hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02103
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BMP1 | Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) | UniProt NCBI |
| TLL1 | Tolloid-like protein 1 (EC 3.4.24.-) | UniProt NCBI |
| TLL2 | Tolloid-like protein 2 (EC 3.4.24.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2214320 | 2.04566594508e-07 | 1.0 | TLL1 BMP1 TLL2 | Anchoring fibril formation |
| REAC:R-HSA-2243919 | 3.66871079381e-07 | 1.0 | TLL1 BMP1 TLL2 | Crosslinking of collagen fibrils |
| REAC:R-HSA-2022090 | 1.24628263731e-05 | 1.0 | TLL1 BMP1 TLL2 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1650814 | 1.70037551742e-05 | 1.0 | TLL1 BMP1 TLL2 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 4.28393920683e-05 | 1.0 | TLL1 BMP1 TLL2 | Collagen formation |
| REAC:R-HSA-1474228 | 0.000153481595091 | 1.0 | TLL1 BMP1 TLL2 | Degradation of the extracellular matrix |
| REAC:R-HSA-1474244 | 0.00141029783843 | 1.0 | TLL1 BMP1 TLL2 | Extracellular matrix organization |
| GO:0022617 | 0.0051907357126 | 1.0 | TLL1 BMP1 TLL2 | extracellular matrix disassembly |
| WP:WP3930 | 0.0499785733994 | 0.333333333333 | BMP1 | EDA Signalling in Hair Follicle Development |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BMP1 | TLL2 | 0.984 | 0.899 | bioplex (BMP1) bioplex_WMM |
| BMP1 | TLL1 | 0.976 | 0.892 | bioplex (BMP1) bioplex_WMM |
| TLL1 | TLL2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02103 has an average edge precision of 0.629 which is ranked 1788 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BMP1 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |
| TLL1 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |
| TLL2 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |