hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02095
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FGFR1 | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | UniProt NCBI |
| FGFR2 | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | UniProt NCBI |
| FGFR3 | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | UniProt NCBI |
| C8orf74 | Uncharacterized protein C8orf74 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003795 | 3.0524177374e-08 | 0.75 | FGFR2 FGFR3 FGFR1 | Short middle phalanx of toe |
| HP:0002676 | 1.06823858061e-07 | 0.75 | FGFR2 FGFR3 FGFR1 | Cloverleaf skull |
| HP:0010183 | 2.56351428753e-07 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the middle phalanges of the toes |
| HP:0004440 | 2.48914185619e-06 | 0.75 | FGFR2 FGFR3 FGFR1 | Coronal craniosynostosis |
| GO:0005007 | 3.6323771075e-06 | 0.75 | FGFR2 FGFR3 FGFR1 | fibroblast growth factor-activated receptor activity |
| HP:0008368 | 5.40093045765e-06 | 0.75 | FGFR2 FGFR3 FGFR1 | Tarsal synostosis |
| HP:0009140 | 7.92789117407e-06 | 0.75 | FGFR2 FGFR3 FGFR1 | Synostosis involving bones of the feet |
| HP:0009138 | 7.92789117407e-06 | 0.75 | FGFR2 FGFR3 FGFR1 | Synostosis involving bones of the lower limbs |
| WP:WP4155 | 8.50820332609e-06 | 0.75 | FGFR2 FGFR3 FGFR1 | Endometrial cancer |
| HP:0000262 | 1.11400508422e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Turricephaly |
| KEGG:05230 | 1.28493032652e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Central carbon metabolism in cancer |
| WP:WP2064 | 1.58039049017e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Neural Crest Differentiation |
| HP:0005819 | 1.99478845841e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Short middle phalanx of finger |
| HP:0008122 | 2.27305921704e-05 | 0.5 | FGFR2 FGFR1 | Calcaneonavicular fusion |
| HP:0005347 | 2.27305921704e-05 | 0.5 | FGFR2 FGFR1 | Cartilaginous trachea |
| WP:WP4540 | 2.38151267007e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Pathways Regulating Hippo Signaling |
| HP:0010055 | 2.57073928928e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Broad hallux |
| HP:0010051 | 3.01047192721e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Deviation of the hallux |
| REAC:R-HSA-1226099 | 3.15562563454e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Signaling by FGFR in disease |
| HP:0100266 | 3.2479768623e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Synostosis of carpals/tarsals |
| HP:0009843 | 3.2479768623e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of the middle phalanges of the hand |
| WP:WP3931 | 3.41541600995e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | ESC Pluripotency Pathways |
| HP:0009833 | 3.75977833456e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal middle phalanx morphology of the hand |
| WP:WP4541 | 3.85485625527e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Hippo-Merlin Signaling Dysregulation |
| HP:0000614 | 4.62400081268e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal nasolacrimal system morphology |
| HP:0001837 | 4.939024284e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Broad toe |
| HP:0100257 | 5.26802663748e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Ectrodactyly |
| HP:0000676 | 6.34193111797e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the incisor |
| HP:0002308 | 6.34193111797e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Arnold-Chiari malformation |
| HP:0005707 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Bilateral triphalangeal thumbs |
| HP:0009740 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Aplasia of the parotid gland |
| HP:0009637 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Absent proximal phalanx of thumb |
| HP:0009899 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Prominent crus of helix |
| HP:0007656 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Lacrimal gland aplasia |
