hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02068
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IRF2BPL | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | UniProt NCBI |
| TEAD3 | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | UniProt NCBI |
| VGLL4 | Transcription cofactor vestigial-like protein 4 (Vgl-4) | UniProt NCBI |
| IRF2BP2 | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | UniProt NCBI |
| IRF2BP1 | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6848 | 1.35146690511e-09 | 0.6 | IRF2BP2 IRF2BPL IRF2BP1 | IRF2BP2-IRF2BP1-IRF2BPL complex |
| HPA:032020_23 | 0.00844057573101 | 0.6 | IRF2BP2 IRF2BPL IRF2BP1 | pancreas; islets of Langerhans[Approved,High] |
| HPA:031020_22 | 0.0108658416178 | 0.8 | IRF2BP2 IRF2BPL VGLL4 IRF2BP1 | ovary; ovarian stroma cells[Approved,Medium] |
| WP:WP4541 | 0.0169715520461 | 0.4 | TEAD3 VGLL4 | Hippo-Merlin Signaling Dysregulation |
| HPA:008020_22 | 0.0306669553978 | 0.8 | IRF2BP2 IRF2BPL VGLL4 IRF2BP1 | cerebral cortex; glial cells[Approved,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VGLL4 | TEAD3 | 1.0 | 0.949 | bioplex (VGLL4) bioplex_WMM |
| IRF2BP2 | VGLL4 | 1.0 | 0.949 | bioplex (VGLL4) bioplex_WMM |
| IRF2BPL | VGLL4 | 0.996 | 0.928 | bioplex (VGLL4) bioplex_WMM |
| IRF2BP1 | VGLL4 | 0.994 | 0.923 | bioplex (IRF2BP1,VGLL4) bioplex_WMM |
| IRF2BPL | IRF2BP2 | 0.352 | 0.539 | bioplex_WMM Malo fraction |
| IRF2BP1 | IRF2BPL | 0.137 | 0.408 | bioplex (IRF2BP1) bioplex_WMM |
| IRF2BP1 | IRF2BP2 | 0.091 | 0.354 | bioplex (IRF2BP1) bioplex_WMM youn_WMM |
| IRF2BPL | TEAD3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| IRF2BP1 | TEAD3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| IRF2BP2 | TEAD3 | 0.008 | 0.067 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02068 has an average edge precision of 0.529 which is ranked 2339 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IRF2BPL | HuMAP2_01837 HuMAP2_02068 HuMAP2_04016 HuMAP2_04843 |
| TEAD3 | HuMAP2_02068 HuMAP2_02569 HuMAP2_04011 HuMAP2_04016 HuMAP2_04805 |
| VGLL4 | HuMAP2_01837 HuMAP2_02068 HuMAP2_02569 HuMAP2_04011 HuMAP2_04016 HuMAP2_04843 |
| IRF2BP2 | HuMAP2_01837 HuMAP2_02068 HuMAP2_04016 HuMAP2_04843 HuMAP2_06180 |
| IRF2BP1 | HuMAP2_00684 HuMAP2_01837 HuMAP2_02068 HuMAP2_04016 HuMAP2_04843 HuMAP2_05903 HuMAP2_06520 |