hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02076

Confidence: Very High

Genename	Protein Name	Links
NIP7	60S ribosome subunit biogenesis protein NIP7 homolog (KD93)	UniProt NCBI
PUM3	Pumilio homolog 3 (HBV X-transactivated gene 5 protein) (HBV XAg-transactivated protein 5) (Minor histocompatibility antigen HA-8) (HLA-HA8)	UniProt NCBI
NOP2	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)	UniProt NCBI
RRP15	RRP15-like protein (Ribosomal RNA-processing protein 15)	UniProt NCBI
RRS1	Ribosome biogenesis regulatory protein homolog	UniProt NCBI
BRIX1	Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)	UniProt NCBI
EBNA1BP2	Probable rRNA-processing protein EBP2 (EBNA1-binding protein 2) (Nucleolar protein p40)	UniProt NCBI
DKC1	H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)	UniProt NCBI
RBM34	RNA-binding protein 34 (RNA-binding motif protein 34)	UniProt NCBI
FTSJ3	pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 (EC 2.1.1.-) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)	UniProt NCBI
RPF2	Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog)	UniProt NCBI
RBM28	RNA-binding protein 28 (RNA-binding motif protein 28)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0042273	6.69016981331e-10	0.583333333333	RPF2 FTSJ3 RRS1 EBNA1BP2 BRIX1 NIP7 NOP2	ribosomal large subunit biogenesis
GO:0005730	2.7777060277e-09	0.916666666667	PUM3 RBM34 FTSJ3 RPF2 NOP2 RRS1 DKC1 BRIX1 NIP7 RBM28 EBNA1BP2	nucleolus
GO:0042254	7.99529516144e-08	0.666666666667	RPF2 FTSJ3 NOP2 RRS1 DKC1 BRIX1 NIP7 EBNA1BP2	ribosome biogenesis
GO:0030687	2.16779860526e-07	0.416666666667	FTSJ3 RRP15 RRS1 EBNA1BP2 NIP7	preribosome, large subunit precursor
REAC:R-HSA-8868773	8.60817403195e-07	0.5	FTSJ3 EBNA1BP2 DKC1 NIP7 RBM28 NOP2	rRNA processing in the nucleus and cytosol
REAC:R-HSA-72312	1.16977202316e-06	0.5	FTSJ3 EBNA1BP2 DKC1 NIP7 RBM28 NOP2	rRNA processing
GO:0022613	3.05403862783e-06	0.666666666667	RPF2 FTSJ3 NOP2 RRS1 DKC1 BRIX1 NIP7 EBNA1BP2	ribonucleoprotein complex biogenesis
GO:0003723	3.3538155932e-06	0.916666666667	PUM3 RBM34 FTSJ3 RPF2 NOP2 RRS1 DKC1 BRIX1 NIP7 RBM28 EBNA1BP2	RNA binding
GO:0030684	9.48856045139e-05	0.416666666667	FTSJ3 RRP15 RRS1 EBNA1BP2 NIP7	preribosome
GO:0006364	9.81886423878e-05	0.5	FTSJ3 EBNA1BP2 RRS1 DKC1 RPF2 NOP2	rRNA processing
GO:0016072	0.000133276026154	0.5	FTSJ3 EBNA1BP2 RRS1 DKC1 RPF2 NOP2	rRNA metabolic process
GO:0000027	0.000178833135092	0.333333333333	RRS1 RPF2 NOP2 BRIX1	ribosomal large subunit assembly
REAC:R-HSA-8953854	0.00122443262607	0.5	FTSJ3 EBNA1BP2 DKC1 NIP7 RBM28 NOP2	Metabolism of RNA
GO:0003676	0.00166278001009	0.916666666667	PUM3 RBM34 FTSJ3 RPF2 NOP2 RRS1 DKC1 BRIX1 NIP7 RBM28 EBNA1BP2	nucleic acid binding
TF:M03988_1	0.00175790166812	0.916666666667	RBM34 DKC1 RRP15 RPF2 RBM28 RRS1 EBNA1BP2 NIP7 BRIX1 FTSJ3 NOP2	Factor: FLI1; motif: ACCGGAARTN; match class: 1
REAC:R-HSA-6791226	0.00233776377863	0.333333333333	RBM28 NIP7 EBNA1BP2 FTSJ3	Major pathway of rRNA processing in the nucleolus and cytosol