| HP:0032107 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Limbal stem cell deficiency |
| HP:0007892 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Hypoplasia of the lacrimal punctum |
| HP:0009741 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Nephrosclerosis |
| HP:0100583 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Corneal perforation |
| HP:0009462 | 6.81856710606e-05 | 0.5 | FGFR2 FGFR3 | Radial deviation of the 3rd finger |
| KEGG:04550 | 8.0940739521e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP51 | 8.39876098155e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Regulation of Actin Cytoskeleton |
| HP:0011304 | 9.89611360418e-05 | 0.75 | FGFR2 FGFR3 FGFR1 | Broad thumb |
| WP:WP4223 | 0.000136289943844 | 0.75 | FGFR2 FGFR3 FGFR1 | Ras Signaling |
| HP:0007732 | 0.000136359131835 | 0.5 | FGFR2 FGFR3 | Lacrimal gland hypoplasia |
| HP:0005037 | 0.000136359131835 | 0.5 | FGFR2 FGFR3 | Proximal radio-ulnar synostosis |
| HP:0007900 | 0.000136359131835 | 0.5 | FGFR2 FGFR3 | Hypoplastic lacrimal duct |
| HP:0008743 | 0.000136359131835 | 0.5 | FGFR2 FGFR3 | Coronal hypospadias |
| HP:0000198 | 0.000136359131835 | 0.5 | FGFR2 FGFR3 | Absence of Stensen duct |
| HP:0009629 | 0.000136359131835 | 0.5 | FGFR2 FGFR3 | Aplasia/Hypoplasia of the proximal phalanx of the thumb |
| HP:0008080 | 0.000136359131835 | 0.5 | FGFR2 FGFR1 | Hallux varus |
| HP:0009317 | 0.000136359131835 | 0.5 | FGFR2 FGFR3 | Deviation of the 3rd finger |
| HP:0011318 | 0.000136359131835 | 0.5 | FGFR2 FGFR1 | Bicoronal synostosis |
| HP:0000678 | 0.00015941280611 | 0.75 | FGFR2 FGFR3 FGFR1 | Dental crowding |
| HP:0009768 | 0.000166542276482 | 0.75 | FGFR2 FGFR3 FGFR1 | Broad phalanges of the hand |
| HP:0001831 | 0.000173880942073 | 0.75 | FGFR2 FGFR3 FGFR1 | Short toe |
| HP:0001850 | 0.000205387753182 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the tarsal bones |
| HP:0006501 | 0.000213817536905 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of the radius |
| HP:0100538 | 0.000222474568357 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the supraorbital ridges |
| HP:0000601 | 0.000222474568357 | 0.75 | FGFR2 FGFR3 FGFR1 | Hypotelorism |
| KEGG:04015 | 0.000226248540233 | 0.75 | FGFR2 FGFR3 FGFR1 | Rap1 signaling pathway |
| HP:0011479 | 0.000227244870274 | 0.5 | FGFR2 FGFR3 | Abnormal lacrimal punctum morphology |
| HP:0008038 | 0.000227244870274 | 0.5 | FGFR2 FGFR3 | Aplastic/hypoplastic lacrimal glands |
| HP:0001092 | 0.000227244870274 | 0.5 | FGFR2 FGFR3 | Absent lacrimal punctum |
| KEGG:04014 | 0.00027234077557 | 0.75 | FGFR2 FGFR3 FGFR1 | Ras signaling pathway |
| KEGG:04810 | 0.000285912023079 | 0.75 | FGFR2 FGFR3 FGFR1 | Regulation of actin cytoskeleton |
| GO:0017134 | 0.000296207880886 | 0.75 | FGFR2 FGFR3 FGFR1 | fibroblast growth factor binding |
| HP:0004279 | 0.000300272400968 | 0.75 | FGFR2 FGFR3 FGFR1 | Short palm |
| HP:0100498 | 0.000311109885143 | 0.75 | FGFR2 FGFR3 FGFR1 | Deviation of toes |
| HP:0001500 | 0.000322204655363 | 0.75 | FGFR2 FGFR3 FGFR1 | Broad finger |
| HP:0000620 | 0.000340836782771 | 0.5 | FGFR2 FGFR3 | Dacryocystitis |
| HP:0011482 | 0.000340836782771 | 0.5 | FGFR2 FGFR3 | Abnormal lacrimal gland morphology |
| HP:0009618 | 0.000340836782771 | 0.5 | FGFR2 FGFR3 | Abnormality of the proximal phalanx of the thumb |
| HP:0001245 | 0.000340836782771 | 0.5 | FGFR2 FGFR3 | Small thenar eminence |
| HP:0010239 | 0.000340836782771 | 0.5 | FGFR2 FGFR3 | Aplasia of the middle phalanx of the hand |
| HP:0009895 | 0.000340836782771 | 0.5 | FGFR2 FGFR3 | Abnormality of the crus of the helix |
| HP:0001227 | 0.000340836782771 | 0.5 | FGFR2 FGFR3 | Abnormality of the thenar eminence |
| HP:0006503 | 0.00034517805512 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/hypoplasia involving forearm bones |
| HP:0009601 | 0.000357062683711 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of the thumb |
