1 ATP1B1 | Aldosterone-regulated sodium reabsorption |
| KEGG:04973 | 0.00333191455164 | 0.4 | ATP1A1 ATP1B1 | Carbohydrate digestion and absorption |
| KEGG:04978 | 0.00441762805526 | 0.4 | ATP1A1 ATP1B1 | Mineral absorption |
| KEGG:04961 | 0.00522578105965 | 0.4 | ATP1A1 ATP1B1 | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04976 | 0.00656425237639 | 0.4 | ATP1A1 ATP1B1 | Bile secretion |
| KEGG:04971 | 0.00779513141567 | 0.4 | ATP1A1 ATP1B1 | Gastric acid secretion |
| KEGG:04918 | 0.00969431019543 | 0.4 | ATP1A1 ATP1B1 | Thyroid hormone synthesis |
| KEGG:04911 | 0.0108715181024 | 0.4 | ATP1A1 ATP1B1 | Insulin secretion |
| KEGG:04970 | 0.0114851584748 | 0.4 | ATP1A1 ATP1B1 | Salivary secretion |
| KEGG:04974 | 0.0117982317972 | 0.4 | ATP1A1 ATP1B1 | Protein digestion and absorption |
| KEGG:04260 | 0.0121154716042 | 0.4 | ATP1A1 ATP1B1 | Cardiac muscle contraction |
| REAC:R-HSA-5578775 | 0.0132857243802 | 0.4 | ATP1A1 ATP1B1 | Ion homeostasis |
| KEGG:04972 | 0.0137641082753 | 0.4 | ATP1A1 ATP1B1 | Pancreatic secretion |
| REAC:R-HSA-936837 | 0.0145030354259 | 0.4 | ATP1A1 ATP1B1 | Ion transport by P-type ATPases |
| KEGG:04925 | 0.0162467151192 | 0.4 | ATP1A1 ATP1B1 | Aldosterone synthesis and secretion |
| KEGG:04919 | 0.0267668372004 | 0.4 | ATP1A1 ATP1B1 | Thyroid hormone signaling pathway |
| KEGG:04261 | 0.0348468299156 | 0.4 | ATP1A1 ATP1B1 | Adrenergic signaling in cardiomyocytes |
| KEGG:04022 | 0.0415917953149 | 0.4 | ATP1A1 ATP1B1 | cGMP-PKG signaling pathway |
| CORUM:3092 | 0.0499494897235 | 0.2 | TOMM40 | APP-TOM40 complex |
| CORUM:6498 | 0.0499494897235 | 0.2 | TOMM40 | TOM7 120K intermediate assembly complex (TOM7, TOM22, TOM40), mitochondrial |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP1A1 | ATP1B1 | 0.26 | 0.482 | bioplex_WMM Guru boldt fraction boldt_WMM |
| MYOF | ATP1A1 | 0.082 | 0.351 | hein_WMM fraction treiber_WMM |
| ATP1B1 | ABCB7 | 0.039 | 0.264 | bioplex_WMM fraction |
| TOMM40 | ATP1B1 | 0.026 | 0.218 | bioplex_WMM fraction |
| ATP1A1 | ABCB7 | 0.013 | 0.141 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| ATP1A1 | TOMM40 | 0.007 | 0.004 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| MYOF | ATP1B1 | 0.006 | 0.008 | fraction |
| TOMM40 | ABCB7 | 0.005 | 0.008 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_02063 has an average edge precision of 0.184 which is ranked 6385 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TOMM40 | HuMAP2_02063 HuMAP2_05418 |
| MYOF | HuMAP2_00221 HuMAP2_02063 HuMAP2_05949 HuMAP2_06898 |
| ATP1B1 | HuMAP2_02063 HuMAP2_05949 |
| ABCB7 | HuMAP2_02063 HuMAP2_02541 |
| ATP1A1 | HuMAP2_00221 HuMAP2_02063 HuMAP2_02393 HuMAP2_04352 HuMAP2_05949 |