TF:M08913_1	0.00260623002564	0.916666666667	RBM34 DKC1 RRP15 RPF2 RBM28 RRS1 EBNA1BP2 NIP7 BRIX1 FTSJ3 NOP2	Factor: FLI-1; motif: NAYTTCCGGT; match class: 1
GO:0042255	0.00346231932775	0.333333333333	RRS1 RPF2 NOP2 BRIX1	ribosome assembly
GO:0034470	0.00354271759279	0.5	FTSJ3 EBNA1BP2 RRS1 DKC1 RPF2 NOP2	ncRNA processing
CORUM:3055	0.00406926978546	0.25	BRIX1 EBNA1BP2 RBM28	Nop56p-associated pre-rRNA complex
TF:M07415_1	0.00641007658134	0.833333333333	RBM34 RRP15 RPF2 NOP2 RRS1 DKC1 FTSJ3 NIP7 RBM28 EBNA1BP2	Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 1
GO:0034660	0.0147801849621	0.5	FTSJ3 EBNA1BP2 RRS1 DKC1 RPF2 NOP2	ncRNA metabolic process
GO:1901363	0.0182019848827	0.916666666667	PUM3 RBM34 FTSJ3 RPF2 NOP2 RRS1 DKC1 BRIX1 NIP7 RBM28 EBNA1BP2	heterocyclic compound binding
TF:M04714_1	0.018289747905	0.833333333333	RBM34 RRP15 RPF2 NOP2 RRS1 DKC1 FTSJ3 NIP7 RBM28 EBNA1BP2	Factor: Elf-1; motif: ACTTCCGGG; match class: 1
TF:M01752_1	0.0207107744603	0.916666666667	RBM34 DKC1 RRP15 RPF2 RBM28 RRS1 EBNA1BP2 NIP7 BRIX1 FTSJ3 NOP2	Factor: ERG; motif: ACCGGAART; match class: 1
GO:0097159	0.0219311472825	0.916666666667	PUM3 RBM34 FTSJ3 RPF2 NOP2 RRS1 DKC1 BRIX1 NIP7 RBM28 EBNA1BP2	organic cyclic compound binding
TF:M02059_1	0.022004918721	0.916666666667	RBM34 DKC1 RRP15 RPF2 RBM28 RRS1 EBNA1BP2 NIP7 BRIX1 FTSJ3 NOP2	Factor: ELK-1; motif: ACCGGAAGTN; match class: 1
TF:M03975_1	0.0227734782987	1.0	PUM3 RBM34 DKC1 RRP15 RPF2 RBM28 RRS1 EBNA1BP2 NIP7 BRIX1 FTSJ3 NOP2	Factor: ERG; motif: ACCGGAARTN; match class: 1
GO:1990904	0.026026605794	0.583333333333	FTSJ3 RRS1 DKC1 RRP15 NIP7 RBM28 EBNA1BP2	ribonucleoprotein complex
TF:M02069_1	0.0275875343166	0.75	RBM34 RRP15 NOP2 RRS1 DKC1 RPF2 NIP7 RBM28 EBNA1BP2	Factor: Erm; motif: ACCGGAAGTN; match class: 1

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BRIX1	EBNA1BP2	1.0	0.949	hein_WMM bioplex (EBNA1BP2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
NIP7	NOP2	1.0	0.949	hein_WMM bioplex_WMM Guru youn_WMM fraction
RRS1	RPF2	1.0	0.949	bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	NOP2	1.0	0.949	hein_WMM bioplex (EBNA1BP2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	NOP2	1.0	0.949	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
NOP2	RBM28	1.0	0.949	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRS1	EBNA1BP2	0.999	0.949	bioplex (EBNA1BP2,RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	RPF2	0.998	0.939	bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRS1	NOP2	0.996	0.926	bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRS1	FTSJ3	0.995	0.924	bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	FTSJ3	0.992	0.912	hein_WMM bioplex (EBNA1BP2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	RBM34	0.99	0.909	hein_WMM bioplex (RBM34) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
EBNA1BP2	RBM28	0.989	0.906	hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
RBM34	FTSJ3	0.988	0.901	hein_WMM bioplex (RBM34) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRP15	EBNA1BP2	0.986	0.9	hein_WMM bioplex (EBNA1BP2) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	EBNA1BP2	0.985	0.899	hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