| HP:0100238 | 0.000369216596452 | 0.75 | FGFR2 FGFR3 FGFR1 | Synostosis involving bones of the upper limbs |
| WP:WP382 | 0.000385360586168 | 0.75 | FGFR2 FGFR3 FGFR1 | MAPK Signaling Pathway |
| HP:0000453 | 0.00039434426573 | 0.75 | FGFR2 FGFR3 FGFR1 | Choanal atresia |
| HP:0006009 | 0.00039434426573 | 0.75 | FGFR2 FGFR3 FGFR1 | Broad phalanx |
| HP:0000889 | 0.000420585039486 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the clavicle |
| HP:0001991 | 0.000434130330519 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of toe |
| HP:0001773 | 0.000447962884412 | 0.75 | FGFR2 FGFR3 FGFR1 | Short foot |
| HP:0000415 | 0.000462085695464 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the choanae |
| HP:0000327 | 0.000476501757358 | 0.75 | FGFR2 FGFR3 FGFR1 | Hypoplasia of the maxilla |
| HP:0004150 | 0.000477128766336 | 0.5 | FGFR2 FGFR3 | Abnormal 3rd finger morphology |
| HP:0000244 | 0.000477128766336 | 0.5 | FGFR2 FGFR1 | Brachyturricephaly |
| HP:0003070 | 0.000477128766336 | 0.5 | FGFR2 FGFR1 | Elbow ankylosis |
| HP:0009659 | 0.000477128766336 | 0.5 | FGFR2 FGFR3 | Partial absence of thumb |
| HP:0006110 | 0.000477128766336 | 0.5 | FGFR2 FGFR1 | Shortening of all middle phalanges of the fingers |
| HP:0005622 | 0.000491214063164 | 0.75 | FGFR2 FGFR3 FGFR1 | Broad long bones |
| HP:0010161 | 0.000491214063164 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the phalanges of the toes |
| HP:0003764 | 0.000491214063164 | 0.75 | FGFR2 FGFR3 FGFR1 | Nevus |
| WP:WP3932 | 0.000615604541072 | 0.75 | FGFR2 FGFR3 FGFR1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| HP:0001844 | 0.000619936255745 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the hallux |
| HP:3000022 | 0.000636114718594 | 0.5 | FGFR2 FGFR3 | Abnormality of cartilage of external ear |
| HP:0000197 | 0.000636114718594 | 0.5 | FGFR2 FGFR3 | Abnormal parotid gland morphology |
| HP:0000326 | 0.000673456927273 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the maxilla |
| HP:0000506 | 0.000710792961621 | 0.75 | FGFR2 FGFR3 FGFR1 | Telecanthus |
| KEGG:04010 | 0.000734165415649 | 0.75 | FGFR2 FGFR3 FGFR1 | MAPK signaling pathway |
| HP:0000104 | 0.000789545884353 | 0.75 | FGFR2 FGFR3 FGFR1 | Renal agenesis |
| HP:0001783 | 0.000817788537784 | 0.5 | FGFR2 FGFR1 | Broad metatarsal |
| HP:0001233 | 0.000817788537784 | 0.5 | FGFR2 FGFR3 | 2-3 finger syndactyly |
| WP:WP4172 | 0.000867148271367 | 0.75 | FGFR2 FGFR3 FGFR1 | PI3K-Akt Signaling Pathway |
| HP:0001363 | 0.000873899018529 | 0.75 | FGFR2 FGFR3 FGFR1 | Craniosynostosis |
| HP:0009602 | 0.00101134633775 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of thumb phalanx |
| HP:0003041 | 0.00102214412276 | 0.5 | FGFR2 FGFR1 | Humeroradial synostosis |
| HP:0003938 | 0.00102214412276 | 0.5 | FGFR2 FGFR1 | Synostosis involving the elbow |
| HP:0002781 | 0.00102214412276 | 0.5 | FGFR2 FGFR3 | Upper airway obstruction |
| HP:0009774 | 0.00108515711152 | 0.75 | FGFR2 FGFR3 FGFR1 | Triangular shaped phalanges of the hand |
| HP:0006711 | 0.00108515711152 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia involving bones of the thorax |
| KEGG:04151 | 0.00118089914293 | 0.75 | FGFR2 FGFR3 FGFR1 | PI3K-Akt signaling pathway |
| HP:0410007 | 0.00124917537299 | 0.5 | FGFR2 FGFR3 | Abnormality of cartilage morphology |
| HP:0009823 | 0.00124917537299 | 0.5 | FGFR2 FGFR3 | Aplasia involving bones of the upper limbs |
| HP:0009802 | 0.00124917537299 | 0.5 | FGFR2 FGFR3 | Aplasia of the phalanges of the hand |
| HP:0001428 | 0.00141618772939 | 0.75 | FGFR2 FGFR3 FGFR1 | Somatic mutation |
| HP:0100240 | 0.0014464612395 | 0.75 | FGFR2 FGFR3 FGFR1 | Synostosis of joints |
| HP:0009944 | 0.00149887618857 | 0.5 | FGFR2 FGFR3 | Partial duplication of thumb phalanx |
| HP:0011386 | 0.00149887618857 | 0.5 | FGFR2 FGFR3 | Narrow internal auditory canal |
| HP:0000680 | 0.00149887618857 | 0.5 | FGFR2 FGFR3 | Delayed eruption of primary teeth |
