hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02097

Confidence: Medium

Genename	Protein Name	Links
PLIN5	Perilipin-5 (Lipid storage droplet protein 5)	UniProt NCBI
KDM5B	Lysine-specific demethylase 5B (EC 1.14.11.-) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1)	UniProt NCBI
PSIP1	PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)	UniProt NCBI
NSUN5	Probable 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)	UniProt NCBI
RBM15	RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)	UniProt NCBI
METAP2	Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)	UniProt NCBI
CDC123	Cell division cycle protein 123 homolog (Protein D123) (HT-1080) (PZ32)	UniProt NCBI
PYM1	Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog)	UniProt NCBI
EIF2S3	Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX)	UniProt NCBI
ABCF1	ATP-binding cassette sub-family F member 1 (ATP-binding cassette 50) (TNF-alpha-stimulated ABC protein)	UniProt NCBI
EIF2S1	Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)	UniProt NCBI
EIF2S2	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5183	1.38505101379e-06	0.25	EIF2S3 EIF2S2 EIF2S1	DNA-PK-Ku-eIF2-NF90-NF45 complex
REAC:R-HSA-72731	5.39300056579e-06	0.25	EIF2S3 EIF2S2 EIF2S1	Recycling of eIF2:GDP
GO:0005850	7.98841194917e-05	0.25	EIF2S3 EIF2S2 EIF2S1	eukaryotic translation initiation factor 2 complex
REAC:R-HSA-382556	0.000210799555282	0.333333333333	EIF2S1 EIF2S3 EIF2S2 ABCF1	ABC-family proteins mediated transport
KEGG:03013	0.000225952692186	0.333333333333	EIF2S3 EIF2S2 PYM1 EIF2S1	RNA transport
REAC:R-HSA-381042	0.000348557527296	0.25	EIF2S3 EIF2S2 EIF2S1	PERK regulates gene expression
WP:WP107	0.000515946869325	0.25	EIF2S3 EIF2S2 EIF2S1	Translation Factors
REAC:R-HSA-72695	0.0020862454363	0.25	EIF2S3 EIF2S2 EIF2S1	Formation of the ternary complex, and subsequently, the 43S complex
REAC:R-HSA-72649	0.00305912137419	0.25	EIF2S3 EIF2S2 EIF2S1	Translation initiation complex formation
REAC:R-HSA-72702	0.00305912137419	0.25	EIF2S3 EIF2S2 EIF2S1	Ribosomal scanning and start codon recognition
REAC:R-HSA-72662	0.00321866618985	0.25	EIF2S3 EIF2S2 EIF2S1	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
GO:0003723	0.00566001652275	0.75	RBM15 EIF2S3 PSIP1 ABCF1 PYM1 METAP2 EIF2S2 EIF2S1 NSUN5	RNA binding
REAC:R-HSA-381119	0.00855235242932	0.25	EIF2S3 EIF2S2 EIF2S1	Unfolded Protein Response (UPR)
GO:0008135	0.0113997157607	0.333333333333	EIF2S1 EIF2S3 EIF2S2 ABCF1	translation factor activity, RNA binding
REAC:R-HSA-156827	0.0198437415335	0.25	EIF2S3 EIF2S2 EIF2S1	L13a-mediated translational silencing of Ceruloplasmin expression
REAC:R-HSA-72706	0.0203856887088	0.25	EIF2S3 EIF2S2 EIF2S1	GTP hydrolysis and joining of the 60S ribosomal subunit
REAC:R-HSA-72613	0.0244527203378	0.25	EIF2S3 EIF2S2 EIF2S1	Eukaryotic Translation Initiation
REAC:R-HSA-72737	0.0244527203378	0.25	EIF2S3 EIF2S2 EIF2S1	Cap-dependent Translation Initiation
GO:0090079	0.0259358061847	0.333333333333	EIF2S1 EIF2S3 EIF2S2 ABCF1	translation regulator activity, nucleic acid binding
GO:0003676	0.0458659567102	0.833333333333	RBM15 KDM5B EIF2S3 PSIP1 ABCF1 PYM1 METAP2 EIF2S2 EIF2S1 NSUN5	nucleic acid binding

