hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02077
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GUCY1B1 | Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) | UniProt NCBI |
| GUCY1A1 | Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) | UniProt NCBI |
| MTFR2 | Mitochondrial fission regulator 2 (DUF729 domain-containing protein 1) | UniProt NCBI |
| GUCY1A2 | Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) | UniProt NCBI |
| MXRA7 | Matrix-remodeling-associated protein 7 | UniProt NCBI |
| TMOD4 | Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-392154 | 4.84853251826e-06 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Nitric oxide stimulates guanylate cyclase |
| CORUM:408 | 8.39001385941e-06 | 0.333333333333 | GUCY1A1 GUCY1B1 | Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3) |
| CORUM:407 | 8.39001385941e-06 | 0.333333333333 | GUCY1B1 GUCY1A2 | Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) |
| WP:WP4222 | 1.7131668569e-05 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Phosphodiesterases in neuronal function |
| WP:WP4008 | 1.84137562659e-05 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | NO/cGMP/PKG mediated Neuroprotection |
| REAC:R-HSA-445355 | 3.23451507706e-05 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Smooth Muscle Contraction |
| KEGG:04924 | 3.91015753854e-05 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Renin secretion |
| KEGG:04730 | 3.91015753854e-05 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Long-term depression |
| REAC:R-HSA-397014 | 4.14836354799e-05 | 0.666666666667 | GUCY1A1 GUCY1A2 GUCY1B1 TMOD4 | Muscle contraction |
| GO:0004383 | 6.35345863999e-05 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | guanylate cyclase activity |
| KEGG:04970 | 0.000107857457806 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Salivary secretion |
| KEGG:04540 | 0.000158298174337 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Gap junction |
| KEGG:04713 | 0.000182197158451 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Circadian entrainment |
| KEGG:04270 | 0.000259985721773 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Vascular smooth muscle contraction |
| KEGG:04611 | 0.000367001333139 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Platelet activation |
| KEGG:00230 | 0.000367001333139 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Purine metabolism |
| REAC:R-HSA-418346 | 0.000430779573811 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Platelet homeostasis |
| KEGG:04921 | 0.000661047116041 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | Oxytocin signaling pathway |
| KEGG:04022 | 0.000753196125616 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | cGMP-PKG signaling pathway |
| GO:0016849 | 0.00147880241807 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | phosphorus-oxygen lyase activity |
| GO:0009975 | 0.00206534926206 | 0.5 | GUCY1A1 GUCY1B1 GUCY1A2 | cyclase activity |
| GO:0008074 | 0.00676235117068 | 0.333333333333 | GUCY1A1 GUCY1B1 | guanylate cyclase complex, soluble |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GUCY1B1 | GUCY1A1 | 0.999 | 0.949 | bioplex (GUCY1B1) bioplex_WMM |
| GUCY1B1 | GUCY1A2 | 0.993 | 0.918 | bioplex (GUCY1B1) bioplex_WMM |
| MXRA7 | GUCY1B1 | 0.826 | 0.774 | bioplex (GUCY1B1) bioplex_WMM |
| MTFR2 | TMOD4 | 0.024 | 0.211 | bioplex (TMOD4) bioplex_WMM |
| MTFR2 | GUCY1B1 | 0.024 | 0.213 | bioplex (GUCY1B1) bioplex_WMM |
| MXRA7 | GUCY1A2 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| MXRA7 | GUCY1A1 | 0.008 | 0.095 | bioplex_WMM WMM_only |
| GUCY1A1 | GUCY1A2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MXRA7 | MTFR2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| MTFR2 | GUCY1A2 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| MTFR2 | GUCY1A1 | 0.008 | 0.034 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02077 has an average edge precision of 0.319 which is ranked 4355 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GUCY1B1 | HuMAP2_02077 HuMAP2_05001 HuMAP2_05081 |
| GUCY1A1 | HuMAP2_02077 HuMAP2_05001 HuMAP2_05081 |
| MTFR2 | HuMAP2_02077 HuMAP2_06835 |
| GUCY1A2 | HuMAP2_02077 HuMAP2_05001 |
| MXRA7 | HuMAP2_02077 HuMAP2_05001 |
| TMOD4 | HuMAP2_02077 |