| HP:0000522 | 0.00149887618857 | 0.5 | FGFR2 FGFR3 | Alacrima |
| HP:0000248 | 0.00173850840205 | 0.75 | FGFR2 FGFR3 FGFR1 | Brachycephaly |
| HP:0009999 | 0.00177124047018 | 0.5 | FGFR2 FGFR3 | Partial duplication of the phalanx of hand |
| HP:0000495 | 0.00177124047018 | 0.5 | FGFR2 FGFR3 | Recurrent corneal erosions |
| HP:0003026 | 0.00177318858184 | 0.75 | FGFR2 FGFR3 FGFR1 | Short long bone |
| HP:0002818 | 0.00202891029227 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the radius |
| HP:0000606 | 0.00202891029227 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the periorbital region |
| HP:0009825 | 0.00206626211915 | 0.5 | FGFR2 FGFR3 | Aplasia involving bones of the extremities |
| HP:0000452 | 0.00206626211915 | 0.5 | FGFR2 FGFR1 | Choanal stenosis |
| HP:0010286 | 0.00206626211915 | 0.5 | FGFR2 FGFR3 | Abnormal salivary gland morphology |
| HP:0006101 | 0.00210622821499 | 0.75 | FGFR2 FGFR3 FGFR1 | Finger syndactyly |
| WP:WP474 | 0.00213272485195 | 0.5 | FGFR1 FGFR3 | Endochondral Ossification |
| HP:0009803 | 0.00230803713009 | 0.75 | FGFR2 FGFR3 FGFR1 | Short phalanx of finger |
| HP:0000410 | 0.00238393503741 | 0.5 | FGFR2 FGFR3 | Mixed hearing impairment |
| HP:0002780 | 0.00238393503741 | 0.5 | FGFR2 FGFR1 | Bronchomalacia |
| HP:0011384 | 0.00238393503741 | 0.5 | FGFR2 FGFR3 | Abnormality of the internal auditory canal |
| HP:0100761 | 0.00238393503741 | 0.5 | FGFR2 FGFR1 | Visceral angiomatosis |
| HP:0000586 | 0.00238393503741 | 0.5 | FGFR2 FGFR1 | Shallow orbits |
| HP:3000030 | 0.00238393503741 | 0.5 | FGFR2 FGFR1 | Abnormality of bony orbit of skull |
| HP:0000272 | 0.00243507881782 | 0.75 | FGFR2 FGFR3 FGFR1 | Malar flattening |
| HP:0040072 | 0.00247843647398 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of forearm bone |
| HP:0006482 | 0.00256668512029 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of dental morphology |
| HP:0002973 | 0.00256668512029 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the forearm |
| HP:0006292 | 0.00261158200619 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of dental eruption |
| HP:0100700 | 0.00272425312749 | 0.5 | FGFR2 FGFR1 | Abnormal arachnoid mater morphology |
| HP:0100702 | 0.00272425312749 | 0.5 | FGFR2 FGFR1 | Arachnoid cyst |
| HP:0010059 | 0.00272425312749 | 0.5 | FGFR2 FGFR1 | Broad hallux phalanx |
| HP:0000633 | 0.00272425312749 | 0.5 | FGFR2 FGFR3 | Decreased lacrimation |
| HP:0012369 | 0.00279638872284 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of malar bones |
| HP:0000520 | 0.00289196481854 | 0.75 | FGFR2 FGFR3 FGFR1 | Proptosis |
| HP:0007461 | 0.00308721029257 | 0.5 | FGFR2 FGFR1 | Hemangiomatosis |
| HP:0002410 | 0.00308721029257 | 0.5 | FGFR2 FGFR1 | Aqueductal stenosis |
| HP:0000348 | 0.00308958022705 | 0.75 | FGFR2 FGFR3 FGFR1 | High forehead |
| HP:0009811 | 0.00324353975762 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the elbow |
| HP:0009826 | 0.00334896067328 | 0.75 | FGFR2 FGFR3 FGFR1 | Limb undergrowth |
| HP:0009767 | 0.00334896067328 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of the phalanges of the hand |
| HP:0006487 | 0.00345663399483 | 0.75 | FGFR2 FGFR3 FGFR1 | Bowing of the long bones |
| HP:0031013 | 0.00347280043641 | 0.5 | FGFR2 FGFR1 | Ankylosis |
| HP:0011065 | 0.00347280043641 | 0.5 | FGFR2 FGFR3 | Conical incisor |
| HP:0006504 | 0.00367883182322 | 0.75 | FGFR2 FGFR3 FGFR1 | Anomaly of the limb diaphyses |
| HP:0010668 | 0.00367883182322 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the zygomatic bone |
| HP:0006494 | 0.00373582573203 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia involving bones of the feet |
| HP:0000579 | 0.0038810174634 | 0.5 | FGFR2 FGFR3 | Nasolacrimal duct obstruction |
| WP:WP4657 | 0.00403274972955 | 0.5 | FGFR2 FGFR1 | 22q11.2 Deletion Syndrome |
| HP:0000882 | 0.00431185527855 | 0.5 | FGFR1 FGFR3 | Hypoplastic scapulae |