Edges

Protein 1	Protein 2	Score	Precision	Evidence
EIF2S3	EIF2S2	1.0	0.949	hein_WMM bioplex (EIF2S2) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM
EIF2S1	EIF2S3	0.981	0.896	hein_WMM bioplex_WMM Malo gupta_WMM fraction treiber_WMM
CDC123	EIF2S2	0.884	0.816	bioplex (EIF2S2) bioplex_WMM youn_WMM gupta_WMM
EIF2S1	EIF2S2	0.511	0.63	hein_WMM bioplex (EIF2S2) bioplex_WMM Malo gupta_WMM fraction treiber_WMM
EIF2S2	PSIP1	0.291	0.493	hein_WMM bioplex (EIF2S2) bioplex_WMM youn_WMM gupta_WMM fraction
EIF2S2	PYM1	0.197	0.45	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
ABCF1	PSIP1	0.152	0.409	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
EIF2S2	RBM15	0.055	0.304	Guru youn_WMM gupta_WMM fraction
EIF2S2	METAP2	0.047	0.29	bioplex_WMM gupta_WMM fraction treiber_WMM
EIF2S2	ABCF1	0.047	0.293	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
EIF2S1	PSIP1	0.046	0.293	hein_WMM bioplex_WMM gupta_WMM fraction
EIF2S3	METAP2	0.034	0.264	bioplex_WMM gupta_WMM fraction treiber_WMM
EIF2S1	KDM5B	0.027	0.23	fraction
EIF2S3	PYM1	0.026	0.221	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
METAP2	PLIN5	0.024	0.215	bioplex (PLIN5) bioplex_WMM
EIF2S3	RBM15	0.023	0.207	bioplex_WMM youn_WMM gupta_WMM fraction
ABCF1	NSUN5	0.022	0.21	bioplex_WMM fraction
RBM15	ABCF1	0.021	0.195	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
EIF2S3	ABCF1	0.009	0.109	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
EIF2S1	RBM15	0.009	0.09	bioplex_WMM gupta_WMM fraction
CDC123	ABCF1	0.007	0.007	bioplex_WMM youn_WMM gupta_WMM WMM_only
EIF2S1	CDC123	0.007	0.009	bioplex_WMM gupta_WMM WMM_only
CDC123	PSIP1	0.007	0.01	bioplex_WMM youn_WMM gupta_WMM WMM_only
CDC123	PYM1	0.007	0.006	bioplex_WMM youn_WMM gupta_WMM WMM_only
CDC123	EIF2S3	0.007	0.005	bioplex_WMM youn_WMM gupta_WMM WMM_only
CDC123	METAP2	0.007	0.0	bioplex_WMM WMM_only
PYM1	ABCF1	0.007	0.002	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
PSIP1	NSUN5	0.007	0.002	bioplex_WMM WMM_only
METAP2	NSUN5	0.007	0.002	WMM_only treiber_WMM
CDC123	RBM15	0.007	0.003	bioplex_WMM youn_WMM gupta_WMM WMM_only
RBM15	NSUN5	0.006	0.011	bioplex_WMM WMM_only
CDC123	NSUN5	0.006	0.002	bioplex_WMM WMM_only
EIF2S3	PSIP1	0.005	0.01	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
RBM15	PSIP1	0.004	0.012	bioplex_WMM youn_WMM gupta_WMM fraction
PYM1	KDM5B	0.004	0.011	fraction
EIF2S2	KDM5B	0.003	0.011	fraction
PYM1	PSIP1	0.003	0.011	hein_WMM bioplex (PYM1) bioplex_WMM youn_WMM gupta_WMM fraction
RBM15	PYM1	0.0	0.009	youn_WMM gupta_WMM fraction
METAP2	RBM15	0.0	0.009	bioplex_WMM gupta_WMM fraction
METAP2	ABCF1	0.0	0.009	bioplex_WMM gupta_WMM fraction treiber_WMM
EIF2S1	ABCF1	0.0	0.013	hein_WMM bioplex_WMM gupta_WMM fraction
EIF2S2	NSUN5	0.0	0.012	hein_WMM fraction treiber_WMM
METAP2	PSIP1	0.0	0.009	bioplex_WMM gupta_WMM fraction
EIF2S1	METAP2	0.0	0.009	bioplex_WMM gupta_WMM fraction treiber_WMM
EIF2S3	NSUN5	0.0	0.002	bioplex_WMM fraction treiber_WMM
METAP2	PYM1	0.0	0.003	gupta_WMM fraction
EIF2S1	PYM1	0.0	0.0	hein_WMM bioplex_WMM gupta_WMM fraction
EIF2S1	NSUN5	0.0	0.002	bioplex_WMM fraction treiber_WMM

Images

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Complex HuMAP2_02097 has an average edge precision of 0.162 which is ranked 6614 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PLIN5	HuMAP2_01153 HuMAP2_02097 HuMAP2_03942 HuMAP2_04383
KDM5B	HuMAP2_02097 HuMAP2_03945 HuMAP2_05219
PSIP1	HuMAP2_02097 HuMAP2_03090
NSUN5	HuMAP2_02097 HuMAP2_04156
RBM15	HuMAP2_00310 HuMAP2_02097
METAP2	HuMAP2_00198 HuMAP2_01153 HuMAP2_02097 HuMAP2_03090 HuMAP2_03942 HuMAP2_04383 HuMAP2_05064 HuMAP2_05786
CDC123	HuMAP2_00042 HuMAP2_01153 HuMAP2_02097 HuMAP2_03090 HuMAP2_04659 HuMAP2_05064 HuMAP2_05786
PYM1	HuMAP2_00752 HuMAP2_01153 HuMAP2_02097 HuMAP2_02221 HuMAP2_02422 HuMAP2_03053 HuMAP2_03472 HuMAP2_05786
EIF2S3	HuMAP2_00042 HuMAP2_00747 HuMAP2_01153 HuMAP2_02097 HuMAP2_03090 HuMAP2_03390 HuMAP2_05064 HuMAP2_05679
ABCF1	HuMAP2_02097 HuMAP2_03090 HuMAP2_04156 HuMAP2_05213
EIF2S1	HuMAP2_00042 HuMAP2_02097 HuMAP2_03090 HuMAP2_05064 HuMAP2_05679
EIF2S2	HuMAP2_00042 HuMAP2_01153 HuMAP2_02097 HuMAP2_03090 HuMAP2_04659 HuMAP2_05064 HuMAP2_05786

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02097