BRIX1	RPF2	0.98	0.896	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRP15	PUM3	0.978	0.894	hein_WMM bioplex (PUM3) bioplex_WMM youn_WMM gupta_WMM fraction
RBM34	RBM28	0.975	0.886	hein_WMM bioplex (RBM34) bioplex_WMM youn_WMM treiber_WMM
RRP15	NOP2	0.973	0.886	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction
RRS1	BRIX1	0.973	0.886	bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
DKC1	BRIX1	0.973	0.886	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
NIP7	EBNA1BP2	0.971	0.883	hein_WMM bioplex (EBNA1BP2) bioplex_WMM youn_WMM treiber_WMM
DKC1	PUM3	0.971	0.882	bioplex (PUM3) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DKC1	RRS1	0.961	0.869	bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DKC1	RPF2	0.948	0.856	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DKC1	RRP15	0.947	0.857	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRP15	RBM28	0.935	0.85	hein_WMM bioplex_WMM Guru youn_WMM fraction treiber_WMM
EBNA1BP2	PUM3	0.933	0.847	hein_WMM bioplex (PUM3) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
NOP2	RBM34	0.931	0.846	hein_WMM bioplex (RBM34) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
RPF2	NOP2	0.927	0.844	bioplex_WMM Guru youn_WMM gupta_WMM fraction
RRP15	NIP7	0.92	0.844	hein_WMM bioplex_WMM Guru youn_WMM fraction
NOP2	PUM3	0.919	0.842	hein_WMM bioplex (PUM3) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRS1	PUM3	0.918	0.84	bioplex (PUM3,RRS1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
BRIX1	PUM3	0.913	0.837	hein_WMM bioplex (PUM3) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRP15	RBM34	0.905	0.828	hein_WMM bioplex (RBM34) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RPF2	FTSJ3	0.862	0.799	bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RPF2	PUM3	0.86	0.796	bioplex (PUM3) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
BRIX1	NOP2	0.822	0.774	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRP15	RRS1	0.745	0.74	bioplex (RRS1) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RBM34	PUM3	0.694	0.717	hein_WMM bioplex (PUM3,RBM34) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
RPF2	RBM34	0.683	0.711	bioplex (RBM34) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
NIP7	RBM28	0.653	0.69	hein_WMM bioplex_WMM Guru youn_WMM fraction treiber_WMM
NIP7	RBM34	0.619	0.675	hein_WMM bioplex (RBM34) bioplex_WMM youn_WMM treiber_WMM
RBM28	PUM3	0.615	0.674	hein_WMM bioplex (PUM3) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
BRIX1	RBM34	0.534	0.639	hein_WMM bioplex (RBM34) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
NOP2	FTSJ3	0.526	0.634	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRP15	RPF2	0.493	0.621	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRS1	RBM34	0.411	0.57	bioplex (RBM34,RRS1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
BRIX1	FTSJ3	0.4	0.56	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