| KEGG:05200 | 0.00437599198048 | 0.75 | FGFR2 FGFR3 FGFR1 | Pathways in cancer |
| GO:0010518 | 0.00447413621813 | 0.75 | FGFR2 FGFR3 FGFR1 | positive regulation of phospholipase activity |
| HP:0011800 | 0.00453092547626 | 0.75 | FGFR2 FGFR3 FGFR1 | Midface retrusion |
| HP:0000940 | 0.00493294361038 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal diaphysis morphology |
| HP:0009381 | 0.00500216701819 | 0.75 | FGFR2 FGFR3 FGFR1 | Short finger |
| HP:0009804 | 0.00507203261353 | 0.75 | FGFR2 FGFR3 FGFR1 | Reduced number of teeth |
| HP:0006713 | 0.00524136889643 | 0.5 | FGFR1 FGFR3 | Aplasia/Hypoplasia of the scapulae |
| HP:0002032 | 0.00524136889643 | 0.5 | FGFR2 FGFR1 | Esophageal atresia |
| HP:0001355 | 0.00524136889643 | 0.5 | FGFR2 FGFR3 | Megalencephaly |
| HP:0008678 | 0.00535797527086 | 0.75 | FGFR2 FGFR3 FGFR1 | Renal hypoplasia/aplasia |
| KEGG:01521 | 0.00537705972469 | 0.5 | FGFR2 FGFR3 | EGFR tyrosine kinase inhibitor resistance |
| HP:0012385 | 0.00543109559899 | 0.75 | FGFR2 FGFR3 FGFR1 | Camptodactyly |
| HP:0000692 | 0.0055048756284 | 0.75 | FGFR2 FGFR3 FGFR1 | Misalignment of teeth |
| WP:WP2261 | 0.00553968457037 | 0.5 | FGFR2 FGFR1 | Signaling Pathways in Glioblastoma |
| HP:0009738 | 0.00574003251223 | 0.5 | FGFR2 FGFR3 | Abnormality of the antihelix |
| HP:0011329 | 0.00588377336147 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of cranial sutures |
| HP:0003974 | 0.00626129254237 | 0.5 | FGFR2 FGFR3 | Absent radius |
| HP:0030044 | 0.00669272218892 | 0.75 | FGFR2 FGFR3 FGFR1 | Flexion contracture of digit |
| HP:0006483 | 0.00677745370645 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal number of teeth |
| HP:0009822 | 0.00680514289491 | 0.5 | FGFR2 FGFR3 | Aplasia involving forearm bones |
| HP:0001377 | 0.00680514289491 | 0.5 | FGFR2 FGFR3 | Limited elbow extension |
| HP:0003953 | 0.00680514289491 | 0.5 | FGFR2 FGFR3 | Absent forearm bone |
| HP:0010109 | 0.00680514289491 | 0.5 | FGFR2 FGFR1 | Short hallux |
| HP:0000047 | 0.00703591510403 | 0.75 | FGFR2 FGFR3 FGFR1 | Hypospadias |
| HP:0011481 | 0.00737157747856 | 0.5 | FGFR2 FGFR3 | Abnormal lacrimal duct morphology |
| HP:0009942 | 0.00737157747856 | 0.5 | FGFR2 FGFR3 | Duplication of thumb phalanx |
| GO:0010517 | 0.00754689803038 | 0.75 | FGFR2 FGFR3 FGFR1 | regulation of phospholipase activity |
| GO:0060193 | 0.00754689803038 | 0.75 | FGFR2 FGFR3 FGFR1 | positive regulation of lipase activity |
| HP:0003312 | 0.00775694691432 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal form of the vertebral bodies |
| HP:0006265 | 0.00785038055614 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of fingers |
| HP:0008362 | 0.00796059020261 | 0.5 | FGFR2 FGFR1 | Aplasia/Hypoplasia of the hallux |
| HP:0000243 | 0.00796059020261 | 0.5 | FGFR2 FGFR1 | Trigonocephaly |
| KEGG:05215 | 0.00796156937098 | 0.5 | FGFR2 FGFR1 | Prostate cancer |
| HP:0100627 | 0.00823158450003 | 0.75 | FGFR2 FGFR3 FGFR1 | Displacement of the urethral meatus |
| HP:0032076 | 0.00823158450003 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal male urethral meatus morphology |
| HP:0006493 | 0.00832876732039 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/hypoplasia involving bones of the lower limbs |
| REAC:R-HSA-5663202 | 0.00839415877685 | 0.75 | FGFR2 FGFR3 FGFR1 | Diseases of signal transduction |
| HP:0002438 | 0.00852541144013 | 0.75 | FGFR2 FGFR3 FGFR1 | Cerebellar malformation |
| HP:0002761 | 0.00857217497701 | 0.5 | FGFR1 FGFR3 | Generalized joint laxity |
| HP:0007360 | 0.00862487853069 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of the cerebellum |
| HP:0001172 | 0.00872511283479 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal thumb morphology |
| HP:0001156 | 0.00872511283479 | 0.75 | FGFR2 FGFR3 FGFR1 | Brachydactyly |
| HP:0000643 | 0.00920632571228 | 0.5 | FGFR2 FGFR3 | Blepharospasm |
| HP:0000698 | 0.00920632571228 | 0.5 | FGFR2 FGFR3 | Conical tooth |
| HP:0009658 | 0.00920632571228 | 0.5 | FGFR2 FGFR3 | Aplasia/Hypoplasia of the phalanges of the thumb |
| HP:0011063 | 0.00920632571228 | 0.5 | FGFR2 FGFR3 | Abnormality of incisor morphology |
| HP:0001631 | 0.00966222349698 | 0.75 | FGFR2 FGFR3 FGFR1 | Atrial septal defect |
| HP:0011994 | 0.00977028900793 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal atrial septum morphology |
| HP:0100871 | 0.00977028900793 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the palm |
| HP:0007392 | 0.00986303631958 | 0.5 | FGFR2 FGFR3 | Excessive wrinkled skin |
| GO:0004714 | 0.0100430829723 | 0.75 | FGFR2 FGFR3 FGFR1 | transmembrane receptor protein tyrosine kinase activity |
| HP:0009702 | 0.0105423007107 | 0.5 | FGFR2 FGFR3 | Carpal synostosis |
| HP:0003319 | 0.0107791805948 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the cervical spine |
| HP:0005120 | 0.0107791805948 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal cardiac atrium morphology |
| HP:0001376 | 0.0110123794702 | 0.75 | FGFR2 FGFR3 FGFR1 | Limitation of joint mobility |
| HP:0005922 | 0.0111302235782 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal hand morphology |
| HP:0011218 | 0.0111302235782 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal shape of the frontal region |
| HP:0002007 | 0.0111302235782 | 0.75 | FGFR2 FGFR3 FGFR1 | Frontal bossing |
| HP:0100728 | 0.011244112798 | 0.5 | FGFR2 FGFR3 | Germ cell neoplasia |
| HP:0031879 | 0.011244112798 | 0.5 | FGFR2 FGFR3 | Abnormal eyelid physiology |
| HP:0032040 | 0.011244112798 | 0.5 | FGFR2 FGFR3 | Abnormal ocular adnexa physiology |
| HP:0100744 | 0.011244112798 | 0.5 | FGFR2 FGFR1 | Abnormality of the humeroradial joint |
| HP:0010174 | 0.011244112798 | 0.5 | FGFR2 FGFR1 | Broad phalanx of the toes |
| HP:0000238 | 0.0116099650177 | 0.75 | FGFR2 FGFR3 FGFR1 | Hydrocephalus |
| HP:0010057 | 0.0119684664945 | 0.5 | FGFR2 FGFR1 | Abnormality of the phalanges of the hallux |
| HP:0002360 | 0.0124821610367 | 0.75 | FGFR2 FGFR3 FGFR1 | Sleep disturbance |
| HP:0002980 | 0.0127153557137 | 0.5 | FGFR2 FGFR3 | Femoral bowing |
| HP:0000956 | 0.0127153557137 | 0.5 | FGFR2 FGFR3 | Acanthosis nigricans |
| HP:0000378 | 0.0127153557137 | 0.5 | FGFR2 FGFR3 | Cupped ear |
| HP:0000795 | 0.013131058654 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the urethra |
| HP:0001159 | 0.0132634655705 | 0.75 | FGFR2 FGFR3 FGFR1 | Syndactyly |
| HP:0000235 | 0.0136659927723 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the fontanelles or cranial sutures |
| HP:0002984 | 0.0142767163782 | 0.5 | FGFR2 FGFR3 | Hypoplasia of the radius |
| HP:0001822 | 0.0150911756538 | 0.5 | FGFR2 FGFR3 | Hallux valgus |
| HP:0002692 | 0.0150911756538 | 0.5 | FGFR2 FGFR1 | Hypoplastic facial bones |
| HP:0010807 | 0.0150911756538 | 0.5 | FGFR2 FGFR3 | Open bite |
| HP:0004278 | 0.0150911756538 | 0.5 | FGFR2 FGFR3 | Synostosis involving bones of the hand |
| HP:0010743 | 0.0159281461127 | 0.5 | FGFR2 FGFR1 | Short metatarsal |
| HP:0200020 | 0.0159281461127 | 0.5 | FGFR2 FGFR3 | Corneal erosion |
| HP:0000256 | 0.015950139398 | 0.75 | FGFR2 FGFR3 FGFR1 | Macrocephaly |
| HP:0040194 | 0.015950139398 | 0.75 | FGFR2 FGFR3 FGFR1 | Increased head circumference |
| HP:0011368 | 0.0162522818241 | 0.75 | FGFR2 FGFR3 FGFR1 | Epidermal thickening |
| HP:0002991 | 0.0167876216717 | 0.5 | FGFR2 FGFR3 | Abnormality of fibula morphology |
| HP:0040070 | 0.0173396229329 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal upper limb bone morphology |
| HP:0003063 | 0.0176695962482 | 0.5 | FGFR2 FGFR1 | Abnormality of the humerus |
| HP:0009380 | 0.0176695962482 | 0.5 | FGFR2 FGFR3 | Aplasia of the fingers |
| HP:0003468 | 0.0179820752901 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal vertebral morphology |
| HP:0001000 | 0.0184741317158 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of skin pigmentation |