RRS1	RBM28	0.383	0.55	bioplex (RRS1) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
NIP7	RRS1	0.38	0.549	bioplex (RRS1) bioplex_WMM youn_WMM treiber_WMM
DKC1	FTSJ3	0.375	0.547	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
NIP7	PUM3	0.339	0.528	hein_WMM bioplex (PUM3) bioplex_WMM youn_WMM
PUM3	FTSJ3	0.328	0.517	hein_WMM bioplex (PUM3) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
RRP15	BRIX1	0.186	0.441	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
DKC1	RBM34	0.127	0.399	bioplex (RBM34) bioplex_WMM youn_WMM gupta_WMM treiber_WMM
NIP7	BRIX1	0.078	0.353	hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM
BRIX1	RBM28	0.058	0.323	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RBM28	FTSJ3	0.054	0.305	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
RPF2	RBM28	0.053	0.302	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
NIP7	RPF2	0.046	0.292	bioplex_WMM youn_WMM WMM_only treiber_WMM
NIP7	FTSJ3	0.026	0.221	hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM
RRP15	FTSJ3	0.018	0.178	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
DKC1	RBM28	0.016	0.155	bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM
DKC1	NIP7	0.01	0.105	bioplex_WMM youn_WMM WMM_only treiber_WMM

Images

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Complex HuMAP2_02076 has an average edge precision of 0.719 which is ranked 1313 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NIP7	HuMAP2_00275 HuMAP2_00537 HuMAP2_00574 HuMAP2_01318 HuMAP2_02076 HuMAP2_02100 HuMAP2_02371 HuMAP2_02746 HuMAP2_05727 HuMAP2_06347
PUM3	HuMAP2_00537 HuMAP2_00574 HuMAP2_00620 HuMAP2_01863 HuMAP2_02076 HuMAP2_04121 HuMAP2_04730 HuMAP2_05274 HuMAP2_05727 HuMAP2_06147
NOP2	HuMAP2_00465 HuMAP2_00537 HuMAP2_01057 HuMAP2_01318 HuMAP2_02076 HuMAP2_02100 HuMAP2_02371 HuMAP2_02746 HuMAP2_05727
RRP15	HuMAP2_00275 HuMAP2_00465 HuMAP2_00537 HuMAP2_00574 HuMAP2_01057 HuMAP2_01318 HuMAP2_01509 HuMAP2_02076 HuMAP2_02100 HuMAP2_05727
RRS1	HuMAP2_00275 HuMAP2_00379 HuMAP2_00537 HuMAP2_02076 HuMAP2_02911 HuMAP2_04505 HuMAP2_04750 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
BRIX1	HuMAP2_00275 HuMAP2_02076 HuMAP2_04505 HuMAP2_04628 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
EBNA1BP2	HuMAP2_00275 HuMAP2_00537 HuMAP2_02076 HuMAP2_04505 HuMAP2_04628 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
DKC1	HuMAP2_00041 HuMAP2_00275 HuMAP2_00537 HuMAP2_01057 HuMAP2_01164 HuMAP2_01512 HuMAP2_01695 HuMAP2_02076 HuMAP2_03262 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347
RBM34	HuMAP2_00537 HuMAP2_00574 HuMAP2_00650 HuMAP2_01878 HuMAP2_02076 HuMAP2_02181 HuMAP2_04121 HuMAP2_04618 HuMAP2_04730 HuMAP2_05274 HuMAP2_05727 HuMAP2_06413 HuMAP2_06779
FTSJ3	HuMAP2_00561 HuMAP2_02076 HuMAP2_05727 HuMAP2_06347 HuMAP2_06502
RPF2	HuMAP2_00275 HuMAP2_00537 HuMAP2_02076 HuMAP2_02911 HuMAP2_04750 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347 HuMAP2_06681
RBM28	HuMAP2_00537 HuMAP2_00574 HuMAP2_01509 HuMAP2_02076 HuMAP2_05439 HuMAP2_05727 HuMAP2_06347

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02076