| HP:0100678 | 0.01857406376 | 0.5 | FGFR2 FGFR3 | Premature skin wrinkling |
| HP:0001964 | 0.0195010181256 | 0.5 | FGFR2 FGFR1 | Aplasia/Hypoplasia of metatarsal bones |
| HP:0006481 | 0.0195010181256 | 0.5 | FGFR2 FGFR3 | Abnormality of primary teeth |
| GO:0060191 | 0.0198185309013 | 0.75 | FGFR2 FGFR3 FGFR1 | regulation of lipase activity |
| GO:0019199 | 0.0206918321066 | 0.75 | FGFR2 FGFR3 FGFR1 | transmembrane receptor protein kinase activity |
| HP:0000494 | 0.021249656241 | 0.75 | FGFR2 FGFR3 FGFR1 | Downslanted palpebral fissures |
| HP:0001199 | 0.0214223630957 | 0.5 | FGFR2 FGFR3 | Triphalangeal thumb |
| HP:0000974 | 0.0214223630957 | 0.5 | FGFR2 FGFR3 | Hyperextensible skin |
| HP:0009891 | 0.0214223630957 | 0.5 | FGFR2 FGFR3 | Underdeveloped supraorbital ridges |
| HP:0030084 | 0.02161486314 | 0.75 | FGFR2 FGFR3 FGFR1 | Clinodactyly |
| HP:0001072 | 0.0219842049556 | 0.75 | FGFR2 FGFR3 FGFR1 | Thickened skin |
| HP:0005280 | 0.0229257986494 | 0.75 | FGFR2 FGFR3 FGFR1 | Depressed nasal bridge |
| HP:0005927 | 0.0231172667769 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/hypoplasia involving bones of the hand |
| HP:0001171 | 0.023433582519 | 0.5 | FGFR1 FGFR3 | Split hand |
| HP:0000995 | 0.0244728799535 | 0.5 | FGFR2 FGFR3 | Melanocytic nevus |
| CORUM:6834 | 0.0249595281251 | 0.25 | FGFR1 | FGF21-FGFR1c-KLB complex |
| CORUM:6828 | 0.0249595281251 | 0.25 | FGFR1 | FGF21-FGFR1c-KLB complex |
| CORUM:912 | 0.0249595281251 | 0.25 | FGFR1 | FGFR1-KAL11 complex |
| CORUM:6836 | 0.0249595281251 | 0.25 | FGFR1 | FGFR1c-KLB complex |
| HP:0000286 | 0.0254980935409 | 0.75 | FGFR2 FGFR3 FGFR1 | Epicanthus |
| HP:0000217 | 0.025534627766 | 0.5 | FGFR2 FGFR3 | Xerostomia |
| HP:0009810 | 0.0257035156736 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of upper limb joint |
| HP:0000629 | 0.0266188198793 | 0.5 | FGFR2 FGFR3 | Periorbital fullness |
| GO:0008543 | 0.0275320606423 | 0.75 | FGFR2 FGFR3 FGFR1 | fibroblast growth factor receptor signaling pathway |
| HP:0001454 | 0.0277254502169 | 0.5 | FGFR2 FGFR1 | Abnormality of the upper arm |
| HP:0040071 | 0.0277254502169 | 0.5 | FGFR2 FGFR3 | Abnormal morphology of ulna |
| HP:0003022 | 0.0277254502169 | 0.5 | FGFR2 FGFR3 | Hypoplasia of the ulna |
| HP:0030962 | 0.0286954928674 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal morphology of the great vessels |
| HP:0045009 | 0.0288545127028 | 0.5 | FGFR2 FGFR3 | Abnormal morphology of the radius |
| HP:0002589 | 0.0288545127028 | 0.5 | FGFR2 FGFR1 | Gastrointestinal atresia |
| HP:0006297 | 0.0288545127028 | 0.5 | FGFR2 FGFR3 | Hypoplasia of dental enamel |
| HP:0009466 | 0.0288545127028 | 0.5 | FGFR2 FGFR3 | Radial deviation of finger |
| HP:0002921 | 0.0295907808511 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the cerebrospinal fluid |
| HP:0006496 | 0.0295907808511 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/hypoplasia involving bones of the upper limbs |
| HP:0011927 | 0.0319094681526 | 0.75 | FGFR2 FGFR3 FGFR1 | Short digit |
| GO:0048705 | 0.0320435644688 | 0.75 | FGFR2 FGFR3 FGFR1 | skeletal system morphogenesis |
| HP:0001360 | 0.0323762323007 | 0.5 | FGFR1 FGFR3 | Holoprosencephaly |
| HP:0011390 | 0.0323762323007 | 0.5 | FGFR2 FGFR3 | Morphological abnormality of the inner ear |
| HP:0001421 | 0.0335949626331 | 0.5 | FGFR2 FGFR3 | Abnormality of the musculature of the hand |
| HP:0000646 | 0.0335949626331 | 0.5 | FGFR2 FGFR3 | Amblyopia |
| HP:0000270 | 0.0348360947433 | 0.5 | FGFR2 FGFR3 | Delayed cranial suture closure |
| HP:0009485 | 0.0348360947433 | 0.5 | FGFR2 FGFR3 | Radial deviation of the hand or of fingers of the hand |
| HP:0006495 | 0.0348360947433 | 0.5 | FGFR2 FGFR3 | Aplasia/Hypoplasia of the ulna |
| HP:0010760 | 0.0348360947433 | 0.5 | FGFR2 FGFR1 | Absent toe |
| HP:0000309 | 0.0356081268728 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the midface |
| HP:0000632 | 0.0360996225593 | 0.5 | FGFR2 FGFR3 | Lacrimation abnormality |
| HP:0006753 | 0.0360996225593 | 0.5 | FGFR2 FGFR3 | Neoplasm of the stomach |
| HP:0008905 | 0.0373855400094 | 0.5 | FGFR1 FGFR3 | Rhizomelia |
| HP:0000294 | 0.0373855400094 | 0.5 | FGFR2 FGFR3 | Low anterior hairline |
| HP:0000444 | 0.0373855400094 | 0.5 | FGFR2 FGFR3 | Convex nasal ridge |
| HP:0000008 | 0.0384935507247 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of female internal genitalia |
| HP:0001357 | 0.0386938410225 | 0.5 | FGFR2 FGFR3 | Plagiocephaly |
| HP:0010535 | 0.0386938410225 | 0.5 | FGFR2 FGFR3 | Sleep apnea |
| HP:0007598 | 0.0386938410225 | 0.5 | FGFR2 FGFR3 | Bilateral single transverse palmar creases |
| HP:0002974 | 0.0386938410225 | 0.5 | FGFR2 FGFR3 | Radioulnar synostosis |
| HP:0002093 | 0.0393064686239 | 0.75 | FGFR2 FGFR3 FGFR1 | Respiratory insufficiency |
| HP:0000175 | 0.0393064686239 | 0.75 | FGFR2 FGFR3 FGFR1 | Cleft palate |
| HP:0100737 | 0.0395799438517 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal hard palate morphology |
| HP:0012179 | 0.0413775694569 | 0.5 | FGFR2 FGFR3 | Craniofacial dystonia |
| HP:0000463 | 0.0418131938681 | 0.75 | FGFR2 FGFR3 FGFR1 | Anteverted nares |
| GO:0044344 | 0.0439367749778 | 0.75 | FGFR2 FGFR3 FGFR1 | cellular response to fibroblast growth factor stimulus |
| HP:0001671 | 0.0450177785718 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal cardiac septum morphology |
| HP:0005288 | 0.0453169017901 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of the nares |
| HP:0010622 | 0.0455708870915 | 0.5 | FGFR1 FGFR3 | Neoplasm of the skeletal system |
| GO:0071774 | 0.0469269676219 | 0.75 | FGFR2 FGFR3 FGFR1 | response to fibroblast growth factor |
| HP:0012640 | 0.0470133620262 | 0.5 | FGFR2 FGFR3 | Abnormality of intracranial pressure |
| HP:0001191 | 0.0470133620262 | 0.5 | FGFR2 FGFR3 | Abnormality of the carpal bones |
| HP:0002516 | 0.0470133620262 | 0.5 | FGFR2 FGFR3 | Increased intracranial pressure |
| HP:0010609 | 0.0470133620262 | 0.5 | FGFR2 FGFR1 | Skin tags |
| HP:0100491 | 0.0471392817231 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormality of lower limb joint |
| HP:0000812 | 0.0477573380446 | 0.75 | FGFR2 FGFR3 FGFR1 | Abnormal internal genitalia |
| HP:0045060 | 0.0480683654971 | 0.75 | FGFR2 FGFR3 FGFR1 | Aplasia/hypoplasia involving bones of the extremities |
| HP:0000260 | 0.048478178044 | 0.5 | FGFR2 FGFR3 | Wide anterior fontanel |
| HP:0000685 | 0.048478178044 | 0.5 | FGFR2 FGFR3 | Hypoplasia of teeth |
| HP:0000218 | 0.0490094782727 | 0.75 | FGFR2 FGFR3 FGFR1 | High palate |
| HP:0000202 | 0.0496436065013 | 0.75 | FGFR2 FGFR3 FGFR1 | Oral cleft |
| REAC:R-HSA-8853333 | 0.0499190562503 | 0.25 | FGFR2 | Signaling by FGFR2 fusions |
| REAC:R-HSA-2033515 | 0.0499190562503 | 0.25 | FGFR3 | t(4;14) translocations of FGFR3 |
| REAC:R-HSA-2023837 | 0.0499190562503 | 0.25 | FGFR2 | Signaling by FGFR2 amplification mutants |
| HP:0100258 | 0.049965329079 | 0.5 | FGFR2 FGFR3 | Preaxial polydactyly |
| HP:0009821 | 0.049965329079 | 0.5 | FGFR2 FGFR3 | Forearm undergrowth |
| HP:0004691 | 0.049965329079 | 0.5 | FGFR2 FGFR1 | 2-3 toe syndactyly |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FGFR2 | FGFR3 | 0.995 | 0.924 | bioplex (FGFR2) bioplex_WMM |
| FGFR2 | FGFR1 | 0.707 | 0.729 | bioplex (FGFR2) bioplex_WMM |
| FGFR2 | C8orf74 | 0.535 | 0.64 | bioplex (C8orf74) bioplex_WMM |
| FGFR1 | FGFR3 | 0.008 | 0.068 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_02095 has an average edge precision of 0.59 which is ranked 1989 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FGFR1 | HuMAP2_02095 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
| FGFR2 | HuMAP2_02095 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
| FGFR3 | HuMAP2_02095 HuMAP2_02142 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
| C8orf74 | HuMAP2_02095 HuMAP2_06014 HuMAP2_06930 |